Clinical trials: sponsored by Vanderbilt University Medical Center
Chronic Kidney Diseases
Effects of GLP1-RA on Ectopic Fat Deposition in Chronic Kidney Disease
Chronic kidney disease (CKD) is a burden of morbidity and mortality. Increased protein breakdown in skeletal muscle (wasting) and ectopic fat deposition are important determinants of poor clinical outcome in patient with CKD.
- Trial name
- GLIMP (NCT05254418)
- Testing
- dulaglutide injection
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm
The objective of this study is to determine whether acetaminophen (APAP), N-acetylcysteine (NAC), and APAP in combination with NAC will inhibit lipid peroxidation in aneurysmal subarachnoid hemorrhage (aSAH), utilizing F2-IsoPs…
- Trial name
- NCT00585559
- Testing
- APAP 1 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly, APAP 1.5 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus
Effects of a Patient Portal Intervention to Address Diabetes Care Gaps
The purpose of this study is to evaluate the effect of a novel patient portal intervention on the number of patients with diabetes care gaps (e.g., no diabetes eye exam i the last 12 months).
- Trial name
- NCT04894903
- Testing
- Diabetes Care Gaps Patient Portal Intervention
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
Infrared Neural Stimulation (INS)
Clinical Safety and Efficacy of Infrared Neural Stimulation During Nerve Transfers
Many surgical procedures such as brachial plexus reconstruction, nerve repair, and dorsal root rhizotomies rely on the spatial selectivity of their neural stimulation methods to identify specific nerve fascicles or rootlets.
- Trial name
- NCT04601337
- Testing
- Infrared Neural Stimulation
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Trigeminal Neuralgia
Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy
A phenome-wide association study (PheWAS) identified an association between a loss of function variant in the human alpha 2B adrenergic receptor gene and trigeminal nerve disorders.
- Trial name
- NCT03865940
- Testing
- Lidocaine, Guanfacine
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
Pancreatic Enzyme Replacement and Glucose Regulation in Type 1 Diabetes
Recent studies have demonstrated reduced pancreatic volume is present within months of T1D diagnosis in children, adolescents, and adults.
- Trial name
- CREON (NCT05266963)
- Testing
- CREON
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes Mellitus
Positive Psychology Intervention to Treat Diabetes Distress in Teens With Type 1 Diabetes
The treatment regimen for type 1 diabetes is complex and demanding, and many adolescents experience diabetes distress related to the daily demands of diabetes care, which can cause problems with diabetes management and glycemic…
- Trial name
- T1D (NCT03845465)
- Testing
- Positive Affect + Education, Education
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 2
My Diabetes Care: A Scalability and Usability Study
The purpose of this study is to conduct a prospective, longitudinal study on the My Diabetes Care (MDC) mobile intervention to assess usage patterns, user experience, and to uncover errors in functionality prior to a larger…
- Trial name
- NCT05448105
- Testing
- My Diabetes Care (MDC)
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson's Disease and Parkinsonism, Glymphatic System
Effects of Exercise on Glymphatic Functioning and Neurobehavioral Correlates in Parkinson's Disease
This study is designed to measure the change in patients diagnosed with Parkinson's disease (PD) before, during and after a 12 week exercise program.The focus of this study is the glymphatic system.
- Trial name
- FIGHTPD (NCT04140708)
- Testing
- Exercise--Rock Steady Boxing class
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes, Healthy
Platelet PAR-1 Activation in Health and Diabetes
Platelet activation has been associated with bad events like heart attack and stroke. There are a variety of platelet activators that regulate how active a platelet is. We are interested in Protease-activated receptors (PAR)-1.
- Trial name
- NCT04280549
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease
Longitudinal Outcomes of DBS in PD
Vanderbilt University Medical Center is one of the largest-volume DBS centers in the country. From 2007 through October 2017, 265 Parkinson's disease (PD) patients underwent deep brain stimulation (DBS), 168 of those implanted in…
- Trial name
- NCT03582163
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Severe Obesity, Renal Failure
Obesity Surgery and Kidney Transplant for Patients With Obesity and Renal Failure
Gastric Bypass followed by renal transplantation is superior to medical management followed by renal transplant for patients with severe obesity and renal failure.
- Trial name
- NCT02128802
- Testing
- Gastric Bypass, Weight Loss Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Bilateral Vocal Fold Paralysis (BVFP)
Laryngeal Pacing Study
Standard treatment options for patients who are diagnosed with BVFP include tracheostomy, cordotomy, arytenoidectomy, and suture tie-back.
- Trial name
- BVFP IDE (NCT03085316)
- Testing
- Investigational device
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University Medical Center
Iatrogenic Withdrawal Syndrome
Jackson Pediatric Acupressure for Opioid Tapering
This intervention pilot feasibility study will assess the impact of auricular acupressure as an additional non-pharmacologic therapy for infants at risk for developing Iatrogenic Withdrawal Syndrome (IWS) in the Pediatric Cardiac…
- Trial name
- NCT05025384
- Testing
- Acupressure
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Mild Cognitive Impairment
Computerized Memory Enhancing Treatment in MCI
The investigators propose to apply neuroplasticity-based computerized cognitive remediation (nCCR) to improve memory function in patients with Mild Cognitive Impairment (MCI).
- Trial name
- COMET (NCT05332522)
- Testing
- Neuroplasticity-based Computerized Cognitive Remediation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes Mellitus
Communication and Coping for Mothers of Adolescents With Type 1 Diabetes
Mothers of adolescents with type 1 diabetes experience high levels of depressive symptoms, which impair their ability to monitor and manage diabetes treatment effectively.
- Trial name
- T1D (NCT03818711)
- Testing
- Communication & Coping Intervention, Education & Check Ins
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- Vanderbilt University Medical Center
Crohn's Disease, Inflammatory Bowel Disease
Reduce Crohn's-Associated Diarrhea With Sodium Channel Therapy
Crohn's disease is an inflammatory disorder that can affect any part of the gastrointestinal (GI) tract. Some patients still experience persistent diarrhea or other symptoms such as abdominal pain even when their Crohn's disease…
- Trial name
- REACT (NCT04456517)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University Medical Center
Rotator Cuff Tear
Comparative Effectiveness of Operative Versus Non-Operative Treatments for Rotator Cuff Tears
Rotator cuff tears are one of the most common causes of shoulder pain. Evidence-based guidance on optimal diagnostic and treatment strategies for rotator cuff tears is lacking.
- Trial name
- ROW (NCT02287090)
- Testing
- Observational Cohort
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt University Medical Center
Cerebral Aneurysm
Framing Eighteen Coils in Cerebral Aneurysms Trial
This trial is being conducted in order to compare angiographic outcomes in patients receiving 0.014-0.0155" platinum framing and filling coils (larger diameter coils) versus those treated solely with coils less than 0.014" (with…
- Trial name
- FEAT (NCT01655784)
- Testing
- Coil Embolization with larger Diameter Coils, Coil Embolization with Standard Diameter Coils
- Where
- 24 sites in United States
- Volunteers
- 651 people
- Sponsor
- Vanderbilt University Medical Center
Opioid Use, Enhanced Recovery After Surgery
The Impact of Perioperative Ketamine Infusion on Surgical Recovery
In order to effectively treat surgical pain with the least amount of opioids required, a multi-modal approach must include medications with different mechanisms of actions at alternative receptors.
- Conditions
- Opioid Use, Enhanced Recovery After Surgery, Anesthesia, Ketamine
- Trial name
- NCT04625283
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 1,570 people
- Sponsor
- Vanderbilt University Medical Center