Clinical trials: sponsored by University of Virginia
Tuberculosis, HIV I Infection
Early Empiric Anti-Mycobacterium Tuberculosis Therapy for Sepsis in Sub-Saharan Africa
In sub-Saharan Africa, tuberculosis (TB) is the etiology of 25-50% of bloodstream infections (BSIs) and the leading cause of sepsis among people living with HIV.
- Conditions
- Tuberculosis, HIV I Infection, Sepsis
- Trial name
- ATLAS (NCT04618198)
- Testing
- Immediate anti-TB therapy, Sepsis-specific dose anti-TB therapy
- Where
- 2 sites in Tanzania, Uganda
- Volunteers
- 437 people
- Sponsor
- University of Virginia
Mental Health Issue, Breast Cancer
Evaluating Digital Micro-Interventions to Reduce Distress and Increase Wellbeing in Breast Cancer Survivors
Digital mental and behavioral health interventions have potential to significantly improve accessibility for the large number of breast cancer survivors who need treatments.
- Trial name
- NCT07160439
- Testing
- Digital Micro-Interventions
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Virginia
Epilepsy; Seizure
Pharmacokinetics Study of Oral 2-Deoxy-D-Glucose (2DG) in Subjects With a Confirmed Diagnosis of Epilepsy
This project studies how 2-deoxy-glucose (2DG) pills are absorbed and distributed in people with epilepsy. 2DG is similar to glucose, the main energy source for the brain, but it cannot be used as energy.
- Trial name
- NCT05605301
- Testing
- Oral 2-Deoxy-D-Glucose (2DG)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Virginia
Pediatric HD, Bleeding
Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients
The aim of the current pilot study proposal is to compare the use of the purified human fibrinogen concentrate (Fibryga®, Octapharma USA) to cryoprecipitate for the treatment of cardiopulmonary bypass (CPB)-associated bleeding in…
- Trial name
- NCT04376762
- Testing
- Fibrinogen, Cryoprecipitate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Type 2 Diabetes
The Effect and Safety of a Novel CGM-Based Titration Algorithm for Basal Insulin in T2DM Participants.
The goal of this clinical trial is to compare the effect of a continuous glucose monitor (CGM) based titration algorithm to standard titration by self-monitoring blood glucose (SMBG) in participants with Type 2 Diabetes already…
- Trial name
- CGM-DTx (NCT06111508)
- Testing
- Continuous Glucose Monitoring (CGM)-based titration algorithm implemented in DiAs
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Metastatic Breast Cancer
Her2-BATS and Pembrolizumab in Metastatic Breast Cancer
This proposal uses HER2Bi armed activated T-cells (HER2 BATs) to target breast cancer in combination with pembrolizumab (PBZ) in women with metastatic breast cancer (MBC).
- Trial name
- Breast-47 (NCT03272334)
- Testing
- HER2 BATs with Pembrolizumab
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Virginia
Sepsis, Necrotising Enterocolitis Neonatal
Integrated Predictive Monitoring for Sepsis and Necrotizing Enterocolitis
Behind the scenes pilot trial in the computer lab involving chart review to use neonatal intensive care unit data to create computer models predicting sepsis and necrotizing enterocolitis in very small premature infants
- Trial name
- PREMO (K) (NCT07254559)
- Testing
- No Intervention: Observational Cohort
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Virginia
Tissue Pain
Optical Measurements of the Skin Surface to Infer Distinctions in Myofascial Tissue Stiffness
This study involves imaging the skin movements of surface tissue on the back. A clinician will perform assessment and intervention procedures manually, using manual and light movements of stretch and compression.
- Trial name
- OptMeasSkin (NCT06390085)
- Testing
- Soft tissue manipulation
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Depression, Anxiety, Engagement, Patient
Mobile Apps to Reduce Distress in Breast Cancer Survivors Using an Adaptive Design
The overarching goals of this project are to provide the first rigorous test of a scalable and publicly accessible mobile health intervention (IntelliCare) to address emotional distress in women with breast cancer, and to test…
- Trial name
- NCT04583891
- Testing
- IntelliCare, Psychoeducation, Coaching
- Where
- United States
- Volunteers
- 313 people
- Sponsor
- University of Virginia
Alcohol Dependence, Nicotine Dependence
New Treatment for Alcohol and Nicotine Dependence
This research study aims to test whether topiramate (a drug that is being used for seizure) will help individuals who have problems with both alcohol and nicotine.
- Trial name
- NCT01182766
- Testing
- Low-Dose Topiramate, High-Dose Topiramate
- Where
- 4 sites in United States
- Volunteers
- 236 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Adapting Diabetes Treatment Expert Systems to Patient in Type 1 Diabetes
This study is evaluate the superior efficacy of a Continuous Glucose Monitor (CGM)-based advisory system in Type 1 Diabetes Mellitus (T1DM), as compared to Sensor Augmented Mode (SAM) therapy, and with characterizing the impact…
- Trial name
- DSS-2 (NCT04443153)
- Testing
- Personalized Feedback, Decision Support System, Sensor Augmented Mode
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Virginia
Diet Habit, Sugar-Sweetened Beverages
iSIPsmarter: An RCT Evaluating the Efficacy of a Technology-Based Intervention to Reduce Sugary Drinks in Rural Appalachia
The proposed randomized controlled trial (RCT) is guided by the RE-AIM (i.e. reach, efficacy, adoption, implementation, maintenance) framework and targets 244 adults from rural Appalachia.
- Trial name
- NCT05030753
- Testing
- iSIPsmarter, Patient Education (PE)
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Septic Shock
Midodrine Use in Septic Shock
The investigators aim to perform a randomized, double-blind, placebo-controlled trial to investigate the efficacy of midodrine in decreasing time to IV vasopressor liberation in patients with septic shock.
- Trial name
- NCT03706053
- Testing
- Midodrine Hydrochloride
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Virginia
CBD, Hand Osteoarthritis
Is Topical CBD Effective in Treating Thumb Joint Arthritis
Rationale: CBD is commonly being used as an over-the-counter treatment for arthritis-related pain, however no clinical trial has been performed to establish efficacy.
- Trial name
- NCT04611347
- Testing
- CBD, Shea Butter
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Ankle Deformity, Ankle Arthritis
ViviGen Cellular Bone Matrix for Hindfoot or Ankle Arthrodesis
To evaluate the fusion status of the hindfoot bones after receiving the ViviGen graft, an FDA approved cellular bone matrix. This is used in a population indicated for hindfoot arthrodesis as an alternative to an autograft.
- Trial name
- ViviGen (NCT04138017)
- Testing
- ViviGen
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Incision, Surgical
Orthopaedic Surgical Wound Closure Comparison Study
This study is trying to find out if there is one method of surgical incision closure is better than another. The three different wound closure methods in this study are currently used in standard of care.
- Trial name
- NCT05251064
- Testing
- Suture, Clozex, Zipline
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Virginia
Sugary Beverages
Kids SipSmartER, an Intervention to Reduce Sugar-sweetened Beverages
Overall Goal: To determine the effectiveness of Kids SIPsmartER in improving sugar-sweetened beverages behaviors among 7th grade students. Secondary aims are to determine (1) changes in secondary student outcomes (e.g.
- Trial name
- NCT03740113
- Testing
- Kids SipSmartER
- Where
- United States
- Volunteers
- 1,013 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Normal, PCOS
Determining How Quickly Progesterone Slows LH Pulse Frequency
The rapidity with which progesterone (P) suppresses daytime lutenizing hormone (LH) (and by inference gonadotropin releasing hormone (GnRH)) pulse frequency is unknown.
- Trial name
- CRM001 (NCT00594217)
- Testing
- oral micronized progesterone suspension
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cervical Cancer
A Randomized Study to Compare a Hydrogel Packing System to Standard Packing During HDR Brachytherapy for Cervical Cancer
In this study, a new, low cost packing system ("BrachyGel VHPS") is being tested as a packing option during brachytherapy along with standard options to make sure that it keeps the unrelated organs away from radiation at least as…
- Trial name
- NCT04499521
- Testing
- BrachyGel VHPS
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Virginia
Smoking Cessation
Establishing the Effectiveness of Publicly Available Smoking Cessation Resource
The purpose of this study is to evaluate the effectiveness of SmokefreeTXT, a smoking cessation text messaging program currently available to anyone in the United States through www.smokefree.gov, and to compare cessation…
- Trial name
- NCT05055778
- Testing
- SmokefreeTXT
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Virginia