Clinical trials: sponsored by University of Zurich
Emergency
Rapid Sequence Intubation at the Emergency Department
All patients undergoing emergent endotracheal intubation (RSI) at the Emergency Department will be screened for inclusion in this clinical study.
- Trial name
- NCT02297113
- Testing
- Macintosh blade, C-MAC videolaryngoscope
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Cholangiocellular Carcinoma
Downsizing of Unresectable Cholangiocarcinoma by Combined Intravenous and Intra-arterial Chemotherapy
An open label, prospective, non-randomized single arm study. Combination of two treatment modalities - HAI with FUDR and systemic chemotherapy with cisplatin and gemcitabine.
- Trial name
- NCT01692704
- Testing
- Selective intra-arterial floxuridine and systemic gemcitabine and cisplatin
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Experimental Dental Pain
Mechanisms of Acupuncture Analgesia on Experimental Dental Pain - A Psychophysical Study (Phase1)
The investigators will assess the effects of manual acupuncture on experimental dental pain in 36 healthy subjects by means of subjective pain intensity ratings and pain-specific autonomic nervous system (ANS) reactions.
- Trial name
- MAC-DENT1 (NCT02589418)
- Testing
- Acupuncture, No Acupuncture
- Where
- 2 sites in Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Arthritis, Rheumatoid, Spondylarthritis
Immunogenicity and Safety of Vaccinations in Immunocompromised Persons
Backgound and relevance of the project: Patients with autoimmune inflammatory rheumatic diseases (AIIRD) are at increased risk of contracting infections.
- Conditions
- Arthritis, Rheumatoid, Spondylarthritis, Vasculitis
- Trial name
- NCT01947465
- Testing
- Hepatitis A vaccine and tetanus vaccine
- Where
- 10 sites in Switzerland
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Thoracic Surgery
Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery
Desflurane and its effect on postoperative morbidity and mortality in patients undergoing thoracic surgery. Halothane, enflurane, isoflurane, sevoflurane, and desflurane are volatile anesthetics, a group of general anesthetics.
- Trial name
- NCT01452256
- Testing
- Desflurane, Propofol
- Where
- Switzerland
- Volunteers
- 460 people
- Sponsor
- University of Zurich
Phenylketonuria (PKU) and Hyperphenylalaninemia
Phenylketonuria and Hyperphenylalaninemia Nutrition Study
The mainstay of PKU treatment is a low-phenylalanine diet (i.e restriction of natural protein), and supplementation with a protein substitute (a mixture of amino acids free from phenylalanine, also containing micronutrients and…
- Trial name
- NCT01879995
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Pancreatic Fistula
Ultrasound Elastography for Prediction of Postoperative Pancreatic Fistula
The purpose of this study is to assess the value of preoperative objective modalities such as endoscopic ultrasound elastography and magnet resonance imaging in predicting development of postoperative pancreatic fistula in…
- Trial name
- PMPPOPF (NCT02589379)
- Testing
- Pancreatic Resection
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Mastocytosis
The Effect of Xolair ® (Omalizumab) in Mastocytosis Patients
Patients with mastocytosis often suffer from associated symptoms such as nausea, vertigo, fatigue, urticaria, abdominal cramps, diarrhea or hypotension due to release of mediators by mast cells.
- Trial name
- XOLMA (NCT01333293)
- Testing
- injections
- Where
- 3 sites in Switzerland
- Volunteers
- 17 people
- Sponsor
- University of Zurich
Medication Incidents
Medication Incidents in Primary Care Medicine
Prospective reporting of safety incidents concerning drug treatment by approximately 120 primary care physicians or pediatricians during 2015.
- Trial name
- MIPC (NCT02295371)
- Where
- Switzerland
- Volunteers
- 213 people
- Sponsor
- University of Zurich
Dysphagia
Dysphagia Handicap Index: A Structured Translation From English to German
Establishment of a questionnaire in German to determine in a structured and quantifiable manner the quality of life of patients with dysphagia.
- Trial name
- NCT01958268
- Testing
- Pretest and validation of a translated questionnaire
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude
Randomized, placebo controlled trial evaluating efficacy of dexamethasone in preventing sleep related breathing disturbances in lowlanders with chronic obstructive lung disease travelling from 700 m to 3200 m.
- Trial name
- NCT02450994
- Testing
- Dexamethasone
- Where
- Kyrgyzstan
- Volunteers
- 124 people
- Sponsor
- University of Zurich
Chronic Diarrhea
Secondary Lactose Intolerance Due to Chronic Norovirus Infection
The objective of this study is to determine the prevalence of secondary lactose intolerance in renal transplant recipients (RTR) with chronic norovirus infection.
- Trial name
- NCT01840891
- Testing
- Lactose H2 breath test (LH2BT)
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Anismus, Incontinence
Seated Evaluation of Anorectal funcTion by High Resolution Anorectal Manometry
To assess whether HR-ARM (High resolution Anorectal Manometry) performed in the more naturalistic / physiological upright, seated position on a commode provides a more valid assessment of anorectal function and simulated…
- Trial name
- SEAT (NCT02633592)
- Testing
- HRARM, MRI Defecography
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Dysphagia
Translation of the Sydney Swallow Questionnaire and Validation of the German Version
Translation of a validated questionnaire (SSQ) from english to german and validation of the german version. The SSQ consists of 17 well-structured questions for the assessment and quantification of patient reported difficulties…
- Trial name
- NCT01965964
- Testing
- Questionnaire
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Ehlers-Danlos Syndrome, Obstructive Sleep Apnea
Obstructive Sleep Apnoea in Ehlers-Danlos Syndrome
Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility.
- Trial name
- OSA in EDS (NCT02435745)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Normal Values for Esophageal High Resolution Manometry in an Advanced Protocol Including Liquid Swallows and a Solid Test Meal
Normal values for measurements of high resolution manometry in a protocol which includes isolated liquid swallows in upright and recumbent position, free drinking of water, a solid test meal and a postprandial observational…
- Trial name
- Rice (NCT02407938)
- Testing
- Rice meal
- Where
- Switzerland
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cystic Fibrosis
Breath Analysis in in Adults With Cystic Fibrosis (CF)
Exploratory comparative evaluation of exhaled breath composition in cystic fibrosis patients with age and gender-matched healthy adults in order to identify a disease-specific exhaled breath pattern as well as to gain insight…
- Trial name
- NCT02209571
- Testing
- Venous blood markers
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Left Ventricular Noncompaction, Isolated Noncompaction of the Ventricular Myocardium
Cardiac Computed Tomography: Characteristics of Isolated Left Ventricular Non-compaction
The diagnostic criteria for isolated left ventricular non-compaction cardiomyopathy (IVNC) have been well established for echocardiography and cardiac magnetic resonance, such validation is lacking for computed tomography (CT).
- Trial name
- NCT01470014
- Where
- Switzerland
- Volunteers
- 39 people
- Sponsor
- University of Zurich
Breast Cancer
Randomized Controlled Single-blind Trial to Evaluate the Mobile Tracking of Symptoms in Ambulatory Breast Cancer Patients
Health care has an increasingly demand for mobile applications (App), but studies are rare, which explore the added value and benefits for patient and physician.
- Trial name
- PatAPP1 (NCT02004496)
- Testing
- Consilium
- Where
- Switzerland
- Volunteers
- 139 people
- Sponsor
- University of Zurich
Multiple Sclerosis
Characterization of the Effects of Prolonged-release Fampridine on Ambulatory Function in Patients With Multiple Sclerosis
The objective of the present investigator-initiated mono-center trial to be performed at the Department of Neurology of the University Hospital Zurich is a detailed characterization of the effects of prolonged-release fampridine…
- Trial name
- FAMPKIN (NCT01576354)
- Testing
- Prolonged-release Fampridine
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University of Zurich
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