Clinical trials: sponsored by Xijing Hospital
Primary Biliary Cholangitis (PBC)
FIREFLY Trial: Fenofibrate Intervention---Randomized Evaluation in First-Line PBC Therapy
The goal of this clinical trial is to learn if the drug Fenofibrate works to treat adults with a liver disease called Primary Biliary Cholangitis (PBC) who have not received previous treatment.
- Trial name
- NCT07296458
- Testing
- Fenofibrate, UDCA (Ursodeoxycholic acid)
- Where
- 2 sites in China
- Volunteers
- 132 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Primary Biliary Cirrhosis
Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid
Ursodeoxycholic acid (UDCA) has been the only treatment for PBC approved by US and European drug administrations. Long-term use of UDCA(13-15 mg/kg/day) in patients with PBC improves serum liver biochemistries and survival free…
- Trial name
- NCT02823366
- Testing
- Fenofibrate, UDCA
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Primary Biliary Cholangitis
Fenofibrate in Patients With Primary Biliary Cholangitis (PBC)
An Open Label Long-Term Study to Evaluate the Safety and Effectiveness of Fenofibrate in Subjects with Primary Biliary Cholangitis (PBC)
- Trial name
- NCT06365424
- Testing
- Fenofibrate, UDCA
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Breast Cancer
Neoadjuvant Inetetamab and Pyrotinib and Nab-paclitaxel for HER2+Breast Cancer
Explore the efficacy and safety of the combination of inetetamab, pyrotinib and nab-paclitaxel in the neoadjuvant treatment of HER2 positive early or locally advanced breast cancer
- Trial name
- NCT05444998
- Testing
- Inetetamab, pyrotinib, nab-paclitaxel
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Homeostasis
Observational Study of Electrical Impedance Tomography for Non-Invasive Assessment of Cerebral Autoregulation in Neurocritical Patients
This is a single-center, prospective, observational, self-controlled clinical study conducted at the Neurosurgical Intensive Care Unit of Xijing Hospital, The First Affiliated Hospital of Air Force Military Medical University.
- Trial name
- NCT07602114
- Testing
- Non-invasive cerebral Electrical Impedance Tomography (EIT) monitoring
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Stomach Neoplasms, Immune Checkpoint Inhibitors
Efficacy and Safety of Serplulimab Combined With Chemotherapy as Neoadjuvant Treatment for Locally Advanced Gastric Cancer or Adenocarcinoma of Esophagogastric Junction
This is a multicenter, randomized, phase 2 trial to investigate the efficacy and safety of serlulimab combined with nab-paclitaxel plus SOX versus nab-paclitaxel plus SOX alone as neoadjuvant treatment for locally advanced GC or…
- Trial name
- NCT06576921
- Testing
- Serplulimab Combined With Chemotherapy
- Where
- 5 sites in China
- Volunteers
- 116 people
- Sponsor
- Xijing Hospital
Breast Cancer
Extended Sentinel Lymph Node Biopsy With Methylene Blue Single Tracer Post-Neoadjuvant Therapy for Node-Positive Breast Cancer
The goal of this clinical trial is to evaluate the safety and feasibility of methylene blue single tracer-based extensive sentinel lymph node biopsy (ESLNB) and provide evidence for simplifying surgical procedures on the basis of…
- Trial name
- NCT07532096
- Testing
- ESLNB
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Xijing Hospital
Locally Advanced Cervical Cancer
Iparomlimab/Tuvonralimab Combined With Nab-paclitaxel and Cisplatin as Neoadjuvant Therapy for Locally Advanced Cervical Cancer
The goal of this clinical trial is to learn if Iparomlimab/Tuvonralimab combined with nab-paclitaxel and cisplatin as neoadjuvant treatment can treat locally advanced cervical cancer in adult female patients.
- Trial name
- NCT07876154
- Testing
- Iparomlimab/Tuvonralimab, nab-paclitaxel, Cisplatin
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Xijing Hospital
Chronic Postoperative Pain
PANDORA: Paravertebral AdjuNctive DexamethasOne Palmitate Reducing Chronic Pain After Caridiac Surgery
The goal of this single-center, prospective, double-blind randomized controlled clinical trial is to explore preventive interventions for chronic postoperative pain (CPSP) in patients undergoing minimally invasive cardiac…
- Trial name
- NCT05920967
- Testing
- Dexamethasone Palmitate, Dexamethasone Sodium Phosphate
- Where
- China
- Volunteers
- 562 people
- Sponsor
- Xijing Hospital
Psoriasis, Psoriasis (PsO)
A Prospective, Interventional, Exploratory Study Evaluating the Efficacy of Small-Molecule Compound XJH05 Ointment in the Treatment of Plaque Psoriasis
Psoriasis is a chronic, recurrent, inflammatory, and systemic disease mediated by immunity, induced by a combination of genetic and environmental factors.
- Trial name
- NCT07780929
- Testing
- XJH05 ointment, Calcipotriol ointment
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Xijing Hospital
Functional Dyspepsia, Probiotics
Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia
Objective: This study aims to evaluate the effectiveness of Clostridium butyricum in improving anxiety and depression in patients diagnosed with functional dyspepsia according to the Rome IV criteria.
- Conditions
- Functional Dyspepsia, Probiotics, Depression, Anxiety
- Trial name
- NCT07182890
- Testing
- Clostridium butyricum
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Functional Dyspepsia, Probiotics
Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia
Objective: This study aims to evaluate the effectiveness of Bacillus coagulans in improving anxiety and depression in patients diagnosed with functional dyspepsia according to the Rome IV criteria.
- Conditions
- Functional Dyspepsia, Probiotics, Depression, Anxiety
- Trial name
- NCT07187492
- Testing
- Bacillus coagulans
- Where
- China
- Volunteers
- 181 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Breast Cancer (Early Breast Cancer)
A Study on the Treatment of Early Small Breast Cancer With Ultrasound-guided Vacuum-assisted Excision Combined With Surgery
The aim of this clinical trial is to assess the feasibility and safety of ultrasound-guided vacuum-assisted excision (VAE) in the treatment of early breast cancer with Tis (carcinoma in situ) or T1 (maximum tumor diameter ≤2cm)…
- Trial name
- NCT07071402
- Testing
- Ultrasound-guided vacuum-assisted excision combined with surgical treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Narcolepsy Type 1 (NT1)
Ofatumumab in Treatment-Refractory¬ Narcolepsy Type 1
The goal of this clinical trial is to learn if ofatumumab works to treat drug-Refractory¬ Narcolepsy Type 1. It will also learn about the safety of ofatumumab.
- Trial name
- NCT07871006
- Testing
- ofatumumab 20mg
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Major Depressive Disorder, Repetitive Transcranial Magnetic Stimulation
Individualized dlPFC-NAcc Modulation for Anhedonia in adMDD
This study evaluates a schedule of precise repetitive transcranial magnetic stimulation for depressive adolescent with anhedonia.
- Trial name
- NCT05544071
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Xijing Hospital
Locally Advanced Colorectal Cancer
Serplulimab Combined With CAPOX and Bevacizumab as Neoadjuvant Therapy for Locally Advanced Colorectal Cancer
This is an exploratory study to evaluate the efficacy and safety of neoadjuvant therapy with serplulimab combined with CAPOX and bevacizumab for patients with locally advanced colorectal cancer.
- Trial name
- NCT07819604
- Testing
- Serplulimab, CAPOX, Bevacizumab
- Volunteers
- 85 people
- Sponsor
- Xijing Hospital
Postoperative Delirium (POD), Diabetes
Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
The present study is a multicenter， randomized controlled clinical trial, which plans to enroll 450 diabetic patients aged more than 60 years.
- Trial name
- NCT06788743
- Testing
- TIVA ( anesthesia with propofol and remifentanil), VA（anesthesia with sevoflurane and remifentanil）
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Xijing Hospital
Postoperative Delirium, Preoperative Sleep Disorder
Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients
Delirium is a common consequence of cardiac surgery and associates with poor outcomes. Multiple causes can trigger delirium occurence, and it has been hypothesised that sleep disturbances can be one of them.
- Trial name
- DREAMS (NCT06619912)
- Testing
- Dexmedetomidine nasal spray
- Where
- China
- Volunteers
- 686 people
- Sponsor
- Xijing Hospital
Colorectal Polyps, Colorectal Adenomas
Optical Diagnosis With vs. Without Three-Dimensional Imaging for Small and Diminutive Colorectal Polyps
This study investigated whether adding a three-dimensional (3D) imaging view during colonoscopy helps doctors classify small colon polyps more accurately than standard colonoscopy without 3D.
- Trial name
- NCT06922877
- Testing
- Optical diagnosis based on JNET classification with WASP features (no 3D assistance), Optical diagnosis based on JNET classification with WASP features plus 3D imaging assistance
- Where
- China
- Volunteers
- 458 people
- Sponsor
- Xijing Hospital of Digestive Diseases
ST Elevation Myocardial Infarction (STEMI), Acute Coronary Syndromes (ACS)
A Single-Center, Retrospective, Propensity-Score-Matched Cohort Study Comparing Drug-Coated Balloon Versus Drug-Eluting Stent for Reducing Immediate Post-Procedural Slow-Flow/No-Reflow in Acute ST-Elevation Myocardial Infarction Patients With High Thrombus Burden
This is a single-center, retrospective, propensity-score-matched observational study. It aims to compare the rate of immediate slow-flow or no-reflow after percutaneous coronary intervention (PCI) between drug-coated balloon…
- Trial name
- STEMI-DCB (NCT07806370)
- Testing
- Drug-Coated Balloon (DCB), Drug-Eluting Stent (DES)
- Where
- China
- Volunteers
- 668 people
- Sponsor
- Xijing Hospital