Clinical trials: sponsored by University of Zurich
Skin Cancer
Photosensitivity of the Skin Under Azathioprin in Renal Transplant Recipients
Photosensitivity of the skin to UVA and UVB will be determined
- Trial name
- NCT00492895
- Testing
- Discontinuation of Azathioprin
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Coagulation
Validation of Thrombelastometry (ROTEM®)
Das Hauptziele der Studie ist das ROTEM® zu validieren durch die Untersuchung von: i) Reproduzierbarkeit von ROTEM® ii) Präzision der ROTEM®-Tests, sowie iii) der Zeitspanne, während derer die Ergebnisse in Zitrat-Blut…
- Trial name
- NCT00705991
- Testing
- ROTEM
- Where
- Switzerland
- Sponsor
- University of Zurich
Pulmonary Hypertension, Breathing-Related Sleep Disorder
Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension
The purpose of this study is to study the differential short-term effect of nocturnal oxygen, acetazolamide tablets and nocturnal non-invasive positive pressure ventilation on symptoms, exercise capacity and nocturnal breathing…
- Trial name
- CSRPH (NCT01427192)
- Testing
- acetazolamide, Supplemental oxygen, Non-invasive ventilation
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University of Zurich
Takotsubo Syndrome
Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome
The aim of this prospective single-center study is to evaluate endothelial function, arterial compliance, sympathetic nervous activity at rest and after mental and physical stress, carotid atherosclerosis, oxidative stress…
- Trial name
- NCT01249599
- Testing
- blood sample analysis
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- University of Zurich
Focus of the Study: DNA Damage Due to Medical Diagnostic X-ray
Impact of Antioxidant Agents on the Number of DNA Double-strand Breaks After Radiation-based Cardiac Examinations
Trial with medicinal products Recent studies revealed that radiation-based procedures in patients may lead to DNA double-strand breaks in human blood lymphocytes.
- Trial name
- NCT01578395
- Testing
- Low-dose radiation exposure, High-dose radiation exposure, No radiation exposure
- Where
- Switzerland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy Participants, Hypertension
Human Intestinal Amino Acid Absorption and the Role of a Local (Renin)-Angiotensin System (RAS)
Aim of this trial is to investigate the expression and localisation of different amino acid transporters and their regulatory proteins derived from the regulatory proteins of the local renin angiotensin system (RAS) in the…
- Trial name
- NCT01252368
- Testing
- hypertension
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Zurich
End-stage Liver Disease
Conditioning With Volatile Anesthetics in Liver Transplantation
The gap between the number of candidates for orthotopic liver transplantation and the availability of suitable liver grafts has led to a rise in deaths on most waiting lists.
- Trial name
- NCT00913276
- Testing
- Propofol, Sevoflurane
- Where
- Switzerland
- Volunteers
- 98 people
- Sponsor
- University of Zurich
Venous Thromboembolism
Increased Rate of Prophylaxis Against Venous Thromboembolism Due to eAlerts
Now, after a cluster randomized controlled trial, eAlerts providing evidence-based guidelines on venous thromboembolism prophylaxis will be rolled out and evaluated hospital-widely.
- Trial name
- NCT01598805
- Testing
- electronic alerts
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- University of Zurich
Dilutional Coagulopathy
Hemodilution and Coagulopathy With 3 Colloids
Aim of this in vitro trial is to assess the effect on blood coagulation after 60 % dilution with different colloids (HES 130/0.42, Gelatin and Gelatin balanced) and investigate reversibility by replacement of fibrinogen (FBG)…
- Trial name
- NCT01727830
- Testing
- Induced Coagulopathy by HES (Tetraspan), Gelatin (Physiogel), Gelatin balanced (Physiogel balanced)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Anorexia Nervosa, Obesity
The Effects of Dietary Intervention on Gastrointestinal Function in Patients With Anorexia Nervosa and Obesity
Diseases characterized by abnormal low and high body weight are common in the community and are associated with significant morbidity, mortality and health care related costs.
- Conditions
- Anorexia Nervosa, Obesity, Healthy Participants
- Trial name
- NCT00946816
- Testing
- Nutritional Intervention
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Healthy Controls
The Effect of Physical Properties of Lipid Emulsions on Gastrointestinal Function
This study will investigate the effects of particle size of different triglyceride emulsions as well as the dynamics of intragastric structure formation and breakdown of the emulsions on GI function, the kinetics of the endocrine…
- Trial name
- NCT01253005
- Testing
- Nutritional intervention
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- University of Zurich
Healthy
Short Protocol Barostat for Assessment of Anorectal Function Versus Standard Protocol Barostat in Healthy Volunteers
The aim of this monocentric, prospective, non randomised study with 25 healthy volunteers is to assess anorectal function ( i.e rectal compliance and sensory thresholds) in health with a short protocol barostat versus…
- Trial name
- NCT01456442
- Testing
- anorectal manometry, barostat
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- University of Zurich
Acute Myocardial Infarction
SWiss Multicenter Intracoronary Stem Cells Study in Acute Myocardial Infarction (SWISS-AMI)
Title: SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI). Study population: Patients with acute myocardial infarction, treated with primary PCI.
- Trial name
- NCT00355186
- Testing
- intracoronary bone marrow cells infusion
- Where
- 4 sites in Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Birch Pollen Allergy
Physiological Study to Determine the Allergic Skin Activity After Different Skin Preparation
The objectives of this monocentric investigator initiated exploratory clinical trial is to optimize allergen delivery across the epidermal barrier.
- Trial name
- NCT01628484
- Testing
- prick lancet, Tape stripping, Microneedle
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Ulcerative Colitis
Photodynamic Therapy for Ulcerative Colitis
Objectives: Primary: The primary study objective is to determine a clinical response as assessed by the Mayo score to low dose PDT in patients with moderate to severe active distal UC.
- Trial name
- NCT01697670
- Testing
- Photodynamic therapy with Gliolan
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University of Zurich
Unipolar Depression
Randomized Clinical Trial of an Exposure-based Cognitive Therapy for Depression
The purpose of this study is to investigate, if exposure-based cognitive therapy (EBCT) is at least as effective as the established cognitive-behavioral therapy and more effective in its long-term efficacy.
- Trial name
- NCT01012856
- Testing
- Cognitive-Behavioral Therapy for Depression, Exposure-Based Cognitive Therapy for Depression
- Where
- Switzerland
- Volunteers
- 142 people
- Sponsor
- University of Zurich
Spinal Cord Injury
Lokomat Versus Strength Training in Chronic Incomplete Spinal Cord Injury
The purpose of this pilot study is to investigate whether gait specific robotic supported bodyweight supported treadmill training and lower extremity strength training have similar beneficial effects on walking function and other…
- Trial name
- NCT01087918
- Testing
- RAGT, Strength Training
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Complication, Death
The Perioperative Value of Platelet Counts in Predicting Outcome After Liver Transplantation
Recent experimental and clinical studies have shown that platelets play a critical role in liver ischemia and regeneration. Thrombocytopenia, a frequent and potentially serious condition in liver transplantation (LT) recipients…
- Trial name
- NCT01711957
- Testing
- Liver transplantation
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University of Zurich
Parkinson's Disease
Multicenter Placebo Controlled Study to Assess the Effect of Rasagiline on Sleep-wake Disturbances in Patients With Parkinson's Disease
Sleep-wake disturbances (SWD) are frequent in Parkinson's disease (PD) and affect the quality of life of affected patients. Rasagiline is a potent, highly selective, irreversible, second-generation, monoamine oxidase type-B…
- Trial name
- Ras-PDS-1 (NCT01178047)
- Testing
- Rasagiline
- Where
- 2 sites in Switzerland
- Volunteers
- 1 people
- Sponsor
- University of Zurich
Healthy
The Effect of Sertindole on Sensory Gating and Cognition in Healthy Volunteers
This study aims to further validate and extend our previous findings insofar that the effect of the atypical antipsychotic and mixed 5-HT2/D2 antagonist sertindole on sensorimotor gating processes and its relationship to…
- Trial name
- NCT00612079
- Testing
- Sertindole
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich