Clinical trials: sponsored by Xijing Hospital
Coronary Artery Disease, Percutaneous Coronary Intervention
Comparing the Components of Composite Endpoints for Healthcare Providers and Patients
Clinical trials often employ a composite primary endpoint to increase event rates and enhance trial efficiency. However, analytic approaches to composite endpoints typically assume that the individual components are of similar…
- Trial name
- REC-CHARTENDS (NCT07378137)
- Testing
- Questionnaire
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Xijing Hospital
Breast Cancer, Breast Reconstruction After Mastectomy
Study on the Cosmetic Outcome and Safety Evaluation of 3D Printed Biodegradable Biological Mesh for One-Stage Breast Reconstruction After Radical Mastectomy
Primary objective of this trial: To evaluate the clinical performance (aesthetic outcome and quality of life) and safety of a 3D-printed biodegradable biological mesh in post-mastectomy immediate breast reconstruction.
- Conditions
- Breast Cancer, Breast Reconstruction After Mastectomy, 3D-Printed Biodegradable Biological Mesh
- Trial name
- NCT07365267
- Testing
- Implantation of a silicone breast prosthesis combined with a 3D-printed biodegradable mesh
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease
Safety and Efficacy of Meplazumab in Patients With Coronary Artery Disease
The development of coronary atherosclerosis is closely related to inflammation, and CD147 may play an important role in its process.
- Trial name
- REC-SAFECAD (NCT06572267)
- Testing
- Mepolizumab low dose group, Mepolizumab middle dose group, Mepolizumab high dose group
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Xijing Hospital
Severe Stroke, Enteral Nutrition
Effect of Intermittent Enteral Feeding in Severe Stroke
This is a single-center, randomized, exploratory clinical trial investigating whether intermittent enteral feeding improves outcomes compared to continuous feeding in patients with severe stroke.
- Trial name
- NCT07353658
- Testing
- Intermittent Enteral Feeding, Continuous Enteral Feeding
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Rebleeding of Portal Hypertension in Liver Cirrhosis, Propranolol
Carvedilol vs. Propranolol for Preventing Rebleeding After Endoscopic Treatment of Cirrhotic Varices
Cirrhosis is a serious liver disease where scar tissue replaces healthy liver tissue, often leading to portal hypertension-a condition where blood pressure in the liver's blood vessels rises.
- Conditions
- Rebleeding of Portal Hypertension in Liver Cirrhosis, Propranolol, Carvedilol
- Trial name
- NCT07352228
- Testing
- Propranolol, Carvedilol
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Xijing Hospital
Gastrointestinal Submucosal Tumors
Evaluation of Short-term and Long-term Efficacy of Endoscopic Treatment for Gastrointestinal Submucosal Tumors
This study aims to comprehensively assess how well endoscopic treatments work for gastrointestinal submucosal tumors (SMTs)-both in the short term right after treatment and over the long run-and to figure out what factors might…
- Trial name
- NCT07353346
- Volunteers
- 700 people
- Sponsor
- Xijing Hospital
Refractory Constipation
Optimization of taVNS Intervention Strategies for Refractory Constipation
The goal of this clinical trial is to learn whether transcutaneous auricular vagus nerve stimulation (taVNS) works to treat refractory constipation in adults. It will also learn about the safety and tolerability of taVNS.
- Trial name
- NCT07344402
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Vitiligo, Halo Nevus
Nevus Removal vs. Conservative Treatment in Halo Nevus With Vitiligo: A Randomized Study
This clinical trial aims to compare the efficacy and safety of central nevus removal versus conservative treatment in patients with halo nevus accompanied by non-segmental vitiligo.
- Trial name
- NCT07307534
- Testing
- Central Nevus Excision, The Standardized Medication Regimen
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Brest Cancer
Neratinib Combined With Fulvestrant and Eribulin in the Treatment ofHR+/HER2+ Advanced Breast Cancer
This study aims to explore the efficacy and safety of neratinib combined with fulvestrant and eribulin in the treatment of HR+/HER2+ advanced breast cancer after trastuzumab deruxtecan resistance.
- Trial name
- NETHER (NCT07333937)
- Testing
- Neratinib Combined with Fulvestrant and Eribulin
- Volunteers
- 35 people
- Sponsor
- Xijing Hospital
Functional Constipation (FC), Somatic Symptom Disorder (DSM-5)
Transcranial Alternating Current Stimulation for Refractory Constipation With Somatic Symptom Disorder
The purpose of this randomized, double-blind, placebo-controlled trial is to evaluate the efficacy and safety of transcranial alternating current stimulation (tACS) in adults with refractory functional constipation comorbid with…
- Conditions
- Functional Constipation (FC), Somatic Symptom Disorder (DSM-5), Refractory Constipation
- Trial name
- RELIEF-tACS (NCT07323407)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Primary Biliary Cholangitis (PBC)
Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cholangitis: a Real World Study
An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Fenofibrate in Combination with Ursodeoxycholic Acid in Subjects with Primary Biliary Cholangitis (PBC)
- Trial name
- NCT06755541
- Testing
- Fenofibrate in Combination With Ursodeoxycholic Acid
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Primary Biliary Cholangitis
Fenofibrate for Compensated Cirrhosis Patients With Primary Biliary Cholangitis
The main objectives of the study were to assess the effects of fenofibrate on serum alkaline phosphatase, as a composite endpoint and on safety in participants with primary biliary cholangitis (PBC).
- Trial name
- NCT05749822
- Testing
- Fenofibrate 200mg, UDCA
- Where
- 12 sites in China
- Volunteers
- 104 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Primary Biliary Cholangitis
Fenofibrate Combined With Ursodeoxycholic Acid in Subjects With Primary Biliary Cholangitis
Current treatment guidelines recommend ursodeoxycholic acid (UDCA) as the first-line treatment for new-diagnosed primary biliary cholangitis (PBC) patients.
- Trial name
- NCT05751967
- Testing
- Fenofibrate Combined With Ursodeoxycholic Acid
- Where
- 7 sites in China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Primary Biliary Cholangitis (PBC)
Fenofibrate in Primary Biliary Cholangitis: a Real World Study
An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Fenofibrate in Combination with Ursodeoxycholic Acid in Subjects with Primary Biliary Cholangitis (PBC)
- Trial name
- NCT06755151
- Testing
- Fenofibrate
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Colitis, Ulcerative, Sleep Quality
Clinical Characteristics of Sleep Disorders in Patients With Ulcerative Colitis
Ulcerative colitis(UC) is one of the two main forms of inflammatory bowel disease(IBD), which seriously affects the quality of life of patients.
- Conditions
- Colitis, Ulcerative, Sleep Quality, Gastrointestinal Microbiome, Autonomic Nervous System Imbalance
- Trial name
- NCT06359808
- Where
- China
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Vitiligo
Building an Assessment Model for Vitiligo Activity and Prognosis Using Peripheral Blood Cytokine Profiles
Vitiligo is a chronic autoimmune disorder characterized by depigmented patches on the skin, which can pose significant psychosocial challenges, particularly for individuals with darker skin tones.
- Trial name
- NCT07298551
- Testing
- Serum Cytokine Assay
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Gastric/Gastroesophageal Junction Adenocarcinoma
Zanidatamab Combined With Chemotherapy as Neoadjuvant Therapy for HER2-high Expression G/GEJC
HER2 overexpression is observed in approximately 20% of gastric cancers and gastroesophageal junction (GEJ) cancers, making it a validated target for anti-tumor therapy .
- Trial name
- NCT07273981
- Testing
- Zanidatamab Combined with Chemotherapy
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital
Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus
Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery
This study is a clinical research project conducted at Xijing Hospital to compare the effects of two different neuromuscular blockade reversal strategies on the recovery of gastrointestinal (GI) function after colorectal surgery.
- Conditions
- Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus, Colorectal Surgery
- Trial name
- NCT07271875
- Testing
- Neostigmine + Atropine, Sugammadex
- Volunteers
- 560 people
- Sponsor
- Xijing Hospital
Palmoplantar Pustulosis (PPP)
A Prospective, Single-arm, Open-label Clinical Trial to Evaluate the Efficacy and Safety of Ivarmacitinib in the Treatment of Palmoplantar Pustulosis
What's the problem? Palmoplantar pustulosis (PPP) is a long-term skin condition that mainly affects the palms of hands and soles of feet.
- Trial name
- NCT07270003
- Testing
- Ivarmacitinib
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Ulcerative Colitis
Exploratory Clinical Trial of Safety and Efficacy of Sacral Nerve Stimulation in Patients With Ulcerative Colitis.
Although the incidence of inflammatory bowel disease is stable in North American and European countries, the incidence of inflammatory bowel disease is increasing in newly industrialized countries, especially in China.
- Trial name
- NCT05895981
- Testing
- G132 system, Beijing PINS Medical Co., China
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Xijing Hospital