Clinical trials: sponsored by University of Washington
Ovarian Cancer
Fallopian Tube Removal as a Method of Ovarian Cancer Prevention: A Descriptive Study
The purpose of this study is to better understand why women choose to have their fallopian tubes removed as a method for ovarian cancer prevention. This will be done through a paper questionnaire and phone interviews.
- Trial name
- NCT01544049
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
HIV Seropositivity, Pregnancy, High-Risk
Safer Conception Intervention for HIV-1 Serodiscordant Couples
The greatest burden of the HIV-1 epidemic lies in sub-Saharan Africa, where a substantial proportion of infections occur in long-term heterosexual HIV-1 serodiscordant partnerships.
- Trial name
- SCIP (NCT03030768)
- Testing
- PrEP, Counseling on timed condomless sex, ART and PrEP adherence
- Where
- 2 sites in United States, Kenya
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections
Optimizing Pediatric HIV-1 Treatment in Infants With Prophylactic Exposure to Nevirapine, Nairobi, Kenya
Globally, children who acquire HIV-1 increasingly do so in the context of maternal antiretroviral prophylaxis. It is important to determine whether maternal antiretroviral prophylaxis should alter infant treatment regimens.
- Trial name
- NCT00427297
- Testing
- AZT/3TC/NVP (zidovudine/lamivudine/nevirapine), d4T/3TC/NVP (stavudine/lamivudine/nevirapine), AZT/3TC/ABC (zidovudine/lamivudine/abacavir)
- Where
- Kenya
- Volunteers
- 34 people
- Sponsor
- University of Washington
Urethritis
Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA)
The purpose of this study is to find out which of 2 different antibiotics, doxycycline or azithromycin, works best against germs that may cause nongonococcal urethritis.
- Trial name
- NCT00358462
- Testing
- Azithromycin, Doxycycline
- Where
- United States
- Volunteers
- 606 people
- Sponsor
- University of Washington
Heart Arrest
Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Using an Impedance Valve
The purpose of this study is to look at two different treatments during a cardiac arrest that occurs outside of the hospital and whether either or both treatments will increase the number of people who live to hospital discharge.
- Trial name
- NCT00394706
- Testing
- Impedance Threshold Device (ITD), Analyze early, Analyze later
- Where
- 9 sites in United States, Canada
- Volunteers
- 11,738 people
- Sponsor
- University of Washington
Cancer, Prostate Neoplasms
Maximal Suppression of the Androgen Axis in Clinically Localized Prostate Cancer
Prostate cancer (CaP) is the most commonly diagnosed cancer among males in the U.S. and the second leading cause of cancer-related mortality.
- Trial name
- TAPS (NCT00298155)
- Testing
- goserelin with dutasteride, goserelin with bicalutamide and dutasteride, goserelin with bicalutamide and dutasteride and ketoconazole
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Washington
Attention Concentration Difficulty, Depression
Training Resiliency in Youth (TRY) Study
The aim of the study is to determine whether a neuroscience-inspired cognitive remediation video game (EVO) that targets the cognitive control network (CCN) will improve executive functioning (EF) and resilience to psychiatric…
- Conditions
- Attention Concentration Difficulty, Depression, Anxiety
- Trial name
- TRY (NCT03429465)
- Testing
- EVO Cognitive Remediation Game
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Washington
Prostate Cancer
Exisulind and Intermittent Androgen Suppression (ADT) in Biochemical Relapsed Prostate Cancer
The purpose of this research study is to determine if an investigational drug called Exisulind will extend the "off-treatment" period of patients receiving Intermittent Androgen Suppression (ADT).
- Trial name
- NCT00283803
- Testing
- Exisulind, luteinizing hormone-releasing hormone (LHRH) agonist, Antiandrogen
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Washington
Prostate Cancer
Effects of IAS in Men With Localized Biochemical Relapsed Prostate Cancer
This study was a prospective analysis in men with localized prostate cancer who had rising Prostate Specific Antigen (PSA) levels after definitive treatment with surgery or radiation.
- Trial name
- IAS (NCT00223665)
- Testing
- Flutamide, Leuprolide Acetate
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Washington
Carcinoma, Hepatocellular
Pair Production PET Imaging to Detect Particle Distribution in Patients Undergoing Yttrium-90 Radioembolization
The primary goal of the study is to see if the PET/CT will be able to determine the precise location of the Y-90 particles within the liver and within the tumors.
- Trial name
- PET-Y90 (NCT02848638)
- Volunteers
- 35 people
- Sponsor
- University of Washington
HIV Infections
Optimizing Pediatric HIV-1 Treatment, Nairobi, Kenya
Given the high mortality associated with infant HIV-1 and the fact that surrogate markers are poorly predictive of mortality risk,empiric highly active antiretroviral therapy (HAART) initiation is started in infants younger than…
- Trial name
- NCT00428116
- Testing
- HAART
- Volunteers
- 140 people
- Sponsor
- University of Washington
Upper Respiratory Tract Infection
Homeopathic Cold Medicine for Children
The purpose of this study is to determine if a commercially available homeopathic cold remedy for children is effective in providing relief from cold symptoms in children 2-5 years old.
- Trial name
- NCT00858494
- Testing
- Hyland's Cold 'n Cough 4 Kids
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
HIV-2 Infection
An Open Label Trial of Stribild for Antiretroviral (ARV)-naïve HIV-2 Infected Adults in Dakar, Senegal
There is a critical need for safe and effective antiretroviral treatment (ART) regimens for HIV-2 infection. This is especially true in West Africa, where the vast majority of the 1-2 million individuals infected with HIV-2 live…
- Trial name
- Stribild HIV-2 (NCT02180438)
- Testing
- Stribild (Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF) 1 tablet daily X 48 weeks
- Where
- Senegal
- Volunteers
- 30 people
- Sponsor
- University of Washington
PTSD, Alcohol Abuse
Sequence of Symptom Change During AUD or PTSD Treatment for Comorbid PTSD/AUD
The broad, long-term objective of the current research is to improve treatment outcomes for individuals with comorbid posttraumatic stress disorder (PTSD) and alcohol abuse and dependence (AUD).
- Conditions
- PTSD, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01663337
- Testing
- Cognitive Processing Therapy (CPT), Relapse Prevention (RP)
- Where
- 2 sites in United States
- Volunteers
- 235 people
- Sponsor
- University of Washington
Myocardial Infarction, Percutaneous Coronary Intervention
Text Message Intervention to Improve Cardiac Rehab Participation
Cardiac rehabilitation (CR) is strongly recommended for patients with coronary heart disease. However, patient enrollment and completion of cardiac rehabilitation is low.
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Bypass Surgery, Heart Valve Repair or Replacement
- Trial name
- NCT03346278
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Washington
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
Treatment for Relapsed/Refractory AML Based on a High Throughput Drug Sensitivity Assay
This clinical trial uses a laboratory test called a high throughput sensitivity assay in planning treatment for patients with relapsed or refractory acute myeloid leukemia.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT01872819
- Testing
- antitumor drug screening assay, chemotherapy, biological therapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Washington
Hiatal Hernia
Veritas Laparoscopic Paraesophageal Hiatal Hernia (PEH) Repair Pilot Trial
This is an investigator initiated pilot study to observe the short-term outcomes (a follow-up period of up to six months) of patients who undergo a laparoscopic paraesophageal Hiatal hernia (PEH) repair using the Veritas®…
- Trial name
- NCT01195545
- Testing
- Veritas® Collagen Matrix
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Computed Tomography, Radiation Dosage
Breast Displacement and CT Radiation Dose
The primary hypothesis of this study is that breast displacement out of the direct plane of imaging during computed tomography (CT) of the abdomen will reduce effective radiation dose to the female breast.
- Trial name
- Chrysalis (NCT01261559)
- Testing
- Chrysalis breast displacement device
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Washington
Risk Behavior, Sex, Unsafe
BEing Safe in Treatment
Prior research has shown that many individuals with substance use disorders engage in HIV/sexual risk behaviors, and could strongly benefit from HIV prevention interventions that were delivered as part of their substance abuse…
- Conditions
- Risk Behavior, Sex, Unsafe, Substance Use, Risk Reduction
- Trial name
- BEST (NCT03575585)
- Testing
- BEST assessment only, BEST assessment plus feedback report, Standard Counselor Training
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- University of Washington
Drug-Drug Interaction, Healthy Volunteers
The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity
Inhibitory drug-drug interactions (DDIs) are a considerable concern as inhibition of drug's clearance can lead to increased plasma concentrations and subsequent adverse events and toxicities.
- Trial name
- FLUOXETINE (NCT01361217)
- Testing
- Fluoxetine, Lovastatin, Omeprazole, caffeine, midazolam, dextromethorphan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Washington
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