Clinical trials: sponsored by West China Hospital
Mechanical Ventilation, Complication
Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients
The purpose of this study was to evaluate effects, safety and cost of midazolam used alone or sequential use of midazolam and propofol/dexmedetomidine for long-term sedation in critically ill, mechanically ventilated patients.
- Conditions
- Mechanical Ventilation, Complication, Delirium
- Trial name
- NCT02528513
- Testing
- midazolam, Fentanyl, propofol
- Where
- China
- Volunteers
- 240 people
- Sponsor
- West China Hospital
Acute Lung Injury
Changes in Alveolar Macrophage Function During Acute Lung Injury
In this study, the investigators aim to observe the change in alveolar macrophage function during acute lung injury.
- Trial name
- NCT02693912
- Testing
- Bronchoscopy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Catheter Site Discomfort
Pudendal Nerve Block for Catheter-related Bladder Discomfort Prevention
Catheter-related bladder discomfort (CRBD) is not uncommon in male patients under general anesthesia, and it may cause patient agitation and exacerbated postoperative pain.
- Trial name
- NCT02683070
- Testing
- Bilateral pudendal nerve block, Intravenous tramadol
- Where
- China
- Volunteers
- 94 people
- Sponsor
- West China Hospital
Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation (APRV) Protocol Early Used in Acute Respiratory Distress Syndrome
The aim of this study is to assess the effects and safety of the early application of BILEVEL-APRV protocol and conventional ventilation strategy that used low tidal volume and adequate PEEP level in ARDS patients .
- Trial name
- NCT02639364
- Testing
- Nellcor Puritan Bennett 840 ventilator system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- West China Hospital
IFI
Treatment Method Research of Invasive Pulmonary Fungal Infection
The purpose of this study is to Comparison clinical efficiency with IPFI patients who treated by different protocols(empirical therapy or preemptive therapy) in ICU.
- Trial name
- 4056 (NCT01693887)
- Where
- 4 sites in China
- Volunteers
- 7 people
- Sponsor
- West China Hospital
Colorectal Cancer
Short-term Effects of LASI Surgery Versus Conventional Laparotomy for Colorectal Liver Metastasis
Surgical resection is still recommended as the optional treatment for colorectal liver metastasis (CLM) patients. There are two main concerns for resectable colorectal liver metastasis which remain controversial: surgical time…
- Trial name
- NCT02350166
- Testing
- laparoscopic surgery
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
Cirrhosis, Acquired Portal-systemic Shunt Due to Cirrhosis
Effect of Transjugular Intrahepatic Portosystemic Shunt on Gut Microbiota in Cirrhotic Patients
The purpose of this study is to determine the effect of transjugular intrahepatic portosystemic shunt on gut microbiota and associated inflammatory factors in cirrhotic patients.
- Conditions
- Cirrhosis, Acquired Portal-systemic Shunt Due to Cirrhosis, Hepatic Encephalopathy
- Trial name
- NCT02427906
- Where
- China
- Volunteers
- 50 people
- Sponsor
- West China Hospital
Respiratory Insufficiency
Noninvasive Ventilation Bundle in Postoperative Respiratory Failure
The investigators assessed the efficacy and safety of this noninvasive Ventilation (NIV) bundle strategy compared with a conventional treatment in postoperative patients with ARF.
- Trial name
- NCT02214368
- Testing
- Early application of NIV, Fiberoptic bronchoscopy, Propofol
- Where
- China
- Volunteers
- 158 people
- Sponsor
- West China Hospital
Portal Hypertension
3D CT Guidance for Transjugular Intrahepatic Portosystemic Shunt Creation
To prospectively evaluate the efficacy of real-time 3D CT-image guidance and CO2 portography during transjugular intrahepatic portosystemic shunt (TIPS) creation.
- Trial name
- NCT02480426
- Testing
- CT-image guidance, CO2 portograms guidance
- Volunteers
- 15 people
- Sponsor
- West China Hospital
Thyrotoxic Periodic Paralysis
Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis
The study aims to analyze the genetic variance between thyrotoxic periodic paralysis (TPP) patients and pure hyperthyroidism individuals.
- Trial name
- NCT02287363
- Testing
- No intervention involved
- Volunteers
- 160 people
- Sponsor
- West China Hospital
Hypertension
Treatment of Hypertension in Tibetan Adult Population
Several surveys had revealed that Tibetan adults had high prevalence of hypertension. However, there was no research studying the antihypertensive effect of the known drugs in Tibetan.
- Trial name
- NCT02217852
- Testing
- Nitrendipine, Hydrochlorothiazide, Captopril,Hydrochlorothiazide
- Where
- China
- Volunteers
- 800 people
- Sponsor
- West China Hospital
Pituitary Neoplasms, Craniopharyngiomas
Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions
The purpose of this four-arm randomized controlled study is to determine whether eliminating glucocorticoids (GC) replacement in perioperative period in surgical patients with sellar lesion could result in similar or better…
- Trial name
- NCT02190994
- Testing
- Hydrocortisone, Prednisone
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Hypertension, Renal Insufficiency
Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency
The purpose of this study is to evaluate the effects of indapamide SR 1.5 mg on renal function, endothelial function, blood pressure variability by comparison with hydrochlorothiazide 25 mg, in patients with Mild to Moderate…
- Trial name
- NCT01172431
- Testing
- Indapamide, Hydrochlorothiazide
- Where
- China
- Volunteers
- 240 people
- Sponsor
- West China Hospital
Transfusion Related Complication, Critical Illness
West-China Transfusion Score for Critically-ill Patients
Guidelines for blood transfusion have been issued for years. According to these guidelines, red blood cells (RBCs) transfusion should be given when the hemoglobin level is less than 6g/dL or 7g/dL and is unnecessary when the…
- Trial name
- NCT02139995
- Testing
- RBC transfusion based on different protocols
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Sedative Withdrawal Delirium
The Psychological Effects of Different Sedation Protocol on Mechanically Ventilated Critically Ill Adults.
The study was designed to explore the effects of different sedation protocol on incidence rates of delirium and PTSD in severe patients with mechanically ventilation.
- Trial name
- NCT02123589
- Testing
- Deep sedation(midazolam and fentanyl ), Deep and daily interruption of sedation(midazolam and fentanyl ), Light sedation(midazolam and fentanyl )
- Volunteers
- 150 people
- Sponsor
- West China Hospital
Etomidate Overdose of Undetermined Intent
A Dose-response Study of Lidocaine and Etomidate
IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.
- Trial name
- NCT01916642
- Testing
- Lidocaine 1mg/kg, Lidocaine 1.5mg/kg, Lidocaine 2mg/kg
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Therapeutics of Bilateral Maxillofacial Injuries
Treatment of Bilateral Maxillofacial Post-traumatic Deformities
Combined application of surgery planning software and rapid prototyping technology and preshaped titanium plates can effectively promote the accuracy of the diagnosis and treatment of bilateral maxillofacial post traumatic…
- Trial name
- NCT01875887
- Testing
- rapid prototyping technology
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Coronary Heart Disease, Essential Hypertension
Danshen Dropping Pill for Coronary Heart Disease Heart and Artery Structure and Function
The Impact of Compound danshen dropping pill for coronary heart disease (CHD) heart and artery structure and function in patients with hypertension
- Trial name
- NCT01825759
- Testing
- danshen dripping pill
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Healthy
Vitamin D Deficiency Epidemiological Research in Sichuan, China
Vitamin D insufficiency and deficiency is pandemic in the world.Sichuan Basin has a subtropical monsoon climate with China's lowest sunshine totals.
- Trial name
- NCT01457365
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Parotid Tumor
The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome
The aim of the study was to explore whether human acellular dermal matrix (ADM) implantation could prevent infraauricular depressed deformities and Frey's syndrome following total parotidectomy.
- Trial name
- NCT01414790
- Testing
- ADM
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital