Clinical trials: sponsored by University of Utah
Pediatric Hydrocephalus
HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)
The Hydrocephalus Clinical Research Network (HCRN) has been established by philanthropic funding to conduct multi-institutional research (clinical trials and observational studies) on pediatric hydrocephalus.
- Trial name
- NCT00670735
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,400 people
- Sponsor
- University of Utah
Amputation, Diabetes
Thermoregulation in Individuals With a Leg Amputation
The goal of this project is to understand the factors that affect skin temperature (e.g., tissue above amputation site, and opposite foot) in people with amputation and diabetes.
- Trial name
- NCT06458426
- Testing
- shock-absorbing prosthesis
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Utah
Metastatic Pancreatic Carcinoma, Stage II Pancreatic Cancer
Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic Cancer
This phase I trial studies the sides effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes or other places in the…
- Conditions
- Metastatic Pancreatic Carcinoma, Stage II Pancreatic Cancer, Stage IIA Pancreatic Cancer, Stage IIB Pancreatic Cancer
- Trial name
- THREAD (NCT03825289)
- Testing
- Hydroxychloroquine, Trametinib
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Utah
Amputation
Can an Array of Micro-electrodes Implanted in a Human Nerve Record Neural Signals and Provide Feedback?
The investigators will investigate the device feasibility of human peripheral nerves and muscles recording and stimulation using percutaneous Utah Slanted Electrode Arrays (pUSEAs) implanted into residual peripheral arm nerves…
- Trial name
- NCT05505513
- Testing
- percutaneous Utah Slanted Electrode Arrays (pUSEAs)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Structured Interview, Narrative Assessment
Refinement of Suicide Risk Management Intervention
Participants will be randomly assigned to 1 of the 4 interventions using a sequential stratified randomization procedure. We will use sex (M, F) and history of suicide attempts (never, 1, and multiple) as our randomization…
- Conditions
- Structured Interview, Narrative Assessment, Safety Plan, Crisis Response Plan
- Trial name
- NCT04888845
- Testing
- Safety Plan, Crisis Response Plan, Structured interview
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Utah
Advanced KRAS Positive Metastatic Colorectal Cancer
A Trial of mFOLFIRI With MEK162 in Patients With Advanced RAS (HRAS, NRAS, or KRAS) Positive Metastatic Colorectal Cancers
This is a Phase 1b, open label, dose-finding study to determine the Maximum Tolerated Dose (MTD) of MEK162 in combination with mFOLFIRI, and to evaluate the response rate, clinical benefit rate and additional safety parameters of…
- Trial name
- NCT02613650
- Testing
- MEK162 and mFOLFIRI
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Utah
Weight Loss, Weight Regain
Testing a Tailored Approach to Long-Term Weight Loss Success
The purpose of this study is to develop and test an adaptive, individually tailored intervention to prevent weight regain in people who have intentionally lost weight.
- Conditions
- Weight Loss, Weight Regain, Obesity & Overweight
- Trial name
- NCT07577765
- Testing
- Adaptive weight regain prevention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Hemiparesis
Improving Myoelectric Prosthetic and Orthotic Limb Control
The purpose of this study is to improve control of myoelectrically-controlled advanced orthotic devices (an exoskeleton device that use the body's muscle signals to drive movements of a robotic brace) by using advanced predictive…
- Trial name
- NCT05509101
- Testing
- commercially available control algorithm, experimental control algorithm
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Utah
Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
Platelet Rich Plasma for Musculoskeletal Conditions
The primary purpose of this study is to follow patients with various musculoskeletal (MSK) conditions over a one-year follow-up period after receiving a platelet rich plasma (PRP) injection, assessing changes in their pain…
- Conditions
- Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Shoulder
- Trial name
- PRP for MSK (NCT07231471)
- Testing
- Platelet Rich Plasma Injection, Platelet Rich Plasma Preparation
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Utah
Studying the Genetic Relationship of Rotator Cuff Tears
Genetic Factors Affecting Risks for Rotator Cuff Disease
This study will begin to evaluate the heritability of rotator cuff disease, and begin creation of a powerful resource for future genetic studies of rotator cuff disease.
- Trial name
- NCT01193647
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Utah
Scapular Dyskinesis, Posterior Shoulder Instability
Shoulder Pacemaker for Scapular Dyskinesia
The investigators purpose of this study is to determine patients-reported outcomes (VAS pain scores) in patients with Scapular Dyskinesis or Posterior Shoulder Instability who undergo rehabilitation with a shoulder pacemaker.
- Trial name
- NCT05116722
- Testing
- Shoulder Pacemaker
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Macular Pigmentation, Skin Pigment
Macular Pigment Measurements in Eye & Other Tissues
The purpose of this study is to understand the role of nutrition and its effects on the eye and other tissues. The investigators propose to study this by validating and correlating various non-invasive measurement methods of…
- Trial name
- NCT03022773
- Testing
- Carotenoid measurements
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Utah
Cognitive Ability, General, Immune System Function
Adolescent Probiotics in Stressed Adolescents
Stress is a normal human reaction to changes surrounding our reality, resulting in physical, emotional, and intellectual responses. Children and adolescents often experience high levels of stress.
- Conditions
- Cognitive Ability, General, Immune System Function, Emotions
- Trial name
- NCT07565883
- Testing
- Probiotics
- Where
- 2 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Utah
Non-small Cell Lung Cancer
Machine Learning Approaches to Personalized Therapy for Advanced Non-small Cell Lung Cancer With Real-World Data
This research will leverage machine learning (ML) and causal inference techniques applied to real-world data (RWD) to generate evidence that personalizes treatment strategies for patients with advanced non-small cell lung cancer…
- Trial name
- NCT06934343
- Where
- United States
- Volunteers
- 144,400 people
- Sponsor
- University of Utah
Oxygen Delivery, Patient Monitoring
On-Demand Oxygen Delivery System Study
The main goal of this study is to determine if supplemental oxygen given only when the patient is inspiring (demand delivery) is more effective than constant-flow oxygen given during all phases of the breath regardless if the…
- Trial name
- NCT02962570
- Testing
- On Demand Oxygen Delivery, Traditional, Always-On, Oxygen Delivery, Oxygen Flow Stopped
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Sleep Deprivation, Insufficient Sleep Syndrome
Biomarkers of Increased Free Living Sleep Time
This protocol will increase sleep duration in participants who maintain less than 6 hours sleep per night, to target the recommended 7 hours of sleep per night.
- Conditions
- Sleep Deprivation, Insufficient Sleep Syndrome, Sleep Wake Disorders
- Trial name
- NCT04214184
- Testing
- Increased sleep duration
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Utah
Cardiogenic Shock
Physiology of Unloading VA ECMO Trial
The goal of this clinical trial is to compare the use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) with and without left ventricular (LV) unloading in patients being treated for cardiogenic shock (CS).
- Trial name
- NCT06336655
- Testing
- IABP
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Utah
Early Mobilization
Early Weight Bearing in Unicondylar Tibial Plateau Fractures
The investigators aim of the study is to assess the effects of early mobilization after surgically treated unicondylar tibia plateau fractures (6 weeks without weight bearing) on gait, patient satisfaction, return to work/sports…
- Trial name
- NCT06389240
- Testing
- 6 weeks post-operatively early weight bearing, 10 weeks post-operatively weight bearing (standard of care)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Tibial Shaft Fracture, Tibial Plateau Fracture
Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome
The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower…
- Trial name
- NCT05521958
- Testing
- Acute injury without compartment syndrome, Acute injury with compartment syndrome, Exertional compartment syndrome
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Tibial Plateau Fractures
Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures
The investigators goal of the proposed research study is to determine the effectiveness of periarticular multimodal analgesia in the setting of tibial plateau fractures.
- Trial name
- NCT05037812
- Testing
- Saline injection, Multimodal injections
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah