Clinical trials: sponsored by Yale University
Obsessive-Compulsive Disorder (OCD)
Aerobic Exercise and Obsessive-Compulsive Disorder Symptoms
The purpose of this study is to examine the acute effects of exercise on cognitive flexibility and symptom reactivity. The main questions it aims to answer are: Does moderate intensity physical activity reduce subjective…
- Trial name
- NCT07103902
- Testing
- Moderate-Intensity Exercise, Low-Intensity Exercise
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Diabetes, Diabetes Type 2
Glucose, Understanding, Integrated Digital Health, and Engagement (GUIDE) Study
The purpose of this study is to evaluate whether an Integrated Digital Health (IDH) intervention with and without healthcare provider engagement, improves glycemic control and diabetes-related outcomes among adults with Type 2…
- Trial name
- GUIDE (NCT07689877)
- Testing
- Integrated Digital Health (IDH) platform, Provider engagement
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Yale University
Opioid Use, Alcohol Use Disorder
rTMS as Add on Treatment for Substance Use Disorders
This pilot study is designed to test feasibility and superiority of rTMS types and target locations for the optimal rTMS intervention for individuals seeking treatment for Alcohol Use Disorder (AUD) or Opioid Use Disorder (OUD).
- Trial name
- NCT06963476
- Testing
- repetitive transcranial magnetic stimulation (rTMS) for AUD, repetitive transcranial magnetic stimulation (rTMS) for OUD
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Yale University
Suicide, Suicide Prevention
Peer Delivered Youth Suicide Prevention in Nepal
South Asia has the highest suicide rate in the world with important risk profile differences from high-income settings. Investigators will conduct formative research to co-design a package of brief interventions and…
- Trial name
- NCT07680179
- Testing
- Enhanced Usual Care (EUC), Youth-focused, Peer-delivered, Family-engaged Suicide Prevention Package (YPF-SuPP)
- Where
- Nepal
- Volunteers
- 160 people
- Sponsor
- Yale University
Speech, Consolidation
Sensory Basis of Speech Motor Learning
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex…
- Trial name
- NCT04497428
- Testing
- Adaptation, cTBS
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Myasthenia Gravis
The Adapting Disease Specific Outcome Measures Pilot Trial for Telehealth in Myasthenia Gravis
The goal of this pilot study is to determine the reliability of myasthenia gravis (MG) specific outcome measures obtained during virtual encounters with patients with myasthenia gravis.
- Trial name
- ADAPT-teleMG (NCT05917184)
- Testing
- Telehealth
- Where
- 5 sites in United States
- Volunteers
- 52 people
- Sponsor
- Yale University
Speech, Consolidation
Contribution of the Somatosensory System to Speech Perceptual Processing
These studies test the hypothesis that the repeated pairing of somatosensory inputs with speech sounds, such as occurs during speech motor learning, results in changes to the perceptual classification of speech sounds.
- Trial name
- NCT04818021
- Testing
- Perceptual Classification of Speech Sounds, Facial Skin Stretch
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Ischemic Stroke, Blood Pressure Variability
Blood Pressure Variability and Ischemic Stroke Outcome
The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are: 1.
- Trial name
- BP-VISO (NCT05756257)
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Yale University
Depression, Parkinson's Disease (PD)
The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.
- Trial name
- PSI-PD (NCT07610369)
- Testing
- Psilocybin (drug)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Parkinson's Disease, Depression
Long Term Follow Up KET-PD
The purpose of this study is to examine a) the longer-term effects of ketamine for treating depression in Parkinson's disease (PD) and b) the effects of CBT on maintaining the effects of ketamine.
- Trial name
- NCT06164756
- Testing
- Cognitive Behavior Therapy (CBT), Treatment As Usual (TAU)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Yale University
Hiv, Alcohol Drinking
HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)
The focus of this pilot will be on falls and neurocognitive symptoms, and the impact of alcohol, cannabis use, and medications on these outcomes.
- Conditions
- Hiv, Alcohol Drinking, Fall, Cannabis Use
- Trial name
- HARP (NCT06513819)
- Testing
- Information Motivation Behavioral and Motivational Interviewing (IMB-MI) technique
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Triple Negative Breast Cancer
Lifestyle, Exercise, And Nutrition (LEAN) Trial on Pathologic Complete Response in TNBC
The purpose of this study is to examine whether a nutrition and exercise program can improve pathologic complete response (pCR) in women with triple-negative breast cancer (TNBC) receiving chemo-immunotherapy before surgery.
- Trial name
- NCT07066189
- Testing
- Exercise and Medical Nutrition
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Yale University
Opioid Abuse (Disorder), Clinical Decision Support
Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 3
This study is stage 2, round 3 of a larger study which refines and optimizes the EMBED clinical decision support (CDS) to increase number of ED physicians following standard of care for the administration of buprenorphine to…
- Trial name
- NCT07793383
- Testing
- Refined EMBED CDS, Provider alert that nurse completed COWS
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Hypertension
FCHV-HTN Implementation Trial in Nepal
The goal of this hybrid type III study incorporating a cluster-randomized trial is to assess the effect of a community health worker-led hypertension prevention and control program (CHPC) on the implementation outcomes and…
- Trial name
- CHPC (NCT06081010)
- Testing
- Community Health Worker Intervention
- Where
- Nepal
- Volunteers
- 3,572 people
- Sponsor
- Yale University
Familial Alcoholism Vulnerability
Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant
The purpose of this study is to evaluate the role of Mavoglurant in clarifying the neurobiology of alcoholism risk. This is a one-site, randomized, within subjects, counterbalanced double-blind study of a single dose (200mg) of…
- Trial name
- NCT05203965
- Testing
- Mavoglurant (AFQ056)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Psychedelic Microdosing Effects on Mood, Cognition, Subjective Well-being and MRI
Psilocybin Microdosing on Cognition, Mood and Quality of Life
This study is being conducted to evaluate how of 30 days of intermittently microdosed psilocybin affects mood, cognition, subjective well-being and structural/functional MRI results compared to a placebo.
- Trial name
- NCT07449351
- Testing
- Psliocybin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Cubital Tunnel Syndrome
Posture Correction in Cubital Tunnel Syndrome
The primary objective of this study is to determine whether the UpRight Go posture trainer reduces the symptoms of cubital tunnel syndrome in patients who have not had corrective surgery, as determined by improvements in VAS…
- Trial name
- NCT06095011
- Testing
- UpRight Go
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Yale University
Neuraxial Technique
Accuracy of the Accuro 3S
The main purpose of this study is to evaluate the feasibility and accuracy of the Accuro 3S to provide live guidance when performing a neuraxial technique (e.g., spinal, or epidural).
- Trial name
- NCT07458087
- Testing
- ACCURO 3S
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV Prevention, PrEP Awareness
Leveraging Chatbot to Improve PrEP in the Southern United States
The purpose of this study is to develop a chatbot intervention to promote PrEP awareness and uptake among Black men who have sex with men (MSM) in the Southern United States.
- Conditions
- HIV Prevention, PrEP Awareness, PrEP Uptake
- Trial name
- NCT05968755
- Testing
- A chatbot designed to promote PrEP awareness and uptake for Black MSM, General educational messages
- Where
- 4 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Yale University
Labor Analgesia
The Impact of Needle Manipulation and Accuracy Between Hand Held Automatic and Traditional Ultrasound Device
In this double blinded randomized controlled trial, the investigators would like to compare the effects on needle manipulation when relatively inexperienced sonographist (< 1 year of ultrasound experience) perform ultrasound…
- Trial name
- NCT05909085
- Testing
- Traditional ultrasound, Automated ultrasound
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale University