Clinical trials: sponsored by University of Washington
Type 1 Diabetes
Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose
This study evaluates direct switching vs use of a bridging dose from insulin glargine to insulin degludec in type 1 DM patients.
- Trial name
- GLIDING (NCT04623086)
- Testing
- Insulin Degludec, Insulin Glargine
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Washington
Multiple Sclerosis (MS), Fatigue
Increasing Physical Activity for Adults With Multiple Sclerosis (MS)
This study aims to advance the scientific understanding and potential future implementation of physical activity promotion by testing the efficacy of a phone-based app for increasing activity in insufficiently active patients…
- Conditions
- Multiple Sclerosis (MS), Fatigue, Physical Inactivity
- Trial name
- NCT06270641
- Testing
- ExerciseRx intervention
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Washington
Breast Cancer, Invasive Breast Carcinoma
Adaptive Training Exercise Programs for Improving Cardiorespiratory Fitness After Breast Cancer Treatment, The ACTIVATE Trial
This clinical trial studies the feasibility of implementing various adaptive training exercise programs to improve cardiorespiratory fitness in patients after receiving breast cancer treatment.
- Trial name
- ACTIVATE (NCT04667481)
- Testing
- Aerobic Exercise Intervention, Resistance Exercise Intervention, Exercise Intervention: Digital copies and outline of sessions
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Washington
Insomnia, End Stage Renal Disease
Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis
Insomnia is a common and distressing symptom for patients on hemodialysis (HD), and there is evidence for a much larger impact on the health of patients.
- Trial name
- Sleep-HD (NCT03534284)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Trazodone
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Washington
Error Disclosure
Optimizing Video Communication Assessment for Teaching Error Disclosure Skills
The goal of this randomized, single-blinded, educational study is to test the effect of providing crowdsourced ratings and feedback to second-year (PGY2) internal medicine (IM) and family medicine (FM) resident physicians' about…
- Trial name
- NCT06234085
- Testing
- VCA feedback report available
- Where
- 7 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Washington
Subarachnoid Hemorrhage, Severe Traumatic Brain Injury
Outcomes Associated With Application of a Normothermia Protocol in Patients With Severe Neurological Insult and Fever
When fever is present in patients with stroke, traumatic brain injury (TBI), or brain hemorrhage, it has been associated with worse outcomes including larger areas of tissue death, increased length of stay, worse degree of coma…
- Trial name
- SNIF (NCT00890604)
- Testing
- Stepwise normothermia protocol, Ibuprofen, Acetominophen
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Dental Caries in Children, Pediatric Dental Sedation
Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years
The primary objective of this randomized controlled trial is to assess the effects of oral sedation using midazolam and hydroxyzine with and without meperidine (a narcotic) on sedation outcomes in pediatric dental patients…
- Conditions
- Dental Caries in Children, Pediatric Dental Sedation, Meperidine, Hydroxyzine
- Trial name
- NCT04068948
- Testing
- Meperidine, Hydroxyzine, Midazolam
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Washington
Infectious Diseases
The Added Value of a Mobile Application of Community Case Management on Pediatric Referral Rates in Malawi
Community Case Management (CCM) is a clinical decision aid used by frontline Health Surveillance Assistants (HSAs) in Malawi to manage uncomplicated cases of pneumonia and malaria (amongst other conditions).
- Trial name
- NCT02763345
- Testing
- Supporting LIFE electronic Community Case Management, Standard care
- Volunteers
- 6,995 people
- Sponsor
- University of Washington
Pregnancy Abnormal
Spontaneous Fetal EEG Recording During Labor
This is a pilot feasibility study for a new application of an approved fetal heart rate monitoring device system. The objective of this study is to validate the feasibility of acquiring the new modality of human fetal…
- Trial name
- NCT03013569
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Fetal Monitoring
Can Conventional ECG Technology Capture Fetal Cardiac Activity?
This is a feasibility study for a new application for capturing fetal cardiac activity. The objective of this study is to determine if it is feasible to capture a fetal ECG signal using a Holter ECG device.
