Clinical trials: sponsored by Zhejiang University
Cancer Pain
Development of a Cloud-Based PRO (Patient-Reported Outcome) Management Program for Home-Based Cancer Pain Care
This study aims to develop and pilot a cloud-based Patient-Reported Outcomes (PROs) management program for home-based cancer pain patients within a hospital setting.
- Trial name
- NCT07308223
- Testing
- Proactive monitoring and patient education
- Where
- China
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Procedural Pain
Effect of Bagua Auriculotherapy on Pain in Patients Undergoing Hysteroscopy
To investigate the application of Bagua ear therapy as an adjunctive intervention for perioperative pain management in patients undergoing hysteroscopic surgery, to analyze its effects on intraoperative and postoperative pain…
- Trial name
- NCT07512791
- Testing
- Paracervical block anesthesia, Bagua Auriculotherapy
- Where
- China
- Volunteers
- 132 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Gastric Cancer
18F-FAPI PET/CT and MRI in Gastric Cancer
The purpose of this study was to evaluate the diagnostic efficacy and prognostic value of 18F-FAPI PET/CT combined with multiparameter MRI in gastric cancer.
- Trial name
- NCT07510867
- Testing
- patients with suspected or confirmed gastric cancer who have undergone 18F-FAPI PET/CT and MRI (non-contrast + contrast-enhanced scans)
- Where
- China
- Volunteers
- 230 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Glioblastoma (GBM)
Prophylactic Regimen With Intrathecal Thiotepa in SVZ-positive or Meningeal-risk Glioblastoma
The goal of this clinical trial is to test whether adding preventive intrathecal chemotherapy (thiotepa) to the standard Stupp regimen can lower the risk of leptomeningeal metastasis (LM) and extend survival in patients with…
- Trial name
- PRISM (NCT07511725)
- Testing
- Maximal surgical resection, Concomitant Chemoradiotherapy (Stupp backbone), Preventive Intrathecal Thiotepa
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Upper Limb Function
A Functional Near- Infrared Spectroscopy Study on the Brain Activation Characteristics of Stroke Patients During Mirror Movement
After the selected patients are determined, the researchers of this study need to have full communication with the patients. The location is the rehabilitation ward of our hospital and the time is Before joining the group.
- Trial name
- NCT07509944
- Testing
- mirror image, healthy hand movement
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Autoimmune Diseases, Systemic Lupus Erthematosus (SLE)
Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease
This is an exploratory, open-label, single-arm Phase 1 clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of QT-219C.
- Conditions
- Autoimmune Diseases, Systemic Lupus Erthematosus (SLE), Multi-Drug Resistant Nephrotic Syndrome, IgA Nephropathy (IgAN)
- Trial name
- NCT07507201
- Testing
- UCAR T-cell
- Where
- China
- Volunteers
- 15 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Urethral Stricture
A Comparative Study of the Antibacterial Effects of Two Preoperative Hair Removal Methods in Male Patients With Urethral Stricture
Male urethral stricture is one of the common diseases in urology, with risk factors including a history of hypospadias surgery, indwelling urinary catheterization or instrumental manipulation, trauma, transurethral surgery, and…
- Trial name
- NCT07508566
- Testing
- Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG).
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Disability
A Digitally-Enabled System for Precision Assessment and Intervention of Disability Risk in Older Adults
1. Identify the primary risk factors for disability in older adults through multi-dimensional risk factor screening. 2. Develop a risk stratification model for disability in older adults by integrating outcome indicators and…
- Trial name
- NCT07508813
- Testing
- Risk Assessment of Disability and Precision Intervention
- Where
- China
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer Disease (AD), Alzheimer Dementia
Efficacy of Lecanemab at Different Therapeutic Doses for Alzheimer's Disease (AD) in Real-World Practice
This study will analyze the clinical indicators, imaging data, and serum biomarkers of Alzheimer's disease (AD) patients receiving different doses of the medication before and after treatment.
- Conditions
- Alzheimer Disease (AD), Alzheimer Dementia, MCI-AD, Early Stage Alzheimer's Disease
- Trial name
- NCT07505095
- Testing
- Lecanemab 10 mg/kg, Lecanemab 5-10mg/kg
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Myeloid Leukemia (AML)
Efficacy and Safety of Lisafotoclax Plus Decitabine and Homoharringtonine in Venetoclax/Azacitidine Pretreated AML Patients
This is a multi-center, prospective, single-arm, phase 2 clinical study conducted in China to evaluate the efficacy and safety of Lisafotoclax combined with Decitabine and Homoharringtonine in patients with acute myeloid leukemia…
- Trial name
- NCT07505160
- Testing
- Lisafotoclax, Decitabine, Homoharringtonine
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Light Chain Cardiac Amyloidosis
CAR-NK Therapy for Cardiac Amyloidosis
Relapsed/refractory (R/R) light chain cardiac amyloidosis is associated with a poor prognosis, and cellular immunotherapy constitutes a crucial therapeutic modality for these patients.
