Clinical trials: sponsored by University of Zurich
Motivation in Healthy Older Adults
Frontopolar Cortex and Motivation in Healthy Older Adults
Motivation represents a core aspect of goal-directed behavior as it determines how much effort individuals are willing to invest to reach their goals.
- Trial name
- NCT03197181
- Testing
- transcranial direct current stimulation
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
Cerebral Bleeding in COVID-19 ARDS Patients on Veno-venous ECMO
Critically ill patients with severe acute respiratory distress syndrome (ARDS) sometimes require treatment with veno-venous extracorporeal membrane oxygenation (ECMO) to support gas exchange.
- Conditions
- Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication, Corona Virus Infection
- Trial name
- NCT04853953
- Testing
- Incidence of bleeding complications in ARDS patients on veno-venous ECMO
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Radiotherapy
FENO, Extended NO Analysis and NO/CO Diffusing Capacity in Thoracic Radiation Therapy
The investigators aim to investigate the impact of thoracic radiation therapy on diffusion capacity of the lung (primary endpoint: diffusion capacity for nitric oxide, DLNO) and on exhaled nitric oxide.
- Trial name
- NCT03431740
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- University of Zurich
Grown-up Congenital Heart Disease (GUCH)
Effect of Short-term Oxygen During CPET in GUCH
In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients…
- Trial name
- NCT04076501
- Testing
- Oxygen application
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University of Zurich
Gastrointestinal Hemorrhage, Diabetes Complications
Therapeutic Conflicts and Multimorbidity
Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or…
- Conditions
- Gastrointestinal Hemorrhage, Diabetes Complications, Multimorbidity
- Trial name
- NCT02928939
- Testing
- drug-drug or drug-disease interaction
- Where
- Switzerland
- Volunteers
- 1,101 people
- Sponsor
- University of Zurich
Covid19
Clinical Efficiency of Surgical Masks and Filtering Face-piece 2 Masks
Recent results demonstrated an increased risk of COVID-19 infection among healthcare workers (HCW), particularly when access to personal protective equipment (PPE) was inadequate. (ref).
- Trial name
- NCT04823351
- Testing
- Surgical Mask
- Where
- Switzerland
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Venous Insufficiency of Leg
SOCKNLEG Compression Stocking Kit: Physical Properties
This study evaluates physical properties of a innovative leg compression stocking compared to a standard compression stocking of the same compression strength in patients with chronic venous insufficiency clinical stadium C3 and…
- Trial name
- SOCKNLEGLCA (NCT03743597)
- Testing
- SOCKNLEG, Sigvaris COTTON
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University of Zurich
Acute Autoimmune Inflammatory Optic Neuritis
Repetitive Transorbital Alternating Current Stimulation in Acute Autoimmune Optic Neuritis
Optic neuritis (ON) is an acute inflammatory, demyelinating attack of the optic nerve that triggers neurodegeneration in the entire visual pathway; translating into visual dysfunction.
- Trial name
- ACSON (NCT03862313)
- Testing
- active-rtACS treatment
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- University of Zurich
Hepatocellular Injury
Hypothermic Oxygenated Perfusion (HOPE) of Human Liver Grafts
The purpose of this study is, in a randomized trial, to test a newly developed machine perfusion technique of human liver allografts before transplantation.
- Trial name
- NCT01317342
- Testing
- Hypothermic oxygenated perfusion (HOPE)
- Where
- 2 sites in Switzerland
- Volunteers
- 179 people
- Sponsor
- University of Zurich
Heart Failure, Diastolic (HFpEF)
Effect of Short-term Oxygen During CPET in HFpEF
In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients…
- Trial name
- NCT04157660
- Testing
- Oxygen application
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Negative Type; Schizophrenic, Anhedonia
Motive-specific Intervention for Negative Symptoms in Schizophrenia
The aim of this study is to test a therapeutic intervention to reduce negative symptomatic among schizophrenia patients. Since the intervention can take place within an inpatient stay, it is a short intervention.
- Conditions
- Negative Type; Schizophrenic, Anhedonia, Apathy
- Trial name
- MoNSS (NCT04793438)
- Testing
- Motive-specific intervention, Supportive conversations
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Healthy Volunteers
Validation of the DyCare® Lynx System for Motion Analysis of the Wrist
This project is set to compare the wrist joint movement measurements of the DyCare® Lynx System with optoelectronic motion analysis using a marker system and infrared cameras.
- Trial name
- NCT04773535
- Testing
- 3D Motion analysis
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Eosinophilic Esophagitis
Endoscopic Characterisation of Inflammation in EoE
In this study, we plan to investigate the accuracy of the EG-760Z endoscope (135x zoom) compared with standard imaging with histology as gold standard in detecting and grading inflammatory activity in patients with eosinophilic…
- Trial name
- ECI-EoE (NCT04769232)
- Testing
- EG-760Z endoscope by Fujifilm
- Volunteers
- 40 people
- Sponsor
- University of Zurich
SARS-CoV 2, COVID
SARS-CoV-2 Associated Respiratory Failure Recovery (COVID-19 CAir)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the current pandemic of coronavirus disease (COVID-19) that can lead to respiratory failure requiring oxygen therapy.
- Trial name
- NCT04365595
- Testing
- Questionnaires, spirometry
- Where
- Switzerland
- Volunteers
- 58 people
- Sponsor
- University of Zurich
Validation Studies
Validation of the German Version of the Injustice Experience Questionnaire
Purpose of the study is the validation of the German version of the Injustice Experience Questionnaire. Pretest: Participants were informed about the aims of the study and fill in a consent form.
- Trial name
- GIEVA (NCT02552719)
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 210 people
- Sponsor
- University of Zurich
Spinal Cord Injury
Investigating Kinematic and Electromyographic Changes After SCI and Their Relation to Clinical and Functional Outcome
The study aims at discerning specific gait patterns and elucidating locomotor control of spinal cord injured patients in order to find sensitive kinematic and electromyographic outcome measures that are able to reveal information…
- Trial name
- NCT02150629
- Where
- Switzerland
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Lower Gastrointestinal Neoplasms Benign, Pancreas Cancer
The Effects of Perioperative Painting Art Therapy (LOM® Solution Centered Art Therapy) in Surgical Patients
The investigators want to study whether the use of painting art therapy has an influence on the quality of life, the complication rate and the general outcome of major abdominal surgery.
- Conditions
- Lower Gastrointestinal Neoplasms Benign, Pancreas Cancer, Posttraumatic Stress Disorder, Depression, Anxiety
- Trial name
- NCT04524260
- Testing
- perioperative painting art therapy (LOM® solution centered art therapy), perioperative painting art therapy (LOM® solution centered art therapy) - control
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Distress, PTSD
Scaling-up Psychological Interventions With Syrian Refugees in Switzerland
The current refugee crisis across the Middle East and Europe has large effects on individual refugees' psychological well-being, as well as on the healthcare systems of countries hosting refugees.
- Conditions
- Distress, PTSD, Anxiety, Depression
- Trial name
- STRENGTHS_CH (NCT03830008)
- Testing
- Problem Management Plus
- Where
- Switzerland
- Volunteers
- 59 people
- Sponsor
- University of Zurich
Sleep Deprivation
Age-related Changes in Sleep-wake Regulation
A sleep deprivation protocol combined with state-of-the-art, simultaneous positron emission tomography and magnetic resonance spectroscopy imaging will be employed to investigate the effects of sleep deprivation and aging on…
- Trial name
- NCT03813082
- Testing
- Prolonged wakefulness
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Stress, Anxiety
Presence of Aquarium in the Waiting Room of a Geriatric Dental Clinic
The participants in this study will be subjected to a specific clinic waiting area ambience (1- no aquarium, 2- presence of aquarium with no fish, and 3- aquarium with fish) for their period of waiting before their intended…
- Conditions
- Stress, Anxiety, Mood
- Trial name
- NCT04630600
- Testing
- No intervention, Partially-equipped aquarium in the waiting area, Fully-equipped aquarium in the waiting area
- Where
- Switzerland
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Zurich
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