Clinical trials: sponsored by Xuanwu Hospital, Beijing
Intracerebral Hemorrhage
Dimethyl Fumarate for the Treatment of Intracerebral Hemorrhage
The investigators conduct this study to investigate whether oral administration of Dimethyl Fumarate, a Food and Drug Administration-approved drug for multiple sclerosis, is safe and effective in alleviating PHE and neurologic…
- Trial name
- NCT04890379
- Testing
- Dimethyl fumarate
- Where
- China
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Arterial Disease
Treatment of Complex Femoropopliteal Artery Lesions Using Drug-coated PTA Balloon
Although DCBs had been widely applicable after registration, there are still lack of clinical data and evidence in the real world condition of Chinese population.
- Trial name
- NCT05616520
- Testing
- drug-coated balloon
- Where
- China
- Volunteers
- 838 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Artery Stenosis, Carotid Artery Stent
Prediction of Hyperperfusion After Carotid Stenting by Multi-parameter Characteristics Based on Cerebral Autoregulation
Cerebral hyperperfusion syndrome (CHS) is one of the severe complication after carotid artery stenting with a high mortality rate.
- Conditions
- Cerebral Artery Stenosis, Carotid Artery Stent, Dynamic Cerebral Autoregulation
- Trial name
- HACASS (NCT06058676)
- Testing
- carotid artery stenting
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Adjacent Segment Degeneration
Extended One-level Interbody Fusion for Adjacent Vacuum Phenomenon in Lumbar Degenerative Disc Disease
The main objective of this study was to validate the clinical effectiveness of interbody fusion with a one-segment extension for the treatment of adjacent segmental space discs in the surgical treatment of lumbar degeneration.
- Trial name
- NCT06029764
- Testing
- extended one-level interbody fusion
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Xuanwu Hospital, Beijing
Cervical Spondylosis
Impact of Lateral Bone Grafting With Intraoperative Fusion in ACDF on Clinical Outcomes
The purpose of this trial was to investigate the safety and efficacy of fuser lateral bone grafting in ACDF. By observing the intervertebral bony fusion rate and clinical outcome scores of patients after fusion device lateral…
- Trial name
- NCT06027827
- Testing
- Addition of fusion device lateral bone graft
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Effectiveness and Safety of Edaravone Dexborneol in Acute Ischemic Stroke
This study is a multicenter, prospective, cohort study to observe the clinical efficacy and safety of edaravone dextrol in patients with acute ischemic stroke in a real-world setting.
- Trial name
- EXPAND (NCT05644223)
- Testing
- edaravone dexborneol
- Where
- China
- Volunteers
- 4,750 people
- Sponsor
- Xuanwu Hospital, Beijing
Infrapopliteal Artery Occlusive Disease, Endovascular Treatment
Results of Endovascular Treatment for Infrapopliteal Arterial Occlusive Disease.
This study is a prospective, multi-center observational study, which evaluates the effectiveness and safety of endovascular therapy in the real world for infrapopliteal arterial occlusive disease from intermittent claudication to…
- Trial name
- NCT06009146
- Testing
- Endovascular treatment
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Atlantoaxial Dislocation
A Prospective Cohort Study of for Surgical Treatment of Irreducible Atlantoaxial Dislocation
The management of irreducible atlantoaxial dislocation associated is challenging. Direct posterior distraction technique we proposed in 2010 could achieve satisfactory reduction.
