Clinical trials: sponsored by University of Zurich
Depressive Symptoms Mild to Moderate in Severity, Anxiety
Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer Patients
With progression of cancer, patients and their caregivers experience challenging emotional distress, which can make them feel depressed and very anxious. Patients with advanced cancer often do not have long to live.
- Conditions
- Depressive Symptoms Mild to Moderate in Severity, Anxiety, Quality of Life (QOL), Caregiver Burden
- Trial name
- Keta-Care (NCT06665568)
- Testing
- Intranasal ketamine hydrochloride
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Malignant Media Infarction, Stroke
Optic Nerve Sonography to Monitor Intracranial Pressure After Ischemic sTrokE - The ONSITE Study
The goal of the ONSITE study is to investigate whether an increase Optic nerve sheath diameter (ONSD) may help to predict intracranial hypertension (IH) after stroke.
- Conditions
- Malignant Media Infarction, Stroke, Intracranial Hypertension
- Trial name
- ONSITE (NCT06939114)
- Where
- Switzerland
- Volunteers
- 107 people
- Sponsor
- University of Zurich
Leukemia, Leukemia, Myeloid
Breath Analysis for the Detection of Invasive Fungal Infections
Patients with leukemia and concomitant neutropenia are at high risk of developing invasive fungal infections (IFI) that are associated with high morbidity and mortality.
- Conditions
- Leukemia, Leukemia, Myeloid, Leukemia, Lymphoblastic, Neutropenia
- Trial name
- REDEFINE (NCT06537726)
- Testing
- Secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS)
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- University of Zurich
Dysmenorrhea Primary
Assessing the Therapeutic Potential of a Traditional Botanical Remedy for Menstrual Pain: Insights From a Prospective Observational Analysis
Primary dysmenorrhea (PDM) affects round 60 to 90% of women and has a great impact on everyday life of affected women, leading to decreased work productivity, cognitive activity and cuts in social life.
- Trial name
- NCT06908044
- Testing
- Bryophyllum
- Where
- 2 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- University of Zurich
Lung Cancer (NSCLC)
Ultrasound-guided Cryobiopsy of Mediastinal/Hilar Lymph Nodes
EBUS-guided cryobiopsy of mediastinal and hilar lymph nodes has shown to be a useful diagnostic tool to obtain tissue for histological analysis and further targeted therapies in lung malignancies.
- Trial name
- NCT06921681
- Testing
- Cryobiopsy of lymph nodes group 6 sec, Cryobiopsy lymphnode group 3 sec
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- University of Zurich
Shunt; Complications, Ventricular (Communicating)
Prospective Shunt Complication Study
Complications in patients with cerebrospinal fluid (CSF) shunts are common. Thus, these patients are frequently admitted for suspicion of a shunt dysfunction (SD).
- Trial name
- ShuCS (NCT02778997)
- Testing
- CSF Shunt treatment for hydrocephalus
- Where
- 2 sites in Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Late-effects of Childhood Cancer
SURfit - A Physical Activity Intervention for Childhood Cancer Survivors
Exercise can play a major role to mitigate or even prevent late effects in cancer survivors, such as cardiovascular disease, obesity, osteoporosis, fatigue, depression, reduced quality of life, mental health and physical…
- Trial name
- SURfit (NCT02730767)
- Testing
- partially supervised exercise intervention
- Where
- Switzerland
- Volunteers
- 151 people
- Sponsor
- University of Zurich
Caregiver Burden, Bereavement
Caregiver Stress and Bereavement
The death of a spouse is considered one of the most stressful and impactful life events and is associated with increased morbidity and premature mortality.
- Conditions
- Caregiver Burden, Bereavement, Cancer
- Trial name
- NCT05867706
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Apnea of Prematurity, Prematurity
Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants
This trial analyzes the effect of an olfactory stimulation with vanilla or strawberry aroma compared to placebo on desaturations and bradycardia in preterm infants with apnea of prematurity.
- Conditions
- Apnea of Prematurity, Prematurity, Infant, Premature, Diseases
- Trial name
- NOSE (NCT05878925)
- Testing
- Aroma
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
SARS-CoV 2, COVID-19
COVID-19: Longitudinal Study of Seroprevalence of SARS-CoV-2 Antibodies and Development of Immunity in School Children
There is a lack of knowledge about how many children are infected with SARS-CoV-2, how often they are asymptomatic, and how long the immunity persists.
