Clinical trials: sponsored by University of Virginia
Neonatal Sepsis
Improved Detection of Neonatal Sepsis Using a Targeted Biomarker Assay
The purpose of this study is to determine whether analysis of specific serum biomarkers will improve the diagnosis of late onset neonatal sepsis and to determine the correlation between plasma levels of specific cytokines and…
- Trial name
- NCT01120678
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Virginia
Healthy Volunteers
Assessing Deformable Image Registration in the Lung Using Hyperpolarized-gas MRI
Recently, the investigators have demonstrated a novel hyperpolarized helium tagging Magnetic Resonance Image (MRI) technique that is capable of directly, in vivo, and non-invasively measuring physiological lung deformation on a…
- Trial name
- NCT02995590
- Testing
- Hyperpolarized He3
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Neurogenic Bladder
Feasibility of Using Contrast Enhanced Voiding Urosonography (CeVUS) During Urodynamic Studies
The investigators will assess the feasibility of replacing fluoroscopy/iodinated contrast with ultrasound/sulfur hexafluoride lipid-type A microspheres during routine urodynamic studies.
- Trial name
- NCT04170413
- Testing
- CeVUS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Chronic Obstructive Pulmonary Disease
Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation.
- Trial name
- NCT03331302
- Testing
- Hyperpolarized Xenon-129 MRI (Experimental), Radioactive Xenon-133 scintigraphy (Active Comparator)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Food Hypersensitivity
Oral Immunotherapy for Peanut and Mammalian Meat Allergies
Pilot study to assess the effect of oral immunotherapy on specific Immunoglobulin E (IgE) levels and antigen consumption in two distinct food allergies.
- Trial name
- NCT02350660
- Testing
- cow's milk, peanut powder
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Decision Support Techniques
Decision Navigation for Advanced Prostate Cancer Treatment Options Using mHealth
Prostate cancer is a commonly diagnosed cancer, and is the second leading cause of cancer deaths among men in the U.S. The subgroup of men with advanced prostate cancer is particularly vulnerable to difficult choices for…
- Trial name
- NCT03327103
- Testing
- CHAMPION
- Where
- 3 sites in United States
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Glaucoma
Comparison of Ex-PRESSTM Mini Glaucoma Shunt to Trabeculectomy in Subjects With Open Angle Glaucoma
A prospective randomized trial to compare the safety and efficacy of the Ex-PRESS to trabeculectomy in patients with open angle glaucoma who failed medical or are allergic to medical treatment and for which filtering surgery is…
- Trial name
- NCT00444080
- Testing
- Trabeculectomy, Ex-PRESS mini shunt
- Where
- 8 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- University of Virginia
Female Puberty
Progesterone Suppression of Nocturnal LH Increases in Pubertal Girls
The purpose of this study is to learn more about how gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) pulses are controlled during puberty.
- Trial name
- JCM017 (NCT01773772)
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Chondromalacia Patella, Patellofemoral Pain Syndrome
Randomized Evaluation of the Efficacy of Synvisc-One® for the Treatment of Patellofemoral Chondromalacia
The purpose of this study is to determine how safe a knee injection called Synvisc-One® is in patients with a condition called chondromalacia patella and how well in works in treating the condition.
- Trial name
- NCT01771952
- Testing
- Synvisc-One™
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Virginia
Inpatient Colonoscopy, Oral Sulfate Solution
Pilot Study to Assess Tolerability and Feasibility of Oral Sulfate Solution (SUPREP) in Hospitalized Patients
This study will test the efficacy, tolerability, and feasibility of an oral sulfate solution (SUPREP) for inpatient colonoscopy preparation, compared to the standard of care (GoLytely).
- Conditions
- Inpatient Colonoscopy, Oral Sulfate Solution, Polyethelene Glycol
- Trial name
- NCT04504292
- Testing
- SUPREP Bowel Prep Kit, Golytely Oral Product
- Volunteers
- 124 people
- Sponsor
- University of Virginia
Islet Transplantation, Type1 Diabetes Mellitus
CGM Use in Islet Transplant Recipients
A study assessing glucose variability in subjects with Type 1 Diabetes who have had islet transplant.
- Trial name
- NCT03427931
- Testing
- Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Virginia
Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy
Neuromuscular Control in Individuals Following ACL-Reconstruction
The purpose of this study is to investigate the neurophysiological contributors to muscle function following ACL Reconstruction and the influence of motor control biofeedback exercise on measures of muscle function.
- Trial name
- NCT04495075
- Testing
- Visuomotor Therapy, Passive Motion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Project Nightlight: Efficacy and System Acceptance of Dinner/Night vs. 24hr Closed Loop Control
The purpose of this study is to use an investigational type of technology called Closed-Loop Control (CLC) Medical Platform System to help control blood sugar in people with type 1 diabetes mellitus in a home setting.
- Trial name
- NCT02679287
- Testing
- CLC
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
The International Diabetes Closed Loop (iDCL) Trial: Clinical Acceptance of the Artificial Pancreas
The objective of the study is to assess efficacy and safety of a closed loop system (t:slim X2 with Control-IQ Technology) in a large randomized controlled trial.
- Trial name
- DCLP3 (NCT03563313)
- Testing
- t:slim X2 with Control-IQ Technology & Dexcom G6 CGM, Sensor-augmented pump (SAP)
- Where
- 7 sites in United States
- Volunteers
- 168 people
- Sponsor
- University of Virginia
Educational Problems, Cervix, Dysplasia
Colposcopy Education Using Operant Learning
Images will be collected during routine colposcopy and paired with their pathology results to be used for resident education
- Trial name
- Colpo (NCT04340011)
- Testing
- Colposcopy
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Study to Test Efficacy of Real-time Reminders on Apple Watch To Decrease Late or Missed Meal Boluses
This will be a randomized, cross-over, unblinded study with subjects randomized upon entry into the study to either begin using the Klue software for 6 weeks or to continue with their usual care for 6 weeks.
- Trial name
- NCT03809858
- Testing
- Klue App
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Ovarian Cancer
Data and Specimen Bank of Patients Diagnosed With, and at High-risk for, Gynecologic Cancers
The purpose of this project is to establish a bank at UVa of tampon samples, cervical swabs, blood, associated tumor specimens that would otherwise be discarded, and relevant medical data from consenting patients that have…
- Trial name
- NCT04170712
- Testing
- Tampons
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus
USS Virginia Closed-Loop for Overnight Control in Type 1 Diabetes
The purpose of this study is to use the USS Virginia Closed-Loop system for overnight insulin delivery in adults with Type 1 Diabetes (T1DM) in an outpatient setting to evaluate the system's ability to significantly improve blood…
- Trial name
- NCT02131766
- Testing
- DiAs, Sensor Augmented Pump Therapy
- Where
- 4 sites in United States, Italy
- Volunteers
- 33 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Development of an Advisory System for Glycemic Control During the Menstrual Cycle in Patient With Type 1 Diabetes
This overall research goal will be to develop a mobile-based module to improve glycemic control during the menstrual cycle in women with Type 1 diabetes mellitus (T1DM).
- Trial name
- NCT01653210
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Prematurity, Cerebral Palsy
NEO Rehab for Infants at Risk of Cerebral Palsy
Premature infants are at increased risk of developing cerebral palsy (CP). Early interventions for at risk infants have the potential to decrease disease severity and improve quality of life.
- Trial name
- NCT03372590
- Testing
- NICU-based rehabilitation bundle, Standard of care
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Virginia