Clinical trials: sponsored by Xuanwu Hospital, Beijing
Stroke
Clinical Validation of an Artificial Intelligence-Based Scoring System for the Modified Rankin Scale (mRS) in Patients With Stroke
This study aims to validate the clinical performance of an artificial intelligence (AI)-based automatic scoring system for the Modified Rankin Scale (mRS).
- Trial name
- NCT07544927
- Volunteers
- 490 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke
Clinical Validation of an Artificial Intelligence-Based G-FAST Score in Patients With Stroke
This study aims to validate the clinical performance of an artificial intelligence (AI)-based automatic assessment system for the G-FAST score.
- Trial name
- NCT07538492
- Volunteers
- 297 people
- Sponsor
- Xuanwu Hospital, Beijing
CDKL5 Deficiency Disorder
The Association Between Fever and CDKL5 Deficiency Disorder: a Nationwide Survey
The primary objective of this research is to study the effects of fever on seizure activity in patients with CDKL5 deficiency disorder
- Trial name
- NCT06663163
- Testing
- Observation
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease
Transcranial Near-infrared Light Therapy for Mild-Moderate Alzheimer's Disease (NIR4AD)
The goal of this study is to explore the efficacy and safety of Near-infrared light Photobiomodulation in patients with mild-moderate Alzheimer's disease(AD).
- Trial name
- NCT06160908
- Testing
- NirsCure
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy; Seizure, Blood Pressure
Observational Study on Dynamic Changes of Blood Pressure During Post-epileptic Seizure Stage (OCBPS)
This article details a multicenter study on changes of blood pressure and heart rate during post-epileptic seizure stage.
- Trial name
- NCT06790810
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Ischemic, Stroke, Acute
Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke
A phase III, multicentre, prospective, randomised, open-label, blinded-endpoint clinical trial will evaluate two thrombolytic agents for the treatment of acute large vessel occlusion stroke within 4.5 hours from symptoms onset…
- Conditions
- Stroke, Ischemic, Stroke, Acute, Thrombosis, Brain, Drug Effect
- Trial name
- TNK-LVO (NCT06658197)
- Testing
- Tenecteplase, Alteplase
- Where
- China
- Volunteers
- 850 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Drug Resistant
The Safety and Efficacy Evaluation of Everolimus as an Adjunctive Treatment for Focal Refractory Epilepsy
The aim of this study is to evaluate the clinical efficacy of everolimus as an adjunctive therapy for refractory epilepsy. The significance lies in addressing whether the mTOR inhibitor sirolimus has antiepileptic adjunctive…
- Trial name
- NCT07095933
- Testing
- Everolimus
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Xuanwu Hospital, Beijing
RT-QuIC
Plasma a-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Neurodegeneration Disease
Synuclein disease, also known as Synucleinopathies, is a general term for a class of degenerative diseases. It mainly includes Parkinson's disease (PD), Dementia with lewy bodies (DLB), Multiple system atrophy (MSA) and so on.
- Trial name
- NCT07498686
- Where
- 2 sites in China
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation
Sodium Sivelestat With Mechanical Thrombectomy for Acute Stroke: A Pilot Study
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as the standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation, Large Vessel Occlusion, Thrombectomy
- Trial name
- NCT07196605
- Testing
- Sodium Sivelestat
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Spinal Cord Injury, Neuromodulation
Rehabilitation Combining Spatiotemporal Spinal Cord Stimulation and Real-time Triggering Exoskeleton After Spinal Cord Injury
Spinal cord injury (SCI) can be caused by trauma, inflammation, tumors, and other factors, often leading to issues such as impaired leg movement, abnormal sensation, and difficulties with bladder and bowel control.
- Conditions
- Spinal Cord Injury, Neuromodulation, Robot Assisted Gait Training
- Trial name
- SCS-EXS (NCT06881134)
- Testing
- SCS+EXS
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke, Basilar Artery Occlusion
Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours
This study is designed to investigate the efficacy and safety of intravenous tenecteplase before interhospital transfer from a non-endovascular capable center(nECC) to an endovascular capable center (ECC) for thrombectomy in…
- Trial name
- OPTION-2 (NCT07203625)
- Testing
- Tenecteplase thrombolysis
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke
A Multicenter, Retrospective, Observational Cohort Study on Intravenous Thrombolysis Beyond the Time Window for Acute Ischemic Stroke
A multicenter, retrospective, observational cohort study on intravenous thrombolysis beyond the time window for acute ischemic stroke
- Trial name
- TRAILBLAZER (NCT07419997)
- Where
- China
- Volunteers
- 2,600 people
- Sponsor
- Xuanwu Hospital, Beijing
Adjacent Segment Degeneration, Multimodal Rehabilitation
Rehabilitation Exercise Against Complications in High-risk Elderly After Lumbar Fusion(REACH)
This is a prospective, randomized controlled trial aimed at evaluating whether a structured multimodal rehabilitation program can delay or reduce the occurrence of adjacent segment degeneration (ASDeg) in frail elderly patients…
- Conditions
- Adjacent Segment Degeneration, Multimodal Rehabilitation, Lumber Fusion
- Trial name
- NCT07396051
- Testing
- Postoperative Multimodal Rehabilitation Program
- Where
- 3 sites in China
- Volunteers
- 212 people
- Sponsor
- Xuanwu Hospital, Beijing
Chiari Malformation Type I, Tonsillectomy
PFDD Versus PFDRT in Chiari Decompression Surgery
The purpose of this study is to determine whether a posterior fossa decompression and duraplasty with or without tonsil manipulation results in better patient outcomes with fewer complications and improved quality of life in…
- Trial name
- NCT06079125
- Testing
- Posterior fossa decompression with duraplasty, PFDD with tonsillar resection/reduction
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Xuanwu Hospital, Beijing
Memory Functions, Cognition
Test-Retest Reliability of DiaMem
The goal of this observational study is to learn how reliable the DiaMem memory assessment tool is when used repeatedly over a short period.
- Trial name
- NCT07416019
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Ischemic, Cerebral Edema
Early Prophylactic Decompressive Hemicraniectomy Following Endovascular Therapy in Large Hemispheric Infarct Trial
Early Decompressive Hemicraniectomy for High-Risk Large Ischemic Core Stroke Post-EVTAcute Ischemic Stroke (AIS), particularly Anterior Circulation Large Vessel Occlusion (LVO), is a major cause of global disability and death.
- Trial name
- NCT07118345
- Testing
- Early prophylactic decompressive hemicraniectomy
- Where
- 2 sites in China
- Volunteers
- 380 people
- Sponsor
- Xuanwu Hospital, Beijing
Polycystic Ovary Syndrome (PCOS)
Effects of a Specific Dietary Program on Overweight/Obese Women With Polycystic Ovary Syndrome: A Multicenter, Prospective, Randomized Controlled Clinical Study
The goal of this clinical trial is to investigate the effects of a specific dietary program on overweight or obese patients with polycystic ovary syndrome (PCOS) through a multicenter, randomized, controlled, prospective study…
- Trial name
- NCT07350889
- Testing
- Specific dietary intervention group, Conventional intervention
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Xuanwu Hospital, Beijing
Polycystic Ovary Syndrome (PCOS)
Promotion of a Standardized Diagnostic and Treatment Pathway for Polycystic Ovary Syndrome Based on a Bidirectional Referral System
The goal of this clinical trial is to: 1. promote and optimize standardized diagnostic and treatment pathways for polycystic ovary syndrome (PCOS) and to investigate the clinical phenotypic characteristics of PCOS; 2.
- Trial name
- NCT07350876
- Testing
- Standardized Diagnostic and Treatment Pathways for PCOS + Lifestyle Intervention + Prebiotic Supplementation, Standardized Diagnostic and Treatment Pathways for PCOS + Lifestyle Intervention
- Where
- China
- Volunteers
- 227 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Venous Thrombosis
Randomized Trial of Anticoagulation Plus Batroxobin for Acute Cerebral Venous Thrombosis
A total of 72 patients meeting the diagnostic criteria for acute cerebral venous thrombosis were included in this study. A multi-center stratified randomization method was adopted, with the stratification factor being each…
- Trial name
- ABACVT (NCT07352358)
- Testing
- batroxobin, Anticoagulation Agents
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Xuanwu Hospital, Beijing
Paraspinal Muscles, Low Back Pain
Multimodal Exercise Therapy for Non-Surgical Intervention of Nonspecific Low Back Pain.
This multicenter, assessor-blinded, two-arm parallel randomized controlled trial (N = 314) will compare the efficacy and safety of a 6-week multidimensional exercise program plus usual pharmacological care (experimental arm)…
- Conditions
- Paraspinal Muscles, Low Back Pain, Machine Learning, Radiomics
- Trial name
- METNLBP (NCT07353372)
- Testing
- Multidimensional exercise intervention, Oral NSAIDs
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Xuanwu Hospital, Beijing