Clinical trials: sponsored by Xijing Hospital
Breast Reconstruction, Breast Cancer
Safety Study of 3D Printing Personalized Biodegradable Implant for Breast Reconstruction
Scope of tumor resection was simulated according to the MR imaging data. After meticulous design, the investigators created the personalized porous biodegradable scaffold and printed by 3D printer, using porous PCL biomaterials.
- Trial name
- NCT03348293
- Testing
- 3D printing
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital
Breast Cancer Metastatic
Zoledronic Acid Combined With EC-T for Triple-Negative Breast Cancer
Exploring the efficacy and safety of zoledronic acid combined with neoadjuvant chemotherapy (EC-T) in neoadjuvant treatment for early-stage or locally advanced triple-negative breast cancer, the trial protocol of zoledronic acid…
- Trial name
- NCT06876636
- Testing
- Zoledronic Acid Combined with Neoadjuvant Chemotherapy (EC-T)
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Xijing Hospital
Triple -Negative Breast Cancer
Sacituzumab Tirumotecan in Neoadjuvant Treatment of Early-Stage TNBC
To explore the application of Sacituzumab Tirumotecan in neoadjuvant treatment of early-stage TNBC, a multicenter, Phase II clinical study of Sacituzumab Tirumotecan in neoadjuvant treatment of early-stage TNBC is proposed.
- Trial name
- NCT07007780
- Testing
- Sacituzumab Tirumotecan
- Volunteers
- 35 people
- Sponsor
- Xijing Hospital
Hypertension
Effect of a Pharmacist-led Multifaceted Intervention on Treatment Outcomes in Hypertensive Patients
The objective of this cluster randomized controlled trial is to evaluate the effectiveness of a pharmacist-led multifaceted intensive blood pressure intervention on poorly controlled hypertensive patients in phase 1 (1 month, 3…
- Trial name
- NCT06558877
- Testing
- pharmacist-led multifaceted intervention, conventional health education
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Xijing Hospital
Constipation - Functional, Refractory Constipation
Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients.
- Conditions
- Constipation - Functional, Refractory Constipation, Fluoxetine, fMRI
- Trial name
- NCT06221722
- Testing
- BOLD-fMRI, Regular treatment of functional constipation, fluoxetine
- Where
- 3 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Pulmonary Arterial Hypertension (PAH)
Long-term Survival and Influencing Factors of Patients With Pulmonary Arterial Hypertension and Diabetes
This is a multicenter retrospective cohort study on pulmonary arterial hypertension. It is expected to collect data from no less than 5,000 patients to compare the long-term overall survival of patients with and without diabetes…
- Trial name
- NCT07082933
- Testing
- Standard medical treatment
- Volunteers
- 5,000 people
- Sponsor
- Xijing Hospital
Epilepsy
Temporal Interference for Temporal Lobe Epilepsy Under SEEG
This study evaluates the effect of temporal interference (TI) stimulation on biomarkers in patients with temporal lobe epilepsy (TLE) under stereo-electroencephalography (SEEG), and provides theoretical basis for non-invasive TI…
- Trial name
- TITE-SEEG (NCT07082101)
- Testing
- temporal interference
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
Symptomatic Cervical Disc Disease
Exploratory Study of 3D Printed Biodegradable Cervical Interbody Fusion Cage
A small sample, single center, non-randomized, noninferiority clinical trial to evaluate the safety and effectiveness of 3D printed biodegradable cervical interbody fusion cage in anterior cervical discectomy and fusion (ACDF)…
- Trial name
- NCT04167878
- Testing
- 3D printed biodegradable cervical fusion cage, PEEK cage
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
Gastric Cancer
Application of Serum Bile Acid Profile in the Diagnosis of Gastric Cancer
In this study, the composition and level of serum bile acids in patients with gastric cancer and non-gastric cancer were analyzed by detecting the serum bile acid profile, so as to develop new serological diagnostic methods for…
- Trial name
- NCT06031779
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection Chronic Gastrit
Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment
The purpose of this study was to evaluate the efficacy and safety of tegoprazan and minocycline dual therapy for Helicobacter pylori initial treatment.
