Clinical trials: sponsored by Uppsala University
Acute Kidney Injury, Critical Illness
Definition of Acute Kidney Injury by Urine Output in Critically Ill Patients
The goal of this observational study is to explore the association between urine output and acute kidney injury in severely ill patients admitted to intensive care units.
- Conditions
- Acute Kidney Injury, Critical Illness, Critical Care, Intensive Care, Critical Care, Fluid Resuscitation
- Trial name
- NCT06722924
- Volunteers
- 15,000 people
- Sponsor
- Uppsala University
Sepsis, AKI - Acute Kidney Injury
Mechanisms of Acute Kidney Injury in Severe Infections
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography.
- Conditions
- Sepsis, AKI - Acute Kidney Injury, Positron Emission Tomography (PET)
- Trial name
- PET-AKI (NCT06372444)
- Testing
- Positron emission tomography (PET)
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Uppsala University Hospital
Neuroendocrine Tumors
Study of Recombinant Adenovirus AdVince in Patients With Neuroendocrine Tumors; Safety and Efficacy
An open-labelled, uncontrolled, single-center Phase I/IIa clinical study to evaluate the safety of repeated infusions of AdVince into the hepatic artery in patients with metastatic neuroendocrine tumors (NETs), and if possible…
- Trial name
- RADNET (NCT02749331)
- Testing
- AdVince
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Uppsala University
Femoral Neck Fractures, Undisplaced Fracture
Hips Screws or (Total) Hip Replacement for Undisplaced Femoral Neck Fractures in Elderly Patients (HipSTHeR)
A registerbased RCT will investigate whether arthroplasty can decrease the reoperation rate compared to internal fixation for patients with an undisplaced femoral neck fracture (Garden I-II).
- Trial name
- HipSTHeR (NCT03966716)
- Testing
- Arthroplasty, Internal Fixation
- Where
- 25 sites in Sweden
- Volunteers
- 1,440 people
- Sponsor
- Uppsala University
Hip Fractures, Femoral Neck Fractures
Functional Outcome After ORIF or Arthroplasty for Femoral Neck Fracture
Aim To investigate the effect of internal fixation versus hip arthroplasty on physical function and pain in elderly patients. Methods This is a substudy of an on-going nationwide multicenter registry-based RCT named HipSTHeR…
- Conditions
- Hip Fractures, Femoral Neck Fractures, Undisplaced Fracture, Treatment Complication
- Trial name
- HipFunct (NCT06152198)
- Testing
- Treatment
- Where
- Sweden
- Volunteers
- 340 people
- Sponsor
- Uppsala University
Myeloma Multiple
Bortezomib-bendamustine-melphalan vs Melphalan for Multiple Myeloma
This project will evaluate the efficacy and safety of the conditioning regimen bortezomib-bendamustine-melphalan (BBM) in combination with autologous hematopoietic stem cell transplantation (ASCT) in relapsed multiple myeloma…
- Trial name
- NCT06245629
- Testing
- Bortezomib-bendamustine-melphalan
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Uppsala University
Socio-economic Status, Comorbidity
Socioeconomic Factors and Mortality in the Intensive Care Population
It is important to find out how much of the socioeconomic factors´ impact on mortality on ICU patient´s can be explained by the presence of comorbidity.
- Trial name
- NCT06554808
- Volunteers
- 101,745 people
- Sponsor
- Uppsala University
Obsessive-Compulsive Disorder, Obsessive-Compulsive Behavior
Rituximab Treatment for Psychosis And/or Obsessive Compulsive Disorder with Probable Immune System Involvement
The primary objective for this study is to evaluate whether Rituximab as compared to placebo is a clinically effective treatment for a subgroup of patients suffering from psychosis and/or obsessive-compulsive disorder (OCD) or…
- Conditions
- Obsessive-Compulsive Disorder, Obsessive-Compulsive Behavior, Schizophrenia, Delusional Disorder
- Trial name
- Ra-P-OCD (NCT04323566)
- Testing
- Rituximab
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University Hospital
Sleep Deprivation, Menstrual Cycle
The Effects of Night Shift Work on Health Across the Menstrual Cycle
The study aims to investigate the effects of sleep deprivation on women's health across different phases of the menstrual cycle.
- Conditions
- Sleep Deprivation, Menstrual Cycle, Brain Health, Metabolism
- Trial name
- MENSLEEP (NCT06683248)
- Testing
- Investigate sleep deprivation
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Complicated Grief Disorder
Alba - a Mobile App to Provide Bereavement Support for Adolescents in Grief
The goal of this two-armed randomised controlled trial is to evaluate a psychosocial self-management mobile app providing bereavement support to adolescents in grief. The main questions it aims to answer are: 1.
- Trial name
- NCT06093113
- Testing
- Alba - Youth in grief, Control website
- Where
- Sweden
- Volunteers
- 126 people
- Sponsor
- Uppsala University
Heart Failure With Preserved Ejection Fraction
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest…
- Trial name
- SPIRRIT (NCT02901184)
- Testing
- Spironolactone, Standard care
- Where
- 78 sites in United States, Sweden
- Volunteers
- 2,000 people
- Sponsor
- Uppsala University
Psychological Disorder
Transdiagnostic Internet Intervention to Improve Mental Health Among University Students: Pilot Study
This study comprises the pilot phase of a randomized controlled trial (NCT05085756) that will investigate the feasibility of a transdiagnostic CBT-based treatment for symptoms of depression and anxiety offered to Swedish…
- Trial name
- NCT05509660
- Testing
- PUMA+, PUMA
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Obsessive-Compulsive Disorder
Concentrated Exposure and Response Prevention for Children With Obsessive-compulsive Disorder
The goal of this clinical trial is to evaluate the preliminary outcomes of concentrated exposure and response prevention for children with obsessive-compulsive disorder (OCD) in regular clinical practice.
- Trial name
- NCT06621381
- Testing
- Concentrated exposure and response prevention
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University Hospital
Eating Disorders, Anorexia Nervosa
Unfolding Severe and Enduring Eating Disorders (U-SEED)
The main aim of this study is to identify biological and psychological characteristics as risk factors in individuals with severe and enduring eating disorders (SEED). Specifically, the investigators aim to: 1.
- Conditions
- Eating Disorders, Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder
- Trial name
- U-SEED (NCT06592963)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University Hospital
Intracranial Hemorrhages
Defining Volume Status with Extracellular Water Measurement in Patients with Intracranial Hemorrhage
The goal of this observational study is to learn about the influence of extracellular water on volume status in adult patients with intracranial hemorrhage presenting with hemodynamic instability.
- Trial name
- NCT06590688
- Volunteers
- 10 people
- Sponsor
- Uppsala University
Fear of Spiders
The Neural Mechanisms of Imaginal Extinction
Imaginal exposure is a widely used and effective psychological treatment technique in which patients are exposed to fearful stimuli and situations using mental imagery.
- Trial name
- NCT05168592
- Testing
- Threat conditioning, Imaginal extinction
- Where
- Sweden
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Fear of Spiders
Neural Mechanisms of Imaginal and in Vivo Exposure
Imaginal exposure is a widely used and effective psychological treatment technique. Recent research suggests that neural activations and emotional responses during imaginal exposure are similar to those elicited during in vivo…
- Trial name
- NCT05193383
- Testing
- Imaginal exposure, Exposure, Approach-avoidance conflict
- Where
- Sweden
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Solid Tumor
A MolEcularly Guided Anti-Cancer Drug Off-Label Trial
This is a prospective, open-label, non-randomized combined basket- and umbrella trial divided in two parts; a limited feasibility-oriented part 1 including 154 patients and 3 treatment cohorts and part 2 that will include an…
- Trial name
- MEGALiT (NCT04185831)
- Testing
- Atezolizumab, Everolimus, Cobimetinib
- Where
- 3 sites in Sweden
- Volunteers
- 167 people
- Sponsor
- Uppsala University Hospital
Cancer, Malnutrition
Exploring Individual Nutrition Care Elements and Nutritional Evaluation Methods Within Dietetic Practice in Cancer Care
The purpose of the study is to explore and deepen the understanding of the dietitian's role and work related to individually tailored nutritional treatment in cancer care.
- Trial name
- NCT06531174
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Auditory Hallucination
SMA Targeted Magnetic Stimulation Against Auditory Verbal Hallucinations
Auditory verbal hallucinations (AVH) are prevalent among patients with psychiatric disorders. Not only being highly stressful and functionally impairing, AVH often persist despite treatment.
- Trial name
- SMA-AVH (NCT04651621)
- Testing
- continuous theta burst stimulation over the SMA
- Where
- Sweden
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Uppsala University