Clinical trials: sponsored by Xijing Hospital
Spinocerebellar Ataxias
Efficacy of Cerebellar Transcranial Magnetic Stimulation to Treat Hereditary Spinocerebellar Ataxias
Spinocerebellar ataxia (SCA) is a type of autosomal dominant ataxia and there is currently no effective treatment. The goal of this clinical trial is to learn the efficacy of navigated iTBS (Intermittent theta-burst stimulation)…
- Trial name
- NCT06898645
- Testing
- navigated iTBS (Intermittent theta-burst stimulation) targeting the cerebellum
- Volunteers
- 80 people
- Sponsor
- Xijing Hospital
Aortic Stenosis
Videodensitometric Angiographic Assessment of AR in the Cath-lab for Intraprocedural Guidance of TAVI in CHINA
This clinical trial, a prospective, randomized, multicenter study, assigns patients to either videodensitometry-guided TAVI or conventional TTE/TEE-guided TAVI (stand of care), with the primary endpoint being regurgitation…
- Trial name
- NCT06891079
- Testing
- Videodensitometric guided, Stand of care guided
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- Xijing Hospital
Atrial Fibrillation, Percutaneous Coronary Intervention
LAAO Versus NOAC in Patients with AF and PCI
Atrial fibrillation (AF) coincides with coronary artery disease (CAD) shared common risk factors and pathophysiologic pathways. CAD affects approximately 25% of AF patient according to the trial Atrial Fibrillation Follow-up…
- Trial name
- NCT05353140
- Testing
- The WATCHMAN/WATCHMAN FLX device, Rivaroxaban + Clopidogre, Aspirin + Clopidogrel
- Where
- China
- Volunteers
- 1,386 people
- Sponsor
- Xijing Hospital
High-surgical Risk Patients with Severe Tricuspid Regurgitation
Characterization and Outcomes of Patients Screened for Transcatheter Tricuspid Valve Replacement
The TRI-RECRUIT Study was conducted of 340 consecutive patients for TTVR screening using LuX-Valve via the trans-jugular vein approach at seven cardiac centers.
- Trial name
- The TRI-RECRUI (NCT06862765)
- Testing
- transcatheter tricuspid valve replacement
- Where
- 8 sites in China
- Volunteers
- 340 people
- Sponsor
- Xijing Hospital
Parkinson's Syndrome
PET/MRI Artificial Intelligence Reconstruction Algorithm AIR Recon DL Image Quality Evaluation and Clinical Study
PET/MRI artificial intelligence reconstruction algorithm AIR Recon DL image quality evaluation and clinical study
- Trial name
- NCT06856096
- Testing
- PET/MRI
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Xijing Hospital
Healthy Volunteers
68Ga-Pentikra PET/CT Imaging Study in Healthy Subjects
This is a prospective, interventional clinical pilot study that recruited 10 normal volunteers who underwent 68Ga-Pentikra PET/CT imaging to evaluate the safety, biodistribution and radiation dosimetry of 68Ga-Pentikra in normal…
- Trial name
- NCT06856109
- Testing
- 68Ga-Pentikra PET/CT Scan
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Hematological Malignancies
A Study Evaluating the Value of 68Ga-Pentixafor PET Imaging in the Staging of Hematological Tumor, and Comparing It with 18F-FDG PET/CT Imaging
This is a prospective, open-label, single-center clinical study targeting hematological malignancies. 120 patients with a confirmed by pathology of non-Hodgkin's lymphoma or myeloma were included.
- Trial name
- NCT06834412
- Testing
- 68Ga-Pentixafor and 18F-FDG PET/CT Scan
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Brain Disease
18F-DPA-714 PET/MR in Dysfunctional Brain Diseases
This is a diagnostic pilot study that recruited 25 normal volunteers and 40 patients with dysfunctional brain diseases and performed 18F-DPA-714 PET/MR imaging to evaluate the correlation between the multimodal imaging features…
- Trial name
- NCT06851143
- Testing
- 18F-DPA-714 PET/MR scan
- Volunteers
- 65 people
- Sponsor
- Xijing Hospital
Depression, Transcranial Magnetic Stimulation
Precision Transcranial Magnetic Stimulation for Depression Based on Orbital Frontal Cortex-habenula Circuitry
Thirty depressed patients will be recruited to select individualized transcranial magnetic stimulation targets based on individual orbital frontal cortex and habenula functional activity connectivity for 10 or 20 treatments to…
- Trial name
- NCT06837207
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital
Chronic Coronary Syndrome, Acute Coronary Syndromes
Optimal LDL-C Target in High-risk Patients After PCI
Extensive evidence from epidemiological, genetic, and randomized controlled trials (RCTs) of lipid-lowering therapies has firmly established a causal relationship between low-density lipoprotein cholesterol (LDL-C) and…
- Conditions
- Chronic Coronary Syndrome, Acute Coronary Syndromes, Percutaneous Coronary Intervention, High Risk Patient
- Trial name
- REC-SAFETARGET (NCT06821711)
- Testing
- Intensive LDL-C control, Conventional LDL-C control
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Xijing Hospital
Heart Neoplasms
The Safety and Efficacy Evaluation of Echocardiography-guided Percutaneous Radiofrequency Ablation for Cardiac Tumors: a Single-arm, Prospective, Single-center Clinical Study
The safety and efficacy evaluation of echocardiography-guided percutaneous radiofrequency ablation (Liwen prcocedure) for cardiac tumors: a single-arm, prospective, single-center clinical study.
