Clinical trials: sponsored by Uppsala University
Sleep, Diet Interventions
Dietary Impact on Sleep, Rhythms and Related Physiology
Sleep and metabolism are closely interconnected, and emerging evidence suggests that dietary composition may influence both sleep quality and key physiological functions such as glucose regulation, cardiovascular activity, and…
- Conditions
- Sleep, Diet Interventions, Circadian Rhythm
- Trial name
- NCT07138313
- Testing
- Low-fat dietary intervention, High-fat dietary intervention
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Brain Tumor, Childhood Cancer
Biomarkers of Brain Injury in Children With Brain Tumors
The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors.
- Conditions
- Brain Tumor, Childhood Cancer, Childhood Brain Tumor
- Trial name
- BiomarkCBT (NCT07381959)
- Where
- Sweden
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Pediatric Delirium, Pediatric Intensive Care
Pediatric Delirium in Swedish Paediatric Intensive Care Units
This observational study aims to determine the incidence of delirium among children in a pediatric intensive care unit (PICU) and to identify associated risk factors.
- Conditions
- Pediatric Delirium, Pediatric Intensive Care, Risk Factors
- Trial name
- PADI (NCT07365215)
- Where
- 3 sites in Sweden
- Volunteers
- 676 people
- Sponsor
- Uppsala University
Pancreatic Neuroendocrine Tumor
Pancreatic Neuroendocrine Tumour - Optimal Surgical Debulking or Not
Pancreatic neuroendocrine tumours (pan-NETs) are neoplasms arising from the endocrine cells of the pancreas. Although pan-NET are quite rare, the incidence is on the rise and together with other abdominal neuroendocrine tumours…
- Trial name
- PANTODON (NCT07273409)
- Testing
- Debulking surgery
- Where
- 4 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Uppsala University
Prostate Cancer
SPCG17: Prostate Cancer Active Surveillance Trigger Trial
A large proportion of men with prostate cancer are overdiagnosed and overtreated mainly due to PSA testing. Active surveillance (AS) aims to reduce these harms by recommending curative treatment only when and if signs of tumor…
- Trial name
- PCASTT (NCT02914873)
- Testing
- Active surveillance
- Where
- 23 sites in Denmark, Finland and 3 more
- Volunteers
- 2,008 people
- Sponsor
- Uppsala University
Pain Management After Surgery
Open TAP-block in Pediatric Abdominal Surgery
The goal of this trial is to evaluate an open TAP-block vs continuous administration of local anestetic via a wound catheter for postoperative pain management in patients 1-15 years of age undergoing open abdominal surgery.
- Trial name
- NCT07352683
- Testing
- TAP-block, Wound catheter
- Where
- Sweden
- Volunteers
- 88 people
- Sponsor
- Uppsala University
Fibromyalgia
The Effect of Autoreactive Autoantibodies on Peripheral and Central Disease Mechanisms in Fibromyalgia.
This observational study aims to compare disease burden and pain characteristics between fibromyalgia patients with high levels of autoreactive autoantibodies, fibromyalgia patients with low levels of autoreactive autoantibodies…
- Trial name
- FINE (NCT07346950)
- Where
- Sweden
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Sepsis
Defining Volume Status in Sepsis With Extracellular Water Measurement
The goal of this observational study is to learn about the influence of extracellular water on volume status in adult sepsis patients presenting with hemodynamic instability.
- Trial name
- NCT06512129
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Sepsis, Surgery
Inflammatory Mediators of Acute Kidney Injury in Intensive Care
Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality.
- Conditions
- Sepsis, Surgery, Acute Kidney Injury
- Trial name
- PronMed (NCT03720860)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uppsala University
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Chronic Non-Cancer Pain
Test-retest and Experiences During Balance Assessment With the Mini-BESTest
The goal of this observational study is to test psychometric properties of a clinical balance assessment scale, the Mini-BESTest, as well as to explore experiences and beliefs about balance and being balance tested.
