Clinical trials: sponsored by Vanderbilt University Medical Center
Back Pain Without Radiation, Low Back Pain
Parallel Versus Perpendicular Technique for Lumbar Medial Branch Radiofrequency Neurotomy
Low back pain is a leading cause of disability worldwide. The lumbar zygapophyseal joints (z-joints) are estimated to be the source of low back pain between 10% and 40% of the time.
- Conditions
- Back Pain Without Radiation, Low Back Pain, Lumbar Radiofrequency Neurotomy
- Trial name
- NCT03912519
- Testing
- Parallel placement of 16 gauge electrodes, Perpendicular placement with 22 gauge electrodes
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Vanderbilt University Medical Center
Salt Sensitivity of Blood Pressure, Hypertension
CARDIA-Salt Sensitivity of Blood Pressure (SSBP)
Salt sensitivity of blood pressure (SSBP) is defined as the change in blood pressure (BP) in relation to change in salt intake. An increase in BP from low- to high-salt diet is common and associated with an increased risk of…
- Trial name
- NCT04258332
- Testing
- High Salt Diet, Low Salt Diet
- Where
- 2 sites in United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Nephrolithiasis
Massage Percussion for Passage of Urolithiasis Fragments After Ureteroscopy.
Flexible ureteroscopy is characterized as first-line therapy for renal stones < 2 cm in size. Stones are commonly treated with dusting or fragmentation techniques which requires passage of stone fragments after surgery.
- Trial name
- NCT05872230
- Testing
- Massage Percussion Therapy device
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Primary Ciliary Dyskinesia
Utility of PCD Diagnostics to Improve Clinical Care
This is a study evaluating the utility of current Primary Ciliary Dyskinesia (PCD) diagnostic tests, including nasal nitric oxide testing.
- Trial name
- NCT03704207
- Testing
- nNO testing
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Acute Heart Failure, Dyspnea
Improving Diagnostic Accuracy for Acute Heart Failure
Acute heart failure is a common reason for emergency department visits and hospitalization, but the diagnosis can be challenging because of non-specific symptoms and signs.
- Conditions
- Acute Heart Failure, Dyspnea, Dyspnea; Cardiac
- Trial name
- INDICATE-HF (NCT04886128)
- Where
- United States
- Volunteers
- 2,469 people
- Sponsor
- Vanderbilt University Medical Center
Peripheral Pulmonary Lesions (PPLs)
Advanced Robotic Techniques and Rapid Onsite Evaluation for Minimally Invasive Diagnosis and Next-Generation Sequencing.
ARTEMIS is a multicenter randomized controlled trial. The goal is to understand whether rapid onsite evaluation during robotic assisted bronchoscopy improves the diagnostic performance of the procedure or not.
- Trial name
- ARTEMIS (NCT07685977)
- Testing
- Rapid onsite evaluation
- Where
- 8 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt University Medical Center
Orthostatic; Hypotension, Neurogenic, Autonomic Failure
Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms
The objective of this study is to find a more objective and accurate way to assess the efficacy of the treatment for neurogenic orthostatic hypotension.
- Conditions
- Orthostatic; Hypotension, Neurogenic, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy
- Trial name
- NCT04782830
- Testing
- Accelerometer, Midodrine or atomoxetine pill
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Vanderbilt University Medical Center
Status Asthmaticus
Treating Exacerbations of Asthma With Oral Montelukast in Children
This research will establish a mg/kg dose for a future RCT to determine the efficacy of high-dose oral montelukast for children with moderate and severe acute asthma exacerbations.
- Trial name
- TEAM (NCT05819541)
- Testing
- Montelukast Oral Granules, Albuterol, Corticosteroid
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Intubation Complication
Incidence of Acute Laryngeal Injury Following Endotracheal Intubation
The purpose of this investigation is to delineate the incidence of acute and chronic laryngeal injury following intubation within our health system.
