Clinical trials: sponsored by University of Utah
Cancer
AI-Driven Survivorship Care Plans (AI-SCP)
This project conducts exploratory work on a HIPAA-compliant, large language model (LLM)-based tool that integrates structured and unstructured oncology electronic health record (EHR) data to automate the development of tailored…
- Trial name
- AI-SCP (NCT07700199)
- Testing
- SCP Chatbot
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Cancer Survivorship
Improving Radon Education and Awareness in Cancer Patients and Their Extended Community
Clinical appointments are an opportunity to provide cancer survivors (defined as patients and survivors) and people in their communities (e.g. caregivers, family members, friends) with education about radon and radon testing.
- Trial name
- NCT07712133
- Testing
- Educational Presentation
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Utah
Overweight and Obesity
Circadian Timing, Information Processing and Energy Balance Study
This study design will test biological and behavioral mechanisms in the cross-sectional analyses and determine the prospective effects of circadian alignment and sleep on changes in cardiometabolic risk factors.
- Trial name
- TIME (NCT04759755)
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity
Partnership to Reduce Obesity in Community Health Center Patients (SMARTLife Utah)
The long-term objective of SMARTLife Utah is to increase the reach of existing digital EBIs for obesity among patients of Community Health Centers (CHCs).
- Trial name
- NCT07582016
- Testing
- Ask-Advise-Connect (AAC), Text Messaging (TM), Connect Only (CO)
- Where
- United States
- Volunteers
- 5,354 people
- Sponsor
- University of Utah
Smoking Cessation
LLM Intervention for Tobacco in Underserved Populations (LIFT-UP)
This study will test a tailored, multilingual tobacco cessation chatbot called LIFT-UP (LLM Intervention for Tobacco in Underserved Populations), designed to better meet the needs of people living in persistent poverty census…
- Trial name
- LIFT-UP (NCT07620301)
- Testing
- LIFT-UP Chatbot
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah
Myelodysplastic Syndromes, Acute Myeloid Leukemia
Use of Electrical Bioimpedance in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Patients (Bioimpedance)
The goal of this project is to test non-invasive, painless skin electrical bioimpedance (BioZ) measurements as an adjunctive biomarker to standard bone marrow biopsies.
- Trial name
- NCT07570056
- Testing
- Bioimpedance (BioZ)
- Volunteers
- 25 people
- Sponsor
- University of Utah
Methamphetamine Use Disorder, Pregnancy
Transcranial Magnetic Stimulation for Methamphetamine Use Disorder During Pregnancy
The goal of this clinical trial is to learn whether transcranial magnetic stimulation, also called TMS, is a practical and acceptable treatment option for methamphetamine use disorder during pregnancy.
- Trial name
- NCT07849530
- Testing
- 4- Week Dual-Target Transcranial Magnetic Stimulation (TMS), Accelerated Dual-Target Transcranial Magnetic Stimulation (aTMS), Treatment as Usual (TAU)
- Volunteers
- 45 people
- Sponsor
- University of Utah
Lung Cancer, Lung Nodule
SPARC - Screening for Lung Cancer With Platelets Via an AI-enabled RNA-based Classifier
The purpose of this study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses lung cancer.
- Trial name
- SPARC (NCT07460440)
- Testing
- Platelet RNA-based assay
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Utah
Fibromyalgia, Duloxetine
Duloxetine Metabolism and Fibromyalgia
People with fibromyalgia report generalized body pain ("pain all over"), increased sensitivity to painful stimulation, chronic tiredness or low energy, sleep problems, and other physical and functional problems.
- Trial name
- DILIGENT (NCT06866444)
- Testing
- Observational
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Lumbar Spinal Stenosis
Sterile Amniotic Fluid Filtrate Epidural Injection.
There is a large population of patients with lumbosacral radicular pain due to spinal stenosis who do not respond to physical therapy or oral medication management, yet wish to avoid spinal surgery or are simply not candidates…
- Trial name
- NCT04537026
- Testing
- Amniotic Fluid Allograft, Dexamethasone sodium phosphate
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Utah
Hydrocephalus
HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants
Hydrocephalus is a potentially debilitating neurological condition that primarily affects babies under a year of age and has traditionally been treated by inserting a shunt between the brain and the abdomen.
