Clinical trials: sponsored by Xuanwu Hospital, Beijing
Alzheimer Disease, Parkinson Disease
Clinical Applicantion of Multi-Tracer PET/MR Imaging in Neurological Disorders/Disease
The goal of this clinical trial is to learn about the application of domestic PET/MR in major brain diseases. The main questions it aims to answer are: Overcome the bottleneck of early accurate diagnosis and treatment in major…
- Conditions
- Alzheimer Disease, Parkinson Disease, Epilepsy, Malignant Brain Tumor
- Trial name
- CAMIND (NCT06092125)
- Testing
- PET/MR
- Where
- China
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Drug Resistant
Subthalamic Nucleus Electrical Stimulation for Drug-resistant Focal Motor Epilepsy
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of subthalamic nucleus (STN) as adjunctive therapy for reducing the frequency of seizures in drug-resistant focal motor…
- Trial name
- STEM (NCT06248333)
- Testing
- STN-DBS ON, STN-DBS OFF
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Xuanwu Hospital, Beijing
Cervical Disc Herniation, Cervical Spinal Stenosis
Edge Computing Platform for Spine Health Risk Management Based on IoT Technology
This project proposes to monitor the spinal posture of a person at rest and in motion in real time through a sensor device that contains spinal health monitoring as its core.
- Conditions
- Cervical Disc Herniation, Cervical Spinal Stenosis, Ossification of Posterior Longitudinal Ligament, Neckbrace Device
- Trial name
- NCT06092138
- Testing
- Wearable Device
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Venous Thrombosis
Steroid for Treatment of Acute/Subacute Severe Cerebral Venous Thrombosis.
The cohort study aims to evaluate the efficacy and safety of steroids combined with anticoagulant therapy compared to standard anticoagulant therapy in acute/subacute severe cerebral venous thrombosis.
- Trial name
- NCT05990894
- Testing
- Methylprednisolone
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Xuanwu Hospital, Beijing
Exoskeleton Device
A Study of the Safety and Efficacy of Intelligent Powered Exoskeletons in Postoperative Spinal Rehabilitation
Systematic and professional rehabilitation training is generally effective for patients with lower limb dyskinesia, but most of them lose the chance of recovery due to failure to receive systematic rehabilitation treatment.
- Trial name
- NCT06097000
- Testing
- powered exoskeletons
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
Refractory Epilepsy, Consciousness, Loss of
Investigating the Role and Electrophysiological Characteristics of the Human Claustrum Based on SEEG
This single-center prospective study aims to investigate the electrophysiological characteristics and functions of the human claustrum by analyzing clinical, imaging, and electrophysiological data from 14~65-year-old patients…
- Trial name
- NCT06575413
- Testing
- Direct Electrical Stimulation
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Xuanwu Hospital, Beijing
Ferric Carboxymaltose
The Effectiveness of Preoperative Iron Therapy in Improving Anemia After Multi-level Lumbar Fusion in the Elderly
Preoperative iron therapy has important value in improving the outcomes after lumbar fusion surgery, but there is significant heterogeneity in both domestic and international studies.
- Trial name
- PITAMLFE (NCT07057973)
- Testing
- Ferric carboxymaltose
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Nutritional Intervention, Spinal Surgery
Staircase Nutritional Intervention for Elderly Patients Undergoing Spinal Fusion Surgery
The goal of this prospective multicenter randomized controlled clinical trial is to evaluate the efficacy of a staircase nutritional intervention in reducing postoperative complications and improving long-term functional recovery…
- Conditions
- Nutritional Intervention, Spinal Surgery, Elderly, Enhanced Recovery After Surgery
- Trial name
- SNIEPUSFS (NCT07056647)
- Testing
- Staircase Nutritional Intervention, Standard ERAS Diet Management Group
- Volunteers
- 88 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease, Parkinson Disease
hUC-MSC-sEV-001 Nasal Drops for Neurodegenerative Diseases
To evaluate the safety and preliminary efficacy of human umbilical cord mesenchymal stem cell-derived small extracellular vesicles hUC-MSC-sEV-001 nasal drops in multiple neurodegenerative diseases, including Alzheimer's disease…
- Conditions
- Alzheimer Disease, Parkinson Disease, Lewy Body Dementia, Multiple System Atrophy
- Trial name
- NCT06607900
- Testing
- hUC-MSC-sEV-001 nasal drops
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xuanwu Hospital, Beijing
Anti-Vimentin Antibody-associated Diseases, Meningoencephalomyelitis Associated With Vimentin IgG Autoantibodies
Efficacy and Safety of Rituximab in the Treatment of Anti-Vimentin Antibody-associated Diseases
In 2025, a novel meningoencephalomyelitis associated with Vimentin IgG in cerebrospinal fluid (CSF) has been identified. Most patients exhibited progressive or recurrent episodes, characterized by prominent cerebellar ataxia…
- Trial name
- NCT07051070
- Testing
- RTX treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System
Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating Diseases
Non-invasive neurostimulation can effectively improve patients' symptoms and has shown good therapeutic efficacy in alleviating the symptoms of IIDDs (Inflammatory Immune-mediated Demyelinating Diseases).
