Clinical trials: sponsored by Vigonvita Life Sciences
Alzheimer Disease
A Phase 2 Clinical Study of Simenafil Hydrochloride Tablets in the Treatment of Alzheimer's Disease
This study is a multicenter, randomized, double-Blind, placebo-controlled Phase 2 clinical study to evaluate the efficacy and safety of Simenafil Hydrochloride Tablets in the treatment of participants with Alzheimer's Disease
- Trial name
- NCT07905352
- Testing
- Simenafil Hydrochloride Tablets 2.5 mg, Simenafil Hydrochloride Tablets 5 mg, Simenafil Hydrochloride Tablets 10 mg
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Vigonvita Life Sciences
Healthy Participants
Study of the Safety, Tolerability, Pharmacokinetics of VV147 Tablets in Chinese Healthy Participants.
This is a single-center, randomized, double-blind, placebo-controlled, single ascending-dose study designed to evaluate the safety, tolerability, and pharmacokinetic characteristics of VV147 tablets in healthy participants.
- Trial name
- NCT07885202
- Testing
- VV147 15mg Group, VV147 30mg Group, VV147 60mg Group
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
MDD
Dose-Finding Clinical Trial to Evaluate the Efficacy and Safety of LV232 Capsules in the Treatment of MDD
This multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-finding Phase II clinical trial aimed to determine the optimal dose of LV232 capsules for treating MDD, evaluate preliminary efficacy and…
- Trial name
- NCT06828887
- Testing
- LV232 40mg, LV232 60mg, Escitalopram
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Vigonvita Life Sciences
Schizophrenia
Study of the Safety, Tolerability, Pharmacokinetics and Food Effects of VV119 Capsules in Chinese Healthy Volunteers
This study will consist of 2 parts: Part Ⅰ - Single Ascending Dose (SAD) study, Part Ⅱ - Food Effect (FE) study
- Trial name
- NCT06105151
- Testing
- VV119(SAD), VV119(FE)
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Schizophrenia
Evaluating Safety, Tolerability and Pharmacokinetic of Multiple Ascending Doses of VV119
This study will consist of 2 parts: Part Ⅰ-in healthy adult subjects, Part Ⅱ-in adult patients with schizophrenia
- Trial name
- NCT06504290
- Testing
- VV119 （in healthy adult subjects）, VV119(in adult patients with schizophrenia)
- Where
- 4 sites in China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Premature Ejaculation
Evaluate the Efficacy and Safety of VV913 Capsules in the Treatment of PE
This trial adopted a multicenter, randomized, double-blind, placebo-controlled design and consisted of two parts: Part Ⅰ and Part Ⅱ.
- Trial name
- NCT07722780
- Testing
- VV913 2mg Capsules, VV913 5mg Capsules, VV913 10mg Capsules
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Vigonvita Life Sciences
Healthy Volunteers
Safety and Pharmacokinetics Study of Multiple Ascending Doses of VV261 Tablets
This is a randomized, double-blind, placebo-controlled, multiple ascending-dose study to evaluate the safety, tolerability and pharmacokinetics characteristics of VV261 tablets in healthy adults.
- Trial name
- NCT07710326
- Testing
- VV261 600mg TID group, VV261 900mg TID group
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Schizophrenia
Evaluating Safety and Efficacy of VV119 in Acute Schizophrenia Adults
This will be a multicenter, randomized, double-blind, placebo and active comparator parallel-controlled study designed to assess the safety and efficacy of VV119 (2.0 to 6.0 mg) for the treatment of adult participants diagnosed…
- Trial name
- NCT07703956
- Testing
- VV119 2mg, VV119 4mg, VV119 6mg
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Vigonvita Life Sciences
Healthy Volunteers
Safety and Pharmacokinetics Study of Multiple Ascending Doses of VV913 Capsules
This study is a single-center, randomized, double-blind, placebo-controlled, dose-escalation trial to assess the safety, tolerability, pharmacokinetics （PK） of multiple doses of VV913 in Chinese healthy adult participants.
- Trial name
- NCT07507838
- Testing
- VV913 4mg group, VV913 8mg group, VV913 15mg group
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Healthy Volunteers
Study of Food Effects of VV913 Capsules in Chinese Healthy Volunteers
This study is a single-center, randomized, open label, 3×3 crossover design to assess the high-fat meal and the standard meal effects on PK of a single oral dose of VV913 in healthy adult volunteers.
