Clinical trials: sponsored by Vanderbilt University Medical Center
Vestibular Abnormality, Vestibular Nerve Disorders
Test-Retest Reliability of oVEMP's Across Different Electrode Montages
"Test-Retest Reliability of ocular vestibular evoked myogenic potentials (oVEMPs) across different electrode montages." The purpose of this project is to compare the response characteristics of the ocular vestibular evoked…
- Trial name
- NCT03251586
- Testing
- oVEMP - infra-orbital electrode montage, oVEMP - belly-tendon electrode montage
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Delirium, Cognitive Impairment
The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status
A combined strategy of Richmond Agitation and Sedation Scale (RASS) clinical targeting plus bispectral index (BIS) guided sedation in mechanically ventilated, critically ill patients will decrease time on mechanical ventilation…
- Conditions
- Delirium, Cognitive Impairment, Critically Ill
- Trial name
- SOMNUS (NCT00469482)
- Testing
- Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Liver Transplant
Serum Markers of Ischemia Reperfusion Injury in Liver Transplant Patients
This is an observational study examining serum markers in patients who are undergoing either a cadaveric liver transplant or a living related liver transplant.
- Trial name
- NCT00698399
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Adenomyosis, Heavy Uterine Bleeding
Effect of Ulipristal Acetate on Bleeding Patterns and Dysmenorrhea in Women With Adenomyosis
Adenomyosis affects approximately 21% of symptomatic women who present to gynecology clinics. The disease is characterized by heavy bleeding and pain during periods.
- Conditions
- Adenomyosis, Heavy Uterine Bleeding, Dysmenorrhea
- Trial name
- NCT03325868
- Testing
- Ulipristal Acetate
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Fatty Liver, Steatosis of Liver
Prediction of Donor Liver Adipose Content by Magnetic Resonance Imaging
A pilot prospective cohort study assessing the clinical utility of MRI evaluation of graft steatosis prior to transplantation will be conducted.
- Trial name
- NCT02873507
- Testing
- MRI of donor liver prior to transplant
- Sponsor
- Vanderbilt University Medical Center
Dehydration, Cardiac Output
Descriptive Study of Cardiac Output During Rehydration With Recombinant Human Hyaluronidase in Pediatrics
The purpose of this study is to non-invasively study the reflective changes in cardiac output as response to fluid therapy in the pediatric moderate hypovolemia/dehydrated pediatric patients using sub-q rehydration using Hylenex…
- Conditions
- Dehydration, Cardiac Output, Pediatrics
- Trial name
- Hylenex (NCT01139294)
- Testing
- Hylenex
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus
Evaluating the Influence of Diabetes Stigma on Medication Adherence
The "Evaluating the iNfluence of Diabetes STIGma on Medication Adherence: The ENDSTIGMA Study" was designed to develop a comprehensive diabetes stigma survey measure.
- Trial name
- ENDSTIGMA (NCT02828995)
- Testing
- Comprehensive Diabetes Stigma Survey
- Where
- United States
- Volunteers
- 508 people
- Sponsor
- Vanderbilt University Medical Center
HIV/AIDS
CareConekta: A Pilot Study of a Smartphone App in South Africa
Population mobility is frequent in South Africa and disrupts the continuity of HIV care. Postpartum, HIV-positive women are at elevated risk of dropping out of HIV care and are highly mobile.
- Trial name
- NCT03157908
- Testing
- CareConekta
- Where
- South Africa
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Heart Failure NYHA Class I, Heart Failure NYHA Class II
Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2
This study tests the hypothesis that endogenous bradykinin contributes to effects of a combined angiotensin receptor blocker/neprilysin inhibitor (LCZ696 or Entresto)
- Conditions
- Heart Failure NYHA Class I, Heart Failure NYHA Class II, Heart Failure NYHA Class III
- Trial name
- NCT03005184
- Testing
- Valsartan 80 mg bid, Enalapril 10 mg bid, Sacubitril-Valsartan 200 mg bid
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Induction of Labor in Multiparous Women
A Study Comparing Vaginal Misoprostol and Intravenous Oxytocin for Induction of Labor
This study will compare the effectiveness of vaginal misoprostol (Cytotec) and intravenous oxytocin (Pitocin) in multiparous women who present at term for labor induction.
