Clinical trials: sponsored by Vanderbilt University Medical Center
Aortic Valve Stenosis
A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement
This study is being performed in patients who have undergone transcatheter aortic valve replacement (TAVR) for aortic stenosis. The goal is to obtain pilot and feasibility data on a novel post-procedure rehabilitation strategy…
- Trial name
- NCT03270124
- Testing
- Daily Activity Goal, Resistance Exercises, Daily Activity Recording
- Where
- 5 sites in United States
- Volunteers
- 85 people
- Sponsor
- Vanderbilt University Medical Center
Tonsillectomy
Honey Used as Adjunct Therapy to Tylenol for Post-Op Tonsillectomy Patients
Tonsillectomies are the second most common surgery with over half a million procedures in the United States for 2006. Tonsillectomies are considered a painful surgical procedure performed on children resulting in pain and…
- Trial name
- NCT03931395
- Testing
- Honey, Standard of Care
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Coronary Artery Disease
Causes of Health Disparities in African Americans With Coronary Artery Disease on Clopidogrel
African Americans with coronary artery disease who have been prescribed clopidogrel (also known as Plavix), an antiplatelet drug will be enrolled.
- Trial name
- NCT04619381
- Testing
- CORONARY ARTERY DISEASE AND CLOPIDOGREL: PATIENT SURVEY
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Visual Impairment
Validity of at Home Visual Acuity Measurements for Telemedicine During Corona Virus (COVID-19) Pandemic
Prompted by the current COVID-19 pandemic, the American Academy of Ophthalmology has recommended the use of telemedicine to continue ophthalmic care while maintaining patient and provider social distancing.
- Trial name
- NCT04391166
- Testing
- Non invasive visual acuity testing
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Bougie or Stylet In Patients Undergoing Intubation Emergently (BOUGIE)
Complications are common during tracheal intubations performed outside of the operating room. Successful intubation on the first attempt has been associated with a lower rate of procedural complications, but the proportion of…
- Trial name
- BOUGIE (NCT03928925)
- Testing
- Bougie, Endotracheal Tube with Stylet
- Where
- 11 sites in United States
- Volunteers
- 1,106 people
- Sponsor
- Vanderbilt University Medical Center
Asthma in Children, Vaccine Adverse Reaction
Safety of LAIV4 in Children With Asthma
This is a prospective randomized, open label clinical trial in approximately 300 children aged 5-11 years with a physician diagnosis of persistent asthma.
- Conditions
- Asthma in Children, Vaccine Adverse Reaction, Vaccine Reaction, Asthma
- Trial name
- NCT03600428
- Testing
- Live Attenuated Influenza Vaccine (LAIV), Inactivated Influenza Vaccine (IIV)
- Where
- 3 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Lumbago, Lumbar Spinal Stenosis
Post Epidural Steroid Injection Follow-up
To determine the expected pain response timeline for patients receiving epidural steroid injections, our team plans to assess patient pain severity and degree of pain relief every 3 days for 23 days.
- Conditions
- Lumbago, Lumbar Spinal Stenosis, Lumbar Disc Herniation
- Trial name
- NCT04207606
- Testing
- Post Epidural Steroid Injection Follow-up
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Brain Diseases
Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry
We are collecting brain tissue specimens and blood samples from patients at Vanderbilt University Medical Center who are undergoing intracranial surgery to remove brain tissue, including brain tumors, tissue from epilepsy surgery…
- Trial name
- NCT00592709
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Vanderbilt University Medical Center
Brain Neoplasm, Primary, Brain Neoplasms, Malignant
Risk Factors for Adult-Onset Brain Tumors
Study Objective: Brain tumors are poorly understood. The purpose of this research is to examine whether factors in lifestyle play a role in brain tumor development.
- Conditions
- Brain Neoplasm, Primary, Brain Neoplasms, Malignant, Brain Neoplasms, Benign
- Trial name
- NCT00592865
- Where
- 5 sites in United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Healthy
Human Immunome Program
The Human Immunome Program is a large-scale, open-source effort seeking to fill a major gap in our knowledge of the immune system.
- Trial name
- HIP (NCT03118687)
- Testing
- Biospecimen and survey collection
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Covid19, Ophthalmopathy
Assessment of COVID-19 in Tearfilm
To assess the co-relation of COVID-19 in nasopharyngeal swabs and tears or saliva, and to determine duration of COVID-19 activity in ocular fluid and saliva by serial tests over 3 months.
- Conditions
- Covid19, Ophthalmopathy, Eye Diseases
- Trial name
- NCT04579458
- Testing
- Collection of tears and saliva.
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Metabolic Syndrome
Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism
Aim 1.Test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system impairs glycemic control via effects on insulin sensitivity and insulin secretion. Aim 2.
- Trial name
- NCT02034435
- Testing
- Low Sodium diet plus Salt tablet, Epleronone, Amlodipine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University Medical Center
Migraine
Outcomes of Migraine Surgery
Migraines are very common and affect over 35 million Americans a year. Migraines can be painful and affect daily life. The cause of migraine is multifactorial and not completely understood.
- Trial name
- NCT04008303
- Testing
- Migraine surgery
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Autonomic Nervous System Disorders, Pure Autonomic Failure
Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure
Pharmacologic approaches to increase levels or actions of the vasodilatory peptide angiotensin-(1-7) are currently in development for the treatment of hypertension based on findings from animal models.
- Conditions
- Autonomic Nervous System Disorders, Pure Autonomic Failure, Shy-Drager Syndrome, Orthostatic Hypotension, Dysautonomic
- Trial name
- NCT02591173
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Parenteral Nutrition Associated Liver Disease
Use of Omega-3 Fat Emulsion (Omegaven) in Infants With Parenteral Nutrition Associated Liver Disease
Babies in the newborn intensive care unit who are dependent upon intravenous nutrition for a long period of time frequently develop liver damage. The fat used is called intralipid and is made from soybean oil.
- Trial name
- NCT00862446
- Testing
- Omegaven
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University Medical Center
Upper Respiratory Tract Infections, Nasal Suction
Effectiveness of the NoseFrida Compared With Bulb Suction at Relieving Objective Signs of Nasal Obstruction and Reducing Return Visits in Pediatric Patients Presenting to the Emergency Department
The mainstay of treatment in viral upper and lower respiratory tract disease is airway clearance. Viral respiratory tract infections account for a substantial amount of emergency department (ED) visits, financial and stress…
- Conditions
- Upper Respiratory Tract Infections, Nasal Suction, Return Emergency Department Visits
- Trial name
- NCT03666429
- Testing
- Bulb suction, NoseFrida
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Childhood Asthma
Smartphone-facilitated Asthma Control
The objective of this protocol is to pilot an innovative approach to medication adherence to determine if such an approach will improve inhaled corticosteroid (ICS) medication adherence, a critical gap in improving the health of…
- Trial name
- SNAPP (NCT02205723)
- Testing
- Asthma teaching in ER, Smartphone Asthma Control
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Asthma
Trial of AccuPAP Device Versus Standard Nebulizer Therapy in Acute Asthma Exacerbation in Children
The objective of this randomized control trial is to investigate the efficacy of an adjunct positive airway pressure (PAP) nebulizer device known as "AccuPAP" in the treatment of moderate-severity acute asthma exacerbations in…
- Trial name
- NCT02458482
- Testing
- AccuPAP, Albuterol and Ipratropium Continuous Nebulizer
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Osteoporosis, Fracture Risk Assessment
New Tools for Assessing Fracture Risk
The goal of this study is to determine whether two new, non-X-ray techniques can discriminate between high-energy fractures of normal bone (trauma) and low-energy fractures (fragility) of osteoporotic bone.
- Trial name
- NCT02436356
- Testing
- Osteoprobe-Reference Point Indentation (RPI), Dual-energy X-ray absorptiometry (DXA) Scans, MRI
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center