Clinical trials: sponsored by University of Virginia
Mental Health Issue
Implementation Supports for Improving Identification and Delivery of School-based Mental Health Supports for Middle Schools Students
This study will assess how different types of training and support influence the way that school staff understand, and respond to, the mental and behavioral health needs of middle school students.
- Trial name
- E-IMPACTS (NCT06047041)
- Testing
- EIS Only, EIS + ECHO
- Where
- 3 sites in United States
- Volunteers
- 21,350 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Ankle Deformity, Ankle Arthritis
ViviGen Cellular Bone Matrix for Hindfoot or Ankle Arthrodesis
To evaluate the fusion status of the hindfoot bones after receiving the ViviGen graft, an FDA approved cellular bone matrix. This is used in a population indicated for hindfoot arthrodesis as an alternative to an autograft.
- Trial name
- ViviGen (NCT04138017)
- Testing
- ViviGen
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Incision, Surgical
Orthopaedic Surgical Wound Closure Comparison Study
This study is trying to find out if there is one method of surgical incision closure is better than another. The three different wound closure methods in this study are currently used in standard of care.
- Trial name
- NCT05251064
- Testing
- Suture, Clozex, Zipline
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Virginia
Breast Cancer, Cardiotoxicity
The Effects of Two Exercise Interventions on Breast Cancer Patients Undergoing Cardiotoxic Chemotherapies
The purpose of this study is to determine if exercise preconditioning can mitigate the off target effects of chemotherapy treatment on measures of cardiovascular function, inflammatory responses, and quality of life.
- Conditions
- Breast Cancer, Cardiotoxicity, Cardiovascular Diseases
- Trial name
- NCT05786014
- Testing
- High Intensity Interval Exercise, Moderate Intensity Walking
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Ovarian Cancer
Exercise Preconditioning in Ovarian Cancer
The purpose of this study is to determine if exercise preconditioning can mitigate the off target effects of chemotherapy treatment on measures of cardiovascular function, peripheral neuropathy, and quality of life.
- Trial name
- NCT05029154
- Testing
- High intensity interval exercise, Attention control
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Virginia
Infant Death, Sudden Infant Death
Get Social Media and Risk-Reduction Training
This study examines the implementation of the TodaysBaby™ mobile safe sleep intervention program in US hospitals. The main aims of this study are to examine: 1) differences in program penetration and the equity of penetration…
- Trial name
- GETSMART (NCT06618586)
- Testing
- TodaysBaby
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Heart Failure With Reduced Ejection Fraction
PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction
This study is trying to find out whether performing a hybrid aerobic-resistance exercise training program (titled PRIME: Peripheral Remodeling via Intermittent Muscular Exercise) results in better health outcomes than the…
- Trial name
- NCT05609097
- Testing
- PRIME, COMBO
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Virginia
Myocardial Infarction
Multimodality Cardiovascular Imaging for the Translation of Therapies for Vascular Activation After MI
Subjects with urgently reperfused type I myocardial infarction (MI) will be recruited and randomized to receive either placebo or the oral inflammasome (NLRP3) inhibitor dapansutrile.
- Trial name
- NCT05880355
- Testing
- Dapansutrile
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Diet Habit, Sugar-Sweetened Beverages
iSIPsmarter: A Pilot RCT to Evaluate a Web-based Behavioral Intervention to Reduce Sugary Beverages Among Black Adults
The proposed pilot randomized controlled trial (RCT) will enroll 24 Black adults. The overall goal is to examine the preliminary efficacy of iSIPsmarter in a 2 group [iSIPsmarter vs.
- Trial name
- NCT06184737
- Testing
- iSIPsmarter, Patient Education (PE)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Complete Tear, Knee, Anterior Cruciate Ligament, Rupture of Anterior Cruciate Ligament
Tibial Tunnel Placement for ACL Reconstruction
Although extensive research has been carried out on Anterior Cruciate Ligament (ACL) femoral tunnel placement, very little attention has been given to the tibial tunnel.
