Clinical trials: sponsored by Uppsala University
Osteoarthritis, Knee, Osteoarthritis, Hip
Promoting Sleep to Alleviate Pain - Arthroplasty
PROSAP-A is a perioperative randomized, controlled trial with a 12-month follow-up period after total knee arthroplasty (TKA) or total hip arthroplasty (THA), aiming to investigate both acute and long-term postoperative effects…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Insomnia, Surgery
- Trial name
- PROSAP-A (NCT06145516)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-I), Sleep education therapy (SET)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Uppsala University
Mechanical Ventilation, Pain
Skin Conductance in Ventilated Preterms
The goal of this observational study is to learn more about the pain and stress experienced by newborn infants receiving mechanical ventilation (breathing through a machine).
- Conditions
- Mechanical Ventilation, Pain, Skin to Skin Care, Kangaroo Mother Care
- Trial name
- SCiP (NCT07568418)
- Testing
- Skin Conductance Measurement
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University Hospital
ARDS, Human, COVID
Mesenchymal Stromal Cell Therapy For The Treatment Of Acute Respiratory Distress Syndrome
This is an open label, dose escalating safety study of the advanced therapy investigational medicinal product (ATIMP) KI-MSC-PL-205, where patients diagnosed with SARS-CoV-2-induced severe acute respiratory distress syndrome…
- Trial name
- ARDS-MSC-205 (NCT04447833)
- Testing
- Mesenchymal Stromal Stem Cells - KI-MSC-PL-205
- Where
- Sweden
- Volunteers
- 7 people
- Sponsor
- Uppsala University
Blood Donation
Sucrosomial Iron and Iron Sulphate to Blood Donors
2 different oral iron supplementations after blood donation are compared.
- Trial name
- NCT05678647
- Testing
- Sucrosomial Iron, Iron Sulfate
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Uppsala University Hospital
Type1diabetes
Mesenchymal Stromal Cells to Treat Type 1 Diabetes in Children and Adolescents
This is a combined phase 1 and 2 study in 66 subjects, male or female, between 7-21 years of age that have recently (< 6 months) been diagnosed with type 1 diabetes.
- Trial name
- NCT05061030
- Testing
- the ATMP Protrans
- Where
- Sweden
- Volunteers
- 66 people
- Sponsor
- Uppsala University Hospital
Long-standing Type 1 Diabetes Mellitus
An Open Label, Pilot Investigation, to Assess the Safety and Efficacy of Transplantation of Macro-encapsulated Human Islets Within the Bioartificial Pancreas Beta-Air in Patients With Type 1 Diabetes Mellitus
The primary objective of this clinical investigation is to investigate the safety of implantation of the human islet containing device Beta-Air in type 1 diabetic subjects.
- Trial name
- NCT02064309
- Testing
- Beta-Air device for encapsulation of transplanted human islets
- Where
- Sweden
- Volunteers
- 4 people
- Sponsor
- Uppsala University Hospital
Cervical Spine Fractures, Cervical Spine Injury
Study on Orthosis in Cervical Spine Fracture Treatment
Background and Purpose: Neck fractures affect over 1,100 people in Sweden each year, with the majority being frail older adults.
- Conditions
- Cervical Spine Fractures, Cervical Spine Injury, Rigid Collar
- Trial name
- SOFT (NCT06848660)
- Testing
- A rigid cervical collar
- Where
- 6 sites in Sweden
- Volunteers
- 616 people
- Sponsor
- Uppsala University Hospital
Shame, Intimate Partner Violence
How a Resilience-Focused Intervention is Perceived by Women Subjected to Domestic Violence
At Uppsala University Hospital, there is an outpatient clinic for women subjected to intimate partner violence. In order to explore how patients experience the biopsychosocial resilience-based intervention in use at the clinic…
- Conditions
- Shame, Intimate Partner Violence, Domestic Violence Exposure, Resilience, Psychological
- Trial name
- EMBER-2 (NCT07235722)
- Testing
- Qualitative interview
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Post Intensive Care Unit Syndrome
Web-based Follow-up to Former ICU Patients
This study evaluates if a web-based 1-year programme is a useful method for follow-up intensive care survivors with short ICU-stay.
- Trial name
- WIVA (NCT04317144)
- Testing
- Web-based follow-up programme., No follow-up
- Where
- Sweden
- Volunteers
- 330 people
- Sponsor
- Uppsala University
Cardiac Arrest, Cognitive Function
Brain Function After Cardiac Arrest (Measured With FMRI and Cognitive Tests)
The aim of this longitudinal study is to determine whether brain function is affected after a cardiac arrest. The primary question is whether cognitive function is affected after cardiac arrest and whether it changes over time…
- Trial name
- BRAINnHEART (NCT03579498)
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Shame
Validation of the Swedish Translation of a Brief Shame Measure, the External and Internal Shame Scale
Shame is a normal emotion that people sometimes have. Experiencing a lot of shame has however been found to have a link to ill mental and somatic health. Therefore it is of interest to have a brief way of measuring shame.
