Clinical trials: sponsored by University of Zurich
Intracerebral Hemorrhage
Insights From the Retina on Cerebral Microvascular Dysfunction in Haemorrhagic Stroke
Fundoscopy, optical coherence tomography (OCT) and OCT-angiography (OCTA) are established examinations and bear minimal risks. The recognition of retinal microvascular signs will enhance the pathophysiological understanding of…
- Trial name
- RETINA-ICH (NCT04363619)
- Testing
- OCT and OCTA
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University of Zurich
Hypoxia Altitude Simulation Test, High Altitude
Hypoxia-altitude Testing to Predict Altitude Related Adverse Health Effects in Chronic Obstructive Pulmonary Disease (COPD) Patients
The predictive value of the hypoxia altitude simulation test (HAST) or other baseline values to predict altitude-related adverse health effects (ARAHE) is not established.
- Trial name
- NCT04915378
- Testing
- hypoxia altitude simulation test (HAST) at 760m, High Altitude (3100m)
- Where
- Kyrgyzstan
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Dental Implant
Clinical Evaluation of Two Different Attachment System
Edentulous patients commonly experience a deterioration in the quality of life; both in terms of oral and general health. Studies demonstrated that conventional dentures do not adequately restore masticatory function nor quality…
- Trial name
- ADLCvsLOC (NCT04544839)
- Testing
- ADLC attachment system with PEEK inserts
- Where
- India
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Gingivitis and Periodontal Diseases, Tooth Loss
Cement Excess at Single Implant Crowns Malmö/Lund
Abstract Aim: The primary aim of this study is to test whether or not cement residues in the submucosal environment of implants lead to a change in the microbiota and induce inflammation of the periimplant tissues.
- Trial name
- NCT04015427
- Testing
- implant crown
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Ulcerative Colitis, Flare Up, Symptom
Effectiveness of Golimumab in Patients With Ulcerative Colitis: Results of a Real-life Study in Switzerland
TNF inhibitors have improved treatment options for patients with inflammatory bowel disease (IBD) and three TNF inhibitors, infliximab, adalimumab and golimumab are available for treatment of ulcerative colitis in Switzerland.
- Trial name
- NCT05405465
- Testing
- Exposure to golimumab
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- University of Zurich
Neurodegenerative Diseases
Exploring the Recovery Function of Sleep in Neurodegeneration
The overall objective of this study is to identify the best approach for assessing the recovery function of sleep in neurodegenerative diseases associated with abnormal protein aggregation with regard to the conception of future…
- Trial name
- RFSN (NCT05402488)
- Testing
- Auditory stimulation
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Generalized Anxiety Disorder
Implementation of Psychological Treatment in Generalized Anxiety
Pragmatic randomized controlled trial (expected N = 80) of cognitive-behavioral therapy (CBT) to contrast two psychotherapeutic implementation strategies (State-of-the-Art welcome phase vs. prolonged focus on sudden changes).
- Trial name
- IMPLEMENT2_0 (NCT03079336)
- Testing
- Implementation - SOTA, Implementation - Prolonged focus on changes, Mastery your Anxiety and Worry (MAW)
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
COVID-19, Pulmonary Embolism, Deep Vein Thrombosis
Enoxaparin for Primary Thromboprophylaxis in Ambulatory Patients With COVID-19
The OVID study will show whether prophylactic-dose enoxaparin improves survival and reduces unplanned hospitalizations in ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe…
- Trial name
- NCT04400799
- Testing
- Enoxaparin 40Mg/0.4Ml Inj Syringe 0.4Ml
- Where
- 8 sites in Germany, Switzerland
- Volunteers
- 475 people
- Sponsor
- University of Zurich
Psychological Distress
Cultural Adaptation of Hap-pas-Hapi (Step-by-Step) for Albanian-speaking Immigrants in Switzerland and Germany
We aim to compare two different levels of cultural adaptation of an Internet- and mobile-based intervention for the treatment of depression called Hap-pas-Hapi among Albanian-speaking immigrants in Switzerland and Germany.
- Trial name
- NCT04230135
- Testing
- Hap-pas-Hapi
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 97 people
- Sponsor
- University of Zurich
Lung Diseases
MRI 3D UTE Hyper-Cones & ZTE for PET/MR Lung Attenuation Correction & for Lung Diagnostic Imaging
MRI 3D UTE Hyper-Cones \& ZTE for PET/MR lung attenuation correction \& for lung diagnostic imaging
- Trial name
- NCT03562806
- Testing
- PET/MR image acquisition
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if photodynamic therapy has an effect on bacterial skin colonization and decrease number of…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- PHOMIC (NCT04067843)
- Testing
- Photodynamic treatment
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension, Oxygen Therapy
Effect of Oxygen Therapy for Patients With Precapillary Pulmonary Hypertension Who Experience an Altitude Related Adverse Health Effect (ARAHE) During 30h Exposure to 2500m
To study whether oxygen therapy titrated to maintain oxygenation (SpO2) > 90% at 2500m would resolve altitude-related adverse health effects, symptoms and impaired exercise during 30h exposure to high altitude.
- Trial name
- NCT05112172
- Testing
- Oxygen Therapy
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension, Sleep
Nocturnal Oxygenation and Sleep-related Breathing Disorders During the First Night of a Stay at 2500m of High Altitude in Patients With Precapillary Pulmonary Hypertension
The impact of hypoxia at 2500m of high altitude on sleep in patients with precapillary pulmonary hypertension
- Trial name
- NCT05089487
- Testing
- Nocturnal rest (sleep study)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
Altitude Related Adverse Health Effects (ARAHE) in Patients With Precapillary Pulmonary Hypertension During 30h Exposure to 2500m
The interest of journeys to high altitude regions for recreational or professional purposes is increasing, also among potentially vulnerable groups including patients with chronic cardiopulmonary diseases such as pulmonary…
- Trial name
- NCT05107700
- Testing
- Stay at altitude 2500 m above sea level (high altitude), Stay at altitude 470 m above sea level (low altitude)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension, Maximal Exercise Capacity
Maximal Exercise Capacity at 2500 m of High Altitude
The impact of hypoxia on maximal work rate during incremental ramp exercise within 3-6 hours after arriving at 2500m of high altitude in patients with precapillary pulmonary hypertension
- Trial name
- NCT05264324
- Testing
- Maximal Exercise Capacity
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
Exercise Endurance Time on the 2nd Day at 2500 m High Altitude
The impact of a sojourn at 2500 m of high altitude for 26-30 h on constant work-rate exercise test time in patients with precapillary pulmonary hypertension
- Trial name
- NCT05131737
- Testing
- High altitude exposure, Low altitude exposure
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Depressive Disorder, Major
Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept
Effects of serotonin 2A/1A receptor stimulation by psilocybin on mood and emotion processing in major depressive disorder: a randomized double-blind placebo-controlled study
- Trial name
- NCT03715127
- Testing
- Psilocybine oral capsule
- Where
- Switzerland
- Volunteers
- 55 people
- Sponsor
- University of Zurich
Acidosis, Renal Insufficiency
Preserve-Transplant Study
The aim of this study is to test if alkali treatment will preserve kidney graft function and diminish the progression of chronic kidney disease in renal transplant patients.
- Conditions
- Acidosis, Renal Insufficiency, Kidney Transplantation
- Trial name
- NCT03102996
- Testing
- Nephrotrans
- Where
- 3 sites in Switzerland
- Volunteers
- 240 people
- Sponsor
- University of Zurich
Edentulous Maxilla
Clinical Study Investigating the Efficiency and Complications Related to Two Different Procedures Used for the Preparation of Dentures Applied in Patients With Edentulous
The principal aim of the study is to evaluate the prosthetic complications with CAD-CAM fabricated provisional prostheses and denture conversion prostheses after 3 months of function.
- Trial name
- NCT05332977
- Testing
- CAD-CAM fabricated provisional prosthesis, DC (denture conversion) provisional prosthesis
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Allergic Rhinitis
Comparison of Innate Immune Responses Induced by Allergy Immunotherapy (AIT) With Different Adjuvants
The primary objective of the pilot study is to compare inflammatory responses in blood sera from patients receiving first allergen immunotherapy (AIT) with aluminium (Alum), microcrystalline tyrosine (MCT), or a combination of…
- Trial name
- NCT04104828
- Testing
- Allergovit, Polvac, Pollinex Quattro
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.