Clinical trials: sponsored by Vastra Gotaland Region
Indirect Calorimetry, Mechanical Ventilation
Effect of PEEP on Indirect Calorimetry in Critically Ill Patients
Indirect calorimetry is used in intensive care to measure how much oxygen a patient consumes and how much carbon dioxide is produced.
- Conditions
- Indirect Calorimetry, Mechanical Ventilation, Positive End-Expiratory Pressure
- Trial name
- IC-PEEP (NCT07796698)
- Testing
- Protocolized PEEP Adjustment
- Volunteers
- 20 people
- Sponsor
- Vastra Gotaland Region
Cough
Influence on Cough and Airway Symptoms by Oral Capsaicin
Study objectives To establish whether an oral intake of Capsicum oleoresin; capsaicinoids expressed as 0.4 mg capsaicin (C18H27N03; Mw: 305.4) in each capsule (from chili extract) can desensitise the cough reflex and improve…
- Trial name
- NCT04125563
- Testing
- Capsicum Oleoresin
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Vastra Gotaland Region
Aged, Home Care, Hospital-Based
Home-based Acute Care for Older Persons Initiated by the Emergency Medical and Ambulance Services - a Retrospective Observation of Effects on Healthcare Utilisation and Mortality
This observational study aims to examine outcomes of home-based acute care delivered by a mobile healthcare team in persons aged 75 years and older following an episode of acute illness.
- Conditions
- Aged, Home Care, Hospital-Based, Home Care Services, Emergency Medical Dispatch Centre
- Trial name
- NCT07472335
- Testing
- Type of care pathway
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Vastra Gotaland Region
Knee Osteoarthrosis, Total Knee Arthroplasty
Patients' Experiences of Information After Total Knee Arthroplasty - A Qualitative Interview Study
The aim of this qualitative interview study is to gain new and in-depth knowledge about patients' experiences of information following total knee arthroplasty. Participants will be interviewed in the recovery phase after surgery.
- Trial name
- NCT06994884
- Where
- 2 sites in Sweden
- Volunteers
- 16 people
- Sponsor
- Vastra Gotaland Region
Pulmonary Atresia With Intact Ventricular Septum
A Comparison of Morbidity Between Patients With Pulmonary Atresia With Intact Ventricular Septum and Uni- or Biventricular Circulation
The goal of this observational study is to compare patients with pulmonary atresia with intact ventricular septum (PA-IVS) with univentricular circulation to patients with the same heart defect but that has a biventricular…
- Trial name
- NCT05928234
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Vastra Gotaland Region
Knee Osteoarthritis, Widespread Chronic Pain
Prevalence and Characteristics of Widespread Pain in People With Knee Osteoarthritis
The goal is to evaluate whether the number of pain sites or pain estimation with Instant and Constant Osteoarthritis Pain (ICOAP) is related to functional impairment in the lower extremity in people with knee osteoarthritis…
- Trial name
- NCT06854237
- Where
- Sweden
- Volunteers
- 114 people
- Sponsor
- Vastra Gotaland Region
Overweight, Obesity
Long-term Health and Economic Effects of an Individualized Lifestyle Intervention (LI-PAD-Extended)
The goal of this clinical trial is to learn if an individualized lifestyle intervention works to improve weight, diet, physical activity, cardiovascular health, health-related quality of life, and cost-effectiveness in overweight…
- Conditions
- Overweight, Obesity, Prediabetic State
- Trial name
- LI-PAD-EXTENDE (NCT07605169)
- Testing
- Individualized physical activity and diet
- Where
- Sweden
- Volunteers
- 103 people
- Sponsor
- Vastra Gotaland Region
Non-progressive Congenital Ataxia, Ataxic Cerebral Palsy
ARTEMIS - The ARTEMIS Cohort
This multinational European observational clinical study focuses on non-progressive congenital ataxia (NPCA), a very rare early-onset neurological condition also within the cerebral palsy (CP) concept as ataxic CP.
