Clinical trials: sponsored by University of Virginia
Aortic Stenosis
Loss of Y Chromosome in Aortic Stenosis
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body.
- Trial name
- NCT06595407
- Testing
- Blood analysis for loss-of-Y chromosome
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Postoperative Pain, Breast Reconstruction
Effectiveness of Exparel TAP Block in Breast Free Flap Reconstruction
Transversus Abdominis Plane (TAP) block is a useful tool in pain management after abdominal surgery. It is a regional nerve block that targets T6-L1 thoracolumbar nerves running in the plane between internal oblique and…
- Trial name
- NCT04777591
- Testing
- Liposomal bupivacaine TAP block, Bupivacain
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Virginia
Idiopathic Pulmonary Fibrosis
The Role of Quantitative CT and Radiomic Biomarkers for Precision Medicine in Pulmonary Fibrosis
This observational study involves obtaining 2 chest CT scans; a historical baseline CT within ±1 year of enrollment into PRECISIONS, and a follow-up CT (either historical or prospective) 12 months ± 180 days after the baseline…
- Trial name
- Radiomics (NCT06323876)
- Testing
- HRCT, Blood Draw
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Virginia
Traumatic Brain Injury, Caregiver
The REACH Intervention for Caregivers of Veterans and Service Members With TBI
This randomized waitlist control trial will evaluate the effects of a psychoeducational intervention called Resources for Enhancing All Caregivers' Health - Traumatic Brain Injury (REACH TBI) to decrease caregiver strain (primary…
- Trial name
- REACH TBI (NCT06111794)
- Testing
- REACH TBI
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Using Total Daily Insulin
The purpose of this proposed study is to assess the use of a new feature of the Control-IQ system, MyTDI.
- Trial name
- NCT03804983
- Testing
- Hybrid Closed Loop (HCL), Control-IQ with MyTDI
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Virginia
Type1 Diabetes
Neural-net Artificial Pancreas (NAP)
This study is intended to assess a Neural-net Artificial Pancreas (NAP) implementation of an established AP controller - the University of Virginia Model Predictive Control Algorithm (UMPC).
- Trial name
- NAP (NCT05876273)
- Testing
- Neural-net Artificial Pancreas, University of Virginia Model Predictive Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Safety and Feasibility of an Insulin Sensitivity-Informed Bolus Calculator in Type 1 Diabetes
This is a single-center randomized crossover trial. The investigators will target completion of 15 adults (age 18-65 years) with Type 1 Diabetes who use an insulin pump.
- Trial name
- NCT03709108
- Testing
- SI-Informed Bolus Calculator
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Obesity, Childhood
A Trial of Two Family-based Childhood Obesity Treatment Programs
The primary aim is to determine the relative effectiveness in child BMI z-scores at 3, 6, and 12-months post baseline of iChoose+ versus Family Connections.
- Trial name
- NCT03245775
- Testing
- iChoose, Family Connections
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hunger, Ingestive Behavior
Hunger and Learning Study in Preschoolers
This prospective random controlled cross-over intervention studies is designed to ascertain if children feel different levels of hunger and fullness before and after eating test meals consisting of high-satiety vs.
- Conditions
- Hunger, Ingestive Behavior, Obesity, Food Preferences
- Trial name
- NCT03861208
- Testing
- diet, usual diet
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Arthropathy of Hip, Perioperative/Postoperative Complications
Living Alone is Predictive of Non-home Discharge Following Elective Total Hip Arthroplasty: a Matched-pairs Cohort Analysis
The goal of this observational study is to assess the effect of living alone on total hip arthroplasty thirty-day outcomes. The main questions it aims to answer are: Is living alone associated with discharge disposition (home…
- Trial name
- NCT06462885
- Testing
- home support, hiving alone, home support, living with others
- Where
- United States
- Volunteers
- 5,677 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Left-Sided Heart Failure, Right-Sided Heart Failure
Echocardiography as Risk-Assessment for Major Adverse Cardiac Events in Major Vascular Surgery Patients
Patient with coronary artery disease (CAD), heart failure and abnormal heart function undergoing major vascular surgery have a high associated high morbidity and mortality with myocardial infarction accounting for 33-50% of…
- Conditions
- Left-Sided Heart Failure, Right-Sided Heart Failure, Heart Valve Diseases
- Trial name
- NCT04836702
- Volunteers
- 813 people
- Sponsor
- University of Virginia
Bariatric Surgery Candidate
Exercise Training Study Before Bariatric Surgery
The goal of this clinical trial is to figure out if 8 weeks of walking exercise before bariatric surgery improves risk factors for diabetes and other markers of health.
