Clinical trials: sponsored by University of Virginia
Exercise Capacity, Metformin
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity
Metformin is the most prescribed blood sugar (glucose)-lowering medication for patients diagnosed with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT06638671
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Sentinel Lymph Node Biopsy (SLNB), Melanoma (Skin Cancer)
Evaluating a Decision Aid for Sentinel Lymph Node Biopsy in Intermediate-Risk Melanoma
This research study is testing a decision aid to help patients think through whether to have sentinel lymph node biopsy for melanoma.
- Trial name
- Mel73 (NCT07653087)
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Virginia
Pancreas Cancer, Pancreatic Cancer
Study of EGFRBi Armed Fresh PBMC in Metastatic or Unresectable Pancreatic Cancer
The purpose of this study is to understand the safety and estimate the efficacy of combining anti-cluster of differentiation 3 (CD3) x anti-Epidermal Growth Factor Receptor (EGFR) bispecific antibody fresh peripheral blood…
- Trial name
- Panc 002 (NCT06479239)
- Testing
- EGFR FPBMC
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Virginia
Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma
BATs Treatment for Pancreatic Cancer, Phase Ib/II
This protocol will confirm toxicities and estimate the clinical efficacy of combining anti-CD3 x anti-EGFR bispecific antibody (EGFRBi) armed activated T cells (EGFR BATs) given to patients with locally advanced or metastatic…
- Trial name
- NCT03269526
- Testing
- EGFR BATs after standard of care chemo
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Virginia
Alcohol Drinking, Binge Drinking
Text-Based Messaging Strategies for Preventing Subsequent Problematic Alcohol Use
Binge drinking, and its health/social consequences are substantial public health concerns, with a high prevalence in young adults, especially in the US military.
- Conditions
- Alcohol Drinking, Binge Drinking, Text Messaging
- Trial name
- NCT06318975
- Testing
- Brief Alcohol Intervention, Automated and Targeted Text Messages
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Breast Cancer, Prostate Cancer
HER2 FPBMC in Patients With Metastatic Breast and Prostate Cancer (AM006)
The purpose of this study is to understand the safety and estimate the efficacy of anti-CD3 x anti-HER2 bispecific antibody (HER2Bi) armed fresh peripheral blood mononuclear cells (HER2 FPBMC) for patients with metastatic breast…
- Trial name
- NCT07441889
- Testing
- HER2 FPBMC
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Virginia
Epilepsy; Seizure
Pharmacokinetics Study of Oral 2-Deoxy-D-Glucose (2DG) in Subjects With a Confirmed Diagnosis of Epilepsy
This project studies how 2-deoxy-glucose (2DG) pills are absorbed and distributed in people with epilepsy. 2DG is similar to glucose, the main energy source for the brain, but it cannot be used as energy.
- Trial name
- NCT05605301
- Testing
- Oral 2-Deoxy-D-Glucose (2DG)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Virginia
Prostate Cancer, Hot Flashes
A Feasibility Study of Biometric Measurements Via Wearable Smart Watch Technology for Evaluation of Vasomotor Symptoms in Patients Treated With Androgen Deprivation Therapy for Prostate Cancer (Prostate 007)
The purpose of this study is to find out if patients with prostate cancer who have vasomotor symptoms, commonly called hot flashes, from their Androgen Deprivation Therapy (ADT) will consistently wear a smartwatch device to track…
- Trial name
- BioWEAR (NCT07535541)
- Testing
- VMS logging
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Virginia
Orthopedic Disorder, Humerus Fracture
Early Versus Delayed Rehabilitation After Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture
Proximal humerus fractures can be a debilitating injury in the elderly, impacting the ability to function independently or complete activities of daily living due to pain and restricted shoulder motion.
- Conditions
- Orthopedic Disorder, Humerus Fracture, Shoulder Arthroplasty, Reverse Shoulder Replacement
- Trial name
- NCT06869343
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Ankle Fractures, Pilon Fracture
Simplified Post Op Rehabilitation for Ankle and Pilon Fractures
The aim of this study is to compare standard post operative rehabilitation with a simplified wooden block stretching protocol that will yield similar results.
- Trial name
- NCT05280639
- Testing
- Wooden block, Formal physical therapy or Home Exercise Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
NAFLD
Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant
In this study, semaglutide will be compared to placebo (a look-alike inactive substance, a "sugar pill") to determine if its use will prevent weight gain after liver transplantation (LT).
- Trial name
- NCT05424003
- Testing
- Semaglutide Pen Injector
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Males, Females
Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes
This study is examining whether short-term supplementation with inorganic nitrate, in the form of beetroot juice, can enhance blood vessel health, insulin sensitivity, and exercise capacity in individuals with prediabetes.
- Conditions
- Males, Females, Sedentary, Metformin
- Trial name
- NO3-PreDM (NCT07131384)
- Testing
- Dietary Supplement: Inorganic Nitrate (Beetroot juice)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Femoral Neck Fractures, Intertrochanteric Fractures
PENG vs FICB for Hip Fracture in ED Patients
Regional anesthesia for hip fractures has been shown to decrease rates of delirium in elderly patients with hip fractures as well as improve pain compared to systemic opioids.
- Trial name
- NCT05505604
- Testing
- PENG, FICB
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Sepsis, Tuberculosis
STeroids and Enhanced Spectrum Antibiotics for the Treatment of Patients in Africa With Refractory Sepsis
Sepsis, a life-threatening condition due to a dysregulated response to infection, is the leading cause of global mortality and is frequently driven by tuberculosis (TB) and drug-resistant bacteria in sub-Saharan Africa…
- Trial name
- STARS (NCT07332325)
- Testing
- Hydrocortisone administration, Expanded antimicrobial therapy
- Where
- 4 sites in Tanzania, Uganda
- Volunteers
- 344 people
- Sponsor
- University of Virginia
Antibiotic Resistance Prevention
Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants
The investigators are examining the role of circulating T follicular helper (Tfh) cells in the induction of the antibody responses.
- Trial name
- NCT07615842
- Testing
- Azithromycin
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Cocaine Use Disorder, Cocaine Dependence
Low-Intensity Focused Ultrasound for Cocaine Use Disorder
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
- Trial name
- NCT05857852
- Testing
- Low-Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Mycobacterium Avium-intracellulare Infection, Mycobacterium Infections, Nontuberculous
Safety, Immunogenicity, and Efficacy of Therapeutic Mycobacterium Bovis BCG (BOOST)
The purpose of this study is to find out if the Mycobacterium bovis Bacillus Calmette Guerin (BCG) vaccine can be used safely to treat Mycobacterium avium complex (MAC) lung disease.
- Trial name
- BOOST (NCT07094711)
- Testing
- Mycobacterium bovis Bacillus Calmette Guerin (BCG) vaccine, preservative-free saline
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Virginia
Opioid Dependence
Utilizing Helpline for Opioid Dependence Treatment
The investigator propose to develop an opioid telephone helpline, where trained counselors and educators provide referral, educational and targeted interventions and support to individuals interested in addressing their addiction…
- Trial name
- NCT03969238
- Testing
- Helpline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD)
Expanding Access to Cognitive Health Biomarker Testing at Home
The goal of this observational study is to learn whether at-home blood biomarker testing for Alzheimer's disease risk is feasible and acceptable in older adults with cognitive concerns.
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD), Subjective Cognitive Decline (SCD), Cognitive Aging
- Trial name
- NCT07594665
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
InsuLearn Feasibility With Type 1 Diabetes Patients Under MDI Therapy
This is a 24-hour, randomized, crossover, single-center trial where participants are randomized to either start with the InsuLearn intervention or the usual care (UC) intervention.
- Trial name
- InsuLearn (NCT06411548)
- Testing
- InsuLearn
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Virginia