- Trial name
- NCT06830512
- Testing
- Echocardiography-guided percutaneous radiofrequency ablation for cardiac tumors
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Myocardial Infarction, Cerebral Infarction
Serum Adiponectin in Chinese Population and Its Correlation to Cardiovascular and Cerebrovascular Diseases
Adiponectin (Ad) is an abundant protein in human body, and reports have shown that it act as a novel risk factor for brain and heart ischemia injury.
- Trial name
- NCT01372800
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Hearing Loss, Bilateral or Unilateral
Reliability of a Portable Audiometric Device Based on Active Noise-Canceling Headphones for Clinical Hearing Assessment
Part One: Research Background Globally, approximately 500 million people suffer from disabling hearing loss, accounting for about 6.8% of the world's population. Hearing loss has emerged as a major global health issue.
- Trial name
- NCT06811610
- Testing
- Participants were tested for hearing using a new type of hearing detection device, Participants' hearing was tested using a new portable pure tone audiometry device
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Erectile Dysfunction, CTCAE
Clinical Study on the Role of Inflammatory Markers in Patients With Erectile Dysfunction
Project Title**: Clinical Study on the Role of Inflammatory Markers in Patients with Erectile Dysfunction Research Objective**: To explore the changes in the levels of inflammatory markers in patients with erectile dysfunction…
- Trial name
- NCT06798350
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Tumour of Epithelial Origin, 68Ga-MY6349
A Study to Evaluate the Diagnostic Efficacy of 68Ga- MY6349 PET/CT in Patients With Tumours
This is a study using an autocontrol approach, enrolling 40 patients with tumours of epithelial origin, who underwent 68Ga- MY6349 and 68Ga-PSMA/18F-FDG PET/CT imaging of patients with tumours of epithelial origin to compare the…
- Trial name
- NCT06770478
- Testing
- 68Ga-MY6349 PET/CT Scan
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
RCC, Renal Cell Cancer
A Study Evaluating the Value of 68Ga-NOTA-RCCB6 PET Imaging for Targeting CD70 in the Clinical Staging, Therapeutic Evaluation, and Restaging of Renal Cell Carcinoma, and Comparing It with 68Ga-PSMA PET/CT Imaging
This is a prospective, open-label, single-center clinical study targeting renal cell carcinoma. Sixty patients with a high clinical suspicion of renal cell carcinoma were included.
- Trial name
- NCT06769893
- Testing
- 68Ga-NOTA-RCCB6 PET/CT Scan
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Breast Cancer
A Randomized Controlled Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined with Systemic Therapy for Early-stage Breast Cancer
A total of 340 early-stage breast cancer patients with axillary lymph node biopsy-confirmed positivity were enrolled and divided into two groups.
- Trial name
- NCT06769919
- Testing
- Neoadjuvant radiotherapy
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xijing Hospital
COVID
Evaluation of Immunogenicity of COVID-19 Vaccine in Chinese Population
The purpose of this study is to evaluate the immunogenicity and immune protection of COVID-19, especially the recently prevalent strains, against the background of current immunization in Chinese population
- Trial name
- NCT06763887
- Testing
- No Interventions
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Bladder Cancer, Prostate Cancer
Study on the Efficacy and Mechanism of METTL3 Peptide Inhibitors in Enhancing Anti-tumor Immune Response by Reshaping the Tumor Microenvironment
This study aims to validate the accuracy and clinical value of METTL3 as a biomarker for predicting immune therapy response in patients with urinary tract tumors through observational studies.
- Conditions
- Bladder Cancer, Prostate Cancer, Kidney Cancer
- Trial name
- NCT06762925
- Testing
- No Interventions
- Volunteers
- 450 people
- Sponsor
- Xijing Hospital
Immune-related Adverse Event, Neoadjuvant Therapy
Exploring the Treatment Duration of PD-1 Neoadjuvant Therapy in Stage II-III dMMR Rectal Cancer
This study aims to explore the optimal number of cycles of PD-1 monotherapy required at minimum, under the premise of ensuring pathological complete response (pCR) among patients with dMMR/MSI-H rectal cancer.
- Conditions
- Immune-related Adverse Event, Neoadjuvant Therapy, dMMR Colorectal Cancer
- Trial name
- NCT06613165
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital