Clinical trials: sponsored by Western University, Canada
Osteoarthritis, Knee
HTO and Tranexamic Acid Study
The purpose of the study is to assess the effect of Tranexamic acid (TXa), a commonly used medication to prevent bleeding, in reducing blood loss during High Tibial Osteotomy (HTO).
- Trial name
- NCT07825350
- Testing
- Tranexamic Acid, Routine medial opening wedge high tibial osteotomy
- Volunteers
- 200 people
- Sponsor
- Western University, Canada
Stroke, Acute, Driving
Evaluating the Practice Resource for Driving After Stroke
After stroke, individuals must be assessed to determine if they can resume driving. Return to driving is very important to people who have experienced a stroke.
- Conditions
- Stroke, Acute, Driving, Occupational Therapy
- Trial name
- NCT06303765
- Testing
- Practice Resource for Driving After Stroke (PReDAS)
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Western University, Canada
Osteo Arthritis Knee, Osteoarthritis
The Technology, Exercise Programming, and Activity Prescription for Enhanced Mobility (TEAM) Study
Many individuals with osteoarthritis (OA) (up to 45%) are referred to an orthopaedic surgeon for a joint replacement prematurely or will not be candidates for surgery.
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Hip Arthritis
- Trial name
- TEAM (NCT04544904)
- Testing
- PAARx, JM
- Where
- Canada
- Volunteers
- 356 people
- Sponsor
- Western University, Canada
Femoral Acetabular Impingement
Labral Repair vs Reconstruction
The purpose of this pilot study is to determine feasibility of a randomized controlled trial comparing labral repair versus reconstruction in patients over 40 years of age undergoing hip arthroscopy for FAIS.
- Trial name
- NCT07608237
- Testing
- Labral Repair, Labral Reconstruction
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Western University, Canada
Coronary Artery Disease
Domain-specific Aerobic Exercise Training in Coronary Artery Disease
Exercise training in cardiac rehabilitation (rehab) is a key part of managing a patient with heart disease. It has been shown that cardiac patients who increase their aerobic ("cardio") fitness by exercise training live longer…
- Trial name
- DOSE-EX-CAD (NCT06143332)
- Testing
- Aerobic exercise training
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Western University, Canada
Osteoarthritis, Hip
Changes in Postural Stability Following THA for OA
Total hip arthroplasty (THA) is a common surgery that eases pain, restores functional movement, and improves the overall quality of life in people with severe hip osteoarthritis (OA).
- Trial name
- CPS (NCT06088160)
- Testing
- Total Hip Arthroplasty
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Western University, Canada
Creatine, Exercise
Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function…
- Conditions
- Creatine, Exercise, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06948149
- Testing
- Creatine monohydrate, Resistance training
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Western University, Canada
Type 2 Diabetes, Cognitive Decline in Older Adults
Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes
Type 2 diabetes and low levels of physical activity are associated with an increased risk of cognitive decline in older adults. Improving blood sugar control and engaging in regular exercise may help support brain health and…
- Trial name
- MOTIVATE (NCT07485062)
- Testing
- semaglutide, Moderate-Intensity Resistance Exercise, Balance and Tone (BAT) Exercise
- Where
- Canada
- Volunteers
- 164 people
- Sponsor
- Western University, Canada
Concussion, Mild
Cervicogenic Concussion Rehabilitation With TopSpin360
Concussions occur most frequently in adolescents and often result in significant disruption to daily living for prolonged periods of time.
- Trial name
- NCT04159298
- Testing
- Top Spin 360
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Western University, Canada
Osteoporosis, Osteoporotic Fracture
Post-osteoporotic Fracture Exercise Program
Those with osteoporosis often have weaker bones and this leads to higher chances of fractures. Therefore, the investigators want to evaluate the feasibility and safety of group exercise classes specifically designed for…
- Trial name
- NCT07595991
- Testing
- Exercise Program
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Hearing Loss, Sensorineural, Cochlear Implants
Place-based Cochlear Implant Mapping
The current standard of care approach for programming cochlear implants uses a generalized pitch-map for all patients. This approach fails to account for individualized inner ear anatomy.
