Clinical trials: sponsored by University of Washington
HIV Prevention, HIV Preexposure Prophylaxis
Streamlining the Efficiency of PrEP Implementation
This is a pilot facility-based direct-to-pharmacy PrEP refill delivery to streamline care pathway in Kenyan public health HIV facilities implementing PrEP.
- Conditions
- HIV Prevention, HIV Preexposure Prophylaxis, Implementation
- Trial name
- Efficiency (NCT04424524)
- Testing
- Direct-to-pharmacy oral PrEP refill visits
- Where
- Kenya
- Volunteers
- 746 people
- Sponsor
- University of Washington
Asthma in Children
Action Towards Health Equity and Improved Air Quality in the Duwamish Valley: A Multilevel Asthma Intervention
The goal of this randomized control trial is to learn if box fans and filters can reduce asthma symptoms and improve indoor air quality in children ages 6 - 17 years old with asthma living in the Duwamish Valley, Seattle…
- Trial name
- DAISY (NCT06552013)
- Testing
- MERV 13 filter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Depression
Mobile Mental Health in Community-Based Organizations
Untreated depression is a significant cause of morbidity and mortality among women in low and middle- income countries (LMIC). The investigators propose to develop and test the feasibility an interactive voice-response, mobile…
- Trial name
- MITHRA (NCT04480021)
- Testing
- MITHRA, EUC
- Where
- India
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Kidney Diseases
A Pilot Study of The CKM JumpStart Tool
This is a randomized pilot study to test the feasibility and acceptability of a tool to promote discussion about conservative kidney management (CKM) among older patients with advanced CKD and their providers.
- Trial name
- NCT05753020
- Testing
- CKM Jumpstart Tool
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pulmonary Arterial Hypertension, Right Heart Failure
Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension
This is a Phase 2, single-center, randomized placebo controlled trial of famotidine (an H2 receptor antagonist) in adults with pulmonary arterial hypertension.
- Trial name
- REHAB-PH (NCT03554291)
- Testing
- Famotidine 20 MG
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Tuberculosis
Prospective Evaluation of Novel Diagnostics for Tuberculosis in KwaZulu-Natal, South Africa
Tuberculosis (TB) infects nearly two billion people and has become the leading infectious cause of mortality worldwide, due in part to inadequate diagnostic and prognostic tests.
- Trial name
- PROVE-TB (NCT04583904)
- Where
- South Africa
- Volunteers
- 843 people
- Sponsor
- University of Washington
Postpartum, Lactation
Drug Excretion in Breast Milk
This is a prospective, non-randomized, phase I study design evaluating the in vivo activities and expression of OCT1 and BCRP in mammary gland of lactating women at three time points postpartum.
- Conditions
- Postpartum, Lactation, Drugs in Breast Milk, Mammary Drug Transporters
- Trial name
- NCT06056583
- Testing
- Cimetidine 200 MG
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Immune Response to SARS-CoV-2 (COVID-19) Vaccines in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
This study evaluates the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
- Trial name
- NCT04852822
- Testing
- Biospecimen Collection, Electronic Health Record Review
- Where
- 11 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Washington
Rheumatoid Arthritis
A Study to Evaluate Biomarkers to Predict Efficacy of Abatacept in Rheumatoid Arthritis
The primary objective of this study is to evaluate if baseline levels of T cell associated biomarkers predict efficacy of abatacept during 24 weeks of treatment in patients with moderate to severe active Rheumatoid Arthritis (RA)…
- Trial name
- NCT03882008
- Testing
- Abatacept
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Washington
Healthy
Reducing Sugared Fruit Drinks in Alaska Native Children
This study in Alaska will test whether providing sugar-free alternatives to sugared fruit drinks and introducing education and social support will help families and children to reduce the amount of sugared fruit drinks consumed…
- Trial name
- NCT05219448
- Testing
- Education and self-efficacy coaching
- Where
- United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alzheimer Disease, Dementia
Innovations in Dementia Empowerment and Action
