Clinical trials: sponsored by University of Virginia
Heart Failure, Decompensated Heart Failure
Colchicine in Acutely Decompensated HFREF
This is a double blind, placebo-controlled pilot trial randomizing patients admitted to the hospital with acutely decompensated heart failure (ADHF) and inflammation to receive either colchicine or matching placebo.
- Conditions
- Heart Failure, Decompensated Heart Failure, Heart Failure With Reduced Ejection Fraction
- Trial name
- NCT06286423
- Testing
- Colchicine 0.6 mg
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Insomnia, Cognitive Dysfunction
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
This randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals…
- Conditions
- Insomnia, Cognitive Dysfunction, Mild Cognitive Impairment, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT05565833
- Testing
- SHUTi OASIS, Patient Education
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Virginia
Healthy
Inorganic Nitrate: Sex Differences in Muscle Contractile Function and Efficiency
Dietary inorganic nitrate, in the form of beet root juice, is a nutritional intervention, considered to be an exercise enhancer due to its capacity to increase Nitric Oxide (NO) bioavailability.
- Trial name
- NCT04588740
- Testing
- concentrated beet root juice
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Virginia
COVID-19
Exercise Interventions in Post-acute Sequelae of Covid-19
The COVID-19 pandemic severely impacted the medical system both directly but also through incomplete recovery from the virus in the form of post-acute sequelae of COVID-19 (PASC).
- Trial name
- NCT06065033
- Testing
- Exercise
- Where
- United States
- Sponsor
- University of Virginia
Heart Failure With Preserved Ejection Fraction
The Effect of a High Fiber Diet and High-Intensity Interval Exercise in Patients With HFpEF
This study is trying to find out how best to improve common measures of health and survival in those diagnosed with heart failure with preserved ejection fraction (HFpEF) through the implementation of 4 weeks of an exercise…
- Trial name
- NCT05236413
- Testing
- High Intensity Interval Exercise, Dietary Approaches to Stop Hypertension (DASH) Diet, Exercise + DASH Diet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Virginia
Lymphoma, Childhood Lymphoma
Study of Genistein in Pediatric Oncology Patients (UVA-Gen001)
Toxicities related to pediatric cancer treatment can lead to significant illness, organ damage, treatment delays, increased health care cost, and decrease in quality of life.
- Conditions
- Lymphoma, Childhood Lymphoma, Solid Tumor, Childhood Solid Tumor
- Trial name
- UVA-Gen001 (NCT02624388)
- Testing
- Genistein
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Virginia
Children, Only, Nutrition, Healthy
Fruit and Vegetable Intake in Preschoolers
The goal of this randomized controlled trial is to examine fruit and vegetable consumption in preschoolers following a nutrition education curriculum. The main questions it aims to answer is: 1.
- Trial name
- NCT05730530
- Testing
- Nutrition education curriculum
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Smoking Behaviors, Cancer
mMe: Motivational Monitoring to Enhance Smoking Cessation Among Cancer Patients
The objectives of this study are to pilot test a protocol of weekly assessments of motivation to quit and other relevant constructs combined with information about how to enroll in cessation programs, which will allow initial…
- Conditions
- Smoking Behaviors, Cancer, Motivation
- Trial name
- mMe (NCT05370859)
- Testing
- There is no intervention for this study
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Immune Deficiency
Undetectable IgE as a Sentinel Biomarker for Humoral Immunodeficiency
This study is trying to find out if an undetectable serum immunoglobulin E (IgE) is a biomarker, or early sign of, the development of immune deficiency.
- Trial name
- NCT03968211
- Testing
- Salmonella typhi polysaccharide vaccine
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Stroke, Medication Adherence
Adherence to Medical Treatments for Telemedicine Patients
This study will test the feasibility of MedRem, a novel medication reminder and tracking system on wearable wrist devices, specifically with the Apple Watch 4.