- Trial name
- ARTEMIS (NCT07421219)
- Where
- 7 sites in Belgium, Denmark and 5 more
- Volunteers
- 50 people
- Sponsor
- Vastra Gotaland Region
Fabry Disease
Quality of Life in Adults With Untreated Fabry Disease in Sweden (QoLUF)
Fabry disease is a rare, inherited condition that can affect multiple organs, including the heart, kidneys, and nervous system. Many people with Fabry disease live for a period of time without receiving disease-specific…
- Trial name
- QoLUF (NCT07560956)
- Testing
- Qualitative Interview
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Vastra Gotaland Region
Melanoma (Skin Cancer)
Neoadjuvant Pembrolizumab in Patients With Stage IIb/c Melanoma
A phase II double-blind placebo-controlled randomized trial. Patients with a clinical suspicion of a thick primary melanoma without clinical suspicion or evidence of lymph-node engagement will undergo a 3 mm punch biopsy to…
- Trial name
- NEOPRIME (NCT07349303)
- Testing
- Pembrolizumab
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Vastra Gotaland Region
Knee Pain
Validity and Reliability of Video-Based Functional Physiotherapy Assessment of Subacute Knee Injuries
This study aims to validate a function-based physiotherapy assessment for subacute knee pain without using specific knee tests. Assessments are conducted either in-person or via video consultations in primary care.
- Trial name
- NCT07212920
- Testing
- Physiotherapy digital assessment, Physiotherapy assessment - only functional tests
- Where
- 3 sites in Sweden
- Volunteers
- 138 people
- Sponsor
- Vastra Gotaland Region
Musculoskeletal Diseases
Video-based First-contact Physiotherapy in Primary Care
This study aims to evaluate the effects and implications of using video-based first-contact consultation in primary care physiotherapy, compared with traditional in-person consultation for musculoskeletal symptoms.
- Trial name
- VIPP (NCT07788651)
- Testing
- Video-based first-contact physiotherapy consultation, In-person first-contact physiotherapy consultation
- Volunteers
- 208 people
- Sponsor
- Vastra Gotaland Region
Anorexia Nervosa, Atypical, Anorexia Nervosa
Frequency of Hypermobility-Related Problems in Patients With Anorexia Nervosa
The purpose of this study is to examine the frequense of generalized hypermobility and pain in patients with Anorexia Nervosa. The study further explores two main questions: (1) whether generalized hypermobility may be an…
- Trial name
- NCT07159867
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Vastra Gotaland Region
Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal)
Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study
The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS).
- Conditions
- Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Respiratory Distress Syndrome of Newborn
- Trial name
- NCT07550218
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Vastra Gotaland Region
Chronic Pain, Pain Management
Interdisciplinary Rehabilitation for Chronic Pain in Primary Healthcare
Purpose: The overall aim is to investigate the effect of interdisciplinary rehabilitation in primary health care (PHC) for patients with chronic pain.
- Trial name
- NCT06084390
- Testing
- Interdisciplinary care + booster session (intervention), Interdisciplinary care (control)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Vastra Gotaland Region
Osteo Arthritis Knee and Hip
Test-Retest Reliability of a Submaximal Exercise Test in Patients With Hip and Knee Osteoarthritis
The aim is to evaluate the test-retest reliability of the primary care-adapted Ekblom-Bak submaximal ergometer bicycle test in patients with hip- and/or knee osteoarthritis (OA).
- Trial name
- NCT07383740
- Testing
- Submaximal cycle ergometer test-retest
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Survivors of Childhood Cancer
Behavioral Reinforcement Intervention for Greater Health Trajectories After Childhood Cancer (BRIGHT)
Survivors of childhood cancer have a substantially increased risk of long-term health problems in adulthood, including cardiovascular disease, metabolic disorders, psychological morbidity, and impaired health-related quality of…
- Trial name
- BRIGHT (NCT07384286)
- Testing
- Lifestyle Management
- Where
- Sweden
- Volunteers
- 900 people
- Sponsor
- Vastra Gotaland Region
Osteoarthritis, Knee, Osteoarthritis, Hip
Digitalization of Osteoarthritis Care
The overall aim of this study is to compare three different care models for patients with hip- and knee osteoarthritis. The primary aim is to evaluate whether an app-based care model is more beneficial for improving function in…
- Trial name
- NCT05584410
- Testing
- Patient information, Smart phone application based exercises, Web based exercises
- Where
- Sweden
- Volunteers
- 315 people
- Sponsor
- Vastra Gotaland Region
Obesity, Childhood
Physical Activity on Prescription for Children With Obesity
Background: physical inactivity is a main cause of childhood obesity. Physical activity on prescription (PAP) is an evidence-based intervention for adults, but has not been evaluated in children with obesity.
- Trial name
- IMPA (NCT04847271)
- Testing
- Physical activity on prescription (PAP)
- Where
- Sweden
- Volunteers
- 42 people
- Sponsor
- Vastra Gotaland Region
Isolated Limb Perfusion
Minimally-Invasive Isolated Limb Perfusion
The aim is to analyse feasibility of a minimally-invasive isolated limb perfusion.
- Trial name
- MI-ILP (NCT03376126)
- Testing
- Minimal-invasive isolated limb perfusion
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Vastra Gotaland Region