The lack of efficacious research-based interventions for such vulnerable older adults with Alzheimer's disease and related dementias (AD/RD) and their caregivers (CGs) is a significant public health problem.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Parkinson Disease Dementia
- Trial name
- IDEA (NCT03550131)
- Testing
- Innovations in Dementia Empowerment and Action (IDEA), Reducing Disabilities in Alzheimer's Disease (RDAD)
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- University of Washington
Psychosis, Mania
Combining mHealth and Nurse-delivered Care to Improve the Outcomes of People With Serious Mental Illness in West Africa
In West Africa, most people with serious mental illness receive care from traditional or faith healers at prayer camps. The stepped-wedge cluster randomized trial aims to evaluate the effectiveness of a dual-pronged intervention…
- Conditions
- Psychosis, Mania, Depression
- Trial name
- NCT05703711
- Testing
- mHealer
- Where
- Ghana
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV
Effects of the Anti-HIV Pill Truvada on Gene Transcription in the Gastrointestinal Tract of HIV-uninfected Individuals
As explained in detail in a recently published hypothesis article (Hladik F. A new hypothesis on HIV cure. F1000Research, 4:77 (2015)), the investigators hypothesize that NRTI drugs may reduce the likelihood of HIV eradication by…
- Trial name
- NCT02621242
- Testing
- Upper endoscopy, Anoscopy, Truvada
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections, HIV/AIDS
Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
This is a randomized clinical trial of doxycycline post-exposure prophylaxis (dPEP) to reduce bacterial STIs among Kenyan women taking pre-exposure prophylaxis (PrEP).
- Conditions
- HIV Infections, HIV/AIDS, Neisseria Gonorrheae Infection, Chlamydia Trachomatis Infection
- Trial name
- dPEP-KE (NCT04050540)
- Testing
- Doxycycline
- Where
- Kenya
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of Washington
Surgery
Nudges for Opioid Reduction After Major Surgery Trial
This is a prospective pilot trial to evaluate a new electronic medical record based intervention to improve discharges after surgery.
- Trial name
- NORMS (NCT04927351)
- Testing
- Electronic Medical Record Based Discharge Medication Order Set
- Where
- United States
- Volunteers
- 484 people
- Sponsor
- University of Washington
Asthma in Children
Improving Asthma Care Together (IMPACT): A Shared Management Pilot Study
This study aims to iteratively develop, refine and test the Improving Asthma Care Together (IMPACT) Intervention for school-age children (7-11 years) with persistent asthma and their parents.
- Trial name
- IMPACT (NCT04908384)
- Testing
- Improving Asthma Care Together (IMPACT)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Washington
Tibial Plateau Fractures
Local Anesthetic for Plateau Fractures
Subjects may receive an injection at the end of the surgery to fix their broken leg that may reduce their pain and hospital stay
- Trial name
- NCT06474949
- Testing
- Bupivacaine injection, Saline
- Volunteers
- 100 people
- Sponsor
- University of Washington
Lower Extremity Amputation
Community Walking Trials: Comparing Prosthetic Feet
The purpose of the study is to obtain performance measurements and participant feedback about use of an investigational prosthetic foot compared to the participant's usual prosthetic foot.
- Trial name
- NCT03703232
- Testing
- Investigational prosthetic foot
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Washington
Bone Demineralization, Hypoestrogenism
The Kampala Women's Bone Study
The primary objective of this study is to address critical safety questions with concurrent TDF-based PrEP and DMPA use. We hypothesize that young women using TDF-based PrEP and DMPA will have lower bone acquisition and altered…
- Conditions
- Bone Demineralization, Hypoestrogenism, Subclinical Kidney Injury, Bone Microarchitecture
- Trial name
- NCT03464266
- Testing
- FTC/TDF and DMPA, FTC/TDF, DMPA
- Where
- Uganda
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Washington
Out-Of-Hospital Cardiac Arrest
First Responder Airway & Compression Rate Trial
The First responder Airway \& Compression rate Trial (FACT) Study will address basic life support (BLS) treatments administered by Emergency Medical Services (EMS) first responders to patients who suffer a sudden circulatory…
- Trial name
- FACT (NCT05969028)
- Testing
- igel, Compression Rate
- Where
- United States
- Volunteers
- 4,200 people
- Sponsor
- University of Washington
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