- Trial name
- NCT04180475
- Testing
- MedRem application
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Smoking Cessation
Strategies to Promote Cessation in Smokers Who Are Not Ready To Quit
To our knowledge, no study has evaluated the independent effects of motivational interviewing and rate reduction, individually versus in combination, for motivating smokers who are not ready to quit (SNRTQ) to increase both quit…
- Trial name
- PACE (NCT02905656)
- Testing
- Brief Advice, Motivational Interviewing, Rate Reduction
- Where
- United States
- Volunteers
- 903 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Musculoskeletal Pain
Topical CBD for Musculoskeletal Pain
Rationale: CBD is commonly being used as an over-the-counter treatment for musculoskeletal pain; however, no clinical trial has been performed to establish efficacy of CBD in humans for musculoskeletal pain.
- Trial name
- NCT05170451
- Testing
- CBD, Control
- Where
- United States
- Sponsor
- University of Virginia
Pancreatic Tumor
Evaluation of EUS-Guided 22 Gauge Core Biopsy Versus Fine-needle Aspiration for Suspected Pancreatic Neoplasms
We aim to compare the efficacy (diagnostic yield), ease of use, and technical success rates of EUS guided 22 gauge fine needle aspiration to core biopsy in the evaluation of pancreatic tumors.
- Trial name
- NCT01673334
- Testing
- Fine Needle Aspiration (FNA) and Core biopsy (FNB)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Pain, Acute, Vocal Fold Polyp
Patient Augmented Reality and Vibratory Array Otorhinolaryngology Procedures
In-office procedures (IOPs) are a cost-effective, and safe alternative to many operating room procedure, with benefits such as reduced anesthesia risk.
- Conditions
- Pain, Acute, Vocal Fold Polyp, Vocal Cord Paralysis, Laryngeal Neoplasms
- Trial name
- PARVA (NCT06227039)
- Testing
- Vibroacoustic stimulation on, Augmented Reality on, Vibroacoustic stimulation off
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Vocal Cord Paralysis
Voice Rest and Injection Laryngoplasty
The purpose of this study is to evaluate the subjective, objective, and aerodynamic impact of voice rest following injection augmentation and compare the outcomes to patients with no post-procedure voice restrictions.
- Trial name
- NCT05542550
- Testing
- Voice Rest, No Voice Rest
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Septic Shock
Midodrine in the Recovery Phase of Septic Shock
The aim of this study is to investigate the role of oral midodrine in the recovery of septic shock. The investigators hypothesize that the oral drug can reduce central line days and ICU length of stay.
- Trial name
- NCT02990546
- Testing
- midodrine, Standard of Care
- Where
- United States
- Sponsor
- University of Virginia
Nasal Valve Incompetence
Alar Batten Graft vs Latera for Nasal Valve Collapse
Nasal obstruction is a common complaint for the patient presenting to the Otolaryngologist and/or the Facial Plastic surgeon. There are numerous potential causes of nasal obstruction, with more easily addressed pathologies such…
- Trial name
- NCT03793218
- Testing
- Latera Device, Alar Batten Graft
- Sponsor
- University of Virginia
Asthma, Allergic Rhinitis
Clinical Response to Rhinovirus Challenge
Rhinovirus (RV) infections represent the most common cause of asthma exacerbations in children and adolescents. The investigators hypothesize that the immune responses generated in the nose of allergic rhinitics and asthmatics…
- Trial name
- NCT02910401
- Testing
- Rhinovirus (GMP RV16 HRV-16)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Choledocholithiasis, Bile Duct Diseases
Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP
Carbon dioxide (CO2) gas is widely used for luminal insufflation during endoscopic retrograde cholangiopancreatography (ERCP) of the biliary tract.
- Conditions
- Choledocholithiasis, Bile Duct Diseases, Bile Duct Carcinoma
- Trial name
- NCT02611453
- Testing
- "Air" contrast cholangiography using carbon dioxide gas
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 2
Telehealth and Meal Replacement Pilot Program for Patients With Diabetes
This pilot study will involve intensive training in self-management of diabetes mellitus. The intensive diabetes self-management program will involve an initial diabetes assessment with the nurse/diabetes educator, an initial…
- Trial name
- NCT04885621
- Testing
- nutrisystem-D
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Virginia