Clinical trials: sponsored by University of Washington
Castration Levels of Testosterone, Castration-Resistant Prostate Carcinoma
Docetaxel and Carboplatin in Treating Patients With Metastatic, Castration Resistant Prostate Cancer Containing Inactivated Genes in the BRCA 1/2 Pathway
This pilot clinical trial studies docetaxel and carboplatin in treating patients with castration resistant prostate cancer that has spread from the primary site (place where it started) to other places in the body (metastatic)…
- Conditions
- Castration Levels of Testosterone, Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Prostate Carcinoma Metastatic in the Bone
- Trial name
- NCT02598895
- Testing
- Carboplatin, Docetaxel, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Washington
Heart Failure, Systolic
Nicotinamide Riboside in Systolic Heart Failure
Mitochondrial dysfunction has been implicated in heart failure (HF), and is associated with an imbalance in intracellular ratio of reduced nicotinamide-adenine dinucleotide (NADH) to oxidized nicotinamide-adenine dinucleotide…
- Trial name
- NCT03423342
- Testing
- nicotinamide riboside
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Muscle Weakness
Best Practice Using Rocuronium and Reversal With Neostigmine or Sugammadex
This is an estimation study, prospectively evaluating the incidence of postoperative residual neuromuscular blockade (PRNB) when a best practice protocol is implemented for a cohort of abdominal surgery and orthopedic surgery…
- Trial name
- NCT03543826
- Testing
- Protocol for rocuronium neuromuscular block
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- University of Washington
HIV, Linkage to Care
Impact of Male Provider Phone Calls to Increase Men's Clinic Linkage After HIVST
Evaluate the impact of phone calls from a male counselor in increasing linkage to HIV care and PrEP among male partners of pregnant women attending PMTCT.
- Conditions
- HIV, Linkage to Care, PMTCT, PrEP
- Trial name
- NCT05194085
- Testing
- POC viral load testing, Wellness visit services for male partners
- Where
- Uganda
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Washington
CYP2D6 Polymorphism
Effects of Retinoids on CYP2D6 Activity During Pregnancy
Prospective drug interaction study during pregnancy.
- Trial name
- NCT03117660
- Testing
- Vitamin A
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Washington
Obesity, Substance Abuse
Yappalli - The Road to Choctaw Health
This is an obesity and alcohol, tobacco, and other drug (ATOD) use risk prevention and health leadership program. This project will include 150 at-risk adult Native women across 5 communities (30 women from each community) in the…
- Trial name
- NCT02400554
- Testing
- Yappalli
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- University of Washington
Autism Spectrum Disorder
An SRT Model for Early Access to ASD Intervention
This project will implement and evaluate an innovative healthcare service delivery model designed to promote earlier access to specialized intervention for toddlers with ASD.
- Trial name
- NCT02409303
- Testing
- Screen-Refer-Treat Intervention
- Where
- United States
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- University of Washington
Posttraumatic Stress Disorder
Efficacy Trial of Stress Check-Up
Untreated posttraumatic stress disorder (PTSD) is associated with high societal and individual costs. Effective interventions for symptoms of posttraumatic stress (PTS) exist but are underutilized by those who could benefit…
- Trial name
- NCT03423394
- Testing
- Motivational Enhancement Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Washington
mHealth, PMTCT
Mobile Strategies for Women's and Children's Health: Optimizing Adherence and Efficacy of PMTCT/ART
The investigators are conducting a 3-arm randomized trial comparing the effects of unidirectional SMS (ie: "push" messaging to participant) vs. bidirectional SMS dialogue between participant and provider vs.
