Clinical trials: sponsored by University of Toronto
Schizophrenia, Schizophrenia Spectrum Disorder
tDCS and Executive Function Training for Schizophrenia
Schizophrenia-spectrum disorders are the most persistent, debilitating, and economically burdensome mental illnesses worldwide. Cognitive remediation (CR) is a psychological intervention based on principles of learning and…
- Conditions
- Schizophrenia, Schizophrenia Spectrum Disorder, Schizophrenia and Related Disorders
- Trial name
- NCT05389345
- Testing
- Transcranial direct current stimulation, Executive function training
- Where
- Canada
- Sponsor
- University of Toronto
Nutrition, Healthy
Effect of Green Coffee Extract Combined With Alpha-Lipoic Acid on Blood Glucose Homeostasis in Healthy Adults
Green coffee extract (GCE) supplementation has been shown to induce favourable health benefits on glucose metabolism and weight management.
- Trial name
- GCE (NCT06121713)
- Testing
- GCE + Low ALA, GCE + High ALA
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Parkinson Disease
CANadian Adaptive DBS TriAl
Parkinsonian symptoms, such as freezing of gait (FOG) or hypophonia, play a significant role in reducing quality of life for Parkinson disease (PD) patients, and are poorly responsive or can worsen with deep brain stimulation…
- Trial name
- CANADA (NCT05402163)
- Testing
- Adaptive DBS, Continuous DBS
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Toronto
Parkinson Disease, Freezing of Gait
Provocation of Freezing of Gait in Parkinson's Disease
Sample Size N= 10 Parkinson's disease patients with self-reported freezing of gait and 10 without self-reported freezing of gait (in total, 20 Parkinson's disease patients) Accrual Period Single visit for 2 hours Study Design…
- Trial name
- NCT04799613
- Testing
- walking speed, visual loading, dual task
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Parkinson Disease, Freezing of Gait
Split-belt Treadmill Training to Rehabilitate Freezing of Gait and Balance in Parkinson's Disease
Parkinson's disease (PD) related gait and balance disorders are challenging to treat because they cannot be optimized with pharmacological intervention alone.
- Conditions
- Parkinson Disease, Freezing of Gait, Gait, Unsteady
- Trial name
- NCT04946812
- Testing
- Split-belt treadmill training
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Toronto
Malnutrition; Diabetes, Malnutrition; Protein
Impact of Pea, Lentil and Oat Flour Particle Size on Glycemic Response in Healthy Adults
The study looks at the comparative effects of food products made with pea, lentil, and oat flour of various particle sizes on postprandial glycemic response, appetite and food intake, and amino acid release in healthy adults.
- Conditions
- Malnutrition; Diabetes, Malnutrition; Protein, Obesity
- Trial name
- PLO (NCT05291351)
- Testing
- Crackers made with whole, coarse, or fine pea and/or wheat flour, Crackers made with whole, coarse, or fine lentil and/or wheat flour, Porridge made with oat flour
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Quality of Life
Implementing an Intervention to Foster Resident and Family Engagement in Care Planning
This study is a pilot test of an intervention to engage residents and their family and the healthcare team in a collaborative approach to decisions about care planning in long-term care.
- Trial name
- NCT04026698
- Testing
- Resident and Family Engagement Intervention
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Physical Inactivity, Cognitive Decline
Developing and Assessing an Innovative Exergaming Technology for Older Adults Living in Long-term Care Homes
Residents living in long-term care (LTC) homes spend up to 75% of their day in sedentary, socially withdrawn situations which increases their risk for depression, dementia, decreased functional status and increased care costs.
- Conditions
- Physical Inactivity, Cognitive Decline, Aging, Social Isolation
- Trial name
- MouvMat (NCT05130203)
- Testing
- MouvMat Exergaming, Standard Recreational Programming
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Oxygen Toxicity
Pulmonary Function After Hyperbaric Oxygen Therapy
Patients receiving hyperbaric oxygen therapy (HBOT) for any indication at the Hyperbaric Medicine Unit (University Health Network, Toronto, ON, Canada) from 2016-2021 were recruited to this prospective cohort study.
- Trial name
- NCT05088772
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- University of Toronto
Attention Deficit Hyperactivity Disorder
A Placebo Controlled Study of Homeopathic Treatment of Children and Youth With ADHD
Attention Deficit Hyperactivity Disorder (ADHD) is a developmental disorder that presents during childhood, with at least some symptoms causing impairment before the age of seven.
- Trial name
- NCT02086864
- Testing
- lactose/sucrose granule (Individualized homeopathic medicine treatment), Homeopathic consultation
- Where
- Canada
- Volunteers
- 151 people
- Sponsor
- University of Toronto
Surgical Patients, Preoperative Care
Prehab for Surgery
Surgical prehabilitation is the process of enhancing one's physical function and mental capacity to enable him/or her to withstand the stressor of surgery.
- Trial name
- NCT04155346
- Testing
- Exercise, nutritional optimization, and psychoeducation
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Toronto
Overweight and Obesity
Effect of Post-exercise Nutrition on Glycemia in Women
The purpose of this study is to assess whether post-exercise Greek yogurt following a single session of aerobic exercise improves metabolic and musculoskeletal health in women with overweight/obesity.
- Trial name
- PEN (NCT05876260)
- Testing
- Greek yogurt, Carbohydrate-based study supplement, Exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Blood Pressure, Cardiovascular Diseases
SRMA of the Effect of Soy Protein on Blood Pressure
Hypertension is one of the leading risk factors for death and significantly increases the risk for cardiovascular (CVD), brain and kidney diseases.
- Trial name
- NCT05638061
- Testing
- Soy protein
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cardiovascular Diseases, Coronary Heart Disease
Meta-analysis of Oat Fiber and Cardiovascular Risk Reduction
Oat fibre has been shown to lower cholesterol and may have cardioprotective effects. However, whether this translates to actual cardiovascular risk reduction is unclear, as there is a lack of controlled human trials.
- Trial name
- NCT05171283
- Testing
- Oats or Oat Fibre
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Metabolic Syndrome, Overweight and Obesity
The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
Strategies to reduce sugar-sweetened beverages (SSB) have become one of the leading public health targets to address the epidemics of obesity and diabetes.
- Conditions
- Metabolic Syndrome, Overweight and Obesity, PreDiabetes, Diabetes
- Trial name
- NCT05191160
- Testing
- Soy Milk, Cow's Milk, Sugar Sweetened Beverages
- Where
- Canada
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dementia, Death
Development and Validation of a Dementia Life Expectancy Tool
Individuals with dementia and their caregivers are faced with challenging decisions throughout the course of the disease. These decisions may be about medical care (e.g., continuation of routine cancer screening, pursuit of…
- Trial name
- NCT06266325
- Testing
- There is no intervention. Exposures are predictor variables of mortality.
- Volunteers
- 202,217 people
- Sponsor
- University of Toronto
Financial Stress, Social Functioning
Livelihoods Intervention With Urban Refugee Youth in Kampala, Uganda
Displaced and refugee youth in Uganda are more vulnerable to health risks due to financial insecurity. As such, the investigators aim to explore the utility of an intervention aimed at improving livelihoods, called Creating…
- Conditions
- Financial Stress, Social Functioning, Social Skills
- Trial name
- NCT06270160
- Testing
- HIVST, mHealth, Creating Futures Livelihoods program
- Where
- Uganda
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Exercise
Bodyweight Interval Exercise in the Fed Versus Fasted State
The purpose of this study is to investigate the effects of a single session of at-home bodyweight interval exercise, performed in the fasted or fed state, on postprandial glycemic management, post-exercise fat oxidation, and…
- Trial name
- BWE (NCT06240442)
- Testing
- Fasted exercise, Fed exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Resistance Exercise, Physical Inactivity
Modified Breath Test to Determine Anabolic Sensitivity Across Physical Activity States
Developing tools to detect when our bodies are more resistant towards protein synthesis is valuable for identification of when someone may be at risk of losing body or muscle mass such as with aging or certain diseases.
- Conditions
- Resistance Exercise, Physical Inactivity, Amino Acids, Dietary Protein
- Trial name
- BTLP (NCT06209424)
- Testing
- Habitual Activity, Step-Reduction, Resistance Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Exercise Training
Exercise Dose-response and Protein Requirements
Study will investigate the impact of training volume on protein metabolism to estimate the impact on daily protein requirements of endurance athletes.
- Trial name
- NCT06138951
- Testing
- Endurance exercise
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Toronto