- Trial name
- NCT06523764
- Testing
- tegoprazan, Minocycline, bismuth potassium citrate
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Radiation Enteritis
Associations of Fecal Bile Acid Profile and Intestinal Flora With Chronic Radiation Enteritis
To explore the fecal bile acid profile of patients with radiation enteritis, to clarify the types of bile acids that are closely related to the occurrence of radiation enteritis; to explore the interaction between fecal bile…
- Trial name
- NCT05728060
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Gastritis, Dyspepsia
Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology
This study was conducted to investigate the effects of high-dose diphtherapy and bismuth quadruple therapy on H. pylori eradication on intestinal microecology, to clarify the changes in intestinal microbiota diversity and…
- Conditions
- Gastritis, Dyspepsia, Helicobacter Pylori Infection, Gastric Cancer
- Trial name
- NCT05742568
- Testing
- Esomeprazole, Amoxicillin, Bismuth
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori
Effect of Oral Helicobacter Pylori Infection on the Efficacy of Gastroluminal Helicobacter Pylori Eradication Therapy
The aim of this study is to assess the effect of oral Helicobacter pylori infection on the efficacy of gastric Helicobacter pylori infection eradication.
- Trial name
- NCT05790525
- Testing
- Standard bismuth quadruple
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection, Chronic Gastritis
Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication
The purpose of this study was to evaluate the efficacy and safety of the triple therapy of berberine hydrochloride, vonorasan and amoxicillin for the primary eradication of Helicobacter pylori.It is hypothesized that berberine…
- Trial name
- NCT06514274
- Testing
- Berberine, Vonoprazan, Amoxicillin
- Where
- China
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Ulcerative Colitis (UC)
Selection and Efficacy-Influencing Factors of First-Line Biologic Agents in Moderate-to-Severe Ulcerative Colitis
The purpose of this prospective, multicenter, real-world study is to compare the efficacy differences and influencing factors of different first-line biologics in patients with moderate to severe ulcerative colitis.
- Trial name
- NCT06962020
- Testing
- first-line biologic：IFX, first-line biologic:VDZ
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Acute Ischemic Stroke (AIS), Endovascular Thrombectomy
Exploration and Establishment of an Early Warning System for Futile Reperfusion - A I S
The goal of this prospective cohort registration study is to establish an early warning system for futile recanalization in acute ischemic stroke by analyzing multi-omics information to identify key regulatory nodes and target…
- Conditions
- Acute Ischemic Stroke (AIS), Endovascular Thrombectomy, Neurovascular Unit- Brain Lymphatic System
- Trial name
- NCT07045987
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xijing Hospital
Drug Resistant Epilepsy, Magnetic Resonance Imaging
Exploring the Characteristics of Epileptogenic Foci in Drug-Resistant Epilepsy Based on Multimodal Imaging Technology
Using multimodal imaging technology, this study aims to explore the characteristics of epileptogenic foci in patients with drug-resistant epilepsy and identify key network nodes (such as central nodes) to provide more assistance…
- Conditions
- Drug Resistant Epilepsy, Magnetic Resonance Imaging, Electroencephalogram (EEG)
- Trial name
- NCT06557720
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xijing Hospital
Vitiligo, Child
Oral Tacrolimus vs Dexamethasone Micro-pulse Therapy in Pediatric Rapidly Progressing Vitiligo: A Multicenter RCT
This clinical study aims to compare the safety and effectiveness of two treatments-oral Tacrolimus capsules and Dexamethasone micro-pulse therapy-in children aged 4-12 years with rapidly progressing vitiligo.
- Conditions
- Vitiligo, Child, Progressive Disease
- Trial name
- NCT06900777
- Testing
- Tacrolimus, Dexamethasone
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Inflammatory Bowel Diseases (IBD)
Evaluating the Effectiveness of 68Ga-grazytracer PET/CT in Inflammatory Bowel Disease
This is a single-centre, prospective, observational cohort study in which 69 patients with inflammatory bowel disease (IBD) were recruited to undergo 68Ga-grazytracer PET/CT imaging in patients with IBD to investigate the…
- Trial name
- NCT07022080
- Testing
- 68Ga-grazytracer PET/CT Scan
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Xijing Hospital
Pancreatic Ductal Adenocarcinoma (PDAC), Adenocarcinoma of the Stomach
Therapeutic Study of 177Lu-CTR-FAPI in Advanced Metastatic Digestive Malignancies
This was a single-centre, single-arm, non-blinded, prospective study using 20 patients with advanced metastatic GI malignancies recruited to treat patients with advanced metastatic GI malignancies with 177Lu-CTR-FAPI to assess…
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Adenocarcinoma of the Stomach, Colorectal Cancer Metastatic, Neuroendocrine Tumor (NET)
- Trial name
- NCT07014254
- Testing
- 177Lu-CTR-FAPI nuclide-targeted therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital