Clinical trials: sponsored by University of Zurich
Atopic Dermatitis
Effects of Tralokinumab in the Skin: an Immunologic and Molecular Investigation
The clinical efficacy of tralokinumab has been demonstrated in the treatment of AD; its MOA however remains insufficiently understood.
- Trial name
- TRALIS (NCT05378698)
- Testing
- Application of Tralokinumab
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Tinnitus, Tinnitus, Subjective
Transcranial Electrical and Acoustic Stimulation for Tinnitus
Transcranial electrical stimulation (tES) is an umbrella term for non-invasive brain stimulation using weak currents. It comprises transcranial direct current stimulation (tDCS), which is the most established and used method…
- Trial name
- tEAS (NCT04551404)
- Testing
- transcranial Random Noise Stimulation (tRNS) with acoustic stimulation (AS), transcranial Random Noise Stimulation (tRNS) without acoustic stimulation (AS)
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University of Zurich
Nipple Lesions
Low-Level Laser Therapy (LLLT) Treatment for Breast-Feeding Women With Painful Nipple Lesions
Around 30 to 90 percent of all breastfeeding women suffer from painful and sore nipple lesions. Reasons for these lesions are still not completely clarified.
- Trial name
- NCT04259619
- Testing
- Low-Level Laser Therapy
- Where
- Switzerland
- Volunteers
- 96 people
- Sponsor
- University of Zurich
Atopic Dermatitis, Asthma
Prospective Longitudinal Observational Research in Atopic Dermatitis
Atopic dermatitis (AD) is a frequent chronic relapsing inflammatory skin disorder, characterized by intensely itchy eczema. AD usually starts within the first 2 years of life.
- Conditions
- Atopic Dermatitis, Asthma, Atopic Dermatitis and Related Conditions
- Trial name
- ProRaD (NCT04240522)
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypersensitivity, Food
Prospective Study About Sensitization Pattern to Insects as Food Source in Patients With House Dust Mite Allergy
Patients allergic to seafood and/or sensitized to Tropomyosin of Skin Prick tests SPT or crustacean origin will may be also be sensitized to edible insects.
- Trial name
- InFood (NCT04239131)
- Testing
- Skin prick test
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Metastasis
Clinical Trial Comparing Dose-intensified SBRT With Conventional Radiation Therapy for Spinal Metastases
This study will compare pain (primary end-point) and local metastatic tumor control (secondary end-point) after dose-intensified image-guided fractionated stereotactic body radiation therapy (SBRT) for painful mass-type spinal…
- Trial name
- DOSIS RCT (NCT02800551)
- Testing
- dose-intensified image-guided SBRT using simultaneous integrated boost, External 3-dimensional conformal radiotherapy (3D-CRT)
- Where
- Switzerland
- Volunteers
- 219 people
- Sponsor
- University of Zurich
Full-arch Impression
The Accuracy of Intraoral Scanning Systems for Full-Arch Impressions Is Examined in 10 Participants
For several decades now, modern procedures have allowed dentists to capture your teeth using digital cameras. This digital procedure is increasingly replacing traditional impressions with a viscous mass that hardens in the mouth.
- Trial name
- NCT06658366
- Testing
- impression of the teeth
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Acute Mountain Sickness
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
Millions of people travel to high altitude for work or leisure activities and are exposed to reduced inspiratory oxygen partial pressure and hypoxemia that may lead to altitude illness, among which the most common form is acute…
- Trial name
- NCT06499727
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), SDB Assessed at HA (3200 m) vs LA (760 m)
To study the effect of relocation from 3200m (Aksay) to 760m (Bishkek) in highlanders with High Altitude Pulmonary Hypertension (HAPH) who permanently live >2500m on sleep disordered breathing
- Trial name
- NCT06489717
- Testing
- SDB assessment
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), 6MWT Assessed at High Altitude (3200m) vs Low Altitude (760m)
To study the effect of relocation from 3200m (Aksay) to 760m (Bishkek) in highlanders with High Altitude Pulmonary Hypertension (HAPH) who permanently live >2500m on 6-minute walk distance (6MWD)
- Trial name
- NCT06489691
- Testing
- 6-minute walk test (6MWT)
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
High Altitude (HA) Residents With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Artery Pressure (PAP) Assessed at HA (3200 m) vs LA (760 m)
To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live >2500 m on pulmonary artery pressure (PAP)
- Trial name
- NCT06489704
- Testing
- Echocardiography
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension
Highlanders With High Altitude Pulmonary Hypertension (HAPH), 6 Minute Walk Distance (6MWD) Assessed at 3200m With and Without Supplemental Oxygen Therapy (SOT)
The investigators aim to study the effect of SOT in highlanders with high altitude pulmonary hypertension (HAPH) who permanently live >2500m on 6-minute walk distance (6MWD) assessed at 3200m.
- Trial name
- NCT06489743
- Testing
- 6-minute walk test (6MWT)
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Spinal Cord Injury, Acute
Transcutaneous Tibial Nerve Stimulation in Acute Spinal Cord Injury
Most patients with spinal cord injury (SCI) develop neurogenic lower urinary tract dysfunction (NLUTD), one of the most devastating sequelae of SCI which ultimately can lead to renal failure.
- Trial name
- TASCI (NCT03965299)
- Testing
- VERUM TTNS
- Where
- 4 sites in Switzerland
- Volunteers
- 114 people
- Sponsor
- University of Zurich
Sarcopenia, Frailty
Sarcopenia Prevention With a Targeted Exercise and Protein Supplementation Program
Physical inactivity and protein malnutrition have been implicated to be key and modifiable causes of enhanced muscle mass loss among seniors.
- Conditions
- Sarcopenia, Frailty, Malnutrition; Protein, Fall
- Trial name
- STRONG (NCT03417531)
- Testing
- Protein Supplement, Protein-free Supplement, Active Exercise
- Where
- 2 sites in Switzerland
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- University of Zurich
the Immediate and Long-lasting Effects of the X10D Sole on Important Aspects of Walking Function in Healthy Participants, Walking
Studying the Effects of the X10D Shoe on Walking in Healthy Adults Aged 50 to 65
The aim of this study is to characterize the biomechanical effects of the X10D sole using objective, quantitative measurement methods.
- Trial name
- NCT07296913
- Testing
- X10D shoe
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Postoperative Complications, Breathing Exercises
Randomized-controlled Trial of Preoperative Inspiratory Muscle Training on Postoperative Complications
Rehabilitation strategies after abdominal surgery enhance recovery and improve outcome. A cornerstone of rehabilitation is respiratory physiotherapy with inspiratory muscle training to enhance pulmonary function.
- Conditions
- Postoperative Complications, Breathing Exercises, Preoperative Period
- Trial name
- INSPIRA (NCT04558151)
- Testing
- preoperative inspiratory muscle training
- Where
- Switzerland
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Multiple Myeloma (MM), Lymphoma, Large B-Cell, Diffuse (DLBCL), Lymphoma, CART Therapy
Pragmatic Geriatric Assessment Before CAR-T or Bispecific Antibody Therapy to Predict Side Effects and Outcomes in Older Patients (GA-ACT Trial)
CAR-T cell or bispecific antibody therapies are a new treatment option for adult patients with aggressive forms of lymphoma or so-called plasma cell diseases ('multiple myeloma', 'plasma cell myeloma') that could not be cured…
- Conditions
- Multiple Myeloma (MM), Lymphoma, Large B-Cell, Diffuse (DLBCL), Lymphoma, CART Therapy, Bispecific Antibody, Geriatric Hematology
- Trial name
- GA-ACT (NCT07309497)
- Testing
- pragmatic geriatric assessment
- Where
- 2 sites in Switzerland
- Volunteers
- 208 people
- Sponsor
- University of Zurich
Prostate Carcinoma, Localized Prostate Adenocarcinoma
Early Magnetic Resonance Imaging Response of the Dominant Intraprostatic Lesion After Online Adaptive Stereotactic Body Radiotherapy for Localized Prostate Cancer and Correlation With Prostate Specific Antigen Response
The aim of this phase II study is to determine the early multiparametric magnetic resonance imaging response of the dominant intraprostatic lesion and correlate these findings with prostate specific antigen response in patients…
- Conditions
- Prostate Carcinoma, Localized Prostate Adenocarcinoma, Stereotactic Body Radiotherapy, Stereotactic Radiotherapy
- Trial name
- PRODART (NCT06822491)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Spinal Injury
MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders
Understanding the onset and progression of spinal cord disorders is an important aim in clinical neurology. An early diagnosis with consequent therapy might prevent the progression of disability.
- Trial name
- NCT02170155
- Where
- Switzerland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Stroke
CNS Changes Following Stroke
The objective of this study is to better understand the structural and functional changes that the CNS undergoes following stroke and how these changes relate to clinical measures.
- Trial name
- NCT04059276
- Testing
- MRI
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Zurich
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