- Trial name
- NCT07504289
- Testing
- CAR-NK
- Volunteers
- 36 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Small Vessel Cerebrovascular Disease
Small Vessel Disease and Cerebral Infarct Healing InErvation Via Limb Distant Adaptation
Cerebral infarction (ischemic stroke) and cerebral small vessel disease (CSVD) represent major global causes of disability, cognitive decline, and mortality.
- Trial name
- SHIELD (NCT07503301)
- Testing
- Medical-grade ischemic preconditioning training instrument, Standard Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Congenital Heart Disease, Postoperative Pulmonary Complications
Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery
Cardiopulmonary bypass-associated pulmonary injury is a common complication after infant cardiac surgery and may contribute to impaired oxygenation, prolonged mechanical ventilation, and longer intensive care stay.
- Conditions
- Congenital Heart Disease, Postoperative Pulmonary Complications, Acute Lung Injury
- Trial name
- PLICS (NCT07499154)
- Testing
- Lidocaine %2 ampoule, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Sarcoma
Preoperative Spatially Fractionated Radiation Therapy (SFRT) in Soft Tissue Sarcoma (neoSFRT-SARC)
The goal of this prospective, single-arm, phase II trial is to evaluate whether a preoperative regimen combining spatially fractionated radiation therapy (SFRT) with subsequent surgery can improve outcomes in patients with large…
- Trial name
- neoSFRT-SARC (NCT07501026)
- Testing
- SFRT
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Primary Monosymptomatic Nocturnal Enuresis, Copeptin
Serum Copeptin as Biomarker for Diagnosis and Classification of Polyuric Primary Monosymptomatic Nocturnal Enuresis
Primary monosymptomatic nocturnal enuresis (PMNE) is one of the most common urinary system problems in childhood. The exact pathological mechanism has not been fully elucidated yet, but excessive nocturnal urination is considered…
- Trial name
- NCT07496541
- Testing
- copeptin levels in NP-PMNE, Testing the level of copeptin in patients with NNP-PMNE, Testing the level of copeptin in healthy children
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Colorectal Carcinoma, Oligometastases
SCRT-CAPEOX-Serplulimab for MSS/pMMR Rectal Cancer With Oligometastases
Background and Significance: Colorectal cancer (CRC) ranks as the third most common cancer and the second leading cause of cancer-related deaths globally.
- Conditions
- Colorectal Carcinoma, Oligometastases, pMMR, MSS
- Trial name
- NCT06850103
- Testing
- short-course radiotherapy, CAPEOX/XELOX, Serplulimab
- Where
- China
- Volunteers
- 51 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Ovarian Cancer, Fallopian Tube Cancers
Benmelstobart in Combination With Anlotinib and Oral Metronomic Cyclophosphamide in the Treatment of Recurrent Epithelial OvariaN, Fallopian Tube, or Primary Peritoneal Cancer
Efficacy and safety of Benmelstobart combined with Anlotinib and oral metronomic Cyclophosphamide in the treatment of recurrent epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer (BACON study) in China
- Conditions
- Ovarian Cancer, Fallopian Tube Cancers, Primary Peritoneal Cancer
- Trial name
- BACON (NCT07489300)
- Testing
- Benmelstobart in combination with Anlotinib and oral metronomic Cyclophosphamide
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
T2DM, MAFLD
The Effect of Alogliptin Combined With Actoplus Met on Glucose and Lipid Metabolism and Pancreatic Function in Patients With T2DM Complicated With MAFLD
To compare the efficacy and safety of the combination of alogliptin and actoplus met with that of actoplus met alone in improving the glucose and lipid metabolism and pancreatic function in T2DM patients complicated with MAFLD.
- Trial name
- NCT07289750
- Testing
- alogliptin and actoplus met, actoplus met
- Volunteers
- 80 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Erythematotelangiectatic Rosacea
The Efficacy and Safety of Anti-inflammation Treatment (Hirudoid Introduction Followed by Yellow Light Therapy) Combined With Tofacitinib and Doxycycline in Chinese Adult Patients With Mild to Moderate Erythematous Telangiectatic Rosacea
The efficacy and safety of anti-inflammation treatment (Hirudoid introduction followed by yellow light therapy) combined with tofacitinib and doxycycline in Chinese adult patients with mild to moderate erythematous telangiectatic…
- Trial name
- NCT07343635
- Testing
- Doxycycline, Hydroxychloroquine, Tofacitinib
- Where
- China
- Volunteers
- 186 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Rheumatic Diseases, Pediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese)
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19/BCMA CAR-NK cell injection in patients with refractory pediatric rheumatic diseases.
- Conditions
- Rheumatic Diseases, Pediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese), Systemic Lupus Erythematosus (SLE), Connective Tissue Disease-associated Interstitial Lung Disease
- Trial name
- Cell therapy (NCT07490041)
- Testing
- KN5601
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
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