Clinical trials: sponsored by University of Zurich
Brain Edema
Swiss Prospective Autologous Bone Flap Resorption Study
The complications after reimplantation of cryoconserved autologous bone flaps are reported inhomogeniously in the literature. Especially the incidence of bone flap resorption varies from 0% to about 30%.
- Trial name
- SPARS (NCT02320955)
- Testing
- Reimplantation of cryoconserved bone flap
- Where
- 2 sites in Switzerland
- Volunteers
- 88 people
- Sponsor
- University of Zurich
Glioblastoma
Glutamate Inhibitors in Glioblastoma
The goal of this 1:1 randomized, multi-center, open-label phase Ib/II clinical trial is to explore the efficacy of the add-on of the anti-glutamatergic drugs gabapentin, sulfasalazine and memantine to standard chemoradiotherapy…
- Trial name
- GLUGLIO (NCT05664464)
- Testing
- Gabapentin, Sulfasalazine, Memantine
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Distorted Sound Perception
Distortion Product After Stapedotomy Surgery
This study aims at capturing for the first time at which frequencies and sound intensities hearing distortions are perceived after successful stapedotomy surgery.
- Trial name
- NCT02245646
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Chronic Otitis Media
Validation of a Questionnaire for Measuring Quality of Life in Patients With Chronic Inflammation of the Middle Ear
For measuring quality of life in patients with chronic inflammation of the middle ear, only two questionnaires currently exist. However, these questionnaires are designed only to measure either disease-specific health or…
- Trial name
- NCT02226718
- Testing
- Administration of questionnaire
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
HIV Infections
Cabotegravir Plus Rilpivirine Long-acting Regimen in the Swiss HIV Cohort Study:Uptake, Outcome, and Risk Factors for Treatment Failures
This study aims to characterize Swiss HIV Cohort Study participants initiating the CAB+RPV LA regimen, assess adherence to Swiss label indications, and describe treatment outcomes in this large, multicentre, heterogeneous…
- Trial name
- NCT06405464
- Testing
- VOCABRIA 30Mg Tablet, EDURANT 25Mg Tablet, Cabotegravir Injectable Suspension
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- University of Zurich
Newly Diagnosed Glioblastoma
Pembrolizumab for Newly Diagnosed Glioblastoma
The study explores the addition of pembrolizumab to temozolomide-based radiotherapy in patients with newly diagnosed glioblastoma.
- Trial name
- PERGOLA (NCT03899857)
- Testing
- Pembrolizumab
- Where
- 3 sites in Switzerland
- Volunteers
- 56 people
- Sponsor
- University of Zurich
Decision Making, Healthy
Studying the Role of Brain Molecules for Decision Making
The aim of the present project is to elucidate the neuropharmacological mechanisms underlying value (choice preference) and attention (choice randomness) processing in humans.
- Trial name
- NCT04384562
- Testing
- Methylphenidate, Reboxetine, Nicotine gum
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Psychological Distress, Anxiety
Feasibility and Acceptability of PRISMA for Prisoners in Switzerland
In response to the significant mental health challenges faced by pretrial detainees, the Swiss Federal Justice Department has initiated a model trial in pretrial detention centres in Zurich and Bern.
- Conditions
- Psychological Distress, Anxiety, Depression, Suicidal Ideation
- Trial name
- NCT06404502
- Testing
- PRISMA
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
CRS
Subjective and Objective Outcome of ESS in CRSwNP
(A): Beidseitige Fronto-Spheno-Ethmoidektomie mit Erweiterung des natürlichen Zuganges zur Stirnhöhle (Draf Typ II): Unter einem Draf Typ II Zugang versteht man die Erweiterung des natürlichen Zuganges zur Stirnhöhle mit…
- Trial name
- NCT04868695
- Testing
- 1) Fronto-Sphenoethmoidektomie 2) Draf 2b 3) Draf 3
- Where
- Switzerland
- Volunteers
- 99 people
- Sponsor
- University of Zurich
Suicidality, Suicide, Attempted
Attempted Suicide Short Intervention Program: a Randomized Controlled Trial
"Attempted Suicide Short Intervention Program" (ASSIP) is a brief psychotherapy intervention after suicide attempts in psychiatric patients.
- Trial name
- EASI (NCT03732300)
- Testing
- ASSIP
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Idiopathic Normal Pressure Hydrocephalus (INPH)
Walking Pattern Characteristics in Normal Pressure Hydrocephalus
20 patients who are diagnosed with NPH receive a set of 5 wearable gyroscopes (IMUs, ZurichMove sensors) for a period of 3 days for measurement and characterization of their walking in an ambulatory setting.