- Trial name
- NCT02374710
- Testing
- ACL Reconstruction: Anterior Tunnel, ACL Reconstruction: Posterior Tunnel
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Virginia
Adhesive Capsulitis, Frozen Shoulder
ZILRETTA™ for Treatment of Idiopathic Adhesive Capsulitis
Adhesive capsulitis is a fairly common orthopedic condition that causes pain and loss of range of motion. There are a variety of ways to treat adhesive capsulitis, one of them being an intra-articular steroid injection.
- Conditions
- Adhesive Capsulitis, Frozen Shoulder, Adhesive Capsulitis of Shoulder
- Trial name
- NCT04831255
- Testing
- triamcinolone acetonide extended-release injectable suspension
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Virginia
Coronary Microvascular Dysfunction (CMD), Angina Patients With Non-obstructive Coronary Artery Disease
Inorganic Nitrate as a Treatment for ANOCA: NO-ANOCA
The purpose of this study is to see if inorganic nitrate in the form of beetroot juice helps blood flow and physical fitness in women with ANOCA and CMD.
- Trial name
- NO-ANOCA (NCT06948201)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Virginia
Lymphedema of Leg, Lymphedema, Secondary
Imaging Sodium and Lymphatics in Lymphedema
Recent evidence supports lymphatic regulation of tissue sodium handling, however fundamental gaps persist in knowledge regarding the role of lymphatics in human diseases of sodium dysregulation.
- Conditions
- Lymphedema of Leg, Lymphedema, Secondary, Lymphedema Related Fibrosis
- Trial name
- NCT05242900
- Testing
- Complete decongestive therapy, Standard imaging protocol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Virginia
Lipedema
Visualizing Vascular Mechanisms of Lipedema
This work will address clinical unmet needs for patients with lipedema using advanced magnetic resonance imaging (MRI) methods, in sequence with portable clinical tools, by testing fundamental hypotheses regarding potential…
- Trial name
- VMP (NCT05464927)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Breast Cancer, Breast Cancer Stage I
Adjuvant Chemoradiation and Biomarkers of Response in High-risk Breast Cancer
The goal of this study is to evaluate the safety and effectiveness of adjuvant chemoradiation therapy in high-risk breast cancer patients who had received neoadjuvant chemotherapy before their lumpectomy and/or mastectomy and…
- Conditions
- Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III
- Trial name
- Breast53 (NCT05288777)
- Testing
- T-DM1, Capecitabine, External Beam Radiation Therapy 0
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Virginia
Sugary Beverages
Kids SipSmartER, an Intervention to Reduce Sugar-sweetened Beverages
Overall Goal: To determine the effectiveness of Kids SIPsmartER in improving sugar-sweetened beverages behaviors among 7th grade students. Secondary aims are to determine (1) changes in secondary student outcomes (e.g.
- Trial name
- NCT03740113
- Testing
- Kids SipSmartER
- Where
- United States
- Volunteers
- 1,013 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Carpal Tunnel Syndrome
Topical Cannabidiol for Treating Carpal Tunnel Syndrome
The Purpose of this study is to assess the safety and efficacy of Cannabidiol on treatment of Carpal Tunnel Syndrome.
- Trial name
- NCT06108349
- Testing
- Cannabidiol
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
HPV Infection, Cervical Cancers
Remote Resilience: Novel Applications of mHealth in Nicaragua's Cancer Control Program
The goal of this clinical trial is to test an mHealth intervention for cervical cancer prevention in under-screened women ages 25-64 on the Caribbean Coast of Nicaragua.
- Trial name
- NCT06921798
- Testing
- mHealth
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Nasal Polyps, Staphylococcus Aureus
Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP
Hypothesis: The investigators hypothesize that in patients with CRSwNP who demonstrate sinus colonization with staphylococcus aureus, the administration of dupilumab will be associated with decreased staph colonization and an…
- Trial name
- NCT05094570
- Testing
- Dupilumab Prefilled Syringe
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Asthma
Viral Infection in Asthma (VIA) Study
Often when people with asthma get a virus caused by the common cold (rhinovirus), they also experience an increase or worsening of their asthma symptoms.
- Trial name
- VIA (NCT04380038)
- Testing
- Dupilumab Injectable Product
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Virginia