Clinical trials: sponsored by West Virginia University
Lipoma
Lipomas Treated With Subcutaneous Injections of Cooled or Warmed Sodium Chloride
Lipomas are benign tumors composed of mature adipose tissue. While harmless, these are the most common type of soft tissue growths with some patients developing numerous lipomas.
- Trial name
- NCT06820164
- Testing
- Cooled Sodium Chloride Injection, Warmed Sodium Chloride Injection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Glioblastoma
Radiation/Temozolomide and Immunotherapy With Daratumumab to Improve Antitumor Efficacy in Glioblastoma
TMZ is a standard therapy for GBM. The study will demonstrate that Daratumumab can collaborate with TMZ to enhance the cytotoxicity against GBM cells.
- Trial name
- PRIDE (NCT04922723)
- Testing
- Daratumumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- West Virginia University
Pancreatic Cancer
Endoscopic Radiofrequency Ablation of Celiac Ganglion for Pain Management and Improvement of Quality of Life in Patients With Unresectable Pancreatic Cancer
This study aims to evaluate the EUS-RFA in terms of efficacy for pain management and improvement in quality-of-life parameters for patients with advanced inoperable pancreatic cancer.
- Trial name
- NCT05535894
- Testing
- Ablation of Celiac Ganglion
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- West Virginia University
Nonalcoholic Fatty Liver Disease
Effectiveness of Endoscopic Sleeve Gastroplasty in Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Endoscopic weight loss procedures, also termed endoscopic sleeve gastroplasty (ESG), has been proposed as a non-surgical procedure for managing obesity and offers a standard weight loss approach.
- Trial name
- NCT05507151
- Testing
- Endoscopic Sleeve Gastroplasty
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- West Virginia University
Myelodysplastic Syndromes
Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic Syndromes
The goal of this interventional clinical trial is to evaluate the safety and tolerability of leflunomide in combination with decitabine as treatment for patients with relapsed or refractory myelodysplastic syndromes (R/R MDS).
- Trial name
- NCT06923488
- Testing
- Leflunomide 10mg, Leflunomide 20mg, Decitabine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- West Virginia University
Actinic Keratoses
Actinic Keratoses Treated With 5-fluorouracil Plus Aluminum
This study is looking at a new way to treat actinic keratoses, which are rough, scaly spots on the skin caused by long-term sun exposure.
- Trial name
- NCT07401277
- Testing
- 5% 5-fluorouracil (5-FU) powder, 5% 5-fluorouracil (5-FU) powder PLUS 15% Aluminum Chloride Hexahydrate (ACH)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- West Virginia University
Circadian Rhythm Disorders
Effects of Blocking Blue Light at Night Post CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH
Purpose The purpose of this study is to determine whether filtering out blue light at nighttime reduces post-surgical inflammation and/or moderates cognitive decline and mood and sleep alterations in patients undergoing elective…
- Trial name
- NCT04578249
- Testing
- Blue light-blocking goggles, Clear goggles
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- West Virginia University
Gallbladder Adenocarcinoma
Safety and Feasibility of HIPEC for High-Risk Gallbladder Adenocarcinoma
Gallbladder adenocarcinoma is a devastating disease associated with a poor prognosis. Gallbladder and other biliary cancers will be responsible for an estimated 11,980 new cases, and 4,090 deaths in the US during 2020.
- Trial name
- NCT05430035
- Testing
- HIPEC
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- West Virginia University
Adenocarcinoma of the Pancreas
Neoadjuvant mFOLFIRINOX With Perioperative Oral Hydroxychloroquine in Resectable Pancreatic Adenocarcinoma
This will be a phase I/II trial examining the safety and tolerability of pre-operative mFOLFIRINOX in combination with peri-operative oral hydroxychloroquine (FHQ) in the treatment of subjects with adenocarcinoma of the pancreas.
