Clinical trials: sponsored by University of Virginia
Common Cold
Effect of Probiotic on Rhinovirus Induced Colds
This is a randomized, double-blind placebo controlled trial to evaluate the effect of a probiotic (Bl-04) on the occurrence of rhinovirus-associated common cold illness in the experimental rhinovirus challenge model.
- Trial name
- MK EPRIC (NCT02679807)
- Testing
- Bifidobacterium animalis subsp. lactis Bl-04, sucrose
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Glioblastoma
FDG and FDOPA PET Demonstration of Functional Brain Abnormalities
The purpose of this pilot study will be to conduct a clinical trial using a time-of-flight PET scanner and MRI scanner to test an improved method for differentiating tumor recurrence from radiation necrosis in glioblastoma…
- Trial name
- NCT04315584
- Testing
- Positron Emission Tomography, Computed Tomography, Multiparametric Magnetic Resonance Imaging Scan
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Metabolic Syndrome, Insulin Sensitivity
Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome
The purpose of this study is to look at how insulin (a hormone that helps the cells get energy from sugar) in our body affects blood vessels (elasticity in the bigger blood vessels and blood flow in the smaller blood vessels in…
- Trial name
- EJB044 (NCT02633488)
- Testing
- metformin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Virginia
Astigmatism
Evaluating and Improving Functional Driving Vision of Patients With Astigmatism
Small amounts of astigmatism are often uncorrected in contact lens wearers. The effect with respect to driving is unknown, but it could threaten safe operation of a motor vehicle, especially under conditions such as nighttime…
- Trial name
- NCT02624791
- Testing
- 1-DAY ACUVUE® MOIST contact lenses, 1-DAY ACUVUE® MOIST for ASTIGMATISM contact lenses, No contact lenses
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Pain, Acute, Pain, Chronic
Noninvasive Brain Stimulation for Pain Relief
Non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial focused ultrasound (FUS), is be applied to healthy human subjects, acute pain patients, and chronic pain patients to investigate…
- Conditions
- Pain, Acute, Pain, Chronic, Pain, Experimental
- Trial name
- NCT04283643
- Testing
- Transcranial Focused Ultrasound, Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Head and Neck Neoplasm, Survivorship
Telemedicine Nurse-Led Intervention for Rural Cancer Survivors
This study will evaluate the impact, cost-effectiveness, and patient perspectives of Comprehensive Assistance: Rural Intervention, Nursing, and Guidance (CARING), a nurse-led supportive care protocol delivered using telemedicine…
- Trial name
- CARING (NCT04267627)
- Testing
- Comprehensive Assistance: Rural Interventions, Nursing, and Guidance (CARING)
- Volunteers
- 450 people
- Sponsor
- University of Virginia
Heart Failure, Systolic
Mechanistic Clinical Trial of Advanced Imaging for CRT
This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.
- Trial name
- NCT03398369
- Testing
- CMR/CTA Guidance for CRT
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Virginia
Heart Failure
Getting Into Light Exercise for Patients With Heart Failure
Despite scientific advances in treatment, patients with heart failure experience daily distressing symptoms and mortality rates are high.
- Trial name
- GENTLE:HF (NCT04248088)
- Testing
- Gentle Stretching and Education
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Acute Ischemic Stroke, Diabetes
Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial
The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial is a multicenter, randomized, controlled clinical trial of 1400 patients that will include approximately 60 enrolling sites.
- Conditions
- Acute Ischemic Stroke, Diabetes, Hyperglycemia
- Trial name
- SHINE (NCT01369069)
- Testing
- IV insulin to maintain target glucose concentration of 80-130 mg/dL, Standard Care control - sliding scale insulin to keep glucose less than 180 mg/dL
- Where
- 70 sites in United States
- Volunteers
- 1,151 people
- Sponsor
- University of Virginia
Type 1 Diabetes
The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
In this protocol, 60 subjects with DM1 will be studied at baseline, after 12 weeks of MCR blockade or 12 weeks of exercise, and again after an additional 12 weeks of MCR blockade, exercise or the combination of both…
- Trial name
- EJB048 (NCT03174288)
- Testing
- Exercise, Spironolactone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes
Use of CGM for Diabetes Management Following a Hospitalization.
Patients with diabetes hospitalized for heart failure or acute myocardial infarction will have a continuous glucose monitor (CGM) placed on the day of discharge which will be downloaded at their outpatient follow up clinic visit…
- Trial name
- NCT04149392
- Testing
- Continuous Glucose Monitor
- Sponsor
- University of Virginia
Focused Ultrasound
The Effects of Ultrasound on Central Nervous System
Focused ultrasound at low intensities is a form of neuromodulation with high spatial resolution that can be applied invasively or non-invasively using acoustic energy to affect neuronal activity.
- Trial name
- NCT04192149
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Virginia
High Intensity Focused Ultrasound, Deep Brain Stimulation
Interactions of Brain Regions in Visuomotor Adaptation
The purpose of this study is to better understand the roles the cerebellum, basal ganglia, and thalamus play in motor learning. Patients undergoing High Intensity Focused Ultrasound (HIFU) treatment will be receiving an ablation…
- Trial name
- NCT04190940
- Testing
- Behavioral Assessment
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Virginia
Ovarian Cancer
Feasibility of Opportunistic Salpingectomy During Non-Gynecologic Surgery
It is now felt that the majority of ovarian cancers originate in the fallopian tubes. Opportunistic salpingectomy has been found to decrease ovarian cancer risk by approximately 65%, with additional removal of the ovaries…
- Trial name
- NCT04176484
- Testing
- Survey
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Healthy Participants
Ultrasound Effects on Human Motor Cortical Plasticity
The purpose of this study is to test the duration and effect of single element focused ultrasound to the primary motor cortex on healthy human participants with the use of transcranial focused ultrasound and transcranial magnetic…
- Trial name
- NCT04168762
- Testing
- Transcranial Ultrasound Magnetic Stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Genetic Predisposition
Family Disclosure in Cascade Testing
Prospective cohort study to evaluate the feasibility and acceptability of using standardized educational and communication tools to assist in communication of genetic test results to family members.
- Trial name
- NCT04168736
- Testing
- Feasibility and Acceptability of Genetic Counseling Materials
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Healthy Participants
Functional Roles of Dorsolateral Prefrontal Cortex
Dorsolateral prefrontal cortex (DLPFC) has been found to be involved in cognitive functions such as executive function, response selection, and working memory.
- Trial name
- NCT03882931
- Testing
- Theta Burst Transcranial Magnetic Stimulation, Focused Ultrasound
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Healthy Participants
Cerebellar Functions in Visuomotor Adaptation
Transcranial focused ultrasound stimulation (tFUS) will be used in this study to functions of the cerebellum in human motor learning. Participants will complete a visuomotor task while receiving stimulation pulses from tFUS.
- Trial name
- NCT04168086
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Ischemic Stroke
A Study of the Relationship of Gut Microbial Composition and Stroke Outcome
The purpose of this study is to investigate the relationship between gut microbiome (bacteria in the gut), inflammation and the injured brain.
- Trial name
- GEMSTONE (NCT03470506)
- Testing
- Stool Samples
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Virginia
Polio
Environmental Surveillance (ES) for Polio and AMR Using the TaqMan Array Card
This study will be used to develop a tool to streamline poliovirus environmental surveillance for the polio endgame and to provide a tool for detecting polio in places where there is no capacity to carry out the gold standard…
- Trial name
- NCT03818477
- Where
- Bangladesh
- Volunteers
- 8,500 people, healthy volunteers welcome
- Sponsor
- University of Virginia