- Trial name
- BaSE (NCT06274606)
- Testing
- Exercise Group
- Where
- United States
- Sponsor
- University of Virginia
Gender Dysphoria
Effect of Nitropaste in Chest Masculinizing Surgery
Nitropaste is a topical agent that contains 2% nitroglycerin. It is an effective vascular smooth dilator, with more powerful effect on venous vasculature than arterial vasculature.
- Trial name
- NCT06428669
- Testing
- Nitro-Bid 2 % Topical Ointment
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of Virginia
Breast Cancer, Blood Loss, Surgical
Role of TXA in Patients Undergoing Breast Free Flap Reconstruction
Tranexamic acid (TXA) is a synthetic, competitive lysine receptor inhibitor on plasminogen. It ultimately stabilizes the fibrin matrix, therefore used as a hemostatic agent for various indications.
- Trial name
- NCT06428682
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Hybrid Closed-Loop Control With Smart Prandial Insulin Dosing in Type 1 Diabetes
The objective of this study is to evaluate the safety and feasibility of a smart bolus calculator that adjusts insulin dosing for meals according to real-time insulin sensitivity (SI) in adolescents with type 1 diabetes (T1D)…
- Trial name
- NCT04878120
- Testing
- Standard HCL System, HCL System with Smart Bolus Calculator
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Diabetes Closed-Loop Project 6 (DCLP6): Fully Automated Closed-Loop Control in Type 1 Diabetes Using Meal Anticipation
The purpose of this study is to test the meal anticipation module on a closed loop algorithm, assessing efficacy and safety.
- Trial name
- NCT04877730
- Testing
- Fully Closed Loop (FCL), Fully Closed Loop with meal anticipation module (FCL+), Hybrid Closed Loop (HCL)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Erectile Dysfunction, Erectile Dysfunction Following Radical Prostatectomy
Low Intensity Shockwave Therapy for Erectile Dysfunction
Low-intensity shockwave therapy (LiSWT) has been deemed "a safe and well-tolerated procedure but its efficacy for the treatment of ED is doubtful and deserves more investigation" by the European Society of Sexual Medicine.
- Conditions
- Erectile Dysfunction, Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction Following Radiation Therapy, Erectile Dysfunction Due to General Medical Condition
- Trial name
- NCT04434352
- Testing
- Storz Duolith Low-Intensity Shockwave Therapy
- Where
- United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Human Papillomavirus Infection, Vaccination Hesitancy
Feasibility Trial of a Multi-level Media Production and Social Marketing Campaign to Reduce HPV Vaccine Hesitancy
Since 2019, the HPV working group of the University of Virginia Cancer Center's Southwest Virginia Community Advisory Board has developed and executed strategies to increase regional HPV vaccination rates.
- Trial name
- NCT05860725
- Testing
- PSA Development, HPV vaccination focused social marketing campaign
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Healthy
Inorganic Nitrate: Sex Differences in Muscle Contractile Function and Efficiency
Dietary inorganic nitrate, in the form of beet root juice, is a nutritional intervention, considered to be an exercise enhancer due to its capacity to increase Nitric Oxide (NO) bioavailability.
- Trial name
- NCT04588740
- Testing
- concentrated beet root juice
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
University of Virginia Natural History Study
Data and specimens will be collected longitudinally from patients seen in the UVA Interstitial Lung Disease (ILD) clinic in order to describe the phenotypic expression of various interstitial lung diseases.
- Conditions
- Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Sarcoidosis, Connective Tissue Diseases
- Trial name
- NCT04896138
- Testing
- Interstitial Lung Disease
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Virginia