Clinical trials: sponsored by Vanderbilt University Medical Center
Osteoporosis, Fracture Risk Assessment
New Tools for Assessing Fracture Risk
The goal of this study is to determine whether two new, non-X-ray techniques can discriminate between high-energy fractures of normal bone (trauma) and low-energy fractures (fragility) of osteoporotic bone.
- Trial name
- NCT02436356
- Testing
- Osteoprobe-Reference Point Indentation (RPI), Dual-energy X-ray absorptiometry (DXA) Scans, MRI
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Back Pain Without Radiation, Back Pain, Low
Postural Training Device (UPRIGHT) for Back Pain
Participants with low back pain who are referred for physical therapy will be randomized to routine physical therapy or routine physical therapy plus receiving a postural training device
- Trial name
- NCT03449160
- Testing
- UPRIGHT, physical therapy
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Prostate Calcification
MR Imaging of Prostatic Calcifications
Prostate calcifications can limit evaluation of the prostate due to artifact on MRI, and can limit therapy by blocking therapeutic ultrasound.
- Trial name
- NCT03625336
- Testing
- MRI
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Education
Education of Providers on Prescribing Best Practices
This study aims to evaluate the impact of spaced education, delivered via a smartphone application, on provider prescribing patterns.
- Trial name
- NCT03771482
- Testing
- Quiztime modules
- Where
- United States
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Vertigo, Benign Paroxysmal Positional Vertigo
Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV)
Benign paroxysmal positional vertigo (BPPV) is the most common inner ear cause of dizziness. It has been reported that up to 900 of every 10,000 people in the United States experience this problem with an estimated annual…
- Trial name
- NCT03161470
- Testing
- Standard Repositioning, Mechanical Chair Repositioning
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Vanderbilt University Medical Center
Knee Arthroplasty, Total, Osteoarthritis
Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial
Given the benefits of genicular nerve radiofrequency ablation (RFA) in improving pain and functional status in non-surgical patients with knee osteoarthritis as well as the high prevalence of postoperative pain from total knee…
- Conditions
- Knee Arthroplasty, Total, Osteoarthritis, Radiologic Tibiofemoral Osteoarthritis
- Trial name
- NCT02947321
- Testing
- Genicular Nerve RFA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
HIV/AIDS
Traditional Healers as Adherence Partners for Persons Living With HIV in Rural Mozambique
The overall goal of this project is to adapt and assess the impact of a traditional healer training program/intervention on the adherence, retention, and viral load of HIV infected patients newly initiated on anti-retroviral…
- Trial name
- PLHIV (NCT03076359)
- Testing
- Traditional Healer Support Program, Standard of Care
- Where
- Mozambique
- Volunteers
- 320 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Pain
Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
Chronic Pain (CP) management has increasingly utilized long-term opioid analgesic therapy, a change associated with increased opioid abuse (via greater exposure in vulnerable individuals), non-pain health consequences (hormone…
- Trial name
- NCT02469077
- Testing
- 6 week aerobic exercise intervention, Morphine, naloxone
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- Vanderbilt University Medical Center
Heart Failure, Multiple Myeloma
Prospective Observation of Cardiac Safety With Proteasome Inhibition
The purpose of this study is to better define and understand potential cardiac toxicities of proteasome inhibitors and to understand optimal management strategies to treat and prevent cardiovascular events.
- Trial name
- PROTECT (NCT02178579)
- Where
- 2 sites in United States
- Volunteers
- 95 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Pain, Fibromyalgia
Mindfulness to Improve Functional Outcomes in Patients With Fibromyalgia or Central Sensitization
The primary aim of the study will be to determine the feasibility of utilizing a web-based mindfulness program in adult patients with chronic pain with a diagnosis of fibromyalgia or central sensitization.
- Conditions
- Chronic Pain, Fibromyalgia, Central Sensitisation
- Trial name
- NCT03693274
- Testing
- BreathAware for Pain Management
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Granulomatosis With Polyangiitis
Natural History of Granulomatosis With Polyangiitis: Clinical and Genetic Biomarkers of Airway Disease NoAAC PR-03 Study
The ultimate goal of this prospective natural history study is to define the natural history of the obstructive airway manifestations of Granulomatosis with polyangiitis (GPA).
