Clinical trials: sponsored by Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke
This study aims to test whether transcranial temporal interference stimulation (tTIs) can improve upper limb motor function in patients in the early subacute stage after acute ischemic stroke.
- Trial name
- TIMES (NCT07896629)
- Testing
- Transcranial Temporal Interference Stimulation (tTIs)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Degenerative Lumbar Disease
Comparing Lumbar Fusion With and Without Stress Endplate Augmentation in Patients With Low Bone Mass
Degenerative lumbar disease can cause back pain, leg pain, and difficulty with daily activities. Some patients require lumbar fusion surgery.
- Trial name
- NCT07891663
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Small Vessel Disease, Vascular Cognitive Impairment
Personalized Intermittent Theta Burst Stimulation for Cognitive Impairment Related to Cerebral Small Vessel Disease
This study will evaluate whether personalized intermittent theta burst stimulation (iTBS), a form of noninvasive transcranial magnetic stimulation, can safely improve cognitive function in people with cognitive impairment related…
- Trial name
- NCT07891650
- Testing
- Active Personalized Intermittent Theta Burst Stimulation
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Prehospital Response and Emergency Stroke Transport Optimisation
This study aims to develop and evaluate an innovative prehospital emergency transport system for patients with acute ischemic stroke to reduce delays in reperfusion treatment.
- Trial name
- PRESTO (NCT07892053)
- Testing
- Innovative pre-hospital emergency transport system for acute ischemic stroke
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Xuanwu Hospital, Beijing
Degenerative Scoliosis
Scoliosis Treatment: Evaluating Patient Suitability
Degenerative scoliosis can cause back pain, leg pain, difficulty walking, and impaired daily functioning. When spinal fusion is required, choosing the appropriate fusion extent remains challenging.
- Trial name
- STEPS (NCT07891676)
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Atlantoaxial Dislocation
Trial for Surgical Treatment of Reducible Atlantoaxial Dislocation
The management of reducible atlantoaxial dislocation associated is challenging. Direct posterior distraction technique we proposed in 2010 could achieve satisfactory reduction.
- Trial name
- NCT06003491
- Testing
- Intra-articular Cages
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracerebral Hemorrhage
TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage
TIME-ICH (TrIal of early Minimally Invasive catheter Evacuation with thrombolysis in IntraCerebral Hemorrhage) is a multicenter, randomized, adaptive clinical trial comparing best medical management to early minimally invasive…
- Trial name
- TIME-ICH (NCT07187687)
- Testing
- Early Minimally Invasive Surgery with Thrombolysis (eMIST)
- Where
- 70 sites in China
- Volunteers
- 750 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Early Administration of Angong Niuhuang Pill for Disabling Acute Ischemic Stroke (EAGER Trial)
This multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial is designed to evaluate the efficacy and safety of early administration of Angong Niuhuang Pill in patients with disabling acute ischemic…
- Trial name
- EAGER (NCT07882030)
- Testing
- Angong Niuhuang Pill
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Xuanwu Hospital, Beijing
Mild Cognitive Impairment (MCI)
A Prospective Cohort Study of Multimodal Biomarkers and Progression From Mild Cognitive Impairment to Dementia
This prospective, longitudinal observational cohort study will examine clinical, cognitive, blood-based, and neuroimaging features across the cognitive continuum.
- Trial name
- NCT07876570
- Testing
- Observational Multimodal Assessment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Lumbar Disc Herniation, Lumbar Spinal Stenosis
Nurse-Led Early Standing Exercise After Lumbar Fusion in Older Adults
This single-center, randomized controlled trial aimed to evaluate the effects of a nurse-led early standing active exercise program on postoperative functional recovery in older adults undergoing short-segment lumbar fusion.
- Conditions
- Lumbar Disc Herniation, Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Degenerative Lumbar Scoliosis
- Trial name
- NCT07870993
- Testing
- Nurse-Led Early Standing Active Exercise Program, Routine Postoperative Rehabilitation
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Xuanwu Hospital, Beijing
CDKL5 Deficiency Disorder
Efficacy and Safety Evaluation of Hyperthermic Baths in the Treatment of Seizures in CDKL5 Deficiency Disorder
The primary objective of this research is to study the efficacy and safety of hyperthermic baths as adjunctive therapy for reducing the frequency of seizures in CDKL5 deficiency.
- Trial name
- NCT06447675
- Testing
- Hyperthermic Baths
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke, Cancer
A Prospective Study to Observe Clinical Outcomes in Patients Receiving Antiplatelet or Anticoagulant Therapy for Cancer-Associated Acute Ischemic Stroke
The goal of this observational study is to learn about the effectiveness and safety of antiplatelet and anticoagulant treatments in people with a history of cancer who have acute ischemic stroke.
- Trial name
- NCT07845903
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Blood Pressure Control, Hypertension
Direct Electrical Stimulation of Central Autonomic Network for Blood Pressure Control: a Mechanism Study
The primary objective of this research is to study direct electrical stimulation of central autonomic network for blood pressure control.
- Trial name
- NCT07844239
- Testing
- direct electrical stimulation
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Artery Stenosis (Symptomatic and Asymptomatic)
CEST-PROTECT: Proximal Flow Control With a Balloon Guide Catheter Plus Distal Embolic Protection: a Randomised, Open-label Trial Evaluating Cerebral Protection Techniques
This randomized controlled trial aims to evaluate whether a proximal-distal dual cerebral protection strategy can reduce the occurrence of new cerebral ischemic lesions compared with a single cerebral protection strategy in…
- Trial name
- CEST-PROTECT (NCT07841132)
- Testing
- BGC proximal flow control plus distal filter embolic protection device during carotid artery stenting, Single distal filter embolic protection device during carotid artery stenting
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Rehabilitation
Neuromodulation for Functional Recovery After Stroke
This study used a multicenter, double-blind, randomized controlled design. The trial protocol was jointly designed by the principal investigator and an executive committee composed of experts in functional neurosurgery…
- Conditions
- Stroke, Rehabilitation, Vagus Nerve Stimulations
- Trial name
- VNS-EARLY (NCT07841431)
- Testing
- active VNS (0.8 mA), Control VNS (0.0 mA)
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Frailty at Older Adults, Sarcopenia
A Clinical Study on the Improvement of Frailty and Sarcopenia in Elderly Community Residents Through Pulsed Electromagnetic Field Therapy
The entire clinical study will be conducted strictly following the following procedure: 1) Informed Consent If you decide to participate in this trial, we will first ensure that you fully understand the research purpose…
- Trial name
- NCT07834697
- Testing
- Standard treatment with pulsed magnetic therapy apparatus, Fake stimulation therapy with pulse magnetic therapy device
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Neurodegenerative Disease, Dementia
Cognition and Affective Research in China
This is a prospective cohort study of patients with cognitive impairment mood disorders and behavioral disorders. Comprehensive baseline and longitudinal follow-up assessments include clinical and epidemiological data, cognitive…
- Conditions
- Neurodegenerative Disease, Dementia, Alzheimer's Disease, Parkinson's Disease
- Trial name
- CARE (NCT07833267)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Subarachnoid Hemorrhage, Traumatic
Osmotic Therapy for Patients With Severe Subarachnoid Hemorrhage
The goal of this prospective multi-center observational study is to learn about the osmotic therapy in severe subarachnoid hemorrhage (SAH).
- Trial name
- OSMO-SAH (NCT05858060)
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Vertebral Artery Stenosis
Drug-eluting Stenting Versus Medical Treatment for Extracranial Vertebral Artery Stenosis
Posterior circulation stroke accounts for 20% of all ischemic stroke. Approximately one quarter of posterior circulation strokes are due to stenosis in the vertebral artery and basilar artery.
- Trial name
- VISTA (NCT05885932)
- Testing
- Drug-eluting stenting plus aspirin and clopidogrel or ticagrelor, Aspirin and clopidogrel or ticagrelor, mono anti-platelet therapy
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Endarterectomy, Carotid Stenting
Carotid Endarterectomy and Stenting Timing
To compare the safety and efficacy of carotid revascularization performed within 48 hours versus after 14 days in patients with symptomatic carotid stenosis accompanied with MRI-confirmed acute infarction (high signal on…
- Trial name
- CEST (NCT06898151)
- Testing
- CEA/CAS plus best medical treatment
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Xuanwu Hospital, Beijing