Clinical trials: sponsored by Zealand University Hospital
Alcohol Use Disorder
The Connect Trial: Connecting Hospital Patients to Alcohol Care
The main objective of this pilot study is to assess feasibility of conducting a definitive RCT with concealed allocation, blinded outcome assessment and a 1:1 parallel group design of A) an invitation to meet an AUD therapist for…
- Trial name
- NCT07482150
- Testing
- AUD treatment sessions with an outreach alcohol therapist at the hospital, Guidance and leaflet on AUD treatment facilities outside the hospital
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Zealand University Hospital
Hip Arthroplasty, Knee Arthroplasty
Anaesthesia for Hip and Knee Arthroplasty (SPIGA)
Beneficial and harmful effects of spinal versus general anaesthesia in patients undergoing hip and knee arthroplasty.
- Conditions
- Hip Arthroplasty, Knee Arthroplasty, Spinal Anesthesia, General Anesthesia
- Trial name
- SPIGA (NCT07834242)
- Testing
- Spinal anaesthesia, General anaesthesia
- Volunteers
- 3,000 people
- Sponsor
- Zealand University Hospital
Large B-Cell Lymphoma (LBCL), Multiple Myeloma (MM)
Restrictive Versus Standard Antibiotic Treatment During CAR-T Therapy
The purpose of the CARMic study is to investigate whether a restrictive, microbiome-sparing antibiotic strategy can better preserve the gut microbiota in patients undergoing chimeric antigen receptor T-cell (CAR-T) therapy…
- Conditions
- Large B-Cell Lymphoma (LBCL), Multiple Myeloma (MM), Gut Microbiota
- Trial name
- CARMic (NCT07842198)
- Testing
- ceftazidime, ciprofloxacin, Standard-of-Care Antibiotic Strategy
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Zealand University Hospital
Undernutrition, Renal Insufficiency, Chronic
Prevalence of Protein-energy Wasting and Obesity Among Danish Dialysis Patients
The purpose of this study is to determine the prevalence of protein-energy wasting and obesity among Danish dialysis patients.
- Conditions
- Undernutrition, Renal Insufficiency, Chronic, Obesity
- Trial name
- NCT02320552
- Testing
- No intervention
- Volunteers
- 105 people
- Sponsor
- Zealand University Hospital
Hearing Aid, Telehealth
Effectiveness and Acceptability of Remote Fine-Tuning of Hearing Aids in Danish Adults
The aim of this clinical trial is to evaluate the effectiveness and user satisfaction of remote fine-tuning of hearing aids compared to traditional face-to-face adjustments.
- Conditions
- Hearing Aid, Telehealth, Hearing Aid Fitting, Effectiveness
- Trial name
- EARFit (NCT06992778)
- Testing
- Remote fine-tuning of hearing aids, Face-to-face fine-tuning of hearing aids
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Zealand University Hospital
Colo-rectal Cancer
The AIDPRO-CRC Trial
The AIDPRO-CRC trial aims to improve outcomes for patients undergoing surgery for colorectal cancer by using artificial intelligence (AI) to assist surgeons in risk assessment.
- Trial name
- AIDPRO-CRC (NCT06645015)
- Testing
- AI augmented risk-stratification, Expert-based Risk-stratification
- Where
- 8 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Zealand University Hospital
Healthy
GLP-1's Effect on Cardiac Parameters and Mesenteric Blood Flow
to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters
- Trial name
- NCT01988545
- Testing
- 1,5 nmol/kg,GLP-1 sc injection, 1,5 nmol/kg GLP-1 9-36amide, sc injection, Exendin-4 ;10 ug,sc injection
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Type 2 Diabetes, Obstructive Sleep Apnea (OSA)
Screening for Obstructive Sleep Apnea in High-risk Patients in a Danish Rural Population: A Pilot Feasibility Study
Background: Obstructive sleep apnea (OSA) is a sleep disorder characterized by recurrent collapse of the upper airway during sleep, resulting in intermittent hypoxia and fragmented sleep.
- Trial name
- NCT07778121
- Testing
- Home Sleep Apnea Test
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Hemodialysis
Prophylactic Antibiotic Treatment in Hemodialysis
The purpose of this study is to assess the efficacy of prophylactic antibiotic treatment on blood stream infections and severe culture negative infections, in patients on newly started hemodialysis(HD), with a central venous…
- Trial name
- PANTHEM (NCT05248620)
- Where
- 7 sites in Denmark
- Volunteers
- 800 people
- Sponsor
- Zealand University Hospital
Hematologic Cancer, Acute Myeloid Leukaemia (AML)
Home-based Intravenous Cytarabine Treatment for Acute Myeloid Leukemia: a National Danish Study of Feasibility, Costs, and Implementation
The goal of this observational multicenter feasibility and implementation study is to evaluate home-based treatment with intravenous Cytarabine for patients with acute myeloid leukemia in Denmark.
- Conditions
- Hematologic Cancer, Acute Myeloid Leukaemia (AML), Hospital At Home, Home-based Chemotherapy
- Trial name
- HOME-CALM (NCT07802015)
- Volunteers
- 80 people
- Sponsor
- Zealand University Hospital
Dementia (Diagnosis), Alzheimer Dementia (AD)
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)
The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic.
- Conditions
- Dementia (Diagnosis), Alzheimer Dementia (AD), Vascular Dementia (VaD), Lewy Body Dementia (LBD)
- Trial name
- DetectAI (NCT07200739)
- Testing
- Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description
- Where
- Denmark
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Upper Gastrointestinal Disorder
Endoscopists' Perspectives on the Use of Single-Use Gastroscopes in Elective and Subacute Patients in the Endoscopy Unit
The aim of this clinical trial is to investigate whether single-use gastroscopes perform comparably to reusable gastroscopes when used in an endoscopy unit during a period of reduced endoscope reprocessing capacity.
- Trial name
- NCT07727226
- Testing
- Ambu aScope Gastro, Reusable diagnostic gastroscopes (Olympus)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Zealand University Hospital
Upper Gastrointestinal Disorder
Performance Characteristics and Technical Outcomes of Single-use Gastroscopes Used Bedside Versus Reusable Gastroscopes Used in the Endoscopy Unit Evaluated in Subacute Patients
The aim of this study is to investigate whether single-use gastroscopes used bedside can reduce the time from indication to procedure compared with re-usable gastroscopes used at the endoscopy unit in patients referred to a…
- Trial name
- NCT06771102
- Testing
- Ambu aScope Gastro, Diagnostic gastroscopes, Olympus
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Zealand University Hospital
Pleural Diseases, Pneumothorax Spontaneous Primary
Evaluating the Use of an App in Pleural Disease: Algorithm-supported Clinical Decision Making Versus Usual Care
Pleural disease is a group of conditions that affect the membrane around the lungs. These conditions-fluid around the lungs, infections, cancer, and collapsed lung-are common and can cause serious illness.
- Conditions
- Pleural Diseases, Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary, Pleural Effusion
- Trial name
- APPLAUS (NCT07625176)
- Testing
- Clinical decision-making support tool, Usual care
- Where
- 10 sites in Denmark
- Volunteers
- 828 people
- Sponsor
- Zealand University Hospital
Alzheimer's Disease
Study on the Effect of 40 Hz Non-Invasive Light Therapy System
The ALZLIGHT STAGE III Study is a continuation of the ALZLIGHT Pilot - Study on Safety, Feasibility and Neural Activation of Non-Invasive Light Therapy System.
- Trial name
- NCT05260177
- Testing
- Light Therapy System (LTS): Active Setting
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- Zealand University Hospital
Anesthesia, Continuous Glucose Monitoring
Metabolic Control in Anesthesia and Surgery
The goal of this observational study is to investigate how a standard dose of the drug dexamethasone affects blood sugar levels during and after non-cardiac surgery in adult patients.
- Conditions
- Anesthesia, Continuous Glucose Monitoring, Hyperglycemia Steroid-induced, Hyperglycemia Stress
- Trial name
- MACS (NCT07573930)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Non-Small Cell Lung Cancer, Chronic Obstructive Lung Disease
Singing Training vs Usual Care 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC)
People who have undergone curative surgery for non-small cell lung cancer (NSCLC) often experience reduced quality of life (QoL), a high burden of symptoms, and physical deconditioning.
- Trial name
- Sing-a-Lung 2 (NCT07460999)
- Testing
- Singing training (Singing for Lung Health (SLH)), Control group: Usual care
- Where
- 5 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Diabetic Foot Ulcer, Diabetes
Inforatio Technique to Promote Wound Healing of Diabetic Foot Ulcers
This randomized clinical trial will examine the effect of inforatio technique on healing of diabetic foot ulcers (DFUs). Inforatio technique is a novel procedure developed by the research group.
- Conditions
- Diabetic Foot Ulcer, Diabetes, Foot Ulcer, Diabetic Foot
- Trial name
- NCT05189470
- Testing
- Inforatio technique, Usual care of the respective outpatient clinics
- Where
- 4 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Cancer Rehabilitation, Cancer
Digitizing Cancer Rehabilitation During and After Systemic Treatment: Feasibility Testing Implementation in South Baltic Countries
Background With increasing cancer incidence and advanced cancer treatment, the growing population of cancer survivors increases the demand on health resources worldwide.
- Trial name
- AMBeR eRehab (NCT06768918)
- Testing
- remote physical rehabilitation
- Where
- 5 sites in Denmark, Germany and 3 more
- Volunteers
- 300 people
- Sponsor
- Zealand University Hospital
Liver Metastases From Colorectal Cancer
Sonoporation and Tumor Microenvironment Response in Colorectal Liver Metastases
This study is an investigator-initiated, randomized controlled trial enrolling patients with colorectal liver metastases. The objectives are to evaluate the safety and efficacy of contrast-enhanced ultrasound (CEUS)-mediated…
- Trial name
- CEUSON (NCT07365527)
- Testing
- Low-intensity contrast enhanced ultrasound, High-intensity contrast enhanced ultrasound
- Where
- 2 sites in Denmark
- Volunteers
- 48 people
- Sponsor
- Zealand University Hospital