Clinical trials: sponsored by Vanderbilt University Medical Center
Cancer, Cancer Head Neck
Neuroinflammation in Chronic Systemic Symptoms (CSS)
The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS).
- Conditions
- Cancer, Cancer Head Neck, Neuroinflammatory Response, Chronic Inflammation
- Trial name
- NCT04636723
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity
The Natriuretic Peptide Response to Saline Infusion
The primary objective is to evaluate the overarching hypothesis that obese and black individuals have relatively lower circulating natriuretic peptide levels compared with lean and white individuals.
- Trial name
- NCT04223531
- Testing
- Normal Saline 0.9% Infusion Solution Bag
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hypertrophic Scar
Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars
Hypertrophic burn scars are experienced by more than 70% of burn victims. They are a major source of decreased quality of life in burn patients due to pain, decreased range of motion, and poor cosmetic appearance.
- Trial name
- NCT03935594
- Testing
- PRP Injection, Saline Injection
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Thromboembolism, Hemolysis
Lavare Cycle in Patients Receiving HeartWare Left Ventricular Assist Device
Left ventricular assist device (LVAD) patients remain at risk for pump thrombus and thromboembolic events through multiple mechanisms.
- Conditions
- Thromboembolism, Hemolysis, Stroke
- Trial name
- NCT04199793
- Testing
- Lavare On, Lavare Off
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Vanderbilt University Medical Center
Pneumonia Childhood
Improving CarE for Community Acquired Pneumonia 1
Children with pneumonia presenting to the emergency department at Monroe Carell Jr. Children's Hospital at Vanderbilt or Children's Hospital of Pittsburgh will be potentially eligible for study.
- Trial name
- ICE-CAP1 (NCT03760419)
- Testing
- Clinical Decision Support
- Where
- United States
- Volunteers
- 1,027 people
- Sponsor
- Vanderbilt University Medical Center
Insulin Resistance, Endothelial Dysfunction
CD36 in Nutrient Delivery and Its Dysfunction
This proposal will test the hypothesis that chronic treatment with sildenafil with and without the use of nitric oxide substrate, L-arginine, protects against fatty acid induced impairment of endothelial function, improves…
- Trial name
- NCT03012386
- Testing
- Sildenafil Citrate in G allele carrier, Sildenafil Citrate in non G allele carrier
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Clostridium Difficile
PROCLAIM -- Misoprostol in the Prevention of Recurrent CDI Prevent Recurrence of Clostridium Difficile Infection With Misoprostol
A total of 440 patients meeting enrollment criteria with a primary episode of C. Difficile Infection (CDI) will be enrolled across 3 sites.
- Trial name
- PROCLAIM (NCT03617172)
- Testing
- Misoprostol 100Mcg Tab
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center
Autism Spectrum Disorder, Developmental Delay
Can Novel Telemedicine Tools Reduce Disparities Related to Early Identification of Autism
In this study, the investigators are trying to find new ways to screen for autism spectrum disorder (ASD) in young children. The investigators want to see if people like pediatricians can screen children for ASD while a…
- Trial name
- NCT03847337
- Testing
- Telehealth-Screening Tool for Autism in Toddlers (STAT), Telehealth-Autism Spectrum Disorder-Pediatrics (ASD-PEDS)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Vanderbilt University Medical Center
Inotropy, Fluid Management
RESIPI for Reducing Perioperative Major Adverse Cardiac Events
This study aims to evaluate the effect of a novel hemodynamic management and monitoring strategy for reducing cardiac bio marker elevations and major adverse cardiac events.
- Conditions
- Inotropy, Fluid Management, Cardiac Event, Perioperative Cardiac Risk
- Trial name
- RESIPI (NCT03208023)
- Testing
- RESIPI Management Strategy, No intervention
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Vanderbilt University Medical Center
Tachycardia, Ventricular, Catheter Ablation
Continuation of Antiarrhythmics Following Ventricular Tachycardia Catheter Ablation
The investigators aim to study if patients that undergo catheter ablation for ventricular tachycardia benefit from continuation of Vaughan-Williams class III antiarrhythmic drugs for 3 months after their ablation.
- Trial name
- AFTER-VT (NCT04208997)
- Testing
- Antiarrhythmic drug
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 2
My Diabetes Care Mobile: A Usability Study
The purpose of this study is to conduct a prospective, longitudinal study on the My Diabetes Care mobile (MDC-m) intervention to assess usage patterns, user experience, and to uncover errors in functionality prior to a larger…
- Trial name
- NCT04894916
- Testing
- My Diabetes Care Mobile (MDC-m)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Vanderbilt University Medical Center
Sexual Dysfunction, Upper Extremity Trauma
Sexual Dysfunction Following Upper Extremity Trauma
Hypothesis 1. The prevalence of sexual dysfunction after upper extremity function in adults (>18yo) is higher than the general population in the early post-operative period (3mo) and at 1 year post-operatively. 2.
- Trial name
- NCT04764578
- Sponsor
- Vanderbilt University Medical Center
Thoracoabdominal Aortic Aneurysm
Visceral Manifold Study for the Repair of Thoracoabdominal Aortic Aneurysms
The primary objective of the clinical investigation is to assess the use of the the Visceral Manifold Thoracoabdominal Aortic Aneurysms (VTAAA) stent graft system to repair thoracoabdominal aortic aneurysms in patients having…
- Trial name
- NCT03113383
- Testing
- Thoracoabdominal Aortic Aneurysm Repair
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University Medical Center
COVID-19, Coronavirus
Passive Immunity Trial for Our Nation to Treat COVID-19 in Hospitalized Adults
The purpose of this study is to test the safety and efficacy of convalescent donor plasma to treat COVID-19 in hospitalized adults in a randomized, placebo-controlled setting.
- Conditions
- COVID-19, Coronavirus, SARS-CoV-2
- Trial name
- PassItOn (NCT04362176)
- Testing
- pathogen reduced SARS-CoV-2 convalescent plasma
- Where
- 26 sites in United States
- Volunteers
- 974 people
- Sponsor
- Vanderbilt University Medical Center
Parents, Stress
Telehealth Mindfulness-Based Music and Songwriting for Parents of Children With Intellectual/Developmental Disabilities
This is a pilot study of the feasibility and potential impact of a Mindfulness-Based Music and Songwriting program (delivered via telehealth) on stress and well-being in parents/caregivers of children with intellectual or…
- Conditions
- Parents, Stress, Developmental Disability, Intellectual Disability
- Trial name
- NCT04962659
- Testing
- Mindfulness-Based Music and Songwriting
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
Pediatric Type 1 Diabetes and Neurocognitive Complications Cohort Study
The proposed project will assess hypothesized risk factors (age of onset, Diabetic ketoacidosis (DKA) at presentation and glycemic control), as well as potentially modifiable protective factors (child sleep quality, caregiver…
- Trial name
- NCT04135365
- Testing
- neurocognitive assessment, neuroimaging assessment
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Muscle Cramp, Cirrhosis
Ropinirole for the Treatment of Muscle Cramps in Patients With Cirrhosis
The investigator's aim is to compare the efficacy of Ropinirole (Requip) to vitamin E in the treatment of muscle cramps in cirrhotic patients.
- Trial name
- NCT03176966
- Testing
- Vitamin E, Ropinirole, Muscle cramp survey
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University Medical Center
Vitrectomy
Beveled-Tip Versus(vs) Standard-Tip Vitrectomy Probe
The purpose of this study is to compare the efficiency of the new Utravit High-Speed 10000 cpm Beveled Probe to the current standard vitrector probe- Alcon (non-beveled) Ultravit 7500 cpm.
- Trial name
- NCT04076072
- Testing
- Utravit High-Speed 10000 cpm Beveled Probe, standard vitrector probe- Alcon (non-beveled) Ultravit 7500 cpm
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity, PreDiabetes
Cardiovascular Effects of GLP-1 Receptor Activation
This project tests the principle hypothesis that stable glucagon like peptide-1 (GLP-1) analogues have specific GLP1R-dependent beneficial effects on vascular endothelial function, fibrinolysis and inflammation in obesity that…
- Trial name
- NCT03101930
- Testing
- Liraglutide, Sitagliptin, hypocaloric diet
- Where
- United States
- Volunteers
- 329 people
- Sponsor
- Vanderbilt University Medical Center
Low Back Pain, Back Pain
Feasibility of Telehealth Mindfulness for Back Pain in the Emergency Department
While guideline-directed nonpharmacological strategies for chronic low back pain are well established, optimal chronic pain management for emergency department patients has yet to be defined.
- Conditions
- Low Back Pain, Back Pain, Pain, Chronic Low-back Pain
- Trial name
- NCT04783532
- Testing
- Telehealth Mindfulness Program
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University Medical Center