- Trial name
- NPH wearables (NCT04702035)
- Testing
- Characterization of walking pattern characteristics in an ambulatory setting using wearable IMUs (ZurichMOVE sensors)
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Radiation Exposure, Lung Embolism
Ultra Low Dose CT and Use of Iomeron 400 in PCD-CT
Evaluation of ultra low dose protocols and Iomeron 400 contrast in PCD-CT
- Conditions
- Radiation Exposure, Lung Embolism, Lung Cancer, Pneumonia
- Trial name
- NCT06360627
- Testing
- Computed Tomography
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Myocardial Infarction With Non-Obstructive Coronary Artery, Myocarditis Acute
Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA and MINOCA-mimics
This clinical study examines patients presenting with acute myocardial infarction and no significant coronary artery disease on coronary angiography (MINOCA) and patients with MINOCA-mimics with advanced CMR.
- Conditions
- Myocardial Infarction With Non-Obstructive Coronary Artery, Myocarditis Acute, Takotsubo Cardiomyopathy, Spontaneous Coronary Artery Dissection
- Trial name
- COPE-CMR (NCT06323811)
- Testing
- CMR
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Venous Thromboses, Stent Stenosis
Aspirin® Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis in Patients With PTS
To show if a combination therapy of rivaroxaban plus Aspirin® is more efficient (superiority testing) as rivaroxaban alone in the prevention of early venous stent thrombosis in patients suffering from post-thrombotic syndrome in…
- Trial name
- ARIVA (NCT04128956)
- Testing
- Aspirin 100mg
- Where
- 6 sites in Austria, Germany and 1 more
- Volunteers
- 172 people
- Sponsor
- University of Zurich
Doxycycline STI PEP
Doxycycline PEP and 4CMenB as a Comprehensive Prevention Strategy in MSM and TGW at High Risk for Bacterial STIs Within the Swiss HIV Cohort Study
The study aims at assessing effectiveness of offering event-driven Doxy PEP and 4CMenB immunization in MSM/TGW at high STI risk.
- Trial name
- DOXY-MEN (NCT06242730)
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Healthy (Controls)
Visa-versa! Breaking Instead of Pushing the Pedals-D
Eccentric muscle work is defined as lengthening of a muscle while applying force. It was shown that with eccentric work, muscles are able to perform four times as much power compared to usual concentric work, which results in…
- Trial name
- NCT05185895
- Testing
- 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pulmonary Hypertension
Visa-versa! Breaking Instead of Pushing the Pedals-A
Eccentric muscle work is defined as lengthening of a muscle while applying force. It was shown that with eccentric work, muscles are able to perform four times as much power compared to usual concentric work, which results in…
- Trial name
- NCT05186987
- Testing
- 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- University of Zurich
Stroke
PEMOCS: Personalized Motor-cognitive Training in Chronic Stroke
In Switzerland, approximately 20'000 persons suffer a stroke each year. Despite carefully considered rehabilitation programs, full recovery is achieved only in a small proportion of stroke survivors (www.swissheart.ch).
- Trial name
- NCT05524727
- Testing
- Concept-guided, personalized, motor-cognitive training by means of an exergame
- Where
- 3 sites in Switzerland
- Volunteers
- 38 people
- Sponsor
- University of Zurich
Organizing Pneumonia, Lung Transplant Rejection
Organizing Pneumonia in Lung Transplant Recipients, a Restrospective Exploratory Study (OPIL-Study)
The aim of this study is to generate evidence regarding organizing pneumonia in lung transplant recipients.
- Trial name
- OPIL (NCT06203964)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 280 people
- Sponsor
- University of Zurich
ST-elevation Myocardial Infarction, Multivessel Coronary Disease
MULTivessel Immediate Versus STAged RevaScularization in Acute Myocardial Infarction -The MULTISTARS AMI Trial
The primary objective of the trial is to compare, in patients presenting with ST segment elevation myocardial infarction (STEMI) and multi-vessel disease (MVD), the safety and efficacy of immediate complete revascularization of…
- Trial name
- MULTISTARS AMI (NCT03135275)
- Testing
- Staged complete PCI, Immediate complete PCI, Synergy™ stent
- Where
- Switzerland
- Volunteers
- 840 people
- Sponsor
- University of Zurich
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