- Trial name
- CiaoCorona (NCT04448717)
- Testing
- COVID-19 Antibody testing
- Where
- Switzerland
- Volunteers
- 4,250 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neurogenic Bladder, Diseases of the Lower Urinary Tract: General Conditions
Lower Urinary Tract Dysfunction Database
Patients with neurological disease/injury often suffer from lower urinary tract symptoms, which frequently have a negative impact on the patients' health related quality of life.
- Trial name
- NCT01293110
- Where
- Switzerland
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Shock, Septic
Sevoflurane Sedation in Patients With Septic Shock
Recent in vivo studies from others as well as the investigators group demonstrated that volatile anesthetics immunomodulate sepsis and improve outcome.
- Trial name
- SSiS (NCT03643367)
- Testing
- Sevoflurane, Control Group
- Where
- 4 sites in Switzerland
- Volunteers
- 153 people
- Sponsor
- University of Zurich
All Transplanted Individuals in Switzerland
Swiss Transplant Cohort Study
The Swiss Transplant Cohort Study is an observational prospective cohort study enrolling all patients after solid organ and stem cell transplantation since 5/2008 in Switzerland.
- Trial name
- STCS (NCT01204944)
- Where
- Switzerland
- Volunteers
- 7,500 people
- Sponsor
- University of Zurich
Opioid Use, Unspecified
Observational Study on the Incorporation of Opioids and Their Metabolites Into Hair of Pediatric Patients
Hair analysis is a well-established and important tool in both forensic and clinical context. When it comes to the interpretation of positive hair analysis results, reliable and comprehensive reference data is essential.
- Trial name
- NCT05740657
- Testing
- Fentanyl
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Hearing Loss, Sensorineural
Cognitive Screening of Patients with Hearing Loss
Hearing loss and cognitive impairment both appear in elderly patients. The goal was to use a modified screening method added to already established cognitive tests to obtain a standardized test for detection of cognitive…
- Trial name
- NCT04672174
- Testing
- Questionnaire: DemTect
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
C. Difficile Enteritis
Support of Colonization Resistance of the Gut Microbiota with the Synbiotic Food Supplement Nagasin®
Double blind, placebo-controlled, parallel, multicentric trial to investigat whether Nagasin® can support the colonization resistance against C.difficile.
- Trial name
- NCT05800704
- Testing
- Nagasin, maltodextrin
- Where
- 6 sites in Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
Glioblastoma Multiforme
Response Assessment During MR-guided Radiation Therapy for Glioblastoma
The study seeks to assess the response of glioblastoma multiforme to treatment using weekly low field (0.35 T) MR-images of the brain at a MRIdian® linac system during standard radiotherapy at the same system.
- Trial name
- MARGA (NCT05565326)
- Testing
- Low field (0.35 T) MR-images of the brain at a MRIdian® linac system
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Depression, Anxiety
Consultation-Liaison Intervention for Patients with Depression and Anxiety in Primary Care
The CoLiPri study is a cluster randomized controlled trial funded by the Swiss National Science Foundation to evaluate the clinical and cost effectiveness as well as the implementation of a complex consultation-liaison…
- Trial name
- CoLiPri (NCT04233853)
- Testing
- CoLiPri intervention, Usual primary care enhanced
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- University of Zurich
Depressive Disorder
Telephone-administered Relapse Prevention for Depression
This study determines the effectiveness of telephone-delivered cognitive-behavioral continuation therapy (T-CT) in comparison to usual care in people with recurrent or chronic depression.
- Trial name
- NaTel (NCT03219879)
- Testing
- Telephone-administered continuation therapy, Usual care
- Where
- 11 sites in Germany, Switzerland
- Volunteers
- 201 people
- Sponsor
- University of Zurich
Keloid Scar Following Surgery, Scars, Hypertrophic
Measuring the Volumes of Hypertrophic Scars and Keloids, Two Specific Kind of Scars, Over Different Points in Time in Patients Who Have Undergone Surgery and Evaluate 3D-cameras As a Possible Measuring and Documenting Tool Including Volumetry
Measuring the volumes of hypertrophic scars and keloids, two specific kind of scars, over different points in time in patients who have undergone surgery and evaluate 3D-cameras as a possible measuring and documenting tool…
- Conditions
- Keloid Scar Following Surgery, Scars, Hypertrophic, Scar Keloid
- Trial name
- NCT06806735
- Testing
- 3D-Pictures
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
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