- Trial name
- NCT05978375
- Testing
- Posterior intra-articular distraction and fusion, Anterior transoral release and posterior cantilever reduction and fusion, TARP
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Arterial Disease
Constrained Balloon Combined With Drug-coated Balloon Angioplasty for Femoropopliteal Lesion
This study will assess the safety and efficacy of Chocolate balloons as a combination with drug-coated balloons in the treatment of popliteal artery lesions in lower limb atherosclerotic occlusive disease and will compare them…
- Trial name
- NCT05894460
- Testing
- Chocolate balloon
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease, Electric Stimulation Therapy
Clinical Exploratory Research of Medial Prefrontal Cortex Combined With Dorsolateral Prefrontal Cortex Electrical Stimulation in the Treatment of Alzheimer's Disease
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by progressive cognitive impairment and memory impairment, and is also a major cause of global dementia, characterized by progressive decline in memory…
- Trial name
- CBS-m/dlPFC-AD (NCT05971030)
- Testing
- Cortical brain stimulation of mPFC and dlPFC
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease
Combined Aerobic Exercise and Cognitive Training in Seniors at Increased Risk for Alzheimer's Disease
The study aims to investigate the effect of a long-term combined aerobic exercise and cognitive training program on cognitive function and blood exosomal synaptic protein levels in seniors at increased risk for Alzheimer's…
- Trial name
- NCT05163626
- Testing
- Combined aerobic exercise and cognitive training program
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease
Combined Aerobic Exercise and Cognitive Training in Seniors With Genetic Susceptibility for Alzheimer's Disease
The study aims to investigate the effect of a long-term combined aerobic exercise and cognitive training program on cognitive function, daily function, psychosocial status, and neural plasticity in seniors with genetic…
- Trial name
- NCT05163067
- Testing
- Combined aerobic exercise and cognitive training program
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Chordoma of Spine, Surgery
A Prospective Study of Surgical Treatment Strategies for Chordoma
Chordoma is a rare but locally invasive cancer that arises from the embryonic notochord. Total resection is challenging in mobile spine because of the complex anatomy and bone invasion.
- Trial name
- NCT05707767
- Testing
- Resection surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Basilar Invagination, Prospective Study
A Prospective Study of Surgical Treatment Strategies for Goal B Type Basilar Invagination
The etiology of Goal B type basilar invagination (BI) is still not clear, and it may be related to platybasia and short slope. There is no unified standard surgical strategy for Goal B type BI, and different surgical strategies…
- Conditions
- Basilar Invagination, Prospective Study, Surgical Outcome
- Trial name
- NCT05849363
- Testing
- Posterior fossa decompression, Posterior Compression-Distraction-Reduction-Fixation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Amnestic Mild Cognitive Impairment
COG-REAGENT: COGnitive tRaining in patiEnts With Amnestic Mild coGnitive impairmENT
This study evaluates the efficacy and mechanism of internet-based cognitive training in patients with amnestic mild cognitive impairment (aMCI).
- Trial name
- NCT04063956
- Testing
- multi-domain internet-based adaptive training program, active-control program
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Xuanwu Hospital, Beijing
Basilar Invagination
A Prospective Study of Natural History and Clinical Outcomes for Basilar Invagination
A Prospective Study of Natural History and Clinical Outcomes for Basilar Invagination
- Trial name
- NCT05909540
- Testing
- Posterior facet distraction and fusion
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Brain Death, Electroencephalogram
Research on the Brain Death Determination in China
Purpose China has a population of 1.4 billion and an enormous medical expenditure burden, and Chinese traditional culture has a long history. It takes time to recognize and accept the concept of brain death (BD) as death.
- Conditions
- Brain Death, Electroencephalogram, Evoked Potential, TCD
- Trial name
- RBDDC (NCT05903443)
- Testing
- ancillary tests
- Where
- China
- Volunteers
- 1,974 people
- Sponsor
- Xuanwu Hospital, Beijing
Lumbar Spondylosis, Lumbar Spinal Stenosis
Modified Enhanced Recovery After Oblique Lateral Interbody Fusion Surgery
The goal of this randomized clinical trial is to investigate whether modified enhanced recovery after surgery (ERAS) in oblique lumbar interbody fusion (OLIF) can shorten the postoperative hospital stay among patients with lumbar…
- Conditions
- Lumbar Spondylosis, Lumbar Spinal Stenosis, Lumbar Disc Herniation
- Trial name
- MERAOLIS (NCT05854043)
- Testing
- Modified ERAS protocol, routine protocol
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Ischemic, Intracranial Atherosclerosis
Comparison of Cerebral Artery Pressure Gradient and Cerebral Blood Flow Measured by Arterial Spin Labeling
The goal of this observational study is to explore the ability of intravascular pressure gradients to identify hemodynamic disturbance in patients with intracranial atherosclerotic diseases (ICAS).
- Trial name
- NCT05623943
- Testing
- Endovascular treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Ischemic, Intracranial Atherosclerosis
Diagnostic Accuracy for Hemodynamically ICAS of MR-FFR Comparing With Pressure-wire-based FFR.
The aim of this study was to determine the diagnostic accuracy of MR-FFR to detect functionally significant ICAS comparing with pressure-wire-based FFR.
- Trial name
- NCT05631470
- Testing
- MR screening
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Xuanwu Hospital, Beijing