- Trial name
- NCT07565792
- Testing
- VV913
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Healthy Volunteers
Study of the Safety, Tolerability, Pharmacokinetics of VV913 Capsules in Chinese Healthy Participants
This is a randomized, double-blind, placebo-controlled, single ascending-dose study to evaluate the safety, tolerability and pharmacokinetics characteristics of VV913 Capsules in healthy adults.
- Trial name
- NCT07372703
- Testing
- VV913 1mg group, VV913 2mg group, VV913 4mg group
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Healthy Volunteers
Study of the Safety, Tolerability, Pharmacokinetics of VV261 Tablets in Chinese Healthy Volunteers
This is a randomized, double-blind, placebo-controlled, single ascending-dose study to evaluate the safety, tolerability and pharmacokinetics characteristics of VV261 tablets in healthy adults.
- Trial name
- NCT07302269
- Testing
- VV261 5mg group, VV261 20mg Group, VV261 50mg group
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Healthy Volunteers
Study of Food Effects of VV119 Capsules in Chinese Healthy Volunteers
This study is a single-center, randomized, open label, 2×2 crossover design to assess the standard meal effects on PK of a single oral dose of VV119 in healthy adult subjects.
- Trial name
- NCT07240636
- Testing
- VV119
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Healthy Subjects
Study of the Safety, Tolerability, and Pharmacokinetics of LV232 Capsules in Chinese Healthy Volunteers
The study consists of 10 dose groups, 8 subjects in each group (male or female), randomly assigned to study drug or placebo group to evaluate the safety, tolerability and pharmacokinetics characteristics.
- Trial name
- NCT06070857
- Testing
- LV232
- Where
- China
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Healthy Subjects
Safety and Pharmacokinetics Study of Multiple Ascending Doses and Food Effect of LV232 Capsules
This study is divided into two parts: the safety, tolerability, pharmacokinetic profiles of LV232 capsules after multiple ascending doses (hereinafter referred to as "PK characteristics of multiple ascending doses study ") and…
- Trial name
- NCT06279533
- Testing
- LV232
- Where
- China
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Healthy Participants
A Study to Evaluate the Bioavailability of Two Specifications of Oral Deuremidevir Hydrobromide for Suspension
The goal of this clinical study is to evaluate the bioavailability of two specifications of oral Deuteriumremidvir Hydrobromide for suspension in Chinese healthy adult participants.
- Trial name
- NCT06749236
- Testing
- test formulation(T) 200 mg deuteriumremidvir hydrobromide for suspension, reference formulation(R) 100 mg deuteriumremidvir hydrobromide for suspension
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Erectile Dysfunction
Long-term Safety of TPN171H Tablet in Erectile Dysfunction.
This is a multicenter, open study to evaluate the long-term safety and efficacy of TPN171H in men with erectile dysfunction.
- Trial name
- NCT06301854
- Testing
- TPN171H
- Where
- 34 sites in China
- Volunteers
- 472 people
- Sponsor
- Vigonvita Life Sciences
Respiratory Syncytial Virus Infection
A Study of Deuremidevir Hydrobromide for Suspension in Chinese Infants Hospitalized With RSV
To evaluate the safety, efficacy, pharmacokinetic (PK) characteristics and antiviral activity of different doses of Deuterium Hydrobromide for suspension in the treatment of respiratory syncytial virus infection in infants.
- Trial name
- NCT06206720
- Testing
- Deuremidevir Hydrobromide for Suspension
- Where
- 22 sites in China
- Volunteers
- 60 people
- Sponsor
- Vigonvita Life Sciences
Major Depressive Disorder
A Study to Assess Serotonin Transporter Occupancy of Healthy Adults Using 11C-DASB PET
This study was a non-randomized, open-label clinical study to assess Serotonin transporter occupancy in the brain of healthy adults using 11C-DASB positron emission tomography (PET)
- Trial name
- NCT06476509
- Testing
- LV232 40mg, Escitalopram 20 mg, LV232 60mg
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Pulmonary Arterial Hypertension
Acute Haemodynamic Study of TPN171H in Patients with Pulmonary Arterial Hypertension
This study is a phase IIa proof-of-concept study to evaluate the effect of single-dose TPN171H tablets on acute haemodynamic parameters in patients with pulmonary arterial hypertension.The trial is expected to include 60…
- Trial name
- NCT04483115
- Testing
- TPN171H, Tadalafil
- Where
- 9 sites in China
- Volunteers
- 60 people
- Sponsor
- Vigonvita Life Sciences