- Trial name
- NCT06942611
- Testing
- transcranial electrical stimulation treatment.
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
Vascular Cognitive Impairment, White Matter Lesions
Mechanism of Gamma Oscillation Synchronization in the Prefrontal-hippocampal Circuit for Memory Dysfunction in Patients With White Matter Lesions of Cerebral Small Vessel Disease
The mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease is still unclear. The disrupted synchronization of gamma oscillations in the prefrontal-hippocampal circuit is a potential…
- Conditions
- Vascular Cognitive Impairment, White Matter Lesions, Gamma Oscillation
- Trial name
- NCT07042633
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Autoimmune Encephalitis
CPI Combination Therapy for Autoimmune Encephalitis
Corticosteroids, intravenous immunoglobulin (IVIG), and plasma exchange (PE) are the first-line therapies for autoimmune encephalitis (AE) patients, but optimal first-line treatment strategy for different AE patients remains…
- Trial name
- CPI (NCT03542279)
- Testing
- Plasma exchange (PE), intravenous immunmoglobulin (IVIG), intravenous methylprednisolone (IVMP)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xuanwu Hospital, Beijing
Refractory Epilepsy, Sleep
Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG
This study aims to collect electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent SEEG.
- Trial name
- NCT06524479
- Testing
- SEEG recordings and SPES
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Cognitive Therapy/Methods, Insomnia Chronic
Memory Training in Insomnia With Cognitive Impairment
This randomized controlled trial investigates the effects of Cognitive Remediation Therapy (CRT) on chronic insomnia (CI) with mild cognitive impairment.
- Conditions
- Cognitive Therapy/Methods, Insomnia Chronic, Cognitive Dysfunction
- Trial name
- NCT06969066
- Testing
- Cognitive Remediation Therapy plus Sleep Hygiene Education (CRT+SHE), Sleep Hygiene Education Only (SHE)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xuanwu Hospital, Beijing
Mind-Body Therapies, Insomnia Chronic
Ba Duan Jin for CI With Hyperarousal/Anxiety
This randomized controlled trial aims to evaluate the effectiveness of Ba Duan Jin exercise in treating chronic insomnia (CI) with comorbid hyperarousal and anxiety symptoms.
- Trial name
- NCT06969079
- Testing
- Ba Duan Jin Exercise plus Sleep Hygiene Education, Sleep Hygiene Education
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Xuanwu Hospital, Beijing
Chronic Insomnia
Effects of Tai Chi on Chronic Insomnia Disorder Combined With Hyperarousal/Anxiety
This study focuses on individuals with chronic insomnia combined with excessive arousal/anxiety, with the main objective of investigating the effectiveness of Tai Chi in treating CI with excessive arousal/anxiety.
- Trial name
- NCT06967974
- Testing
- Tai Chi + Sleep Hygiene Education, Sleep Hygiene Education
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
Insomnia
The Effect of Standard Cognitive-behavioral Therapy+Transcranial Alternating Current on Refractory Insomnia Disorder
The main purpose of this study is to investigate the efficacy of CBTI + transcranial alternating current (TAC) technology in the treatment of refractory insomnia and the mechanism of 'cognitive-behavioural-brain network'…
- Trial name
- NCT06969040
- Testing
- CBTI + tACS
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Insomnia Disorder
Impact of Analytic-integrative Cognitive Behavioural Therapy on Acute Insomnia Disorder (Stress)
The main objective of this study, conducted in a population with acute insomnia disorder (stress), was to investigate the efficacy of Analytic-Integrative Cognitive Behavioural Therapy in the treatment of acute insomnia disorder…
- Trial name
- NCT06967922
- Testing
- Analytic-Integrative Cognitive Behavioural Therapy, Sleep hygiene education
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xuanwu Hospital, Beijing
Chronic Insomnia, Anxiety Disorders
Effect of MIT for CI With Anxiety
This randomized controlled trial aims to investigate the efficacy of Mindfulness Intervention Therapy (MIT) in treating Chronic Insomnia (CI) comorbid with anxiety symptoms.
- Trial name
- NCT06969053
- Testing
- Mindfulness Intervention Therapy plus Sleep Hygiene Education, Sleep Hygiene Education
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xuanwu Hospital, Beijing