- Trial name
- EMBER-1 (NCT07206966)
- Where
- Sweden
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Out-of-Hospital Cardiac Arrest
Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest
The overall aim of this prospective, randomized study is to investigate whether acute coronary angiography (within 120 minutes) with a predefined strategy for revascularization, will improve 30-day survival in patients with out…
- Trial name
- DISCO (NCT02309151)
- Testing
- Immediate coronary angiography
- Where
- 21 sites in Denmark, Netherlands and 1 more
- Volunteers
- 1,003 people
- Sponsor
- Uppsala University
Out-of-Hospital Cardiac Arrest, Pulmonary Ventilation
CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- an Observational Study
The aim of this observational study is to investigate how ventilations is given during cardiopulmonary resuscitation (CPR) given by advanced life support providers (ALS).
- Trial name
- CAvent (NCT04237727)
- Testing
- Fluxmed GrH portable pneumotachograph
- Where
- 5 sites in Netherlands, Sweden
- Volunteers
- 241 people
- Sponsor
- Uppsala University
Pedicle Screw Fixation of Spine
Robotic-Assisted Pedicle Screw Placement in Spine Surgery
This prospective multicenter observational cohort study evaluates robotic-assisted pedicle screw placement compared with non-robotic-assisted techniques in spinal surgery.
- Trial name
- ROBOTICSS (NCT07461636)
- Testing
- Robotic-assisted pedicle screw placement
- Where
- 9 sites in Sweden
- Volunteers
- 7,200 people
- Sponsor
- Uppsala University
High-risk Melanoma
Assessment of Short Immunotherapy After Radical Surgery of High-risk Malignant Melanoma
1. Rational Every year, around 5,000 people in Sweden are diagnosed with malignant skin melanoma. In the early stages of malignant skin melanoma, the chance of cure with surgery is very good.
- Trial name
- NCT06488482
- Testing
- nivolumab or pembrolizumab
- Where
- 26 sites in Finland, Norway and 1 more
- Volunteers
- 1,792 people
- Sponsor
- Uppsala University
Type 2 Diabetes
SGLT2 Inhibitor or Metformin as Standard Treatment of Early Stage Type 2 Diabetes
A real-world, nationwide, register-based, randomised trial (RRCT) comparing SGLT2 inhibitors with metformin as standard treatment in early typ 2 diabetes.
- Trial name
- SMARTEST (NCT03982381)
- Testing
- Metformin, Dapagliflozin 10 MG
- Where
- Sweden
- Volunteers
- 2,067 people
- Sponsor
- Uppsala University
Mental Health, Socio-emotional Well-being
Combining Mental Health and Parenting Interventions to Improve Child Wellbeing Among Refugee Families in Tanzania
The goal of this clinical trial is to learn whether improving caregivers' mental health and parenting practices can enhance child wellbeing among Congolese refugee families living in the Nyarugusu Refugee Camp, Tanzania.
- Conditions
- Mental Health, Socio-emotional Well-being, Functioning, Psychosocial, Parenting Behavior
- Trial name
- WEMA (NCT07447921)
- Testing
- Self Help Plus, Interaction Competencies with Children - for Parents
- Where
- 2 sites in Tanzania
- Volunteers
- 1,296 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Panic Disorder, Healthy
Neurobehavioral Correlates of Caffeine on Anxiety, Avoidance and Interoception in Healthy Individuals and Panic Disorder.
The current study is a placebo-controlled, double-blind, randomized controlled study using a cross-over design, including Healthy Controls (HC) and participants with Panic Disorder (PD).
- Trial name
- BINCAP (NCT06145490)
- Testing
- Caffeine
- Where
- 2 sites in Sweden
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Mental Health, Psychological Distress
Self-Help Plus to Enhance Early Development: A Cluster-Randomized Controlled Trial of Maternal Mental Health, Child Cognitive Abilities, and Socio-Behavioral Skills Among Refugee Mothers and Their Preschool-Aged Children in Rhino Camp, Uganda
This study evaluates whether the group-based mental health program Self-Help Plus (SH+) can improve the mental health, wellbeing, and functioning of refugee mothers and their preschool-aged children living in Rhino Refugee…
- Conditions
- Mental Health, Psychological Distress, Child Wellbeing, Child Mental Health
- Trial name
- SEED (NCT07062341)
- Testing
- Self-Help Plus (SH+), Enhanced Usual Care (EUC)
- Where
- Uganda
- Volunteers
- 725 people
- Sponsor
- Uppsala University
Continuity of Patient Care
IMPACT-care (Improved Medication Communication and Patient Involvement at Care Transitions)
Background: Transitions of care, especially at hospital discharge, pose significant risks to patient safety. The World Health Organization (WHO) identifies this as a critical area for improvement, particularly for older patients…
- Trial name
- IMPACT-care (NCT06610214)
- Testing
- IMPACT-care intervention
- Where
- Sweden
- Volunteers
- 231 people
- Sponsor
- Uppsala University Hospital