- Trial name
- NCT03250975
- Testing
- Budesonide and Azithromycin
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Vanderbilt University Medical Center
Obstructive Sleep Apnea
Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA
Polysomnography (PSG) and drug-induced sleep endoscopy (DISE) are widely used diagnostic studies for assessing obstructive sleep apnea (OSA) severity and collapse patterns of the upper airway anatomy during sleep.
- Trial name
- NCT05501236
- Testing
- Grass S88 Muscle Stimulator
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Neoplastic Syndromes, Hereditary, Comparative Effectiveness Research
Family History and Cancer Risk Study
Investigators from Vanderbilt University Medical Center (VUMC), Duke University, and Meharry Medical College (MMC) are collaborating on a family health history study to deploy a family health history (FHH) platform, MeTree.
- Trial name
- FOREST (NCT05079334)
- Where
- 2 sites in United States
- Volunteers
- 1,847 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Stress Urinary Incontinence in Women
Comparison of Two Over the Counter Intravaginal Devices for the Treatment of Stress Urinary Incontinence
The goal of this pilot study is to compare two commercially available over the counter devices for treatment of stress urinary incontinence in a web based format. The main questions it aims to answer 1.
- Trial name
- IMPRIVE (NCT06698627)
- Testing
- Daily Disposable Continence Device, Monthly Disposable Continence Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Down Syndrome, Down Syndrome, Partial Trisomy 21
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
Progressive age-related cognitive deficits occurring in both AD and DS have been connected to the degeneration of several neuronal populations, but mechanisms are not fully elucidated.
- Conditions
- Down Syndrome, Down Syndrome, Partial Trisomy 21, Alzheimer Disease
- Trial name
- NCT05231798
- Testing
- [18F]-FEOBV Radiotracer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Arterial Hypertension
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension
Based on existing literature and clinical trials, 2- hydroxbenzylamine (2-HOBA) has clear impact on mechanisms that much of the international field of pulmonary hypertension (PH) research agrees are central to disease…
- Trial name
- NCT06176118
- Testing
- 2-HOBA
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University Medical Center
Sickle Cell Disease, Malnutrition
Prevention of Malnutrition in Children With Sickle Cell Disease
The investigators are studying how to prevent malnutrition in children with sickle cell disease (SCD) in northern Nigeria. Community health workers will teach mothers about nutritious local foods that might help children grow…
- Trial name
- PMC-SCD (NCT06397118)
- Testing
- Maternal Nutrition Education, Standard Care
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Vanderbilt University Medical Center
Postpartum Depression (PPD), Self-Efficacy
NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)
The study's objective is to conduct a Phase II randomized controlled trial examining the preliminary efficacy of the VoiceLove app compared to usual care on maternal postpartum depression in mothers with infants admitted to the…
- Conditions
- Postpartum Depression (PPD), Self-Efficacy, Parental Anxiety, Engagement, Patient
- Trial name
- NURTURE (NCT07214597)
- Testing
- VoiceLove mobile phone application
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Peripheral Nerve Injury
Nerve Repair Using Hydrophilic Polymers to Promote Immediate Fusion of Severed Axons and Swift Return of Function
Current strategies for peripheral nerve repair are severely limited. Even with current techniques, it can take months for regenerating axons to reach denervated target tissues when injuries are proximally located.
- Trial name
- NCT02359825
- Testing
- Polyethylene glycol (PEG)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease
Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain…
- Trial name
- NCT04715984
- Testing
- Neurophysiology recordings, Neural stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Psychiatric Disorder, Memory Disorders
Neural Correlates of Psychiatric Disorders
This ClincialTrials.gov record originally corresponded to the protocol approved under IRB # 202370. The study was expanded to include stimulation and recordings approved under new IRB #211037.
- Trial name
- NCT04725409
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Pharmacogenomic Testing
VICE-MPRINT: Maternal and Pediatric Pharmacogenetics Survey
The field of pharmacogenetics has progressed from the discovery of genetic variants that cause variable function of drug metabolism enzymes to a cornerstone of clinical precision medicine.
- Trial name
- MPRINT (NCT05037305)
- Testing
- Educational video
- Where
- 2 sites in United States
- Volunteers
- 798 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center