- Trial name
- NCT03111173
- Testing
- Holter Device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
High Grade Ovarian Serous Adenocarcinoma, Stage III Ovarian Cancer AJCC v8
Lavage of the Uterine Cavity for Diagnosis of Ovarian Cancer
The goal of this project is to develop a minimally invasive test to detect ovarian cancer, by searching for mutations from the tumor in samples obtained from the cervix (Pap smears), and from the uterus (uterine lavage) in…
- Conditions
- High Grade Ovarian Serous Adenocarcinoma, Stage III Ovarian Cancer AJCC v8, Stage IIIA Ovarian Cancer AJCC v8, Stage IIIA1 Ovarian Cancer AJCC v8
- Trial name
- NCT03606486
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis, Lavage
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Washington
Dental Implants
Mandibular Overdenture Clinical Trial Comparing Parallel Sided and Tapered Dental Implants
The purpose of the study is to compare two different types of dental implants which will be used to support/retain a removable denture in the edentulous mandible.
- Trial name
- NCT03272828
- Testing
- Nobel Biocare titanium dental implants
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Washington
Frailty
Mobile Health Intervention to Support Healthful Diet
This will be a pilot clinical trial to evaluate preliminary efficacy of a newly designed mobile intervention designed to support healthy eating in old people.
- Trial name
- NCT05236712
- Testing
- Mobile app
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lung
Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers
This phase I/II trial studies the side effects and how well nivolumab and ipilimumab works when given together with stereotactic body radiation therapy (SBRT) in treating patients with salivary gland cancers.
- Conditions
- Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lung, Salivary Gland Carcinoma, Stage IV Major Salivary Gland Cancer AJCC v8
- Trial name
- NCT03749460
- Testing
- Nivolumab, Ipilimumab, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Type 2 Diabetes
FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR)
Results of recent studies using standard long and short acting insulin therapy (Basal - Bolus or BBI) in type 2 diabetes mellitus (T2DM) have not shown benefits to lower risks for heart attacks, strokes, or eye, nerve and kidney…
- Trial name
- FLAT-SUGAR (NCT01524705)
- Testing
- Insulin Glargine, Metformin, Prandial insulin
- Where
- 12 sites in United States
- Volunteers
- 102 people
- Sponsor
- University of Washington
Type 2 Diabetes Mellitus, Myocardial Fibrosis
Effects of SGLT-2 Inhibition on Myocardial Fibrosis and Inflammation as Assessed by Cardiac MRI in Patients With DM2
There is an unmet need for Cardiovascular Disease (CVD) risk reduction in patients with Type 2 Diabetes. In recent trials there has been promising findings of more effective glucose management and reductions in overall CVD events…
- Conditions
- Type 2 Diabetes Mellitus, Myocardial Fibrosis, Myocardial Inflammation
- Trial name
- NCT03782259
- Testing
- dapagliflozin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Washington
Cystic Fibrosis
Lung Transplant READY Pilot Study
Lung transplant is an option for treating end-stage lung disease in cystic fibrosis (CF). More than half of people with CF who die without a lung transplant were never referred for consideration.
- Trial name
- NCT05135156
- Testing
- Investigator-designed lung transplant education resource (Research Intervention), Publicly available transplant education resource (Attention Control)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Washington
Neonatal Death, Perinatal Death
Leveraging Interactive Text Messaging to Monitor and Support Maternal Health in Kenya
Mobile health (mHealth) interventions such as interactive short message service (SMS) text messaging with healthcare workers (HCWs) have been proposed as efficient, accessible additions to traditional health care in…
- Conditions
- Neonatal Death, Perinatal Death, Depression
- Trial name
- AI-NEO (NCT05369806)
- Testing
- Interactive two-way SMS dialogue
- Where
- 2 sites in Kenya
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Washington
Myeloid Neoplasm, Recurrent Acute Myeloid Leukemia
Continuous Infusion Chemotherapy (CI-CLAM) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms
This phase I trial studies the side effects and best dose of a chemotherapy regimen given by continuous intravenous infusion (CI-CLAM), and to see how well it works in treating patients with acute myeloid leukemia that has come…
- Conditions
- Myeloid Neoplasm, Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
- Trial name
- NCT04196010
- Testing
- Cladribine, Cytarabine, Recombinant Granulocyte Colony-Stimulating Factor
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Washington
Vitamin K Status
Vitamin K Supplementation Study in Healthy Volunteers (Aim 2B)
The overall purpose of this study is to determine how variation in the CYP4F2 gene modulates the synthesis of vitamin K-dependent clotting factors.
- Trial name
- NCT04450212
- Testing
- Phase I, Buccal Swab Collection for DNA Isolation, Phase II, Vitamin K (Vitacost) Supplementation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Washington
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