- Trial name
- NoAAC PR-03 (NCT03182049)
- Testing
- Airway assessment, Rheumatology assessment
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 2
Improving Medication Adherence Among Underserved Patients With Type 2 Diabetes
This study evaluates a mobile phone-delivered intervention, called REACH (Rapid Education/Encouragement And Communications for Health), in supporting adults with type 2 diabetes in their self-management relative to a control…
- Trial name
- NCT02409329
- Testing
- REACH, Helpline and A1c results, REACH + FAMS
- Where
- United States
- Volunteers
- 512 people
- Sponsor
- Vanderbilt University Medical Center
Sickle Cell Disease, Stroke
Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II
The overall goal of this proposal is to conduct a partial double-blind randomized Phase III clinical trial for primary stroke prevention in children with sickle cell anemia (SCA) in sub-Saharan Africa.
- Trial name
- SPRING (NCT02560935)
- Testing
- Hydroxyurea (Moderate Dose), Hydroxyurea (Low Dose)
- Where
- 3 sites in Nigeria
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
Sickle Cell Anemia, Sickle Cell Disease
Sickle Cell Disease - Stroke Prevention in Nigeria Trial
Given large absolute numbers of individuals with sickle cell disease in Nigeria, hydroxyurea therapy for all individuals with sickle cell disease may not be initially feasible; however, a targeted strategy of hydroxyurea use for…
- Conditions
- Sickle Cell Anemia, Sickle Cell Disease, Stroke
- Trial name
- SPIN (NCT01801423)
- Testing
- Hydroxyurea
- Where
- Nigeria
- Volunteers
- 29 people
- Sponsor
- Vanderbilt University Medical Center
Adolescent Depression, Depression
Predictors of Response to Treatment for Depression
The current study will examine neurophysiological, specifically event-related potential (ERP), measures of emotional processing as predictors of response to cognitive behavior therapy for adolescent depression.
- Trial name
- PORT (NCT03154008)
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Vanderbilt University Medical Center
Human Immunodeficiency Virus, Obesity
Adipose Tissue and Immune Activation in HIV
The prevalence of HIV-associated wasting declined dramatically with the introduction of effective antiretroviral therapy (ART), but as patients survive longer on treatment the proportion of overweight (body mass index [BMI] >25…
- Trial name
- AIAC (NCT04439448)
- Testing
- dual-energy X-ray absorptiometry (DEXA) scan, Carotid and branchial artery ultrasound, 2-hour oral glucose tolerace test
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Glucocorticoids Toxicity, Glucose Intolerance
Pharmacogenomics of the Variability in the In Vivo Response to Glucocorticoids
This study evaluates the effect of acute administration of oral prednisone in white blood cells counts and glucose tolerance and the relationship of these measures with changes in gene expression in healthy volunteers.
- Trial name
- NCT03023891
- Testing
- Prednisone
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Tobacco Use Cessation
PRecision Interventions for SMoking in the SCCS
Precision Care (PC) interventions, developed with guidance from a Community Advisory Board (CAB), will be piloted in a Randomized Clinical Trial (RCT) of approximately 100 eligible, consenting daily smokers in the Southern…
- Trial name
- PRISM-SCCS (NCT03521141)
- Testing
- Nicotine patch, Varenicline, Nicotine metabolism
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Vanderbilt University Medical Center
Cardiac Disease, Cancer
Electronic Medical Records and Genomics (eMERGE) Phase III
The Electronic Medical Records and Genomics (eMERGE) Network is in its third phase and during this time is enrolling and sequencing 25,000 individuals on a custom sequencing panel of clinically relevant, actionable genes.
- Conditions
- Cardiac Disease, Cancer, Hypercholesterolemia, Diabetes
- Trial name
- eMERGE (NCT03394859)
- Volunteers
- 25,380 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pediatric Crohns Disease
Clinical Hypnosis in Pediatric Crohn's Disease
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, immune-mediated disease increasingly prevalent in youth.
- Trial name
- HypnoCrohns (NCT03809195)
- Testing
- Clinical Hypnosis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center