- Conditions
- mHealth, PMTCT, Adherence, Medication, SMS
- Trial name
- Mobile WAChx (NCT02400671)
- Testing
- SMS messaging
- Where
- 6 sites in Kenya
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alzheimer Disease
University of Washington Alzheimer's Disease Research Center (UW ADRC) Imaging & Biomarker Core
This is a cross-sectional, observational study that characterizes research participants with Alzheimer's disease (AD) for their patterns of brain degeneration with the investigational tau positron emission tomography (PET)…
- Trial name
- NCT04437290
- Testing
- investigational radiotracer [18F]MK6240
- Volunteers
- 300 people
- Sponsor
- University of Washington
Residual Paralysis, Post Anesthesia
Best Management of Muscle Relaxation- Objective Monitoring
The purpose of this study is to demonstrate that the investigators can reduce residual paralysis to a very low incidence, and that the investigators can do this while preserving a role for the older and less expensive reversal…
- Trial name
- NCT03958201
- Testing
- Protocol for Management of Muscle Relaxation With Rocuronium Using Objective Monitoring and Reversal With Neostigmine or Sugammadex
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Washington
Brain Injuries, Traumatic, Chronic Pain
TBI Care: Collaborative Care for Pain After Traumatic Brain Injury (TBI)
The purpose of this study is to (1) test the benefits of the patient-centered collaborative care treatment approach for persons who have had a TBI and who have pain, including headache; and also (2) test whether this approach…
- Conditions
- Brain Injuries, Traumatic, Chronic Pain, Post-Traumatic Headache
- Trial name
- NCT03523923
- Testing
- Collaborative Care
- Where
- 2 sites in United States
- Volunteers
- 158 people
- Sponsor
- University of Washington
Hypotension
Washington Study of AxoTrack-Guided Central Venous Cannulation
Undifferentiated hypotension is a medical emergency where a patient's blood pressure drops to critical levels due to several possible reasons.
- Trial name
- WASHCAN (NCT03027323)
- Testing
- AxoTrack System
- Where
- United States
- Sponsor
- University of Washington
Immune-Mediated Necrotizing Myopathy
Monotherapy IVIG Gamunex-C for HMG-CoA Reductase Auto-Antibody Positive Necrotizing Myopathy Treatment (The MIGHT Trial)
This is a phase 2, pilot, randomized, placebo-controlled trial of Gamunex-C IVIG as mono-therapy for HMGCoA reductase auto-antibody positive (HMGCR) necrotizing myopathy.
- Trial name
- NCT04450654
- Testing
- Gamunex-C, Albumin
- Where
- United States
- Sponsor
- University of Washington
Depression, Anxiety
Mobile Mental Health Apps for Suicide Prevention
Access to mental health care by essential workers and the unemployed during the COVID19 pandemic has been challenging. Usual access to mental health care is limited by social distancing, and for many now unemployed due to…
- Conditions
- Depression, Anxiety, Emotional Regulation
- Trial name
- NCT04536935
- Testing
- Mobile Mental Health App - 1, Mobile Mental Health App - 2, Mobile Mental Health App - 3
- Where
- United States
- Volunteers
- 838 people
- Sponsor
- University of Washington
Hiv
Assisted Partner Services and HIVST in Western Kenya
This study includes different designs with Aim 1 being a cluster randomized controlled trial to investigate the use of HIV self-testing (HIVST) as a mode of HIV testing in Western Kenya in addition to the standard of care…
- Trial name
- NCT04774835
- Testing
- HIVST, Standard aPS
- Where
- United States
- Volunteers
- 4,941 people
- Sponsor
- University of Washington
HIV/AIDS
Standardized Patient Encounters to Improve PrEP Counseling for Adolescent Girls and Young Women in Kenya
The goal of this study is to facilitate uptake of and adherence to HIV pre-exposure prophylaxis (PrEP) among adolescent girls and young women (AGYW) in Kenya.
- Trial name
- PrIYA-SP (NCT03875950)
- Testing
- Clinician training intervention
- Where
- Kenya
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Pain
Functional Restoration and Integrative Therapies in Service Members With Neuromusculoskeletal Injury
This study will (1) compare the effectiveness of standard rehabilitative pain care with complementary and integrative pain therapies; (2) identify subgroups of patients who do and do not respond to the intervention(s); (3)…
- Trial name
- NCT03297905
- Testing
- Complementary and Integrative Therapies, Standard Rehabilitative Care
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Washington
Diabetic Foot Ulcer, Diabetes Mellitus, Type 2
Effects of a Exercise Program on Health Outcomes in People With Diabetic Foot Ulcers
People with diabetes are at risk for life altering complications, including diabetic foot ulcers. To heal a diabetic foot ulcer, people are often required to refrain from bearing weight on their affected limb for months.
- Trial name
- NCT03002155
- Testing
- EnhanceFitness community exercise program
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Depression
Adapting Behavioral Activation to Technology Platform
This project aims to use an asynchronous remote communities (ARC) approach both to discover the design requirements for adapting Behavioral Activation (BA) to ARC as well as design/build an ARC platform for administering BA.
- Trial name
- NCT03783533
- Testing
- Behavioral Activation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
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