- Trial name
- NCT01634854
- Testing
- Vaginal Misoprostol, Intravenous Oxytocin
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Dermatitis Herpetiformis
Use of Dapsone Gel, 5% for Treating Dermatitis Herpetiformis
The primary objective of this study is to evaluate the efficacy of dapsone gel, 5% in the treatment of dermatitis herpetiformis.
- Trial name
- NCT01115244
- Testing
- Dapsone gel, 5%
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University Medical Center
Gestational Diabetes
Evaluation of the Gestational Diabetes Self-Management Education Program and Quality Improvement Plan
The broad, long-term objectives are to generate and test hypotheses leading to theories that guide improved care of patients with gestational diabetes.
- Trial name
- GDM Elasy (NCT01030744)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity, Hyperinsulinemia
Natriuretic Peptides and Metabolic Risk in Obesity
The investigators are examining: 1. the relationships of insulin levels and natriuretic peptide hormone levels, and 2. the effects of administering an infusion of natriuretic peptide hormone on the breakdown of fat in healthy…
- Trial name
- NCT02642523
- Testing
- Nesiritide, Insulin, Saline
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Tobacco Dependence
Preventing Tobacco Relapse With Omega-3s Trial
Almost 12% of women report smoking during pregnancy. Smoking during pregnancy is associated with adverse fetal outcomes and up to 35-75% of women quit smoking during their pregnancy.
- Trial name
- PRO-3 (NCT03113370)
- Testing
- Fish Oil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Subarachnoid Hemorrhage, Seizures
Seizure Prophylaxis With Levetiracetam in Aneurysmal Subarachnoid Hemorrhage - Pilot Study
The purpose of this study is to determine the feasibility of prospectively enrolling and randomizing patients with aneurysmal subarachnoid hemorrhage (aSAH) to receive levetiracetam or not to receive levetiracetam, and…
- Trial name
- SPLASH - Pilot (NCT01935908)
- Testing
- levetiracetam
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Acute Asthma
Optimal Albuterol Regimens for Acute Asthma Exacerbations: DBRCT Pilot Study
Our overall objective is to model a pediatric Acute Asthma Clinical Decision Rule (ADR) for personalized medicine by identification of treatment-response phenotypes that are important determinants of outcome.
- Trial name
- OARS (NCT01196377)
- Testing
- Albuterol
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Acute Coronary Syndrome (ACS)
Improving Medication Adherence Through Graphically Enhanced Interventions in Acute Coronary Syndromes
Coronary heart disease (CHD) is the leading cause of death in the United States. Most people who die from CHD die of a heart attack.
- Trial name
- IMAGE-ACS (NCT00399880)
- Testing
- Health literacy intervention
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation, Atrial Flutter
Use of Dabigatran Etexilate to Prevent Stroke and Thromboembolism
The purpose of this study is to evaluate major adverse bleeding risks, and thromboembolic event rates post radiofrequency (RF) ablation.
- Trial name
- NCT01976507
- Testing
- dabigatran etexilate mesylate
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Vanderbilt University Medical Center
Clinical Trial
Increasing Minority Participation in Clinical Trials
This study will measure the effects of an office-based, clinical trial education video on clinical trial knowledge and enrollment in clinical trials, in a clinical sample with no previous history of clinical trial participation.
- Trial name
- NCT02600533
- Testing
- Video viewing group
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Vanderbilt University Medical Center
Acute Coronary Syndrome, Heart Failure
Pharmacist Intervention to Decrease Medication Errors in Heart Disease Patients (The PILL-CVD Study)
Many people who have recently left the hospital have difficulties managing their medications, and medication errors are common. Patients with low health literacy levels may have a particularly difficult time understanding…
- Trial name
- PILL-CVD (NCT00632021)
- Testing
- Pharmacist Intervention for Low-Literacy in Cardiovascular Disease
- Where
- 2 sites in United States
- Volunteers
- 862 people
- Sponsor
- Vanderbilt University Medical Center