- Trial name
- NCT05558514
- Testing
- Place-based cochlear implant mapping, Default cochlear implant mapping
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Western University, Canada
COPD (Chronic Obstructive Pulmonary Disease)
Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab
The goal of this study is to evaluate the effect of mepolizumab on patients with COPD using MRI and CT imaging as well as breathing tests.
- Trial name
- ADORE (NCT07749001)
- Testing
- Mepolizumab 100 MG Injection
- Volunteers
- 36 people
- Sponsor
- Western University, Canada
Asthma; Eosinophilic
REverse LuNg Airway and Vascular RemOdeling in Asthma ReMission (ReNORM)
In this program of research, the investigators aim to answer the question: In patients with asthma aged 18-80, how do the lung airways and vessels respond to biologic therapy and what role does age and asthma duration have in…
- Trial name
- ReNORM (NCT07174713)
- Testing
- Biologic Therapy
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Chronic Obstructive Pulmonary Disease (COPD)
129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With Moderate-severe Dyspnea and/or Poor Health Status With High or Low Risk of Exacerbation
The goal of this study is to study how 12-weeks daily (and optional 48-weeks) single inhaler triple therapy (fluticasone furoate (FF)-an inhaled corticosteroid; umeclidinium (UMEC)-a long-acting muscarinic antagonist; vilanterol…
- Trial name
- MUST (NCT07192016)
- Testing
- fluticasone furoate(FF)/umeclidinium (UMEC)/vilanterol(VI) (100/62.5/25) mcg
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Major Depression Severe
Oral and Sublingual Ketamine
Major Depressive Disorder (MDD) is one of the most common and severe mental illnesses in the world. Ketamine treatment, especially intravenous ketamine (IVK) and intranasal esketamine (INE), is becoming more popular and is being…
- Trial name
- NCT07683988
- Testing
- 75 mg of oral ketamine, Sublingual ketamine 75 mg
- Volunteers
- 10 people
- Sponsor
- Western University, Canada
Obesity, Chronic Kidney Disease
Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2
OK-TRANSPLANT 2 is a vanguard study for a large randomized, pragmatic, open-label trial. We will randomize participants with obesity, high-risk CKD/dialysis who are hoping for lose weight for the purpose of kidney transplant.
- Trial name
- NCT06396416
- Testing
- Semaglutide, Virtual Weight Management Coaching
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Organ Transplant
Confirming Permanent Lack of Blood Flow to the Brain During A-NRP DCC Organ Transplant
This study aims to evaluate the surgical technique used in Abdominal Normothermic Regional Perfusion (A-NRP) in death determination by circulatory criteria (DCC) organ donors.
- Trial name
- CONCLUDE (NCT05884736)
- Testing
- Neuromonitoring
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
LET, ACL Reconstruction
Long-term Follow up of the Stability 1 Trial
From 2014-2017, across 7 Canadian and 2 European sites, we randomized 618 patients at high-risk of re-injury, to anterior cruciate ligament reconstruction (ACLR) with or without a lateral extraarticular tenodesis (LET) and…
- Conditions
- LET, ACL Reconstruction, Osteoarthritis (OA) of the Knee
- Trial name
- STABILITY LTF (NCT06885372)
- Testing
- Lateral Extra-Articular Tenodesis (LET), ACL Reconstruction
- Where
- 8 sites in Canada, United Kingdom
- Volunteers
- 510 people
- Sponsor
- Western University, Canada
Shoulder Dislocation
Remplissage Versus Latarjet Coracoid Transfer for Recurrent Shoulder Instability
This is a pilot study designed as a prospective, randomized controlled trial comparing arthroscopic Bankart repair and Remplissage with an open Latarjet coracoid transfer for the treatment of recurrent anterior glenohumeral…
- Trial name
- NCT03453710
- Testing
- Bankart Repair plus Remplissage, Latarjet coracoid transfer
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
Hip Osteoarthritis
Hip Arthroscopy Versus Total Hip Arthroplasty RCT
The aim of the proposed study is to perform a comparative pilot, randomized controlled trial of hip arthroscopy versus definitive total hip arthroplasty (THA) for the treatment of early hip osteoarthritis (Tönnis Grade 1-2) in…
- Trial name
- NCT04166227
- Testing
- Hip Arthroscopy, Total Hip Arthroplasty
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- Western University, Canada