Clinical trials: sponsored by Xuanwu Hospital, Beijing
Radiation-induced Carotid Artery Stenosis
Carotid Revascularization for Radiation Induced Carotid Artery Stenosis
Cervical radiotherapy (RT) has greatly reduced the mortality of patients with malignant head and neck tumors, which, however, causes a higher risk of carotid artery stenosis, namely, radiation-induced carotid artery stenosis…
- Trial name
- CRICS (NCT05134246)
- Testing
- Carotid endarterectomy (CEA), Carotid artery stenting (CAS)
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- Xuanwu Hospital, Beijing
Behavioral Variant Frontotemporal Dementia
The Ketogenic Diet in the Treatment of Behavioral Variant Frontotemporal Dementia
This study is an exploratory clinical research on the use of JT821 (a ketogenic diet formulation) for the treatment of patients with behavioral variant frontotemporal dementia (bvFTD), aiming to evaluate the effectiveness…
- Trial name
- JT821 (NCT06761729)
- Testing
- Ketogenic diet
- Volunteers
- 3 people
- Sponsor
- Xuanwu Hospital, Beijing
Deep Brain Stimulation, Drug Resistant Epilepsy
Evaluating Modulation Effects of Temporal Interference Using SEEG
This single-center prospective study aims to investigate the electrophysiological mechanisms of temporal interference (TI) in humans by analyzing clinical, imaging, and electrophysiological data from patients aged 14-60 with…
- Trial name
- NCT06663969
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Fasting
Fasting Effects on Metabolism and Immunity Study in Human
This study aims to investigate the effects of 1-week fasting but not prohibiting water drink on human immune function, metabolic indicators, and brain function in human, and to explore the underlying mechanisms of these changes…
- Trial name
- NCT06779201
- Testing
- Fasting
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy
Evaluating Modulation Effects of Burst Stimulation Patterns Using SEEG
The study aims to evaluate modulation effects of burst stimulation patterns via SEEG.
- Trial name
- NCT06667232
- Testing
- Single-pulse stimulation, Paired-pulse stimulation, Stepwise frequency stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Tourette Syndrome
Effect of RNS in Treatment-refractory Tourette's Syndrome
The study is to investigate the effect of personalized responsive neurostimulation (RNS) therapy guided by stereoelectroencephalography (SEEG) in patients with treatment-resistant Tourette's Syndrome (TR-TS).
- Trial name
- NCT06785532
- Testing
- Responsive Neurostimulation (RNS)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Obsessive-Compulsive Disorder (OCD)
RNS for Treatment-resistant Obsessive-compulsive Disorder
The purpose of this study is to investigate the effect of personalized responsive neurostimulation (RNS) therapy guided by stereoelectroencephalography (SEEG) in patients with treatment-resistant obsessive-compulsive disorder…
- Trial name
- NCT06782867
- Testing
- Responsive Neurostimulation (RNS)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Spontaneous Intracranial Hemorrhage, Hypertension
Tranexamic Acid with Intensive Blood Pressure Management in Ultra-Early Intracerebral Hemorrhage
This is a prospective, multicenter, randomized, quadruple-blind, placebo-controlled study. This study aims to estimate the safety and efficacy of intravenous tranexamic acid (TXA) combined with intensive blood pressure lowering…
- Trial name
- TIME-ICH (NCT06760078)
- Testing
- intravenous tranexamic acid (TXA) infusion
- Where
- 2 sites in China
- Volunteers
- 532 people
- Sponsor
- Xuanwu Hospital, Beijing
Autoimmune Encephalitis
A Multicentric Cohort of Autoimmune Encephalitis
This study aims to establish an autoimmune encephalitis cohort and observe the prognosis of patients with different subtypes and subgroups (e.g. epilepsy subgroup and teratoma subgroup ).
- Trial name
- NCT06760091
- Testing
- baseline data collection and follow-up
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Neuromyelitis Optica Spectrum Disorders, Myasthenia Gravis, Generalized
Universal CAR-T Cells in Patients with Refractory Autoimmune Diseases of the Nervous System.
This is an open label, single-site, dose-escalation study in up to 25 participants with refractory autoimmune diseases of nervous system.