- Trial name
- ESTHI (NCT04177914)
- Testing
- Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC), Ventriculoperitoneal Shunt
- Where
- 21 sites in United States, Canada
- Volunteers
- 165 people
- Sponsor
- University of Utah
Cancer, Financial Toxicity
SAFE.AI: Developing and Testing an AI-based Hybrid Chatbot for Financial Empowerment in Rural Cancer Care
This is a randomized, two-arm, parallel-group pilot trial investigating a new chatbot tool designed to support cancer patients and caregivers, particularly those in rural communities.
- Trial name
- NCT07410689
- Testing
- Rule-Based Chatbot, Hybrid Chatbot
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Skin Cancer
Mobile Sun Health Intervention EnabLing Daily Protection
The overall purpose of this proposal is to refine a mobile-health (mHealth) system to reduce excessive unprotected sun exposure among young adults.
- Trial name
- mSHIELD (NCT07830394)
- Testing
- Text Message Reminders, Sun Protection Education Modules, Action Planning Module
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Waldenstrom Macroglobulinemia
Mosunetuzumab in Combination With Pirtobrutinib in Patients With Relapsed or Refractory Waldenstrom Macroglobulinemia (MPOWER)
The purpose of this clinical trial it to test the safety and tolerability of the study drugs mosunetuzumab in combination with pirtobrutinib in patients with relapsed or refractory Waldenstrom's Macroglobulinemia.
- Trial name
- MPOWER (NCT07548450)
- Testing
- Pirtobrutinib, Mosunetuzumab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Utah
Stroke
Digital Technology-Informed Stroke Rehabilitation
The goal of this study is to determine the effects of lab and home-based technology guidance during movement training post-stroke.
- Trial name
- NCT07698522
- Testing
- Lab-based movement guidance, Home-based movement guidance
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Amyotrophic Lateral Sclerosis & Other Neuromuscular Disorders
Using Gaze to Enable Head-neck Movements in Patients With Head Drop
The investigators will develop and evaluate controllers for a powered neck exoskeleton in patients with amyotrophic lateral sclerosis (ALS) to understand how to allow adequate personalization and function and achieves…
- Trial name
- NCT07836751
- Testing
- neck exoskeleton controller
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Total Shoulder Arthroplasty
Subscapularis-Sparing Total Shoulder Arthroplasty
The investigators purpose of this study are to perform a prospective clinical study to determine the following after subscapularis-sparing anatomic total shoulder arthroplasty performed for glenohumeral osteoarthritis: 1.
- Trial name
- NCT07410650
- Testing
- Subscapularis-Sparing Total Shoulder Arthroplasty
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Malignant Ascites
At-Home Paracentesis for Cancer-Related Malignant Ascites (Paracentesis)
The goal of this study is to evaluate the change in symptoms for cancer-related malignant ascites who complete an at-home paracentesis procedure.
- Trial name
- Paracentesis (NCT07490626)
- Testing
- At-home Paracentesis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Muscle-invasive Bladder Urothelial Carcinoma
A Phase 2 Study Evaluating Bladder Preservation With Enfortumab Vedotin Plus Pembrolizumab in Patients With Muscle-Invasive Urothelial Cancer
The purpose of this study is to evaluate whether Enfortumab Vedotin in combination with Pembrolizumab can achieve a clinical response that preserves the bladder and avoids the need for cystectomy or radiation therapy in patients…
- Trial name
- PRESERVE (NCT07822373)
- Testing
- Enfortumab vedotin, Pembrolizumab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Utah
Major Depressive Episode
Personalized Ultrasonic Brain Stimulation for Depression
This study will evaluate a new form of non-invasive brain stimulation for individuals with depression. Personalized low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation…
- Trial name
- NCT05301036
- Testing
- Diadem prototype
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah