Clinical trials: sponsored by University of Zurich
Healthy
Effect of Mental Stress on Platelet Function in Healthy Subject
Psychological stress is an independent cardiovascular risk factor. Activation of platelets plays an important role in atherosclerosis development and it could one of the mechanisms linking psychological stress and cardiovascular…
- Trial name
- NCT00621738
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Renal Failure
Novel Prediction Score for Postoperative Acute Renal Failure (ARF) Following Liver Resection
ARF is a frequent event after hepatic resection and therefore clinically highly relevant. There is limited evidence on the incidence of postoperative ARF and its clinical relevance in patients undergoing liver resection.
- Trial name
- StV 11-2008 (NCT00743132)
- Where
- Switzerland
- Volunteers
- 569 people
- Sponsor
- University of Zurich
Chronic Posttraumatic Stress Disorder
Brief Eclectic Psychotherapy for PTSD - a Randomized Controlled Trial
Participants are randomly assigned to either 16 sessions of Brief Eclectic Psychotherapy (Gersons et al. (2000) Journal Trauma Stress 13: 333-348), comprising psychoeducation, exposure, mementos and writing assignments, domain of…
- Trial name
- NCT00329992
- Testing
- Brief Eclectic Psychotherapy for PTSD
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Posttraumatic Stress Disorder
Low-dose Cortisol in Chronic Posttraumatic Stress Disorder
The aim of this prospective, double-blind, placebo-controlled, cross-over study is to determine the therapeutic efficacy of low-dose cortisol for symptoms of chronic posttraumatic stress disorder.
- Trial name
- NCT00362661
- Testing
- Cortisol
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Phobia
Cortisol in the Treatment of Phobias
The aim of this prospective, double-blind, placebo-controlled, randomized study is to investigate if glucocorticoid treatment, in combination with exposure therapy, helps to reduce phobic fear in patients with phobia.
- Trial name
- NCT00451750
- Testing
- Cortisol
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Melanoma Stage III or IV, No Prior Chemotherapy
Monocentric Pilot Study Investigating the Metabolic Activity of Melanoma in Vivo During Sorafenib and Dacarbazine
Investigation of the metabolic activity of sorafenib and sorafenib plus dacarbazine on melanoma metastasis in patients with melanoma stage III or IV on the basis of PET/CT, LDH and S-100 evaluation.
- Trial name
- NCT00794235
- Testing
- Sorafenib (Nexavar), Dacarbazine (DTIC)
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Hematopoietic Stem Cell Transplantation
Ambulatory Physical Exercise Program in Hematopoietic Stem Cell Transplantation Recipients
The proposed study in an inception cohort of patients with hematological malignancies treated with PBSCT is designed to evaluate the effects of a physical exercise intervention on muscular-skeletal, physical activity and quality…
- Trial name
- NCT00402753
- Testing
- Ambulatory Physical Exercise Program
- Where
- 4 sites in Netherlands, Switzerland
- Volunteers
- 128 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnea Syndrome, Rhinitis
Nasal Decongestion and Obstructive Sleep Apnea
Whether impaired nasal breathing contributes to sleep related breathing disturbances has not been known. Therefore, the purpose of the study is to compare the effect of xylometazoline, a drug that decongests the nasal mucosa when…
- Trial name
- NCT00630474
- Testing
- xylometazoline
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Injury of the Right Upper Extremity
Effects of Sensory and Motor Deprivation on Brain Plasticity
Investigation of changes in gray and white matter during immoblisation after injury of the right upper extremity via two MR Investigations of the brain at two different times.
- Trial name
- NCT01029093
- Testing
- no intervention, MRI and motor skill test
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Major Surgical Procedures
Severe Complications Triplicate the Costs of Major Surgical Procedures
The purpose of this study is to prospectively assess the impact of surgical quality on the overall cost of major surgical procedures using the incidence and severity of complications as surrogate markers of quality.
- Trial name
- NCT00855387
- Testing
- No additional intervention than the intended major surgery in pancreas, liver, colorectal, gastric bypass and small bowel
- Where
- Switzerland
- Volunteers
- 1,235 people
- Sponsor
- University of Zurich
Anesthesia
Preconditioning Volatile Anesthesia in Liver Surgery
The purpose of this study is to compare the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.
- Trial name
- NCT01021228
- Where
- Switzerland
- Volunteers
- 257 people
- Sponsor
- University of Zurich
Serious Complications Following Liver Resection
Novel Preoperative Score Predicting Outcome Following Liver Resection
To develop and validate a score to predict serious complications following liver resection using pre-operative risk factors.
- Trial name
- NCT01003197
- Where
- Switzerland
- Sponsor
- University of Zurich
Heart Failure
Effects of Chocolate in Patients With Chronic Heart Failure
The aim of the present study is to investigate whether in patients with chronic heart failure endothelial dysfunction and baroreceptor function is altered by ingestion of a flavonoid-rich dark chocolate in comparison to placebo…
- Trial name
- NCT00538941
- Testing
- Nestlé Noir intense 40 grx2
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University of Zurich
Bipolar Disorder
Effects of a Lifestyle Intervention on Body Mass Index in Patients With Bipolar Disorder
Patients with bipolar disorder are at increased risk of weight gain, which in turn, increases the risk for somatic disease and non-adherence to maintenance therapy.
- Trial name
- NCT00980863
- Testing
- lifestyle intervention to increase physical activity
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Catheters, Indwelling
Seldinger Technique Versus Venous Cut-Down for Placement of Totally Implantable Venous Access Ports
Since the first placement of a totally implantable venous access port (TIVAP) by Niederhuber et al in 1982 its application to provide long-term central venous access has dramatically increased.
- Trial name
- NCT00272623
- Testing
- Seldinger technique or venous cut-down for port placement
- Where
- Switzerland
- Volunteers
- 152 people
- Sponsor
- University of Zurich
Scheduled for Surgery
Impact of General Anaesthetics on Excitability of the Peripheral Sensory Nerve
The aim of this study is to investigate the effect of general anaesthetics on nerve excitability. We use the method of threshold tracking to measure selected parameters of nerve excitability.
- Trial name
- NCT00696254
- Testing
- Nerve excitability measurement
- Where
- Switzerland
- Sponsor
- University of Zurich
Stress Disorders, Post-Traumatic
Affect Management Group for Adult Survivors of Childhood Trauma
Problems of self regulation, e.g. emotional dysfunction, represent a core symptom of adult patients with traumatic childhood experiences.
- Trial name
- NCT00383006
- Testing
- Skills for affect regulation (behavior)
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University of Zurich
Glaucoma
Efficacy of SLT in Patients With Insufficient IOP Control Under Maximum Tolerated Drug Therapy (Eye Drops)
Examination and follow-up of efficacy and safety of SLT in patients with unsufficient IOP control despite maximum tolerated topical therapy.
- Trial name
- NCT00801658
- Testing
- selective Laser Trabeculoplasty (SLT)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Allergy to Cats
IVN-CAT-001A Performance of CAST With Different Allergens in Patients With Cat Dander Allergy
Primary objective of the trial: To determine at which concentration the fusion protein MAT Fel d1 degranulates basophils of cat dander allergic patients, in comparison to a cat dander extract and to Fel d1 alone
- Trial name
- NCT00620880
- Testing
- Blood sample
- Where
- Switzerland
- Sponsor
- University of Zurich
General Practitioners
Placebo Interventions in General Practice
Physicians often have an ambivalent relationship to placebo interventions. On the one hand they know of the intriguing effect of sugar pills or saline infusions but on the other hand they mostly feel constrained to adopt…
- Trial name
- NCT00603928
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Zurich
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