- Conditions
- Neuromyelitis Optica Spectrum Disorders, Myasthenia Gravis, Generalized, Multiple Sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
- Trial name
- NCT06485232
- Testing
- Universal BCMA CAR-T, Universal CD19 CAR-T, Universal BCMA CAR-T; Universal CD19 CAR-T
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Drug Resistant
Sirolomus Adjuvant Treatment of Focal Refractory Epilepsy (SATFRE)
The aim of this study is to evaluate the clinical efficacy of sirolimus as an adjunctive therapy for refractory epilepsy. The significance lies in addressing whether the mTOR inhibitor sirolimus has antiepileptic adjunctive…
- Trial name
- NCT06719791
- Testing
- Sirolimus
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Xuanwu Hospital, Beijing
Severe Autoimmune Encephalitis
Risk Prediction Model for Severe Autoimmune Encephalitis
A prospective study aims to establish a multicenter clinical diagnosis and treatment database for patients with autoimmune encephalitis (AE).
- Trial name
- NCT06697678
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson's Disease (PD)
Constant Current Versus Constant Voltage Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson's Disease
To compare the efficacy, programming burden, power consumption, and physicians' and patients' satisfaction between current mode and voltage mode of deep brain stimulation in each period one year after surgery.
- Trial name
- NCT06742450
- Testing
- Constant current (CC) subthalamic nucleus deep brain stimulation, Constant voltage (CV) subthalamic nucleus deep brain stimulation
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracranial Atherosclerotic Stenosis (ICAS), Stroke
The New Clinical Registration Trial of Interventional Treatment for Patients with Symptomatic Intracranial Artery Stenosis
Background: Intracranial atherosclerotic stenosis (ICAS) is a major etiology of stroke worldwide, especially in East and South Asia, accounting for up to 50% of all ischemic stroke.
- Trial name
- CRTICAS-2 (NCT06740513)
- Testing
- Endovascular Treatment
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Drug Resistant
Propranolol Adjuvant Treatment of Focal Refractory Epilepsy (PATFRE)
The aim of this study is to evaluate the clinical efficacy of propranolol as an adjunctive treatment for refractory epilepsy. The significance of this research lies in exploring whether propranolol, as an inhibitor of the…
- Trial name
- NCT06719804
- Testing
- Propranolol
- Volunteers
- 15 people
- Sponsor
- Xuanwu Hospital, Beijing
Treatment
The Safety and Efficacy of Single Antiplatelet Therapy After Pipeline Flex with Shield for Intracranial Aneurysms
The objective of this study was to evaluate the safety and efficacy of single antiplatelet therapy after Pipeline flex with Shield stent implantation for intracranial aneurysms.
- Trial name
- NCT06474884
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Xuanwu Hospital, Beijing
Insomnia
Intelligent Diagnosis and Treatment Model for Insomnia Disorder
To establish a multicenter, multi-dimensional cohort on insomnia disorder and to develop an intelligent model for the diagnosis and treatment of insomnia disorder.
- Trial name
- NCT06375447
- Testing
- Routine clinical treatment
- Where
- 5 sites in China
- Volunteers
- 16,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracranial Atherosclerosis
ICAS Screen Based on RIC
Intracranial atherosclerosis stenosis (ICAS) is a leading cause of ischemic stroke worldwide and increase the global burden of stroke, especially in the Asian population.
- Trial name
- RICAS (NCT06610578)
- Testing
- fundus imaging
- Where
- China
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Amyotrophic Lateral Sclerosis
Exploring Nasal Drop Therapy With Small Extracellular Vesicles for ALS
This is a multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial. The goal of this clinical trial is to evaluate the safety and preliminary efficacy of nasal drop exosomes derived from human umbilical…
- Trial name
- de-ALS (NCT06598202)
- Testing
- exosomes derived from human umbilical cord blood mesenchymal stem cells for nasal drop
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Xuanwu Hospital, Beijing
Drug Resistant Epilepsy, Traumatic Brain Injury Without Open Intracranial Wound
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients
In patients with drug-resistant epilepsy (DRE), there may be changes at the genetic, proteomic, and metabolomic levels when comparing epileptic tissues from DRE to normal tissues in traumatic brain injury (TBI).
- Trial name
- NCT06665880
- Testing
- Routine clinical treatment
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Xuanwu Hospital, Beijing