Clinical trials: sponsored by Vanderbilt University Medical Center
Parkinson Disease
Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain…
- Trial name
- NCT04715984
- Testing
- Neurophysiology recordings, Neural stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Anastomotic Leak Rectum, Anastomotic Leak Large Intestine
Endoscopic COlorectal Mucosal Evaluation of Oxygen Tension
Anastomosis refers to the surgical connection between two segments of the bowel, typically performed during colon and rectal surgeries to restore the continuity of the digestive tract after a section has been removed.
- Trial name
- e-COMET (NCT07467980)
- Testing
- A novel endoscopic imaging system that displays real-time oxygen saturation levels
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Vanderbilt University Medical Center
Duchenne Muscular Dystrophy (DMD)
Glucagon-Like Peptide-1 Receptor Agonists to Attenuate Metabolic Risk in Individuals With Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy (DMD) is a rare, genetic disease that leads to muscle weakness, breathing difficulties, heart disease, and early death.
- Trial name
- NCT07642635
- Testing
- Semaglutide (Rybelsus®)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Epilepsy, Sudden Unexpected Death in Epilepsy
Effect of Rose Odor Exposure on Ictal Apnea
This study will investigate the potential benefits of rose scent in reducing the risk of Sudden Unexpected Death in Epilepsy (SUDEP) in patients with epilepsy.
- Trial name
- NCT07116421
- Testing
- 2-phenylethanol rose scent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Obesity
Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans
The overall hypothesis of this proposal is that nutrient sensing in the foregut regulates metabolic hormone secretion and nutrient metabolism via enteric neural signals, and these mechanisms might be defective in obesity.
- Trial name
- NCT02537314
- Testing
- benzocaine
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Critical Illness
Enhancing Parent/Caregiver Engagement in the Pediatric Intensive Care Unit (PICU): A PICU Journal
Admission to the pediatric intensive care unit (PICU) is well-recognized to be extremely distressing and stressful for the patient and family.
- Trial name
- PICUJournal (NCT06117345)
- Testing
- PICU Journal
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Preterm Labor, Tobacco Use Disorder
Omega-3 Fatty Acids for Smoking Cessation in Pregnancy
Smoking is the most important modifiable risk factor for adverse pregnancy outcomes including preterm birth, neonatal death, and maternal complications.
- Trial name
- INFANTS (NCT04417595)
- Testing
- Fish Oil (Containing Omega-3 Acids), Olive Oil
- Where
- United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Subjective Cognitive Decline
Attentional Mechanisms in SCD
This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by…
- Trial name
- AMoCC-SCD (NCT06002477)
- Testing
- Mecamylamine Challenge
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Extracorporeal Membrane Oxygenation Complication
The ECMO-Free Trial
Decannulation from venovenous extracorporeal membrane oxygenation (VV-ECMO) at the earliest and safest time would be expected to improve outcomes and reduce cost.
- Trial name
- NCT05486559
- Testing
- ECMO-free protocol, Usual Care
- Where
- 8 sites in United States, Canada
- Volunteers
- 225 people
- Sponsor
- Vanderbilt University Medical Center
Cardiovascular Diseases, Coronary Disease
Soy Food and Coronary Heart Disease in Women
To investigate whether soy food intake reduces risk of non-fatal myocardial infarction (MI) and fatal coronary heart disease in Chinese women.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases
- Trial name
- NCT00241735
- Volunteers
- 135,896 people
- Sponsor
- Vanderbilt University Medical Center
Cannabis Use, SCHIZOPHRENIA
Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia
The central hypothesis is this: Brain circuits most relevant to cannabis use in schizophrenia are distinct from pathways identified in healthy controls who use cannabis.
- Conditions
- Cannabis Use, SCHIZOPHRENIA, Psychosis, rTMS
- Trial name
- NCT07196462
- Testing
- 3 Minute iTBS to the L DLPFC, One-Minute, Personalized, DMN Targeted CTBS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Dysphagia, Healthy Aging
Swallowing Impairments in ICU Survivors and Community-Dwelling Adults
Post-intensive care syndrome (PICS), which consists of physical, cognitive, and psychosocial problems, is a pervasive complication for older intensive care unit (ICU) survivors and contributes to detrimental health outcomes and…
- Conditions
- Dysphagia, Healthy Aging, Post Intensive Care Syndrome, Caregiver Burden
- Trial name
- NCT07005037
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hemothorax; Traumatic, Hemopneumothorax; Traumatic
Suction vs Underwater Seal for HemoPneumoThoraX Trial
Traumatic pneumothorax and hemothorax are common consequences of chest injury, often requiring prompt tube thoracostomy to re-expand the lung and drain accumulated blood or air.
- Trial name
- SUS-HPTX (NCT07551791)
- Testing
- Suction, Water Seal
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University Medical Center
Lipedema
Building Lipedema Research Resources
Lipedema is a disease marked by subcutaneous adipose tissue accumulation in the lower extremities of females that is accompanied by somatic pain and edema.
- Trial name
- BRR (NCT06180850)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Esophagectomy, Pulmonary Wedge Resection
A Retrospective Analysis of Statin Use and Outcome After Thoracic Cancer Surgery
There is data to support an association between impaired preoperative endothelial function and adverse postoperative outcome. This study will investigate the potential association between perioperative statin use and improved…
- Conditions
- Esophagectomy, Pulmonary Wedge Resection, Pulmonary Lobectomy, Pulmonary Pneumonectomy
- Trial name
- NCT01169051
- Volunteers
- 569 people
- Sponsor
- Vanderbilt University Medical Center
Kidney Calculi
Ureteral Stent Placement After Ureteroscopy for Renal Stones: A Randomized Controlled Trial
The rationale for this study is to determine if there is a difference in complications among patients undergoing ureteroscopy for renal stones who receive a stent compared to not receiving a stent postoperatively.
- Trial name
- NCT03855787
- Testing
- Ureteroscopy
- Where
- 7 sites in United States, Canada
- Volunteers
- 103 people
- Sponsor
- Vanderbilt University Medical Center
Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension
Right Ventricle Lipid in Pulmonary Arterial Hypertension (PAH)
The investigators propose to study the relationship between right ventricle (RV) steatosis and RV function, exercise capacity, and outcomes in humans with pulmonary arterial hypertension (PAH) and to identify potential drivers of…
- Conditions
- Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
- Trial name
- NCT05462574
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Subchondral Insufficiency Fracture
Bio-Integrative, Fiber-Reinforced Kneebar for Treating Subchondral Insufficiency of the Knee
The OSSIOfiber® Trimmable Fixation Nails are indicated for maintenance of alignment and fixation of bone fractures, osteotomies, arthrodesis and bone grafts in the presence of appropriate additional immobilization (e.g., rigid…
- Trial name
- NCT06423378
- Testing
- OSSIOfiber® Trimmable Fixation Nails
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Lumbar Puncture
Hemorrhage Elimination During Lumbar Puncture Using Ultrasound Measurements (HELPUS)
This is a clinical trial to determine the extent to which ultrasound-assisted lumbar puncture using a standardized procedure, including use of ultrasound to ascertain the presence of cerebrospinal fluid (CSF) at L3 - L5 and the…
- Trial name
- HELP (NCT07612644)
- Testing
- ultrasound contrast
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Vanderbilt University Medical Center
Achalasia
Mechanisms of Weight Loss in Patients Diagnosed With Achalasia
Currently there are no existing data to determine why some achalasia patients lose weight while others do not. The purpose of this study is to gather data from patients diagnosed with achalasia to determine if differences may be…
- Trial name
- NCT03063463
- Testing
- pneumatic dilation, surgical myotomy
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center