- Trial name
- NCT06244602
- Where
- Sweden
- Volunteers
- 73 people
- Sponsor
- Uppsala University
Febrile Urinary Tract Infection
Pivmecillinam as Oral Step-Down Treatment for Escherichia Coli Febrile Urinary Tract Infection Versus Standard of Care
The goal of this clinical trial is to learn if oral treatment with pivmecillinam is effective to treat febrile urinary tract infections in adult patients.
- Trial name
- PIVOT (NCT07236944)
- Testing
- Pivmecillinam, Standard of Care (Investigator Choice)
- Where
- 13 sites in Norway, Sweden
- Volunteers
- 560 people
- Sponsor
- Uppsala University
Infective Endocarditis
Betalactam Pharmacokinetics in Endocarditis Patients
Infectious endocarditis (IE) is associated with mortality rates of 10-12%. Adequate antibiotic therapy is crucial for survival and is administered in high doses due to the severity of the disease.
- Trial name
- NCT04647331
- Where
- 4 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Clavicle Fracture
The Scandinavian Displaced Lateral Clavicle Trial
A multicentre multinational RCT to investigate whether non-surgical treatment is non-inferior to surgical treatment for displaced extraarticular lateral clavicle fractures in adults.
- Trial name
- ScanDiLaC (NCT06981065)
- Testing
- Simple Sling and Physiotherapy, Surgical treatment
- Where
- 11 sites in Denmark, Finland and 2 more
- Volunteers
- 96 people
- Sponsor
- Uppsala University
MS (Multiple Sclerosis), Multiple Sclerosis (MS) - Relapsing-remitting
Comparison of Efficacy and Safety in Patients Switching From MabThera® to Rixathon® in Relapsing-Remitting Multiple Sclerosis
This observational study investigates if switching from MabThera® to Rixathon® is associated with changes in disease activity and/or safety in people with multiple sclerosis (MS).
- Conditions
- MS (Multiple Sclerosis), Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (Relapsing Remitting)
- Trial name
- NCT07235644
- Where
- Sweden
- Volunteers
- 184 people
- Sponsor
- Uppsala University
Exhaustion Disorder, Clinical Burnout
A Biopsychosocial Treatment for Exhaustion Due to Persistent Non-traumatic Stress
Currently, there are no established theoretical models for developing and maintaining Exhaustion due to persistent non-traumatic stress (ENTS).
- Trial name
- NCT05811156
- Testing
- Hybrid Multimodal digital intervention
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Uppsala University
Femoral Neck Fractures
Dual Mobility Cups in Hip Fracture Patients
Our aim is to develop a strategy that reduces the risk of dislocations after total hip arthroplasty surgery performed due to femoral neck fracture.
- Trial name
- DUALITY (NCT03909815)
- Testing
- Dual mobility cup, Standard cup
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 1,600 people
- Sponsor
- Uppsala University
Idiopathic Adolescent Scoliosis, Idiopathic Juvenile Scoliosis
Minimal Invasive Scoliosis or Open Surgery
Surgical treatment for idiopathic scoliosis usually involves open surgery from the back (posterior approach). This method corrects the curve and stabilizes the spine using screws and rods, followed by a fusion of the treated…
- Trial name
- MISCOS (NCT07203586)
- Testing
- Minimally invasive scoliosis surgery, Traditional open scoliosis surgery group
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Uppsala University
Anxiety Depression
A Metacognitive Group Therapy of Depression and Anxiety in Youth With Autism
The goal of this open clinical trial is to try out and evaluate a group metacognitive treatment protocol, for adolescents aged 15-18 years of age with anxiety and/or depression and an autism diagnosis.
- Trial name
- NCT06441786
- Testing
- A metacognitive group therapy of depression and anxiety in youth with autism
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Uppsala University
Learning Development, Quality of Life
Social Working Dogs Support to Children With Problematic School Absence
The purpose of this project is to investigate whether trained social service dogs can increase students' school attendance and school motivation, and ultimately contribute to students reaching the basic learning goals.
- Conditions
- Learning Development, Quality of Life, School Attendance
- Trial name
- NCT07168460
- Testing
- Dog-assisted support, Special education teacher support
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Uppsala University