Clinical trials: sponsored by University of Zurich
Spinal Cord Injury, Acute
NISCI - Nogo Inhibition in Spinal Cord Injury
The purpose of the NISCI trial is to test if an antibody therapy can improve movement and quality of life of tetraplegic patients. A previous trial showed this treatment is safe and well accepted.
- Trial name
- NISCI (NCT03935321)
- Testing
- NG-101
- Where
- 13 sites in Czechia, Germany and 2 more
- Volunteers
- 129 people
- Sponsor
- University of Zurich
Stress
Development and Feasibility Test of an Ecological Momentary Intervention (EMI) - ReApp, to Increase Reappraisal.
The aim of the current project is to develop and test Ecological Momentary Interventions (EMIs) to promote and improve stress resilience, specifically, an EMI to increase positive reappraisal.
- Trial name
- NCT05784831
- Testing
- Reappraisal training, Ecological Momentary Assessment
- Where
- Switzerland
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Altitude Hypoxia
Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude.
Randomized, placebo controlled trial evaluating efficacy of acetazolamide on right heart function at rest in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03540914
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Superficial Digital Flexor Tendonitis
Intratendinous Genipin Injection in Horses With Tendon Injuries
Our study is the first to use genipin, a naturally occurring collagen cross-linking agent, as a therapeutic agent to treat superficial digital flexor tendon (SDFT) injuries in horses.
- Trial name
- NCT05755750
- Testing
- Genipin
- Where
- Switzerland
- Volunteers
- 74 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease, Altitude Sickness
Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate efficacy of acetazolamide in preventing overt altitude-related adverse health effects (ARAHE) in lowlanders with chronic obstructive pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Altitude Sickness, Altitude Hypoxia
- Trial name
- NCT04913389
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Sleep
Electromagnetic Field Effects of Mobile Communication (LTE) on Sleep in the Context of Genetic Variation
The effect of electromagnetic fields of the latest standard in mobile communication (long term evolution, LTE) on sleep is studied in healthy, young individuals.
- Trial name
- NCT03074617
- Testing
- LTE field
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Intrusive Memories, PTSD
Sleep's Influence on the Treatment of Intrusive Emotional
Intrusive memories represent a debilitating core feature of PTSD, one of the most prevalent psychiatric disorders following trauma.
- Trial name
- SLEPT (NCT05678361)
- Testing
- Sleep/Nap
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Zurich
Bacteremia
Effect of Vitamin B12 on the Development of Sepsis, in Culture Positive Patients
This is an prospective observational study assessing the effect of vitamin B12 on the odds of developing sepsis in patients with infection confirmed by a positive culture result.
- Trial name
- Vit B12 (NCT04008446)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Leukemia, Lymphocytic, Chronic, B-Cell, Abnormalities Cell Epithelial
Determination of Blood Tumor Cells
Magnetic nanoparticles coated with anti-EpCAM or anti-CD52 antibodies will be tested ex-vivo in patients blood .
- Trial name
- NCT04290923
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- University of Zurich
Heart Failure Acute, Acute Myocardial Infarction
The SWISSHEART Failure Network (SHFN)
A retrospective cohort study will be conducted on patients who were hospitalized at the University Hospital Basel (USB), University Hospital Bern (Inselspital), University Hospital Geneva (HUG) and the University Hospital Zurich…
- Trial name
- Swissheart (NCT05603247)
- Where
- 4 sites in Switzerland
- Volunteers
- 8,000 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Early Signs of Altitude Illness in Patients With COPD
This study evaluates whether structured self-monitoring (SSM) by a symptom checklist in combination with a pulse oximeter worn at the wrist allows lowlanders with COPD to accurately identify whether or not they will experience an…
- Trial name
- NCT03957759
- Testing
- Structured self-monitoring during an altitude ascent and stay at high altitude
- Where
- Kyrgyzstan
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Post Traumatic Stress Disorder (PTSD), Complex Post-Traumatic Stress Disorder (CPTSD)
Psychometric Properties of the International Trauma Interview (ITI) for ICD-11 PTSD and CPTSD
The aim of the project is to evaluate the psychometric properties (e.g. validity, reliability) of the International Trauma Interview (ITI) - German version.
- Trial name
- NCT04086654
- Testing
- International Trauma Interview (ITI) for ICD-11 PTSD and Complex PTSD - German version
- Where
- Switzerland
- Volunteers
- 77 people
- Sponsor
- University of Zurich
Electric Stimulation Therapy, Transcranial Magnetic Stimulation
Enhancing Speech Intelligibility Using Transcranial Alternating Current Stimulation (tACS)
This study contributes to fundamental research investigating the role of the articulatory-motor integration and cerebro-acoustic coherence in speech comprehension.
- Trial name
- StimSpeechCom (NCT04036630)
- Testing
- Transcranial alternating current stimulation (tACS), Transcranial magnetic stimulation (TMS) induced motor-evoked potentials (MEPs)
- Where
- Switzerland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Stress
Feasibility and Efficacy of a Digital Training Intervention to Increase Reward Sensitivity- Imager
Development and feasibility test of an Ecological Momentary Intervention (EMI) - Imager, to promote and improve stress resilience, specifically to increase reward sensitivity.
- Trial name
- IMAGER (NCT05623826)
- Testing
- Cognitive- behavioral imagery-based training
- Where
- Switzerland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Parkinson Disease, Mild Cognitive Impairment
Auditory Slow Wave Enhancement in Parkinson Disease and Mild Cognitive Impairment
The study aims to assess the efficacy of auditory slow-wave sleep (SWS) enhancement in PD patients and patients with amnestic MCI.
- Trial name
- PDMCI-TS (NCT04736017)
- Testing
- TSB Axo
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Stress, Self Efficacy
Feasibility and Efficacy of a Brief Digital Self-efficacy Training
The study investigates the effects of a digital, scalable self-efficacy training of repeated recall of self-efficacy memories on mental health outcomes, such as self-efficacy, anxiety, stress, hopelessness, and other mental…
- Trial name
- SEAPP (NCT05617248)
- Testing
- Self-efficacy App
- Where
- Switzerland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Coronary Artery Disease
Ultra-low-dose CACS in a Large Population
Radiation exposure to patients from CT for CAC scoring has steadily decreased in recent years. This is mainly achieved through lowering tube currents alongside with the introduction of iterative reconstruction algorithms which…
- Trial name
- ULDCACSLARGE (NCT03637231)
- Testing
- Ultra low-dose CTAC
- Where
- Switzerland
- Volunteers
- 301 people
- Sponsor
- University of Zurich
Pulmonary Hypertension
Pulmonary Hypertension Registry Switzerland
Registry Data from PH-patients in Switzerland, who have given consent to records for research purposes.
- Trial name
- NCT05610631
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University of Zurich
Healthy Individuals
The Effects of Standardized vs Individualized Seat Height on 1-minute Sit-to-stand Performance
The 1-minute sit-to-stand test (1MSTS) is a widely used functional capacity test and has promising predictive potential. Current standards of practice suggest the use of a chair with a standardized height.
- Trial name
- ESTI-STS (NCT04772417)
- Testing
- Standardized 1-minute sit-to-stand test, Individualized 1-minute sit-to-stand test
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Transposition of Great Vessels
Comprehensive Long-term Follow up of Adults With Arterial Switch Operation
Background: Long-term outcomes in adults with prior arterial switch operation (ASO) have not yet been well defined. The aim of this study is to elucidate incidence and predictors of adverse cardiac outcomes in a prospectively…
- Trial name
- EPOCH-ASO (NCT04335448)
- Testing
- No intervention is planed
- Where
- 11 sites in Austria, France and 3 more
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- University of Zurich
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