- Trial name
- NCT04911816
- Testing
- Hydroxychloroquine sulfate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- West Virginia University
Impulse Control Disorder, Parkinson Disease
rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease
This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control…
- Trial name
- NCT06237868
- Testing
- rTMS Active
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- West Virginia University
Hematological Malignancy, Neutropenia
Prospective Evaluation of Xerava Prophylaxis in Hematological Malignancy Patients With Prolonged Neutropenia
Antibacterial prophylaxis is recommended in patients at high risk of infection, specifically patients undergoing acute leukemia induction therapy or hematopoietic stem cell transplant (HSCT) who are expected to have profound…
- Trial name
- NCT05537896
- Testing
- Eravacycline
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- West Virginia University
Obesity
Prospective Evaluation of Adjusted Body Weight Dosing of Acyclovir in Obesity
Patients receiving acyclovir as standard of care will be enrolled into this study. The currently recommended dosing strategy at our institution for obese patients is to receive intravenous acyclovir dosed per an adjusted body…
- Trial name
- NCT02879630
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- West Virginia University
Cervical Myelopathy, Balance Assessment
Impact of Tai Chi in Cervical Myelopathy
The goal of this observational study is to determine if patients with cervical myelopathy who participate in a Tai Chi program will demonstrate improved gait and balance compared to patients who undergo usual care.
- Conditions
- Cervical Myelopathy, Balance Assessment, Fall Risk
- Trial name
- NCT06876012
- Testing
- Tai Chi Program
- Volunteers
- 20 people
- Sponsor
- West Virginia University
CD19 Positive, Mixed Phenotype Acute Leukemia (MPAL)
Subcutaneous Blinatumomab for Treatment of Adult Patients With CD19-Positive Mixed Phenotype Acute Leukemia (MPAL)
This is a multicenter, non-randomized, open-label, phase II study evaluating blinatumomab administered subcutaneously in adult subjects with CD19+ MPAL.
- Trial name
- NCT07222579
- Testing
- Subcutaneous Blinatumomab
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- West Virginia University
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Sustaining Home Heart Failure Palliative Care in Rural Appalachia
The aim of this mixed methods randomized controlled trial is to test the integrated nurse-led intervention bundle for family home care management of end-stage heart failure and palliative care in rural Appalachia.
- Trial name
- NCT06791850
- Testing
- HF-FamPALhomeCARE
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- West Virginia University
Opioid-Related Disorders
Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder
The purpose of this clinical study is to investigate the safety, tolerability, and feasibility of Deep Brain Stimulation (DBS) of the nucleus accumbens (NAc) and ventral internal capsule (VC) for participants with treatment…
- Trial name
- NCT05903495
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- West Virginia University
Skin Lesion, Skin Cancer
Measurement of the Partial Pressure of Oxygen in Cutaneous Tumors Using Electron Paramagnetic Resonance (EPR) Oximetry
This protocol will take measurements of a variety of tumors involving the skin in order to assess changes in tumor oxygen from hyperoxygenation therapy and standard cancer-directed treatments, to demonstrate the clinical…
- Conditions
- Skin Lesion, Skin Cancer, Skin Melanoma, Tumor Skin
- Trial name
- NCT03716193
- Testing
- Oxygen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- West Virginia University
Bariatric Surgery Candidate
Xpan Non-Inferiority Study
A trocar is a surgical instrument with a sharp point and tube and is used to create endoscopic access in the abdomen or chest where endoscopic instruments can be entered \& used in minimally invasive surgical procedures.
- Trial name
- NCT07385690
- Testing
- Xpan Trocar System, Standard of Care (Non-expanding Trocar)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- West Virginia University
Breast Cancer, Fatigue
Lifting More Than Weights: Resistance Exercise Program Across Socioeconomic Groups for Cancer-Related Fatigue Management
The long-term goal of this project is to improve the implementation of tailored resistance exercise interventions for Appalachian breast cancer survivors.
- Trial name
- NCT06960720
- Testing
- Resistance Exercises
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- West Virginia University
Orthodontic Appliances
Orthodontic Pain Alleviation With Chewing Gum
The aim of this study is to determine whether chewing gum can alleviate orthodontic treatment discomfort and improve orthodontic treatment experience.
- Trial name
- NCT07210697
- Testing
- Xylitol Gum
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- West Virginia University